{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:32:50Z","timestamp":1778830370876,"version":"3.51.4"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2010,11,9]],"date-time":"2010-11-09T00:00:00Z","timestamp":1289260800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neural Comput & Applic"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1007\/s00521-010-0479-0","type":"journal-article","created":{"date-parts":[[2010,11,8]],"date-time":"2010-11-08T02:44:21Z","timestamp":1289184261000},"page":"1131-1139","source":"Crossref","is-referenced-by-count":29,"title":["Functional modeling of astrocytes in epilepsy: a feedback system perspective"],"prefix":"10.1007","volume":"20","author":[{"given":"Mahmood","family":"Amiri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariba","family":"Bahrami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahyar","family":"Janahmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,11,9]]},"reference":[{"issue":"1","key":"479_CR1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jneumeth.2009.05.015","volume":"183","author":"K Lehnertz","year":"2009","unstructured":"Lehnertz K, Bialonski S, Horstmann MT, Krug D, Rothkegel A, Staniek M, Wagner T (2009) Synchronization phenomena in human epileptic brain networks. J Neurosci Meth 183(1):42\u201348","journal-title":"J Neurosci Meth"},{"issue":"12","key":"479_CR2","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1109\/TBME.2009.2028015","volume":"56","author":"S Demont-Guignard","year":"2009","unstructured":"Demont-Guignard S, Benquet P, Gerber U, Wendling F (2009) Analysis of intracerebral EEG recordings of epileptic spikes: insights from a neural network model. IEEE Trans Biomed Eng 56(12):2782\u20132795","journal-title":"IEEE Trans Biomed Eng"},{"key":"479_CR3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s10867-009-9157-9","volume":"35","author":"G Ricci","year":"2009","unstructured":"Ricci G, Volpi L, Pasquali L, Petrozzi L, Siciliano G (2009) Astrocyte-neuron interactions in neurological disorders. J Biol Phys 35:317\u2013336","journal-title":"J Biol Phys"},{"key":"479_CR4","unstructured":"Seifert G, Carmignoto G, Steinh\u00e4user C (in press) Astrocyte dysfunction in epilepsy. Brian Res Rev"},{"issue":"9","key":"479_CR5","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1523\/JNEUROSCI.3965-04.2005","volume":"25","author":"P Gertrudis","year":"2005","unstructured":"Gertrudis P, Araque A (2005) Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes. J Neurosci 25(9):2192\u20132203","journal-title":"J Neurosci"},{"key":"479_CR6","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0166-2236(03)00237-6","volume":"26","author":"EA Newman","year":"2003","unstructured":"Newman EA (2003) New roles for astrocytes: regulation of synaptic transmission. Trends Neurosci 26:536\u2013542","journal-title":"Trends Neurosci"},{"key":"479_CR7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/glia.20080","volume":"47","author":"A Voltarra","year":"2004","unstructured":"Voltarra A, Steinhauser C (2004) Glial modulation of synaptic transmission in the hippocampus. GLIA 47:249\u2013257","journal-title":"GLIA"},{"issue":"12","key":"479_CR8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.tins.2004.10.008","volume":"27","author":"L Hertz","year":"2004","unstructured":"Hertz L, Zielke HR (2004) Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci 27(12):735\u2013743","journal-title":"Trends Neurosci"},{"key":"479_CR9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0166-2236(98)01349-6","volume":"22","author":"A Araque","year":"1999","unstructured":"Araque A, Parpura V, Sanzgiri RP, Haydon PG (1999) Tripartite synapses: glia, the unacknowledged partner. Trends Neurosci 22:208\u2013215","journal-title":"Trends Neurosci"},{"issue":"2","key":"479_CR10","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molmed.2006.12.005","volume":"13","author":"MM Halassa","year":"2007","unstructured":"Halassa MM, Fellin T, Haydon PG (2007) The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med 13(2):54\u201363","journal-title":"Trends Mol Med"},{"issue":"4","key":"479_CR11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropharm.2009.06.031","volume":"57","author":"MM Halassa","year":"2009","unstructured":"Halassa MM, Fellin T, Haydon PG (2009) Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior. Neuropharmacol 57(4):343\u2013346","journal-title":"Neuropharmacol"},{"key":"479_CR12","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1152\/physiol.00161.2005","volume":"21","author":"T Fellin","year":"2006","unstructured":"Fellin T, Pascual O, Haydon PG (2006) Astrocytes coordinate synaptic networks: balanced excitation and inhibition. Physiology 21:208\u2013215","journal-title":"Physiology"},{"key":"479_CR13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1113\/jphysiol.2004.063214","volume":"559","author":"T Fellin","year":"2004","unstructured":"Fellin T, Carmignoto G (2004) Neuron-to-astrocyte signaling