{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:14:50Z","timestamp":1780064090195,"version":"3.54.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Engineering with Computers"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s00366-025-02268-z","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T01:49:57Z","timestamp":1775008197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Optimization in latent space for real-time intraoperative characterization of digital twins"],"prefix":"10.1007","volume":"42","author":[{"given":"Sidaty","family":"El Hadramy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belkacem","family":"Acidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Padoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Cotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"issue":"5","key":"2268_CR1","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1109\/TMECH.2012.2209673","volume":"18","author":"P Boonvisut","year":"2013","unstructured":"Boonvisut P, Cavu\u015fo\u011flu MC (2013) Estimation of soft tissue mechanical parameters from robotic manipulation data. IEEE ASME Trans. Mechatron. 18(5):1602\u20131611","journal-title":"IEEE ASME Trans. Mechatron."},{"key":"2268_CR2","unstructured":"Brunet J-N. Exploring new numerical methods for the simulation of soft tissue deformations in surgery assistance. https:\/\/inria.hal.science\/tel-03130643\/document. Accessed: 2025-8-14"},{"key":"2268_CR3","doi-asserted-by":"crossref","unstructured":"Chauhan VK, Zhou J, Lu P, Molaei S, Clifton DA (2023) A brief review of hypernetworks in deep learning","DOI":"10.1007\/s10462-024-10862-8"},{"key":"2268_CR4","doi-asserted-by":"crossref","unstructured":"El Hadramy S, Padoy N, Cotin S (April 2025) Deform any liver in real-time. In 2025 IEEE 22nd International Symposium on Biomedical Imaging (ISBI), pages\u00a01\u20135, Houston, TX, USA. IEEE","DOI":"10.1109\/ISBI60581.2025.10981061"},{"key":"2268_CR5","doi-asserted-by":"crossref","unstructured":"El Hadramy S, Padoy N, Cotin S (2024) Hyperu-mesh: real-time deformation of soft-tissues across variable patient-specific parameters. In","DOI":"10.1007\/978-3-031-94128-3_12"},{"key":"2268_CR6","doi-asserted-by":"crossref","unstructured":"El hadramy S, Verde J, Beaudet K-P, Padoy N, Cotin S (2023) Trackerless volume reconstruction from intraoperative ultrasound images. In Lecture Notes in Computer Science, Lecture notes in computer science, pages;\u00a0303\u2013312. Springer Nature Switzerland, Cham","DOI":"10.1007\/978-3-031-43999-5_29"},{"key":"2268_CR7","doi-asserted-by":"crossref","unstructured":"El Hadramy S, Verde J, Padoy N, Cotin S (2024) Towards real-time vessel guided augmented reality for liver surgery. In 2024 IEEE International Symposium on Biomedical Imaging (ISBI)","DOI":"10.1109\/ISBI56570.2024.10635104"},{"key":"2268_CR8","doi-asserted-by":"crossref","unstructured":"Faure F, Duriez C, Delingette H, Allard J, Gilles B, Marchesseau S, Talbot H, Courtecuisse H, Bousquet G, Peterlik I, Cotin S (2012) SOFA: a multi-model framework for interactive physical simulation. Studies in Mechanobiology. Tissue Engineering and Biomaterials. Springer, Berlin Heidelberg, Berlin, Heidelberg, pp 283\u2013321","DOI":"10.1007\/8415_2012_125"},{"key":"2268_CR9","unstructured":"Ha D, Dai A, Le QV (2016) HyperNetworks"},{"issue":"2","key":"2268_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1088\/0031-9155\/57\/2\/455","volume":"57","author":"L Han","year":"2012","unstructured":"Han L, Hipwell JH, Tanner C, Taylor Z, Mertzanidou T, Cardoso J, Ourselin S, Hawkes DJ (2012) Development of patient-specific biomechanical models for predicting large breast deformation. Phys Med Biol 57(2):455\u2013472","journal-title":"Phys Med Biol"},{"key":"2268_CR11","doi-asserted-by":"crossref","unstructured":"Haouchine N, Dequidt J, Peterlik I, Kerrien E, Berger M-O, Cotin S (2013) Image-guided simulation of heterogeneous tissue deformation for augmented reality during hepatic surgery. Australia. IEEE, In IEEE International Symposium on Mixed and Augmented Reality (ISMAR), Adelaide","DOI":"10.1109\/ISMAR.2013.6671780"},{"issue":"7","key":"2268_CR12","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s11548-014-1118-5","volume":"10","author":"SF Johnsen","year":"2015","unstructured":"Johnsen SF, Taylor ZA, Clarkson MJ, Hipwell J, Modat M, Eiben B, Han L, Yipeng H, Mertzanidou T, Hawkes DJ, Ourselin S (2015) NiftySim: a GPU-based nonlinear finite element package for simulation of soft tissue biomechanics. Int J Comput Assist Radiol Surg 10(7):1077\u20131095","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"2268_CR13","unstructured":"LeCun Y, Bengio Y (October 1998) Convolutional networks for images, speech, and time series. In The handbook of brain theory and neural networks, pages\u00a0255\u2013258. MIT Press, London, England"},{"issue":"5","key":"2268_CR14","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1007\/s00366-021-01597-z","volume":"38","author":"A Mazier","year":"2022","unstructured":"Mazier A, Bilger A, Forte AE, Peterlik I, Hale JS, Bordas SPA (2022) Inverse deformation analysis: an experimental and numerical assessment using the FEniCS project. Eng Comput 38(5):4099\u20134113","journal-title":"Eng