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Depending on the extent and severity of the valvular disease, replacement operations are often required to ensure that the heart continues to operate properly in the cardiac system. Transcatheter aortic valve replacement (TAVR) procedures have recently emerged as a promising alternative to surgical replacement approaches because the percutaneous methods used in these implant operations are significantly less invasive than open heart surgery. Despite the advantages of transcatheter devices, the precise deployment, proper valve sizing, and stable anchoring required to securely place these valves in the aorta remain challenging even in successful TAVR procedures. This work proposes a parametric modeling approach for transcatheter heart valves (THVs) that enables flexible valvular development and sizing to effectively generate existing and novel valve designs. This study showcases two THV configurations that are analyzed using an immersogeometric fluid\u2013structure interaction (IMGA FSI) framework to demonstrate the influence of geometric changes on THV performance. The proposed modeling framework illustrates the impact of these features on THV behavior and indicates the effectiveness of parametric modeling approaches for enhancing THV performance and efficacy in the future.<\/jats:p>","DOI":"10.1007\/s00366-024-01973-5","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T16:19:44Z","timestamp":1719505184000},"page":"3405-3427","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Parameterization, algorithmic modeling, and fluid\u2013structure interaction analysis for generative design of transcatheter aortic valves"],"prefix":"10.1007","volume":"40","author":[{"given":"Xianyu George","family":"Pan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashton M.","family":"Corpuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoj R.","family":"Rajanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2657-9906","authenticated-orcid":false,"given":"Emily L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"1973_CR1","doi-asserted-by":"crossref","unstructured":"Stewart B, Siscovick D, Lind BK, Gardin JM, Gottdiener JS, Smith VE, Kitzman DW, Otto CM, and null null (1997) Clinical factors associated with calcific aortic valve disease fn1. 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