{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T21:19:47Z","timestamp":1649193587685},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2008,10,31]],"date-time":"2008-10-31T00:00:00Z","timestamp":1225411200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Soft Comput"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00500-008-0380-2","type":"journal-article","created":{"date-parts":[[2008,10,30]],"date-time":"2008-10-30T10:49:13Z","timestamp":1225363753000},"page":"1073-1080","source":"Crossref","is-referenced-by-count":3,"title":["Design principles of adaptive cellular immunity for artificial immune systems"],"prefix":"10.1007","volume":"13","author":[{"given":"Hugo Antonius","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,31]]},"reference":[{"key":"380_CR1","unstructured":"Aickelin U, Cayzer S (2003) The danger theory and its application to artificial immune systems. In: Timmis et\u00a0al. [41], pp 141\u2013148"},{"key":"380_CR2","unstructured":"Ayara M, Timmis J, de Lemos R, de Castro LN, Duncan R (2002) Negative selection: How to generate detectors. In: Timmis and Bentley [40], pp 89\u201398"},{"key":"380_CR3","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.bulm.2004.01.001","volume":"66","author":"HA Berg van den","year":"2004","unstructured":"van den Berg HA, Kiselev YN (2004) Expansion and contraction of the cytotoxic T lymphocyte response\u2014an optimal control approach. Bull Math Biol 66:1345\u20131369","journal-title":"Bull Math Biol"},{"key":"380_CR4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0022-5193(03)00162-0","volume":"224","author":"HA Berg van den","year":"2003","unstructured":"van den Berg HA, Rand DA (2003) Antigen presentation on MHC molecules as a diversity filter that enhances immune efficacy. J Theor Biol 224:249\u2013267","journal-title":"J Theor Biol"},{"key":"380_CR5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.jtbi.2004.02.002","volume":"228","author":"HA Berg van den","year":"2004","unstructured":"van den Berg HA, Rand DA (2004a) Dynamics of T cell activation threshold tuning. J Theor Biol 228:397\u2013416","journal-title":"J Theor Biol"},{"key":"380_CR6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jtbi.2004.07.008","volume":"231","author":"HA Berg van den","year":"2004","unstructured":"van den Berg HA, Rand DA (2004b) Foreigness as a matter of degree: the relative immunogenicity of peptide\/MHC ligands. J Theor Biol 231:535\u2013548","journal-title":"J Theor Biol"},{"key":"380_CR7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1600-065X.2006.00491.x","volume":"216","author":"HA Berg van den","year":"2007","unstructured":"van den Berg HA, Rand DA (2007) Quantitative theories of T-cell responsiveness. Immunol Rev 216:81\u201392","journal-title":"Immunol Rev"},{"key":"380_CR8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1006\/jtbi.2001.2281","volume":"209","author":"HA Berg van den","year":"2001","unstructured":"van den Berg HA, Rand DA, Burroughs NJ (2001) A reliable and safe T cell repertoire based on low-affinity T cell receptors. J Theor Biol 209:465\u2013486","journal-title":"J Theor Biol"},{"key":"380_CR9","unstructured":"Bersini H (2003) Self-assertion versus self-recognition: a tribute to Francisco Varela. In: Timmis et\u00a0al. [41], pp 107\u2013112"},{"key":"380_CR10","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1002\/(SICI)1521-1878(199805)20:5<412::AID-BIES8>3.0.CO;2-P","volume":"20","author":"P Bongrand","year":"1998","unstructured":"Bongrand P, Malissen B (1998) Quantitative aspects of T-cell recognition: from within the antigen-presenting cell to within the T cell. BioEssays 20:412\u2013422","journal-title":"BioEssays"},{"key":"380_CR11","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00251-004-0691-0","volume":"56","author":"N Burroughs","year":"2004","unstructured":"Burroughs N, Kesmir C, de Boer R (2004) Discriminating self from nonself with short peptides from large proteomes. Immunogenetics 56:311\u2013320","journal-title":"Immunogenetics"},{"key":"380_CR12","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1145\/1107458.1107489","volume":"49","author":"M Czerwinski","year":"2006","unstructured":"Czerwinski M, Cage D, Gemmell J, Catarci T, Marshall CC, Perez-Quinones M, Skeels MM (2006) Digital memories in an era of ubiquitous computing and abundant storage. Commun ACM 49:44\u201350","journal-title":"Commun