{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:14:12Z","timestamp":1772572452700,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2010,4,2]],"date-time":"2010-04-02T00:00:00Z","timestamp":1270166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biol Cybern"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1007\/s00422-010-0387-5","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T12:29:12Z","timestamp":1270124952000},"page":"135-150","source":"Crossref","is-referenced-by-count":3,"title":["Adaptive force produced by stress-induced regulation of random variation intensity"],"prefix":"10.1007","volume":"103","author":[{"given":"Yury P.","family":"Shimansky","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2010,4,2]]},"reference":[{"key":"387_CR1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1098\/rspb.1991.0101","volume":"245","author":"Z Agur","year":"1991","unstructured":"Agur Z, Mazor G, Meilijson I (1991) Maturation of the humoral immune response as an optimization problem. Proc R Soc Lond B 245: 147\u2013150","journal-title":"Proc R Soc Lond B"},{"key":"387_CR2","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/(SICI)1521-1878(200004)22:4<388::AID-BIES9>3.0.CO;2-4","volume":"22","author":"LH Caporale","year":"2000","unstructured":"Caporale LH (2000) Mutation is modulated: implications for evolution. BioEssays 22: 388\u2013395","journal-title":"BioEssays"},{"key":"387_CR3","volume-title":"On the origin of species by means of natural selection, or preservation of favored races in the struggle for life","author":"C Darwin","year":"1859","unstructured":"Darwin C (1859) On the origin of species by means of natural selection, or preservation of favored races in the struggle for life. Murray, London"},{"key":"387_CR4","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.biosystems.2004.05.011","volume":"76","author":"DK Dunn-Walters","year":"2004","unstructured":"Dunn-Walters DK, Edelman H, Mehr R (2004) Immune system learning and memory quantified by graphical analysis of B-lymphocyte phylogenetic trees. BioSystems 76: 141\u2013155","journal-title":"BioSystems"},{"key":"387_CR5","doi-asserted-by":"crossref","DOI":"10.1142\/p303","volume-title":"Chemotaxis","author":"M Eisenbach","year":"2004","unstructured":"Eisenbach M (2004) Chemotaxis. Imperial College Press, River Edge, NJ"},{"key":"387_CR6","volume-title":"Models in paleobiology","author":"N Eldredge","year":"1972","unstructured":"Eldredge N, Gould SJ (1972) Punctuated equilibria: an alternative to phyletic gradualism. In: Schopf TJM (eds) Models in paleobiology. Freeman, San Francisco"},{"key":"387_CR7","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.27468","volume-title":"The genetical theory of natural selection","author":"RA Fisher","year":"1930","unstructured":"Fisher RA (1930) The genetical theory of natural selection. Oxford University Press, Oxford, UK"},{"key":"387_CR8","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/1521-1878(200012)22:12<1067::AID-BIES4>3.0.CO;2-Q","volume":"22","author":"PL Foster","year":"2000","unstructured":"Foster PL (2000) Adaptive mutation: implications for evolution. BioEssays 22: 1067\u20131074","journal-title":"BioEssays"},{"key":"387_CR9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/10409230701648494","volume":"42","author":"PL Foster","year":"2007","unstructured":"Foster PL (2007) Stress-induced mutagenesis in bacteria. Crit Rev Biochem Mol Biol 42: 373\u2013397","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"387_CR10","volume-title":"Evolutionary biology","author":"DJ Futuyma","year":"1998","unstructured":"Futuyma DJ (1998) Evolutionary biology. Sinauer Associates, Inc., Sunderland, Massachusetts"},{"key":"387_CR11","doi-asserted-by":"crossref","DOI":"10.2307\/j.ctvjsf433","volume-title":"The structure of evolutionary theory","author":"SG Gould","year":"2002","unstructured":"Gould SG (2002) The structure of evolutionary theory. The Belknap Press of Harvard University Press, Cambridge, Massachusetts"},{"key":"387_CR12","volume-title":"Evolutionary genetics and environmental stress","author":"AA Hoffman","year":"1991","unstructured":"Hoffman AA, Parsons PA (1991) Evolutionary genetics and environmental stress. Oxford University Press, Oxford"},{"key":"387_CR13","volume-title":"Learning, development, and culture","author":"DL Hull","year":"1982","unstructured":"Hull DL (1982) The naked meme. In: Plotkin HC (eds) Learning, development, and culture. Wiley, Chichester"},{"key":"387_CR14","doi-asserted-by":"crossref","first-page":"8219","DOI":"10.1073\/pnas.92.18.8219","volume":"92","author":"TB Kepler","year":"1995","unstructured":"Kepler TB, Perelson AS (1995) Modeling and optimization of populations subject to time-dependent mutation. Proc Natl Acad Sci 92: 8219\u20138223","journal-title":"Proc Natl Acad Sci"},{"key":"387_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nature01568","volume":"423","author":"RE Lenski","year":"2003","unstructured":"Lenski RE, Ofria C, Pennock RT, Adami C (2003) The evolutionary origin of complex features. Nature 423: 139\u2013144","journal-title":"Nature"},{"key":"387_CR16","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/342929a0","volume":"342","author":"Y-J Liu","year":"1989","unstructured":"Liu Y-J, Joshua D, Williams G, Smith C, Gordon J, MacLennan ICM (1989) Mechanism of antigen-driven selection in germinal centers. Nature 342: 929\u2013931","journal-title":"Nature"},{"key":"387_CR17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng846","volume":"30","author":"JM Lucht","year":"2002","unstructured":"Lucht JM, Mauch-Mani B, Steiner H-Y, Metraux J-P, Ryals J, Hohn B (2002) Pathogen stress increases somatic recombination frequency in Arabidopsis. Nat Genet 30: 311\u2013314","journal-title":"Nat Genet"},{"key":"387_CR18","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/jb.179.2.417-422.1997","volume":"179","author":"EF Mao","year":"1997","unstructured":"Mao EF, Lane L, Lee J, Miller JH (1997) Proliferation of mutators in a cell population. J Bacteriol 179: 417\u2013422","journal-title":"J Bacteriol"},{"key":"387_CR19","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1126\/science.15739260","volume":"226","author":"B McClintock","year":"1984","unstructured":"McClintock B (1984) The significance of responses of the genome to challenge. Science 226: 792\u2013801","journal-title":"Science"},{"key":"387_CR20","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0092-8674(00)80869-7","volume":"101","author":"D Metzgar","year":"2000","unstructured":"Metzgar D, Wills C (2000) Evidence for the adaptive evolution of mutation rates. Cell 101: 581\u2013584","journal-title":"Cell"},{"key":"387_CR21","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-76214-7","volume-title":"Introduction to theoretical population genetics","author":"T Nagylaki","year":"1992","unstructured":"Nagylaki T (1992) Introduction to theoretical population genetics. Springer-Verlag, New York"},{"key":"387_CR22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0952-7915(95)80010-7","volume":"7","author":"MS Neuberger","year":"1995","unstructured":"Neuberger MS, Milstein C (1995) Somatic hypermutation. Curr Opin Immunol 7: 248\u2013254","journal-title":"Curr Opin Immunol"},{"key":"387_CR23","volume-title":"Fundamental immunology","author":"WE Paul","year":"1993","unstructured":"Paul WE (1993) Fundamental immunology. Raven Press, New York"},{"key":"387_CR24","volume-title":"Adaptational biology","author":"CL Prosser","year":"1986","unstructured":"Prosser CL (1986) Adaptational biology. Wiley, New York"},{"key":"387_CR25","volume-title":"Evolutionary theory: mathematical and conceptual foundations","author":"SH Rice","year":"2004","unstructured":"Rice SH (2004) Evolutionary theory: mathematical and conceptual foundations. Sinauer Associates, Inc., Sunderland, Massachusetts"},{"key":"387_CR26","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35080556","volume":"2","author":"SM Rosenberg","year":"2001","unstructured":"Rosenberg SM (2001) Evolving responsively: adaptive mutation. Nat Rev Genet 2: 502\u2013515","journal-title":"Nat Rev Genet"},{"key":"387_CR27","first-page":"95","volume-title":"Biological cybernetics research trends","author":"YP Shimansky","year":"2007","unstructured":"Shimansky YP (2007) Role of optimization in simple and learning-based adaptation and its biologically plausible mechanisms. In: Williams TO (eds) Biological cybernetics research trends. Nova Science Publishers, NY, pp 95\u2013164"},{"key":"387_CR28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00422-009-0341-6","volume":"101","author":"YP Shimansky","year":"2009","unstructured":"Shimansky YP (2009) Biologically plausible learning in neural networks: a lesson from bacterial chemotaxis. Biol Cybernet 101: 379\u2013385","journal-title":"Biol Cybernet"},{"key":"387_CR29","volume-title":"The latest on the best","author":"JM Smith","year":"1987","unstructured":"Smith JM (1987) How to model evolution. In: Dupr\u00e9 J (eds) The latest on the best. MIT Press, Cambridge, MA"},{"key":"387_CR30","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/42701","volume":"387","author":"PD Sniegowski","year":"1997","unstructured":"Sniegowski PD, Gerrish PJ, Lenski RE (1997) Evolution of high mutation rates in experimental populations of E. coli. Nature 387: 703\u2013705","journal-title":"Nature"},{"key":"387_CR31","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/1521-1878(200012)22:12<1057::AID-BIES3>3.0.CO;2-W","volume":"22","author":"PD Sniegowski","year":"2000","unstructured":"Sniegowski PD, Gerrish PJ, Johnson T, Shaver A (2000) The evolution of mutation rates: separating causes from consequences. BioEssays 22: 1057\u20131066","journal-title":"BioEssays"},{"key":"387_CR32","volume-title":"Adaptation and natural selection","author":"GC Williams","year":"1966","unstructured":"Williams GC (1966) Adaptation and natural selection. Princeton University Press, Princeton, NJ"},{"key":"387_CR33","doi-asserted-by":"crossref","unstructured":"Winter DB, Gearhart PJ (1998) Dual enigma of somatic hypermutation of immunoglobulin variable genes: targeting and mechanism. In: Somatic hypermutation of immunoglobulin genes, vol 162 of Immunological reviews. Munksgaard, Copenhagen","DOI":"10.1111\/j.1600-065X.1998.tb01432.x"},{"key":"387_CR34","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1002\/eji.1830241020","volume":"24","author":"M Ziegner","year":"1994","unstructured":"Ziegner M, Steinhauser G, Berek C (1994) Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol 24: 2393\u20132400","journal-title":"Eur J Immunol"}],"container-title":["Biological Cybernetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00422-010-0387-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00422-010-0387-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00422-010-0387-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T12:47:57Z","timestamp":1591188477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00422-010-0387-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["387"],"URL":"https:\/\/doi.org\/10.1007\/s00422-010-0387-5","relation":{},"ISSN":["0340-1200","1432-0770"],"issn-type":[{"value":"0340-1200","type":"print"},{"value":"1432-0770","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,2]]}}}