{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:14:32Z","timestamp":1750997672397,"version":"3.41.0"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T00:00:00Z","timestamp":1509321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neural Comput &amp; Applic"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00521-017-3245-8","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T17:03:08Z","timestamp":1509382988000},"page":"2955-2978","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Nonlinear single-input single-output model-based estimation of cardiac output for normal and depressed cases"],"prefix":"10.1007","volume":"31","author":[{"given":"Islam Ismail","family":"Mohamed","sequence":"first","affiliation":[]},{"given":"Mohamed Abdelkader","family":"Aboamer","sequence":"additional","affiliation":[]},{"given":"Ahmad Taher","family":"Azar","sequence":"additional","affiliation":[]},{"given":"Khaled","family":"Wahba","sequence":"additional","affiliation":[]},{"given":"Andy","family":"Schumann","sequence":"additional","affiliation":[]},{"given":"Karl J\u00fcrgen","family":"B\u00e4r","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"3245_CR1","volume-title":"Kaplan and Sadock\u2019s pocket handbook of clinical psychiatry","author":"BJ Sadock","year":"2002","unstructured":"Sadock BJ, Sadock VA (2002) Kaplan and Sadock\u2019s pocket handbook of clinical psychiatry, 3rd edn. Lippincott Williams & Wilkins, Philadelphia","edition":"3"},{"issue":"9758","key":"3245_CR2","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1016\/S0140-6736(10)61508-5","volume":"376","author":"V Patel","year":"2010","unstructured":"Patel V, Weiss HA, Chowdhary N, Naik S, Pednekar S, Chatterjee S, De Silva MJ, Bhat B, Araya R, King M, Simon G, Verdeli H, Kirkwood BR (2010) Effectiveness of an intervention led by lay health counsellors for depressive and anxiety disorders in primary care. Lancet 376(9758):2086\u20132095","journal-title":"Lancet"},{"issue":"10","key":"3245_CR3","doi-asserted-by":"publisher","first-page":"e13196","DOI":"10.1371\/journal.pone.0013196","volume":"5","author":"G Andrews","year":"2010","unstructured":"Andrews G, Cuijpers P, Craske MG, McEvoy P, Titov N (2010) Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis. PLoS ONE 5(10):e13196","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"3245_CR4","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0304-4076(03)00145-3","volume":"118","author":"J Schuppen","year":"2004","unstructured":"Schuppen J (2004) System theory for system identification. J Econom 118(1\u20132):313\u2013339","journal-title":"J Econom"},{"issue":"4","key":"3245_CR5","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1177\/026988110201600410","volume":"16","author":"B Silke","year":"2002","unstructured":"Silke B, Campbell C, King DJ (2002) The potential cardiotoxicity of antipsychotic drugs as assessed by heart rate variability. J Psychopharmacol 16(4):355\u2013360","journal-title":"J Psychopharmacol"},{"issue":"9","key":"3245_CR6","doi-asserted-by":"publisher","first-page":"783","DOI":"10.2165\/00002018-200730090-00005","volume":"30","author":"CA Murphy","year":"2007","unstructured":"Murphy CA, Dargie HJ (2007) Drug-induced cardiovascular disorders. Drug Saf 30(9):783\u2013804","journal-title":"Drug Saf"},{"issue":"1","key":"3245_CR7","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/hup.915","volume":"23","author":"P Mackin","year":"2008","unstructured":"Mackin P (2008) Cardiac side effects of psychiatric drugs. Hum Psychopharmacol 23(1):3\u201314","journal-title":"Hum Psychopharmacol"},{"issue":"4","key":"3245_CR8","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1007\/s00210-002-0595-1","volume":"366","author":"J Magyar","year":"2002","unstructured":"Magyar J, B\u00e1ny\u00e1sz T, Bagi Z, Pacher P, Szentandr\u00e1ssy N, F\u00fcl\u00f6p L, Kecskem\u00e9ti V, N\u00e1n\u00e1si PP (2002) Electrophysiological effects of risperidone in mammalian cardiac cells. Naunyn Schmiedebergs Arch Pharmacol 366(4):350\u2013356","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"10","key":"3245_CR9","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1056\/NEJMra032426","volume":"350","author":"DM Roden","year":"2004","unstructured":"Roden DM (2004) Drug-induced prolongation of the QT interval. N Engl J Med 350(10):1013\u20131022","journal-title":"N Engl J Med"},{"issue":"1","key":"3245_CR10","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1067\/mem.2003.233","volume":"42","author":"PE McKinney","year":"2003","unstructured":"McKinney PE, Rasmussen R (2003) Reversal of severe tricyclic antidepressant-induced cardiotoxicity with intravenous hypertonic saline solution. Ann Emerg Med 42(1):20\u201324","journal-title":"Ann Emerg Med"},{"issue":"2","key":"3245_CR11","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1517\/14740338.7.2.181","volume":"7","author":"Serge Sicouri","year":"2008","unstructured":"Sicouri Serge, Antzelevitch Charles (2008) Sudden cardiac death secondary to antidepressant and antipsychotic drugs. Expert Opin Drug Saf 7(2):181\u2013194","journal-title":"Expert Opin Drug Saf"},{"issue":"7296","key":"3245_CR12","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1136\/bmj.322.7296.1207","volume":"322","author":"DM Coulter","year":"2001","unstructured":"Coulter DM, Bate A, Meyboom RH, Lindquist M, Edwards IR (2001) Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study. BMJ 322(7296):1207\u20131209","journal-title":"BMJ"},{"issue":"3","key":"3245_CR13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.etp.2005.09.003","volume":"57","author":"D Belhani","year":"2006","unstructured":"Belhani D, Frassati D, Megard R, Tsibiribi P, Bui-Xuan B, Tabib A, Fanton L, Malicier D, Descotes J, Timour Q (2006) Cardiac lesions induced by neuroleptic drugs in the rabbit. Exp Toxicol Pathol 57(3):207\u2013212","journal-title":"Exp Toxicol Pathol"},{"issue":"9","key":"3245_CR14","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.medin.2011.01.014","volume":"35","author":"X Garcia","year":"2011","unstructured":"Garcia X, Mateu L, Maynar J, Mercadal J, Ochagav\u00eda A, Ferrandiz A (2011) Estimating cardiac output. Utility in the clinical practice. Available invasive and non-invasive monitoring. Med Intensiva 35(9):552\u2013561","journal-title":"Med Intensiva"},{"issue":"5","key":"3245_CR15","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.mpaic.2010.02.009","volume":"11","author":"E Kirkman","year":"2010","unstructured":"Kirkman E, Sawdon M (2010) Neurological and humoral control of blood pressure. Anaesth Intensive Care Med 11(5):159\u2013164","journal-title":"Anaesth Intensive Care Med"},{"issue":"5","key":"3245_CR16","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.jpsychires.2004.12.007","volume":"39","author":"KJ Bar","year":"2005","unstructured":"Bar KJ, Letzsch A, Jochum T, Wagner G, Greiner W, Sauer H (2005) Loss of efferent vagal activity in acute schizophrenia. J Psychiatr Res 39(5):519\u2013527","journal-title":"J Psychiatr Res"},{"issue":"3","key":"3245_CR17","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.jpsychires.2009.07.011","volume":"44","author":"LH Brook","year":"2010","unstructured":"Brook LH, Arpi M, Martin PP, Mark AG, William P (2010) Heart rate variability in bipolar mania and schizophrenia. J Psychiatr Res 44(3):168\u2013176","journal-title":"J Psychiatr Res"},{"issue":"1\u20133","key":"3245_CR18","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.schres.2008.12.026","volume":"109","author":"MN Castro","year":"2009","unstructured":"Castro MN, Vigo DE, Chu EM, Fahrer RD, de Ach\u00e1val D, Costanzo EY, Leiguarda RC, Nogu\u00e9s M, Cardinali DP, Guinjoan SM (2009) Heart rate variability response to mental arithmetic stress is abnormal in first-degree relatives of individuals with schizophrenia. Schizophr Res 109(1\u20133):134\u2013140","journal-title":"Schizophr Res"},{"issue":"1","key":"3245_CR19","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/S0022-3999(97)00202-X","volume":"44","author":"BH Friedman","year":"1998","unstructured":"Friedman BH, Thayer JF (1998) Autonomic balance revisited: panic anxiety and heart rate variability. J Psychosom Res 44(1):133\u2013151","journal-title":"J Psychosom Res"},{"issue":"1","key":"3245_CR20","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10484-006-9029-z","volume":"32","author":"MK Karavidas","year":"2007","unstructured":"Karavidas MK, Lehrer PM, Vaschillo E, Vaschillo B, Marin H, Buyske S, Malinovsky I, Radvanski