Comput"},{"issue":"3","key":"2268_CR15","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1007\/s00366-023-01877-w","volume":"40","author":"A Mazier","year":"2024","unstructured":"Mazier A, El Hadramy S, Brunet J-N, Hale JS, Cotin S, Bordas SPA (2024) Sonics: develop intuition on biomechanical systems through interactive error controlled simulations. Eng Comput 40(3):1857\u20131876","journal-title":"Eng Comput"},{"key":"2268_CR16","doi-asserted-by":"crossref","unstructured":"Mehrabian H, Samani A (February 2009) Constrained hyperelastic parameters reconstruction of PVA (polyvinyl alcohol) phantom undergoing large deformation. In Medical Imaging: 2009 Visualization, Image-Guided Procedures, and Modeling, Lake Buena Vista. FL, SPIE","DOI":"10.1117\/12.813871"},{"issue":"101569","key":"2268_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2019.101569","volume":"59","author":"A Mendizabal","year":"2020","unstructured":"Mendizabal A, Marquez-Neila P, Cotin S (2020) Simulation of hyperelastic materials in real-time using deep learning. Med Image Anal 59(101569):101569","journal-title":"Med Image Anal"},{"issue":"7","key":"2268_CR18","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s11548-020-02188-x","volume":"15","author":"S Nikolaev","year":"2020","unstructured":"Nikolaev S, Cotin S (2020) Estimation of boundary conditions for patient-specific liver simulation during augmented surgery. Int J Comput Assist Radiol Surg 15(7):1107\u20131115","journal-title":"Int J Comput Assist Radiol Surg"},{"key":"2268_CR19","doi-asserted-by":"crossref","unstructured":"Niroomandi S, Alfaro I, Cueto E, Chinesta F (September 2008) Real-time deformable models of non-linear tissues by model reduction techniques. Comput. Methods Programs Biomed.:223\u2013231","DOI":"10.1016\/j.cmpb.2008.04.008"},{"key":"2268_CR20","unstructured":"Nienhuys NW (2003) Phd dissertation. utrecht university; cutting in deformable objects"},{"key":"2268_CR21","unstructured":"Ortiz JJG, Guttag J, Dalca A (2023) Magnitude invariant parametrizations improve hypernetwork learning"},{"issue":"1","key":"2268_CR22","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10439-015-1419-z","volume":"44","author":"R Plantefeve","year":"2016","unstructured":"Plantefeve R, Peterlik I, Haouchine N, Cotin S (2016) Patient-specific biomechanical modeling for guidance during minimally-invasive hepatic surgery. Ann Biomed Eng 44(1):139\u2013153","journal-title":"Ann Biomed Eng"},{"issue":"835","key":"2268_CR23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1098\/rsta.1948.0024","volume":"241","author":"RS Rivlin","year":"1948","unstructured":"Rivlin RS (1948) Large elastic deformations of isotropic materials IV. further developments of the general theory. Philos Trans R Soc Lond 241(835):379\u2013397","journal-title":"Philos Trans R Soc Lond"},{"key":"2268_CR24","unstructured":"Roewer-Despres F, Khan N, Stavness I (2018) Towards finite-element simulation using deep learning"},{"key":"2268_CR25","doi-asserted-by":"crossref","unstructured":"Servin F, Collins JA, Heiselman JS, Frederick-Dyer KC, Planz VB, Geevarghese SK, Brown DB, Jarnagin WR, Miga MI (2024) Simulation of image-guided microwave ablation therapy using a digital twin computational model. IEEE Open J Eng Med Biol","DOI":"10.1109\/OJEMB.2023.3345733"},{"key":"2268_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.isurg.2021.10.001","volume":"1","author":"M Sun","year":"2022","unstructured":"Sun M, Li W, Zhang C, Li S, Zhou F, Zhu Y, Zhou X (2022) Da vinci xi$$^{\\rm TM}$$ robot-assisted liver resection. Intell Surg 1:16\u201320","journal-title":"Intell Surg"},{"key":"2268_CR27","doi-asserted-by":"crossref","unstructured":"Tagliabue E, Piccinelli M, Dall\u2019Alba D, Verde J, Pfeiffer M, Marin R, Speidel S, Fiorini P, Cotin S (2021) Intra-operative update of boundary conditions for patient-specific surgical simulation. In MICCAI 2021. Springer International Publishing,","DOI":"10.1007\/978-3-030-87202-1_36"},{"key":"2268_CR28","doi-asserted-by":"crossref","unstructured":"Veronda DR, Westmann RA (January 1970) Mechanical characterization of skin-finite deformations. J Biomech: 111\u2013124","DOI":"10.1016\/0021-9290(70)90055-2"},{"key":"2268_CR29","doi-asserted-by":"crossref","unstructured":"Wasserthal J, Breit H-C, Meyer MT, Pradella M, Hinck D, Sauter AW, Heye T, Boll D, Cyriac J, Yang S, Bach M, Segeroth M (2022) TotalSegmentator: robust segmentation of 104 anatomical structures in CT images","DOI":"10.1148\/ryai.230024"}],"container-title":["Engineering with Computers"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00366-025-02268-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00366-025-02268-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00366-025-02268-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T14:00:14Z","timestamp":1780063214000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00366-025-02268-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2268"],"URL":"https:\/\/doi.org\/10.1007\/s00366-025-02268-z","relation":{},"ISSN":["0177-0667","1435-5663"],"issn-type":[{"value":"0177-0667","type":"print"},{"value":"1435-5663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"11 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"74"}}