ACM"},{"key":"380_CR13","first-page":"1","volume":"4","author":"SJ Davis","year":"2003","unstructured":"Davis SJ, Ikemizu S, Evans EJ, Fugger L, Bakker TR, van der Merwe PA (2003) The nature of molecular recognition by T cells. Nat Immunol 4:1\u20138","journal-title":"Nat Immunol"},{"issue":"8","key":"380_CR14","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s00500-002-0237-z","volume":"7","author":"LN Castro de","year":"2003","unstructured":"de Castro LN, Timmis JI (2003) Artificial immune systems as a novel soft computing paradigm. Soft Comput 7(8):526\u2013544","journal-title":"Soft Comput"},{"key":"380_CR15","doi-asserted-by":"crossref","unstructured":"de Castro LN, von Zuben FJ (eds) (2005) Recent developments in biologically inspired computing. Idea Group, January 2005","DOI":"10.4018\/978-1-59140-312-8"},{"key":"380_CR16","unstructured":"Dunkin MA (1999) A maverick researcher bucks the establishment. In: Arthritis today magazine, March\u2013April 1999"},{"key":"380_CR17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0952-7915(00)00191-6","volume":"13","author":"S Gallucci","year":"2001","unstructured":"Gallucci S, Matzinger P (2001) Danger signals: SOS to the immune system. Curr Opin Immunol 13:114\u2013119","journal-title":"Curr Opin Immunol"},{"key":"380_CR18","volume-title":"Genetic algorithms in search, optimization and machine learning","author":"DE Goldberg","year":"1988","unstructured":"Goldberg DE (1988) Genetic algorithms in search, optimization and machine learning. Addison Wesley, Reading"},{"key":"380_CR19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/46218","volume":"402","author":"AW Goldrath","year":"1999","unstructured":"Goldrath AW, Bevan MJ (1999) Selecting and maintaining a diverse T-cell repertoire. Nature 402:255\u2013262","journal-title":"Nature"},{"key":"380_CR20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nri1374","volume":"4","author":"B Goldstein","year":"2004","unstructured":"Goldstein B, Faeder JR, Hlavacek W (2004) Mathematical and computational models of immune-receptor signalling. Nat Rev Immunol 4:445\u2013456","journal-title":"Nat Rev Immunol"},{"key":"380_CR21","unstructured":"Gonz\u00e1lez F, Dasgupta D (2003) Neuro-immune and self-organizing map approaches to anomaly detection: a comparison. In: Timmis et\u00a0al. [41], pp 203\u2013211"},{"key":"380_CR22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/cplx.1046","volume":"6","author":"U Hershberg","year":"2001","unstructured":"Hershberg U, Efroni S (2001) The immune system and other cognitive systems. Complexity 6:14\u201321","journal-title":"Complexity"},{"key":"380_CR23","doi-asserted-by":"crossref","unstructured":"Hone A, van den Berg HA (2007) Mathematical analysis of artificial immune system dynamics and performance. In: Flower D, Timmis J (eds) Silico immunology. Springer, Heidelberg","DOI":"10.1007\/978-0-387-39241-7_17"},{"key":"380_CR24","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1126\/science.290.5489.92","volume":"290","author":"A Lanzavecchia","year":"2000","unstructured":"Lanzavecchia A, Sallusto F (2000) Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells. Science 290:92\u201397","journal-title":"Science"},{"key":"380_CR25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12065-007-0003-3","volume":"1","author":"PL Lanzi","year":"2008","unstructured":"Lanzi PL (2008) Learning classifier systems: then and now. Evol Intel 1:63\u201382","journal-title":"Evol Intel"},{"key":"380_CR26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-3083.2001.00974.x","volume":"54","author":"P Matzinger","year":"2001","unstructured":"Matzinger P (2001) Essay 1: the danger model in its historical context. Scand J Immunol 54:4\u20139","journal-title":"Scand J Immunol"},{"key":"380_CR27","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-065X.1998.tb01244.x","volume":"165","author":"JFAP Miller","year":"1998","unstructured":"Miller JFAP, Kurts C, Allison J, Kosaka H, Carbone F, Heath WR (1998) Induction of peripheral CD 8+ T cell tolerance by cross-presentation of self antigens. Immunol Rev 165:267\u2013277","journal-title":"Immunol Rev"},{"key":"380_CR28","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1471-4906(03)00028-0","volume":"24","author":"V M\u00fcller","year":"2003","unstructured":"M\u00fcller V, Bonhoeffer S (2003) Quantitative constraints on the scope of negative selection. TRENDS Immunol 24:132\u2013135","journal-title":"TRENDS