D, Hassett A (2007) Preliminary results of an open label study of heart rate variability biofeedback for the treatment of major depression. Appl Psychophysiol Biofeedback 32(1):19\u201330","journal-title":"Appl Psychophysiol Biofeedback"},{"issue":"5","key":"3245_CR21","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/1469-8986.00072","volume":"40","author":"M Valkonen-Korhonen","year":"2003","unstructured":"Valkonen-Korhonen M, Tarvainen MP, Ranta-Aho P, Karjalainen PA, Partanen J, Karhu J, Lehtonen J (2003) Heart rate variability in acute psychosis. Psychophysiology 40(5):716\u2013726","journal-title":"Psychophysiology"},{"key":"3245_CR22","unstructured":"Azar AT, Vaidyanathan S (2015) Handbook of research on advanced intelligent control engineering and automation. Advances in computational intelligence and robotics (ACIR) book series, IGI Global, USA. ISBN: 9781466672482"},{"key":"3245_CR23","unstructured":"Azar AT, Vaidyanathan S (2015) Computational intelligence applications in modeling and control. Studies in Computational Intelligence, vol 575, Springer, Berlin. ISBN: 978-3-319-11016-5"},{"key":"3245_CR24","isbn-type":"print","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-13132-0","volume-title":"Chaos modeling and control systems design, studies in computational intelligence","author":"AT Azar","year":"2015","unstructured":"Azar AT, Vaidyanathan S (2015) Chaos modeling and control systems design, studies in computational intelligence, vol 581. Springer, Berlin. ISBN 978-3-319-13131-3","ISBN":"https:\/\/id.crossref.org\/isbn\/9783319131313"},{"key":"3245_CR25","unstructured":"Azar AT, Zhu Q (2015) Advances and applications in sliding mode control systems. Studies in computational intelligence, vol 576. Springer, Berlin. ISBN: 978-3-319-11172-8"},{"key":"3245_CR26","doi-asserted-by":"crossref","unstructured":"Zhu Q, Azar AT (2015) Complex system modelling and control through intelligent soft computations. Studies in fuzziness and soft computing, vol 319. Springer, Berlin. ISBN: 978-3-319-12882-5","DOI":"10.1007\/978-3-319-12883-2"},{"issue":"12","key":"3245_CR27","first-page":"1691","volume":"31","author":"J Sjoberg","year":"1995","unstructured":"Sjoberg J, Zhang Q, Ljung L, Benveniste A, Delyon B, Glorennec PY, Hjalmarsson H, Juditsky A (1995) Non-linear black-box modeling in system identification a unified overview. Auromarica 31(12):1691\u20131724","journal-title":"Auromarica"},{"key":"3245_CR28","volume-title":"System identification theory for the user","author":"Ljung Lennart","year":"1999","unstructured":"Lennart Ljung (1999) System identification theory for the user. Prentice Hall PTR, Link\u00f6ping"},{"issue":"1\/2","key":"3245_CR29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1504\/IJMIC.2011.040495","volume":"13","author":"AT Azar","year":"2011","unstructured":"Azar AT (2011) Neuro-fuzzy system for cardiac signals classification. Int J Model Identif Control (IJMIC) 13(1\/2):108\u2013116","journal-title":"Int J Model Identif Control (IJMIC)"},{"issue":"6","key":"3245_CR30","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1007\/s00521-014-1566-4","volume":"25","author":"MM Aboamer","year":"2014","unstructured":"Aboamer MM, Azar AT, Wahba K, Mohamed ASA (2014) Linear model-based estimation of blood pressure and cardiac output for Normal and Paranoid cases. Neural Comput Appl 25(6):1223\u20131240","journal-title":"Neural Comput Appl"},{"issue":"7\u20138","key":"3245_CR31","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1007\/s00521-014-1621-1","volume":"25","author":"MM Aboamer","year":"2014","unstructured":"Aboamer MM, Azar AT, Mohamed ASA, Bar KJ, Berger BS, Wahba K (2014) Nonlinear features of heart rate variability in paranoid schizophrenic. Neural Comput Appl 25(7\u20138):1535\u20131555","journal-title":"Neural Comput Appl"},{"issue":"1","key":"3245_CR32","first-page":"15","volume":"26","author":"TG Coleman","year":"1983","unstructured":"Coleman TG, Randall JE (1983) HUMAN\u2014a comprehensive physiological model. Physiologist 26(1):15\u201321","journal-title":"Physiologist"},{"key":"3245_CR33","first-page":"1977","volume-title":"A computer model of human respiration: ventilation-blood gas transport and exchange hydrogen ion regulation","author":"C