{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T17:14:25Z","timestamp":1780593265670,"version":"3.54.1"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T00:00:00Z","timestamp":1493337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neural Comput & Applic"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00521-017-2996-6","type":"journal-article","created":{"date-parts":[[2017,4,28]],"date-time":"2017-04-28T11:31:43Z","timestamp":1493379103000},"page":"239-248","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Application of ANN and RSM techniques for modeling electrospinning process of polycaprolactone"],"prefix":"10.1007","volume":"31","author":[{"given":"Tahere","family":"Khatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Naderi-Manesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mehdi","family":"Kalantar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,28]]},"reference":[{"issue":"10","key":"2996_CR1","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.progpolymsci.2010.04.002","volume":"35","author":"MA Woodruff","year":"2010","unstructured":"Woodruff MA, Hutmacher DW (2010) The return of a forgotten polymer\u2014polycaprolactone in the 21st century. Prog Polym Sci 35(10):1217\u20131256","journal-title":"Prog Polym Sci"},{"issue":"12","key":"2996_CR2","doi-asserted-by":"publisher","first-page":"3228","DOI":"10.1021\/bm100476r","volume":"11","author":"M Alves da Silva","year":"2010","unstructured":"Alves da Silva M, Martins A, Costa-Pinto A, Costa P, Faria S, Gomes M, Reis R, Neves N (2010) Cartilage tissue engineering using electrospun PCL nanofiber meshes and MSCs. Biomacromolecules 11(12):3228\u20133236","journal-title":"Biomacromolecules"},{"issue":"1","key":"2996_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2004.01.044","volume":"278","author":"V Sinha","year":"2004","unstructured":"Sinha V, Bansal K, Kaushik R, Kumria R, Trehan A (2004) Poly-\u03f5-caprolactone microspheres and nanospheres: an overview. Int J Pharm 278(1):1\u201323","journal-title":"Int J Pharm"},{"issue":"7","key":"2996_CR4","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1163\/156856207781367693","volume":"18","author":"KW Ng","year":"2007","unstructured":"Ng KW, Achuth HN, Moochhala S, Lim TC, Hutmacher DW (2007) In vivo evaluation of an ultra-thin polycaprolactone film as a wound dressing. J Biomater Sci Polym Ed 18(7):925\u2013938","journal-title":"J Biomater Sci Polym Ed"},{"issue":"23","key":"2996_CR5","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1016\/S0142-9612(00)00101-0","volume":"21","author":"JC Middleton","year":"2000","unstructured":"Middleton JC, Tipton AJ (2000) Synthetic biodegradable polymers as orthopedic devices. Biomaterials 21(23):2335\u20132346","journal-title":"Biomaterials"},{"issue":"1","key":"2996_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijpharm.2004.04.013","volume":"282","author":"S Freiberg","year":"2004","unstructured":"Freiberg S, Zhu X (2004) Polymer microspheres for controlled drug release. Int J Pharm 282(1):1\u201318","journal-title":"Int J Pharm"},{"issue":"1","key":"2996_CR7","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.jconrel.2005.09.034","volume":"109","author":"G Gaucher","year":"2005","unstructured":"Gaucher G, Dufresne M-H, Sant VP, Kang N, Maysinger D, Leroux J-C (2005) Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release 109(1):169\u2013188","journal-title":"J Control Release"},{"issue":"2","key":"2996_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/pen.20937","volume":"48","author":"C Marrazzo","year":"2008","unstructured":"Marrazzo C, Di Maio E, Iannace S (2008) Conventional and nanometric nucleating agents in poly (\u03f5-caprolactone) foaming: crystals vs. bubbles nucleation. Polym Eng Sci 48(2):336\u2013344","journal-title":"Polym Eng Sci"},{"issue":"4","key":"2996_CR9","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/S0032-3861(02)00820-0","volume":"44","author":"K