{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:40:15Z","timestamp":1685029215276},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T00:00:00Z","timestamp":1244073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"},{"start":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T00:00:00Z","timestamp":1244073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/2.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Informatik Spektrum"],"published-print":{"date-parts":[[2009,8]]},"DOI":"10.1007\/s00287-009-0352-7","type":"journal-article","created":{"date-parts":[[2009,6,5]],"date-time":"2009-06-05T23:39:10Z","timestamp":1244245150000},"page":"320-331","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatische Unterst\u00fctzung der Auswahl von HIV-Therapien"],"prefix":"10.1007","volume":"32","author":[{"given":"Thomas","family":"Lengauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Altmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Thielen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,4]]},"reference":[{"issue":"7","key":"352_CR1","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1086\/597305","volume":"199","author":"A Altmann","year":"2009","unstructured":"Altmann A, D\u00e4umer M, Beerenwinkel N, Peres Y, Sch\u00fclter E, Buch J, Rhee SY, S\u00f6nnerborg A, Fessel WJ, Shafer RW, Zazzi M, Kaiser R, Lengauer T (2009) Predicting the response to combination antiretroviral therapy: Retrospective validation of geno2pheno-THEO on a large clinical database. J Infect Dis 199(7):999\u20131006","journal-title":"J Infect Dis"},{"issue":"12","key":"352_CR2","doi-asserted-by":"publisher","first-page":"8271","DOI":"10.1073\/pnas.112177799","volume":"99","author":"N Beerenwinkel","year":"2002","unstructured":"Beerenwinkel N, Schmidt B, Walter H, Kaiser R, Lengauer T, Hoffmann D, Korn K, Selbig J (2002) Diversity and complexity of HIV-1 drug resistance: a bioinformatics approach to predicting phenotype from genotype. Proc Natl Acad Sci USA 99(12):8271\u20138276","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"352_CR3","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1093\/nar\/gkg575","volume":"31","author":"N Beerenwinkel","year":"2003","unstructured":"Beerenwinkel N, D\u00e4umer M, Oette M, Korn K, Hoffmann D, Kaiser R, Lengauer T, Selbig J, Walter H (2003) Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes. Nucleic Acids Res 31(13):3850\u20133855","journal-title":"Nucleic Acids Res"},{"issue":"21","key":"352_CR4","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1093\/bioinformatics\/bti654","volume":"21","author":"N Beerenwinkel","year":"2005","unstructured":"Beerenwinkel N, Sing T, Lengauer T, Rahnenf\u00fchrer J, Roomp K, Savenkov I, Fischer R, Hoffmann D, Selbig J, Korn K, Walter H, Berg T, Braun P, F\u00e4tkenheuer G, Oette M, Rockstroh J, Kupfer B, Kaiser R, D\u00e4umer M (2005) Computational methods for the design of effective therapies against drug resistant HIV strains. Bioinformatics 21(21):3943\u20133950","journal-title":"Bioinformatics"},{"issue":"11","key":"352_CR5","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1086\/430005","volume":"191","author":"N Beerenwinkel","year":"2005","unstructured":"Beerenwinkel N, D\u00e4umer M, Sing T, Rahnenf\u00fchrer J, Lengauer T, Selbig J, Hoffmann D, Kaiser R (2005) Estimating HIV evolutionary pathways and the genetic barrier to drug resistance. J Infect Dis 191(11):1953\u20131960","journal-title":"J Infect Dis"},{"issue":"6","key":"352_CR6","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1089\/cmb.2005.12.584","volume":"12","author":"N Beerenwinkel","year":"2005","unstructured":"Beerenwinkel N, Rahnenf\u00fchrer J, D\u00e4umer M, Hoffmann D, Kaiser R, Selbig J, Lengauer T (2005) Learning multiple evolutionary pathways from cross-sectional data. J Comput Biol 12(6):584\u2013598","journal-title":"J Comput Biol"},{"key":"352_CR7","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1145\/1390156.1390164","volume-title":"25th International Conference on Machine Learning (ICML 2008)","author":"S Bickel","year":"2008","unstructured":"Bickel S, Bogojeska J, Lengauer T, Scheffer T (2008) Multi-task learning for HIV therapy screening. In: McCallum A, Roweis S (eds) 25th International Conference on Machine Learning (ICML 2008). Omnipress, Helsinki, pp 56\u201363"},{"issue":"1","key":"352_CR8","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1010933404324","volume":"45","author":"L Breiman","year":"2001","unstructured":"Breiman L (2001) Random forests. Mach Learn 45(1):5\u201332","journal-title":"Mach Learn"},{"issue":"1","key":"352_CR9","first-page":"62","volume":"16","author":"VA Johnson","year":"2008","unstructured":"Johnson VA, Brun-Vezinet F, Clotet B, Gunthard HF, Kuritzkes DR, Pillay D, Schapiro JM, Richman DD (2008) Update of the drug resistance mutations in HIV-1: Spring 2008. Top HIV Med 16(1):62\u201368","journal-title":"Top HIV Med"},{"issue":"10","key":"352_CR10","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrmicro1477","volume":"4","author":"T Lengauer","year":"2006","unstructured":"Lengauer T, Sing T (2006) Bioinformatics-assisted anti-HIV therapy. Nat Rev Microbiol 4(10):790\u2013797","journal-title":"Nat Rev Microbiol"},{"key":"352_CR11","volume-title":"Molekulare