Dickinson","year":"1977","unstructured":"Dickinson C (1977) A computer model of human respiration: ventilation-blood gas transport and exchange hydrogen ion regulation. University Park Press, Baltimore, p 1977"},{"issue":"2","key":"3245_CR34","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1086\/402631","volume":"34","author":"FS Grodins","year":"1959","unstructured":"Grodins FS (1959) Integrative cardiovascular physiology: a mathematical synthesis of cardiac and blood vessel hemodynamics. Q Rev Biol 34(2):93\u2013116","journal-title":"Q Rev Biol"},{"issue":"3","key":"3245_CR35","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1152\/jappl.1954.7.3.283","volume":"7","author":"FS Grodins","year":"1954","unstructured":"Grodins FS, Gray JS, Schroeder KR, Norins AL, Jones RW (1954) Respiratory responses to CO2 inhalation; a theoretical study of a nonlinear biological regulator. J Appl Physiol 7(3):283\u2013308","journal-title":"J Appl Physiol"},{"key":"3245_CR36","first-page":"799","volume-title":"Respiratory physiology: an analytical approach","author":"MC Khoo","year":"1989","unstructured":"Khoo MC, Yamashiro SM (1989) Models of control of breathing. In: Chang HK, Pavia M (eds) Respiratory physiology: an analytical approach. Marcel Dekker, New York, pp 799\u2013829"},{"issue":"6 Pt 2","key":"3245_CR37","first-page":"H1573","volume":"256","author":"JB Madwed","year":"1989","unstructured":"Madwed JB, Albrecht P, Mark RG, Cohen RJ (1989) Low-frequency oscillations in arterial pressure and heart rate: a simple computer model. Am J Physiol 256(6 Pt 2):H1573\u2013H1579","journal-title":"Am J Physiol"},{"issue":"1","key":"3245_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0006-3495(65)86701-7","volume":"5","author":"HT Milhorn","year":"1965","unstructured":"Milhorn HT, Benton R, Ross R, Guyton AC (1965) A mathematical model of the human respiratory control system. Biophys J 5(1):27\u201346","journal-title":"Biophys J"},{"issue":"2","key":"3245_CR39","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1142\/S0219635203000275","volume":"2","author":"M Ursino","year":"2003","unstructured":"Ursino M, Magosso E (2003) Short-term autonomic control of cardiovascular function: a mini-review with the help of mathematical models. J Integr Neurosci 2(2):219\u2013247","journal-title":"J Integr Neurosci"},{"issue":"2\u20133","key":"3245_CR40","first-page":"153","volume":"69","author":"A McCulloch","year":"1998","unstructured":"McCulloch A, Bassingthwaighte J, Hunter P, Noble D (1998) Computational biology of the heart: from structure to function. Prog Biophys Prog Biophys Mol Biol 69(2\u20133):153\u2013155","journal-title":"Prog Biophys Prog Biophys Mol Biol"},{"issue":"6","key":"3245_CR41","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1152\/japplphysiol.00520.2004","volume":"97","author":"MH Tawhai","year":"2004","unstructured":"Tawhai MH, Hunter P, Tschirren J, Reinhardt J, McLennan G, Hoffman EA (2004) CT-based geometry analysis and finite element models of the human and ovine bronchial tree. J Appl Physiol 97(6):2310\u20132321","journal-title":"J Appl Physiol"},{"issue":"4\u20135","key":"3245_CR42","first-page":"261","volume":"36","author":"J Bai","year":"1997","unstructured":"Bai J, Lu H, Zhang J, Zhou X (1997) Simulation study of the interaction between respiration and the cardiovascular system. Methods Inf Med 36(4\u20135):261\u2013263","journal-title":"Methods Inf Med"},{"issue":"1","key":"3245_CR43","doi-asserted-by":"publisher","first-page":"45","DOI":"10.2170\/physiolsci.RP001305","volume":"56","author":"FY Liang","year":"2006","unstructured":"Liang FY, Liu H (2006) Simulation of hemodynamic responses to the Valsalva maneuver: an integrative computational model of the cardiovascular system and the autonomic nervous system. J Physiol Sci 56(1):45\u201365","journal-title":"J Physiol Sci"},{"issue":"6","key":"3245_CR44","doi-asserted-by":"publisher","first-page":"H2661","DOI":"10.1152\/ajpheart.2001.281.6.H2661","volume":"281","author":"K Lu","year":"2001","unstructured":"Lu K, Clark JW Jr, Ghorbel FH, Ware DL, Bidani A (2001) A human cardiopulmonary system model applied to the analysis of the Valsalva maneuver. Am J Physiol Heart Circ Physiol 