Lee","year":"2003","unstructured":"Lee K, Kim H, Khil M, Ra Y, Lee D (2003) Characterization of nano-structured poly (\u03b5-caprolactone) nonwoven mats via electrospinning. Polymer 44(4):1287\u20131294","journal-title":"Polymer"},{"issue":"4","key":"2996_CR10","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s00339-011-6381-5","volume":"103","author":"S Hong","year":"2011","unstructured":"Hong S, Kim G (2011) Fabrication of size-controlled three-dimensional structures consisting of electrohydrodynamically produced polycaprolactone micro\/nanofibers. Applied Physics A 103(4):1009\u20131014","journal-title":"Applied Physics A"},{"issue":"1","key":"2996_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0376-7388(96)00088-9","volume":"117","author":"P Van de Witte","year":"1996","unstructured":"Van de Witte P, Dijkstra P, Van den Berg J, Feijen J (1996) Phase separation processes in polymer solutions in relation to membrane formation. J Membr Sci 117(1):1\u201331","journal-title":"J Membr Sci"},{"issue":"2","key":"2996_CR12","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1350-4487(98)00009-2","volume":"29","author":"S Chakarvarti","year":"1998","unstructured":"Chakarvarti S, Vetter J (1998) Template synthesis\u2014a membrane based technology for generation of nano\u2212\/micro materials: a review. Radiat Meas 29(2):149\u2013159","journal-title":"Radiat Meas"},{"issue":"14","key":"2996_CR13","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1088\/0957-4484\/17\/14\/R01","volume":"17","author":"W Teo","year":"2006","unstructured":"Teo W, Ramakrishna S (2006) A review on electrospinning design and nanofibre assemblies. Nanotechnology 17(14):R89","journal-title":"Nanotechnology"},{"key":"2996_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/9780470229842","volume-title":"Science and technology of polymer nanofibers","author":"AL Andrady","year":"2008","unstructured":"Andrady AL (2008) Science and technology of polymer nanofibers. John Wiley & Sons, Hoboken"},{"issue":"15","key":"2996_CR15","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1016\/S0266-3538(03)00178-7","volume":"63","author":"Z-M Huang","year":"2003","unstructured":"Huang Z-M, Zhang Y-Z, Kotaki M, Ramakrishna S (2003) A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol 63(15):2223\u20132253","journal-title":"Compos Sci Technol"},{"issue":"10","key":"2996_CR16","doi-asserted-by":"publisher","first-page":"4262","DOI":"10.1007\/s10853-012-6276-7","volume":"47","author":"P Agarwal","year":"2012","unstructured":"Agarwal P, Mishra P, Srivastava P (2012) Statistical optimization of the electrospinning process for chitosan\/polylactide nanofabrication using response surface methodology. J Mater Sci 47(10):4262\u20134269","journal-title":"J Mater Sci"},{"issue":"4","key":"2996_CR17","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1016\/j.compositesb.2012.01.051","volume":"43","author":"A Doustgani","year":"2012","unstructured":"Doustgani A, Vasheghani-Farahani E, Soleimani M, Hashemi-Najafabadi S (2012) Optimizing the mechanical properties of electrospun polycaprolactone and nanohydroxyapatite composite nanofibers. Compos Part B 43(4):1830\u20131836","journal-title":"Compos Part B"},{"issue":"1","key":"2996_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/app.36726","volume":"126","author":"K Nasouri","year":"2012","unstructured":"Nasouri K, Bahrambeygi H, Rabbi A, Shoushtari AM, Kaflou A (2012) Modeling and optimization of electrospun PAN nanofiber diameter using response surface methodology and artificial neural networks. J Appl Polym Sci 126(1):127\u2013135","journal-title":"J Appl Polym Sci"},{"issue":"6","key":"2996_CR19","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1007\/s00521-012-1111-2","volume":"23","author":"K Gunoglu","year":"2013","unstructured":"Gunoglu K, Demir N, Akkurt I, Demirci ZN (2013) ANN