Virologie","author":"S Modrow","year":"2003","unstructured":"Modrow S, Falke D, Truyen U (2003) Molekulare Virologie, 2. Aufl. Spektrum Akademischer Verlag, Heidelberg Berlin","edition":"2"},{"issue":"1","key":"352_CR12","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1093\/nar\/gkg100","volume":"31","author":"SY Rhee","year":"2003","unstructured":"Rhee SY, Gonzales MJ, Kantor R, Betts BJ, Ravela J, Shafer RW (2003) Human immunodeficiency virus reverse transcriptase and protease sequence database. Nucleic Acids Res 31(1):298\u2013303","journal-title":"Nucleic Acids Res"},{"key":"352_CR13","volume-title":"Third International Workshop on Data Integration in the Life Sciences (DILS 2006)","author":"K Roomp","year":"2006","unstructured":"Roomp K, Beerenwinkel N, Sing T, Sch\u00fclter E, B\u00fcch J, Sierra-Aragon S, D\u00e4umer M, Hoffmann D, Kaiser R, Lengauer T, Selbig J (2006) Arevir: A secure platfrom for designing personalized antiretroviral therapies against HIV. In: Third International Workshop on Data Integration in the Life Sciences (DILS 2006). Springer, Hinxton"},{"issue":"13","key":"352_CR14","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/bioinformatics\/btn141","volume":"24","author":"M Rosen-Zvi","year":"2008","unstructured":"Rosen-Zvi M, Altmann A, Prosperi M, Aharoni E, Neuvirth H, S\u00f6nnerborg A, Sch\u00fclter E, Struck D, Peres Y, Incardona F, Kaiser R, Zazzi M, Lengauer T (2008) Selecting anti-HIV therapies based on a variety of genomic and clinical factors. Bioinformatics 24(13):399\u2013406","journal-title":"Bioinformatics"},{"issue":"3","key":"352_CR15","doi-asserted-by":"publisher","first-page":"e58","DOI":"10.1371\/journal.pcbi.0030058","volume":"3","author":"O Sander","year":"2007","unstructured":"Sander O, Sing T, Sommer I, Low AJ, Cheung PK, Harrigan PR, Lengauer T, Domingues FS (2007) Structural descriptors of gp120 V3 loop for the prediction of HIV-1 coreceptor usage. PLoS Comput Biol 3(3):e58","journal-title":"PLoS Comput Biol"},{"key":"352_CR16","first-page":"43","volume-title":"Antiretroviral resistance in clinical practice","author":"T Sing","year":"2006","unstructured":"Sing T, D\u00e4umer M (2006) Interpretation algorihms. In: Geretti M (ed) Antiretroviral resistance in clinical practice. Medscript, London, pp 43\u201356"},{"issue":"7","key":"352_CR17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1177\/135965350701200709","volume":"12","author":"T Sing","year":"2007","unstructured":"Sing T, Low AJ, Beerenwinkel N, Sander O, Cheung PK, Domingues FS, B\u00fcch J, D\u00e4umer M, Kaiser D, Lengauer T, Harrigan PR (2007) Predicting HIV coreceptor usage on the basis of genetic and clinical covariates. Antiviral Therapy 12(7):1097\u20131106","journal-title":"Antiviral Therapy"},{"issue":"14","key":"352_CR18","doi-asserted-by":"publisher","first-page":"7186","DOI":"10.1128\/JVI.02084-05","volume":"80","author":"V Svicher","year":"2006","unstructured":"Svicher V, Sing T, Santoro MM, Forbici F, Rodriguez-Barrios F, Bertoli A, Beerenwinkel N, Bellocchi MC, Gago F, d\u2019Arminio Monforte A, Antinori A, Lengauer T, Ceccherini-Silberstein F, Perno CF (2006) Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors. J Virol 80(14):7186\u20137198","journal-title":"J Virol"},{"issue":"1\u20132","key":"352_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1386-6532(99)00010-4","volume":"13","author":"H Walter","year":"1999","unstructured":"Walter H, Schmidt B, Korn K, Vandamme AM, Harrer T, \u00dcberla K (1999) Rapid, phenotypic HIV-1 drug sensitivity assay for protease and reverse transcriptase inhibitors. J Clin Virol 13(1\u20132):71\u201380","journal-title":"J Clin Virol"},{"issue":"11","key":"352_CR20","doi-asserted-by":"publisher","first-page":"3478","DOI":"10.1128\/AAC.47.11.3478-3484.2003","volume":"47","author":"K Wolf","year":"2003","unstructured":"Wolf K, Walter H, Beerenwinkel N, Keulen W, Kaiser R, Hoffmann D, Lengauer T, Selbig J, Vandamme AM, Korn K, Schmidt B (2003) Tenofovir resistance and resensitization. Antimicrob Agents Chemother 47(11):3478\u20133484","journal-title":"Antimicrob Agents Chemother"},{"key":"352_CR21","unstructured":"http:\/\/www.euresist.org, letzter Aufruf: 18.5.2009"},{"key":"352_CR22","unstructured":"http:\/\/www.genafor.de, letzter Aufruf: 18.5.2009"},{"key":"352_CR23","unstructured":"http:\/\/www.geno2pheno.org, letzter Aufruf: 18.5.2009"}],"container-title":["Informatik-Spektrum"],"original-title":[],"language":"de","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00287-009-0352-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00287-009-0352-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00287-009-0352-7.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00287-009-0352-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T14:58:12Z","timestamp":1685026692000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00287-009-0352-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,8]]}},"alternative-id":["352"],"URL":"https:\/\/doi.org\/10.1007\/s00287-009-0352-7","relation":{},"ISSN":["0170-6012","1432-122X"],"issn-type":[{"value":"0170-6012","type":"print"},{"value":"1432-122X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6,4]]},"assertion":[{"value":"4 June 2009","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}