281(6):H2661\u2013H2679","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"3245_CR45","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1152\/jappl.1991.70.5.2014","volume":"70","author":"MC Khoo","year":"1991","unstructured":"Khoo MC, Gottschalk A, Pack AI (1991) Sleep-induced periodic breathing and apnea: a theoretical study. J Appl Physiol 70(5):2014\u20132024","journal-title":"J Appl Physiol"},{"issue":"3","key":"3245_CR46","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.resp.2003.10.011","volume":"139","author":"R Stephenson","year":"2004","unstructured":"Stephenson R (2004) A theoretical study of the effect of circadian rhythms on sleep-induced periodic breathing and apnoea. Respir Physiol Neurobiol 139(3):303\u2013319","journal-title":"Respir Physiol Neurobiol"},{"issue":"1\u20132","key":"3245_CR47","first-page":"4","volume":"174","author":"C Limei","year":"2010","unstructured":"Limei C, Olga I, Hsing-Hua F, Michael CKK (2010) An integrative model of respiratory and cardiovascular control in sleep disordered breathing. Respir Physiol Neurobiol 174(1\u20132):4\u201328","journal-title":"Respir Physiol Neurobiol"},{"issue":"8","key":"3245_CR48","first-page":"879","volume":"8","author":"B Pennock","year":"1968","unstructured":"Pennock B, Attinger EO (1968) Optimization of the oxygen transport system. Biophysics 8(8):879\u2013896","journal-title":"Biophysics"},{"key":"3245_CR49","doi-asserted-by":"publisher","unstructured":"Lehman AF, Lieberman JA, Dixon LB, McGlashan TH, Miller AL, Perkins DO, Kreyenbuhl J (2004) Practice guidelines for the treatment of patients with schizophrenia second edition. APA Pract Guide. doi: 10.1176\/appi.books.9780890423363.45859","DOI":"10.1176\/appi.books.9780890423363.45859"},{"key":"3245_CR50","unstructured":"Excellence, N. I. f. C (2002) Guidance on the use of newer (atypical) antipsychotic drugs for the treatment of schizophrenia. IOP Publishing Physics. http:\/\/www.nice.org.uk\/nicemedia\/pdf\/ANTIPSYCHOTICfinalguidance.pdf . Accessed May 2005"},{"key":"3245_CR51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051688","author":"J Lieberman","year":"2005","unstructured":"Lieberman J, Stroup TS, Mcevoy JP, Swartz MS, Rosenheck RA, Perkins DO, Keefe RSE, Davis SM, Davis CE, Lebowitz BD, Severe J, Hsiao JK (2005) Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. doi: 10.1056\/NEJMoa051688","journal-title":"N Engl J Med."},{"key":"3245_CR52","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1192\/pb.bp.106.012955","volume":"31","author":"B Stephen","year":"2007","unstructured":"Stephen B, Olubanke O, David T (2007) Which antipsychotics would mental health professionals take themselves? Psychiatrist 31:94\u201396. doi: 10.1192\/pb.bp.106.012955","journal-title":"Psychiatrist"},{"issue":"11","key":"3245_CR53","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.2165\/00003495-200262110-00006","volume":"62","author":"PM Haddad","year":"2002","unstructured":"Haddad PM, Anderson IM (2002) Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs 62(11):1649\u20131671","journal-title":"Drugs"},{"issue":"9209","key":"3245_CR54","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/S0140-6736(00)02035-3","volume":"355","author":"JG Reilly","year":"2000","unstructured":"Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas HL (2000) QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients. Lancet 355(9209):1048\u20131052","journal-title":"Lancet"},{"issue":"2","key":"3245_CR55","first-page":"77","volume":"13","author":"SH Thomas","year":"1994","unstructured":"Thomas SH (1994) Drugs, QT interval ab normalities and ventricular arrhythmias. Adverse Drug React Toxicol Rev 13(2):77\u2013102","journal-title":"Adverse Drug React Toxicol Rev"},{"issue":"1","key":"3245_CR56","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0014-2999(02)02074-5","volume":"450","author":"S Kongsamut","year":"2002","unstructured":"Kongsamut S, Kang J, Chen XL, Roehr J, Rampe D (2002) A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs. Eur J Pharmacol 450(1):37\u201341","journal-title":"Eur J Pharmacol"},{"issue":"Supplement K","key":"3245_CR57","doi-asserted-by":"publisher","first-page":"K70","DOI":"10.1016\/S1520-765X(01)90009-4","volume":"3","author":"B Darpo","year":"2001","unstructured":"Darpo