modeling of the bremsstrahlung photon flux in tantalum target. Neural Comput & Applic 23(6):1591\u20131595","journal-title":"Neural Comput & Applic"},{"issue":"3\u20134","key":"2996_CR20","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00521-012-1268-8","volume":"24","author":"A El-Shafie","year":"2014","unstructured":"El-Shafie A (2014) Neural network nonlinear modeling for hydrogen production using anaerobic fermentation. Neural Comput & Applic 24(3\u20134):539\u2013547","journal-title":"Neural Comput & Applic"},{"issue":"6","key":"2996_CR21","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1016\/j.matdes.2007.02.009","volume":"28","author":"W Sha","year":"2007","unstructured":"Sha W, Edwards K (2007) The use of artificial neural networks in materials science based research. Mater Des 28(6):1747\u20131752","journal-title":"Mater Des"},{"issue":"1","key":"2996_CR22","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.matdes.2006.12.013","volume":"29","author":"O Y\u00f6rdem","year":"2008","unstructured":"Y\u00f6rdem O, Papila M, Mencelo\u011flu YZ (2008) Effects of electrospinning parameters on polyacrylonitrile nanofiber diameter: an investigation by response surface methodology. Mater Des 29(1):34\u201344","journal-title":"Mater Des"},{"issue":"11","key":"2996_CR23","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.1016\/j.eurpolymj.2005.05.008","volume":"41","author":"S Gu","year":"2005","unstructured":"Gu S, Ren J, Vancso G (2005) Process optimization and empirical modeling for electrospun polyacrylonitrile (PAN) nanofiber precursor of carbon nanofibers. Eur Polym J 41(11):2559\u20132568","journal-title":"Eur Polym J"},{"issue":"3\u20134","key":"2996_CR24","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s00521-014-1554-8","volume":"25","author":"HM Khanlou","year":"2014","unstructured":"Khanlou HM, Sadollah A, Ang BC, Kim JH, Talebian S, Ghadimi A (2014) Prediction and optimization of electrospinning parameters for polymethyl methacrylate nanofiber fabrication using response surface methodology and artificial neural networks. Neural Comput & Applic 25(3\u20134):767\u2013777","journal-title":"Neural Comput & Applic"},{"key":"2996_CR25","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.eurpolymj.2015.11.014","volume":"74","author":"MK Sadan","year":"2016","unstructured":"Sadan MK, Ahn H-J, Chauhan G, Reddy N (2016) Quantitative estimation of poly (methyl methacrylate) nano-fiber membrane diameter by artificial neural networks. Eur Polym J 74:91\u2013100","journal-title":"Eur Polym J"},{"issue":"7","key":"2996_CR26","doi-asserted-by":"publisher","first-page":"3156","DOI":"10.1016\/j.jmatprotec.2008.07.032","volume":"209","author":"K Sarkar","year":"2009","unstructured":"Sarkar K, Ghalia MB, Wu Z, Bose SC (2009) A neural network model for the numerical prediction of the diameter of electro-spun polyethylene oxide nanofibers. J Mater Process Technol 209(7):3156\u20133165","journal-title":"J Mater Process Technol"},{"issue":"8","key":"2996_CR27","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s12221-012-1007-x","volume":"13","author":"A Rabbi","year":"2012","unstructured":"Rabbi A, Nasouri K, Bahrambeygi H, Shoushtari AM, Babaei MR (2012) RSM and ANN approaches for modeling and optimizing of electrospun polyurethane nanofibers morphology. Fibers and Polymers 13(8):1007\u20131014","journal-title":"Fibers and Polymers"},{"key":"2996_CR28","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.cej.2012.08.087","volume":"210","author":"N Sarlak","year":"2012","unstructured":"Sarlak N, Nejad MAF, Shakhesi S, Shabani K (2012) Effects of electrospinning parameters on titanium dioxide nanofibers diameter and morphology: an investigation by Box\u2013Wilson central composite design (CCD). Chem Eng J 210:410\u2013416","journal-title":"Chem Eng J"},{"issue":"4","key":"2996_CR29","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1515\/secm-2013-0017","volume":"20","author":"A