in the brain represents a distinct multifunctional unit. J Physiol 559:3\u201315","journal-title":"J Physiol"},{"issue":"3","key":"479_CR14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10439-008-9625-6","volume":"37","author":"N Chakravarthy","year":"2009","unstructured":"Chakravarthy N, Tsakalis K, Sabesan S, Iasemidis LD (2009) Homeostasis of brain dynamics in epilepsy: a feedback control systems perspective of seizures. Ann Biomed Eng 37(3):565\u2013585","journal-title":"Ann Biomed Eng"},{"issue":"4","key":"479_CR15","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1109\/JPROC.2006.871773","volume":"94","author":"P Suffczynski","year":"2006","unstructured":"Suffczynski P, Wendling F, Bellanger JJ, Lopes da Silva FH (2006) Some insights into computational models of (patho) physiological brain activity. Proc IEEE 94(4):784\u2013804","journal-title":"Proc IEEE"},{"key":"479_CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1088\/1478-3967\/1\/1\/004","volume":"1","author":"S Nadkarni","year":"2004","unstructured":"Nadkarni S, Jung P (2004) Dressed neurons: modeling neural-glial interactions. Phys Biol 1:35\u201341","journal-title":"Phys Biol"},{"key":"479_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1478-3975\/4\/1\/001","volume":"4","author":"S Nadkarni","year":"2007","unstructured":"Nadkarni S, Jung P (2007) Modeling synaptic transmission of the tripartite synapse. Phys Biol 4:1\u20139","journal-title":"Phys Biol"},{"issue":"5","key":"479_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pcbi.1000088","volume":"4","author":"S Nadkarni","year":"2008","unstructured":"Nadkarni S, Jung P, Levine H (2008) Astrocytes optimize the synaptic transmission of information. PLoS Comput Biol 4(5):1\u201311","journal-title":"PLoS Comput Biol"},{"key":"479_CR19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.biosystems.2006.04.012","volume":"89","author":"DE Postnove","year":"2007","unstructured":"Postnove DE, Ryazanova LS, Sosnovtseva OV (2007) Functional modeling of neural-glial interaction. BioSystems 89:84\u201391","journal-title":"BioSystems"},{"key":"479_CR20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10867-009-9156-x","volume":"35","author":"DE Postnov","year":"2009","unstructured":"Postnov DE, Koreshkov RN, Brazhe NA, Brazhe AR, Sosnovtseva OV (2009) Dynamical patterns of calcium signaling in a functional model of neuron-astrocyte networks. J Biol Phys 35:425\u2013445","journal-title":"J Biol Phys"},{"key":"479_CR21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10867-009-9143-2","volume":"35","author":"AD Garbo","year":"2009","unstructured":"Garbo AD (2009) Dynamics of a minimal neural model consisting of an astrocyte, a neuron, and an interneuron. J Biol Phys 35:361\u2013382","journal-title":"J Biol Phys"},{"key":"479_CR22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.ceca.2005.10.009","volume":"39","author":"G Ullah","year":"2006","unstructured":"Ullah G, Jung P, Cornell-Bell AH (2006) Anti-phase calcium oscillations in astrocytes via inositol (1, 4, 5)-trisphosphate regeneration. Cell Calcium 39:197\u2013208","journal-title":"Cell Calcium"},{"key":"479_CR23","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.biosystems.2006.05.013","volume":"89","author":"AD Garbo","year":"2007","unstructured":"Garbo AD, Barbi M, Chillemi S, Alloisio S, Nobile M (2007) Calcium signaling in astrocytes and modulation of neural activity. BioSystems 89:74\u201383","journal-title":"BioSystems"},{"issue":"4","key":"479_CR24","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.jtbi.2007.12.011","volume":"251","author":"M Lavrentovich","year":"2008","unstructured":"Lavrentovich M, Hemkin SA (2008) Mathematical model of spontaneous calcium (II) oscillations in astrocytes. J Theoretic Biol 251(4):553\u2013560","journal-title":"J Theoretic Biol"},{"issue":"2","key":"479_CR25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuroscience.2004.03.014","volume":"126","author":"P Suffczynski","year":"2004","unstructured":"Suffczynski P, Kalitzin S, Lopes da Silva FH (2004) Dynamics of non-convulsive epileptic phenomena modeled by a bistable neuronal network. Neuroscience 126(2):467\u2013484","journal-title":"Neuroscience"},{"key":"479_CR26","doi-asserted-by":"crossref","unstructured":"Hung J, Colicos MA (2008) Astrocytic Ca2+ waves guide CNS growth cones to remote regions of neuronal activity. PLoS ONE 3(11):e3692","DOI":"10.1371\/journal.pone.0003692"},{"key":"479_CR27","doi-asserted-by":"crossref","unstructured":"Suffczynski P, Kalitzin S, Lopes da Silva FH (2008) A neuronal network model of corticothalamic oscillations: the emergence of epileptiform absence seizures. In: Soltesz I, Staley K (eds) Computational neuroscience in epilepsy. Elsevier, Amsterdam, pp 403\u2013418","DOI":"10.1016\/B978-012373649-9.50028-4"},{"key":"479_CR28","doi-asserted-by":"crossref","unstructured":"Destexhe A (2008) Corticothalamic feedback: a key to explain absence seizures. In: Soltesz I, Staley K (eds) Computational