Immunol"},{"key":"380_CR29","doi-asserted-by":"crossref","unstructured":"Neal M, Timmis J (2005) Once more unto the breach: towards artifical homeostasis? In: de Castro, von Zuben [15], pp 340\u2013365","DOI":"10.4018\/978-1-59140-312-8.ch014"},{"key":"380_CR30","doi-asserted-by":"crossref","unstructured":"Nicosia G, Cutello V, Bentley P, Timmis J (eds) (2004) Third international conference on artificial immune systems, September 2004. Lecture Notes in Computer Science, vol 3239. Springer, Heidelberg","DOI":"10.1007\/b100486"},{"key":"380_CR31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0022-5193(79)90275-3","volume":"81","author":"AS Perelson","year":"1979","unstructured":"Perelson AS, Oster GF (1979) Theoretical studies of clonal selection: minimal antibody repertoire size and reliability of self-non-self discrimination. J Theor Biol 81:645\u2013670","journal-title":"J Theor Biol"},{"key":"380_CR32","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-61068-4","volume-title":"Neural networks: a systematic introduction","author":"R Rojas","year":"1996","unstructured":"Rojas R (1996) Neural networks: a systematic introduction. Springer, Heidelberg"},{"key":"380_CR33","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0952-7915(00)00162-X","volume":"12","author":"M-G Roncarolo","year":"2000","unstructured":"Roncarolo M-G, Levings MK (2000) The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol 12:676\u2013683","journal-title":"Curr Opin Immunol"},{"key":"380_CR34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2567.2000.00121.x","volume":"101","author":"DM Sansom","year":"2000","unstructured":"Sansom DM (2000) CD28, CTLA-4 and their ligands: Who does what and to whom? Immunology 101:169\u2013177","journal-title":"Immunology"},{"key":"380_CR35","volume-title":"The sciences of the artificial","author":"HA Simon","year":"1996","unstructured":"Simon HA (1996) The sciences of the artificial, 3rd edn. MIT Press, Cambridge","edition":"3"},{"key":"380_CR36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-0-387-39241-7_13","volume-title":"Silico immunology","author":"S Stepney","year":"2007","unstructured":"Stepney S (2007) Embodiment. In: Flower D, Timmis J (eds) Silico immunology. Springer, Heidelberg, pp 265\u2013288"},{"key":"380_CR37","doi-asserted-by":"crossref","unstructured":"Stepney S, Smith RE, Timmis J, Tyrell AM (2004) Towards a conceptual framework for artificial immune systems. In Nicosia et\u00a0al. [30], pp 53\u201364","DOI":"10.1007\/978-3-540-30220-9_5"},{"key":"380_CR38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1006\/smim.1999.0195","volume":"11","author":"S Stevanovi\u0107","year":"1999","unstructured":"Stevanovi\u0107 S, Schild H (1999) Quantitative aspects of T cell activation\u2014peptide generation and editing by MHC class I molecule. Semin Immunol 11:375\u2013384","journal-title":"Semin Immunol"},{"key":"380_CR39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s12065-007-0004-2","volume":"1","author":"J Timmis","year":"2008","unstructured":"Timmis J, Andrews P, Owens N, Clark E (2008) An interdisciplinary perspective on artificial immune systems. Evol Intel 1:5\u201326","journal-title":"Evol Intel"},{"key":"380_CR40","unstructured":"Timmis J, Bentley P (eds) (2002) 1st International conference on artificial immune systems. University of Kent at Canterbury, September 2002"},{"key":"380_CR41","doi-asserted-by":"crossref","unstructured":"Timmis J, Bentley P, Hart E (eds) (2003) Proceedings of the 2nd international conference on artificial immune systems, September 2003. Lecture Notes in Computer Science, vol 2787. Springer, Heidelberg","DOI":"10.1007\/b12020"}],"container-title":["Soft Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00500-008-0380-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00500-008-0380-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00500-008-0380-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T01:39:55Z","timestamp":1559093995000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00500-008-0380-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,31]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["380"],"URL":"https:\/\/doi.org\/10.1007\/s00500-008-0380-2","relation":{},"ISSN":["1432-7643","1433-7479"],"issn-type":[{"value":"1432-7643","type":"print"},{"value":"1433-7479","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,31]]}}}