Sadollah","year":"2013","unstructured":"Sadollah A, Ghadimi A, Metselaar IH, Bahreininejad A (2013) Prediction and optimization of stability parameters for titanium dioxide nanofluid using response surface methodology and artificial neural networks. Sci Eng Compos Mater 20(4):319\u2013330","journal-title":"Sci Eng Compos Mater"},{"issue":"2","key":"2996_CR30","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/app.35170","volume":"124","author":"R Faridi-Majidi","year":"2012","unstructured":"Faridi-Majidi R, Ziyadi H, Naderi N, Amani A (2012) Use of artificial neural networks to determine parameters controlling the nanofibers diameter in electrospinning of nylon-6,6. J Appl Polym Sci 124(2):1589\u20131597","journal-title":"J Appl Polym Sci"},{"issue":"6","key":"2996_CR31","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.elstat.2014.09.003","volume":"72","author":"AA Ali","year":"2014","unstructured":"Ali AA, Eltabey M, Farouk W, Zoalfakar SH (2014) Electrospun precursor carbon nanofibers optimization by using response surface methodology. J Electrost 72(6):462\u2013469","journal-title":"J Electrost"},{"issue":"11","key":"2996_CR32","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/mame.200500215","volume":"290","author":"SY Gu","year":"2005","unstructured":"Gu SY, Ren J (2005) Process optimization and empirical modeling for electrospun poly (D,L-lactide) fibers using response surface methodology. Macromol Mater Eng 290(11):1097\u20131105","journal-title":"Macromol Mater Eng"},{"issue":"4","key":"2996_CR33","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s12221-014-0767-x","volume":"15","author":"M Naghibzadeh","year":"2014","unstructured":"Naghibzadeh M, Adabi M (2014) Evaluation of effective electrospinning parameters controlling gelatin nanofibers diameter via modelling artificial neural networks. Fibers and Polymers 15(4):767\u2013777","journal-title":"Fibers and Polymers"},{"issue":"3","key":"2996_CR34","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1134\/S0965545X16030093","volume":"58","author":"S Khalili","year":"2016","unstructured":"Khalili S, Khorasani SN, Saadatkish N, Khoshakhlagh K (2016) Characterization of gelatin\/cellulose acetate nanofibrous scaffolds: prediction and optimization by response surface methodology and artificial neural networks. Polymer Science Series A 58(3):399\u2013408","journal-title":"Polymer Science Series A"},{"issue":"5","key":"2996_CR35","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1002\/ceat.201400323","volume":"38","author":"S\u00d6 G\u00f6nen","year":"2015","unstructured":"G\u00f6nen S\u00d6, Taygun ME, K\u00fc\u00e7\u00fckbayrak S (2015) Effects of electrospinning parameters on gelatin\/poly (\u03f5-caprolactone) nanofiber diameter. Chemical Engineering & Technology 38(5):844\u2013850","journal-title":"Chemical Engineering & Technology"},{"issue":"2","key":"2996_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1515\/epoly-2014-0198","volume":"15","author":"MA Karimi","year":"2015","unstructured":"Karimi MA, Pourhakkak P, Adabi M, Firoozi S, Adabi M, Naghibzadeh M (2015) Using an artificial neural network for the evaluation of the parameters controlling PVA\/chitosan electrospun nanofibers diameter. E-Polymers 15(2):127\u2013138","journal-title":"E-Polymers"},{"key":"2996_CR37","unstructured":"Ketabchi N, Naghibzadeh M, Adabi M, Esnaashari SS, Faridi-Majidi R (2016) Preparation and optimization of chitosan\/polyethylene oxide nanofiber diameter using artificial neural networks. Neural Computing and Applications:1\u201313"},{"issue":"4","key":"2996_CR38","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/mame.200300224","volume":"289","author":"CM Hsu","year":"2004","unstructured":"Hsu CM, Shivkumar S (2004) N, N-Dimethylformamide additions to the solution for the electrospinning of poly (\u03b5-caprolactone) nanofibers. Macromol