neuroscience in epilepsy. Elsevier, Amsterdam, pp 184\u2013211","DOI":"10.1016\/B978-012373649-9.50016-8"},{"issue":"2","key":"479_CR29","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1142\/S0129065707000993","volume":"17","author":"N Chakravarthy","year":"2007","unstructured":"Chakravarthy N, Sabesan S, Iasemidis LD, Tsakalis K (2007) Modeling and controlling synchronization in a neuron level population model. Int J Neural Syst 17(2):123\u2013138","journal-title":"Int J Neural Syst"},{"key":"479_CR30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.pharmthera.2004.05.004","volume":"103","author":"R D\u2019Ambrosio","year":"2004","unstructured":"D\u2019Ambrosio R (2004) The role of glial membrane ion channels in seizures and epileptogenesis. Pharmacol Therapeut 103:95\u2013108","journal-title":"Pharmacol Therapeut"},{"key":"479_CR31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00422-007-0196-7","volume":"98","author":"AN Silchenko","year":"2008","unstructured":"Silchenko AN, Tass PA (2008) Computational modeling of paroxysmal depolarization shifts in neurons induced by the glutamate release from astrocytes. Biol Cybern 98:61\u201374","journal-title":"Biol Cybern"},{"key":"479_CR32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuron.2008.04.002","volume":"58","author":"J Wetherington","year":"2008","unstructured":"Wetherington J, Serrano G, Dingledine R (2008) Astrocytes in the epileptic brain. Neuron 58:168\u2013178","journal-title":"Neuron"},{"key":"479_CR33","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2007.08.044","volume":"267","author":"J Keyser De","year":"2008","unstructured":"De Keyser J, Mostert JP, Koch MW (2008) Dysfunctional astrocytes as key players in the pathogenesis of central nervous system disorders. J Neurol Sci 267:3\u201316","journal-title":"J Neurol Sci"},{"issue":"9","key":"479_CR34","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nm0905-919","volume":"11","author":"MA Rogawski","year":"2005","unstructured":"Rogawski MA (2005) Astrocytes get in the act in epilepsy. Nat Med 11(9):919\u2013920","journal-title":"Nat Med"},{"issue":"4","key":"479_CR35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s004220000160","volume":"83","author":"F Wendling","year":"2000","unstructured":"Wendling F, Bellanger JJ, Bartolomei F, Chauvel P (2000) Relevance of nonlinear lumped-parameter models in the analysis of depth-EEG epileptic signals. Biol Cybern 83(4):367\u2013378","journal-title":"Biol Cybern"},{"key":"479_CR36","doi-asserted-by":"crossref","unstructured":"Wendling F, Chauvel P (2008) Transition to ictal activity in temporal lobe epilepsy: insights from macroscopic models. In: Soltesz I, Staley K (eds) Computational neuroscience in epilepsy. Elsevier, Amsterdam, pp 356\u2013386","DOI":"10.1016\/B978-012373649-9.50026-0"},{"key":"479_CR37","doi-asserted-by":"crossref","unstructured":"Binder DK, Steinh\u00e4user C (2009) Role of astrocytes in epilepsy. astrocytes in (Patho)physiology of the nervous system. Springer, Berlin, pp 649\u2013671","DOI":"10.1007\/978-0-387-79492-1_25"},{"issue":"1","key":"479_CR38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuroscience.2008.03.039","volume":"158","author":"M Santello","year":"2009","unstructured":"Santello M, Volterra A (2009) Synaptic modulation by astrocytes via Ca2+-dependent glutamate release. Neuroscience 158(1):253\u2013259","journal-title":"Neuroscience"},{"issue":"12","key":"479_CR39","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.0013-9580.2003.12005.x","volume":"44","author":"FH Lopes da Silva","year":"2003","unstructured":"Lopes da Silva FH, Blanes W, Kalitzin SN, Parra J, Suffczynski P, Velis DN (2003) Epilepsies as dynamical diseases of brain systems: basic models of the transition between normal and epileptic activity. Epilepsia 44(12):72\u201383","journal-title":"Epilepsia"},{"key":"479_CR40","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1109\/RBME.2008.2008246","volume":"1","author":"FH Lopes da Silva","year":"2008","unstructured":"Lopes da Silva FH (2008) The impact of EEG\/MEG signal processing and modeling in the diagnostic and management of epilepsy. IEEE Rev Biomed Eng 1:143\u2013156","journal-title":"IEEE Rev Biomed Eng"}],"container-title":["Neural Computing and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-010-0479-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00521-010-0479-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-010-0479-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:47:18Z","timestamp":1559792838000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00521-010-0479-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,9]]},"references-count":40,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["479"],"URL":"https:\/\/doi.org\/10.1007\/s00521-010-0479-0","relation":{},"ISSN":["0941-0643","1433-3058"],"issn-type":[{"value":"0941-0643","type":"print"},{"value":"1433-3058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,9]]}}}