Mater Eng 289(4):334\u2013340","journal-title":"Macromol Mater Eng"},{"issue":"3","key":"2996_CR39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1089\/ten.2006.0205","volume":"13","author":"M Chen","year":"2007","unstructured":"Chen M, Patra PK, Warner SB, Bhowmick S (2007) Role of fiber diameter in adhesion and proliferation of NIH 3T3 fibroblast on electrospun polycaprolactone scaffolds. Tissue Eng 13(3):579\u2013587","journal-title":"Tissue Eng"},{"issue":"4","key":"2996_CR40","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/00401706.1960.10489912","volume":"2","author":"GE Box","year":"1960","unstructured":"Box GE, Behnken DW (1960) Some new three level designs for the study of quantitative variables. Technometrics 2(4):455\u2013475","journal-title":"Technometrics"},{"issue":"4","key":"2996_CR41","first-page":"620","volume":"4","author":"M Manohar","year":"2013","unstructured":"Manohar M, Joseph J, Selvaraj T, Sivakumar D (2013) Application of Box Behnken design to optimize the parameters for turning Inconel 718 using coated carbide tools. International Journal of Scientific & Engineering Research 4(4):620\u2013642","journal-title":"International Journal of Scientific & Engineering Research"},{"issue":"12","key":"2996_CR42","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1163\/156856205774576655","volume":"16","author":"N B\u00f6lgen","year":"2005","unstructured":"B\u00f6lgen N, Mencelo\u011flu YZ, Acatay K, Vargel I, Pi\u015fkin E (2005) In vitro and in vivo degradation of non-woven materials made of poly (\u03b5-caprolactone) nanofibers prepared by electrospinning under different conditions. J Biomater Sci Polym Ed 16(12):1537\u20131555","journal-title":"J Biomater Sci Polym Ed"},{"issue":"5","key":"2996_CR43","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/0893-6080(89)90020-8","volume":"2","author":"K Hornik","year":"1989","unstructured":"Hornik K, Stinchcombe M, White H (1989) Multilayer feedforward networks are universal approximators. Neural Netw 2(5):359\u2013366","journal-title":"Neural Netw"},{"key":"2996_CR44","volume-title":"Learning and soft computing: support vector machines, neural networks, and fuzzy logic models","author":"V Kecman","year":"2001","unstructured":"Kecman V (2001) Learning and soft computing: support vector machines, neural networks, and fuzzy logic models. MIT Press, Cambridge"},{"key":"2996_CR45","volume-title":"Data mining with computational intelligence","author":"L Wang","year":"2006","unstructured":"Wang L, Fu X (2006) Data mining with computational intelligence. Springer Science & Business Media, Berlin"},{"issue":"3","key":"2996_CR46","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1109\/TSMCB.2003.810911","volume":"33","author":"X Fu","year":"2003","unstructured":"Fu X, Wang L (2003) Data dimensionality reduction with application to simplifying RBF network structure and improving classification performance. IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics) 33(3):399\u2013409","journal-title":"IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics)"}],"container-title":["Neural Computing and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00521-017-2996-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-017-2996-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-017-2996-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T06:27:19Z","timestamp":1556346439000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00521-017-2996-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,28]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["2996"],"URL":"https:\/\/doi.org\/10.1007\/s00521-017-2996-6","relation":{},"ISSN":["0941-0643","1433-3058"],"issn-type":[{"value":"0941-0643","type":"print"},{"value":"1433-3058","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,28]]},"assertion":[{"value":"16 June 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}