B (2001) Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes. Eur Heart J Suppl 3(Supplement K):K70\u2013K80","journal-title":"Eur Heart J Suppl"},{"issue":"3","key":"3245_CR58","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00004714-198406000-00006","volume":"4","author":"MA Liberatore","year":"1984","unstructured":"Liberatore MA, Robinson DS (1984) Torsade de pointes: a mechanism for sudden death associated with neuroleptic drug therapy? J Clin Psychopharmacol 4(3):143\u2013146","journal-title":"J Clin Psychopharmacol"},{"issue":"7372","key":"3245_CR59","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1136\/bmj.325.7372.1070","volume":"325","author":"S Hennessy","year":"2002","unstructured":"Hennessy S, Bilker WB, Knauss JS, Margolis DJ, Kimmel SE, Reynolds RF, Glasser DB, Morrison MF, Strom BL (2002) Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data. BMJ 325(7372):1070\u20131071","journal-title":"BMJ"},{"issue":"12","key":"3245_CR60","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1001\/archpsyc.58.12.1161","volume":"58","author":"WA Ray","year":"2001","unstructured":"Ray WA, Meredith S, Thapa PB, Meador KG, Hall K, Murray KT (2001) Antipsychotics and the risk of sudden cardiac death. Arch Gen Psychiatry 58(12):1161\u20131167","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"3245_CR61","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1192\/bjp.180.6.515","volume":"180","author":"JG Reilly","year":"2002","unstructured":"Reilly JG, Ayis SA, Ferrier IN, Jones SJ, Thomas SH (2002) Thioridazine and sudden unexplained death in psychiatric inpatients. Br J Psychiatry 180(6):515\u2013522","journal-title":"Br J Psychiatry"},{"issue":"12","key":"3245_CR62","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1001\/archinte.164.12.1293","volume":"164","author":"SM Straus","year":"2004","unstructured":"Straus SM, Bleumink GS, Dieleman JP, van der Lei J, Jong GW, Kingma JH, Sturkenboom MC, Stricker BH (2004) Antipsychotics and the risk of sudden cardiac death. Arch Intern Med 164(12):1293\u20131297","journal-title":"Arch Intern Med"},{"issue":"12","key":"3245_CR63","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1001\/archpsyc.58.12.1168","volume":"58","author":"CA Zarate Jr","year":"2001","unstructured":"Zarate CA Jr, Patel J (2001) Sudden cardiac death and antipsychotic drugs. Arch Gen Psychiatry 58(12):1168\u20131171","journal-title":"Arch Gen Psychiatry"},{"issue":"1","key":"3245_CR64","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1097\/01.jcp.0000104913.75206.62","volume":"24","author":"EP Harrigan","year":"2004","unstructured":"Harrigan EP, Miceli JJ, Anziano R, Watsky E, Reeves KR, Cutler NR, Sramek J, Shiovitz T, Middle M (2004) A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition. J Clin Psychopharmacol 24(1):62\u201369","journal-title":"J Clin Psychopharmacol"},{"issue":"3","key":"3245_CR65","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1176\/appi.psy.47.3.264","volume":"47","author":"TW Heinrich","year":"2006","unstructured":"Heinrich TW, Biblo LA, Schneider J (2006) Torsades de pointes associated with ziprasidone. Psychosomatics 47(3):264\u2013268","journal-title":"Psychosomatics"},{"issue":"5","key":"3245_CR66","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1176\/appi.psy.45.5.450","volume":"45","author":"Y Tei","year":"2004","unstructured":"Tei Y, Morita T, Inoue S, Miyata H (2004) Torsades de pointes caused by a small dose of risperidone in a terminally ill cancer patient. Psychosomatics 45(5):450\u2013451","journal-title":"Psychosomatics"},{"issue":"4","key":"3245_CR67","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/j.1600-0447.2005.00592.x","volume":"112","author":"WV Vieweg","year":"2005","unstructured":"Vieweg WV, Schneider RK, Wood MA (2005) Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine. Acta Psychiatr Scand 112(4):318\u2013322","journal-title":"Acta Psychiatr Scand"},{"key":"3245_CR68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1056\/NEJMoa0806994","volume":"360","author":"AR Wayne","year":"2009","unstructured":"Wayne AR, Cecilia PC, Katherine TM, Kathi H, Michael S (2009) Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 360:225\u2013235. doi: 10.1056\/NEJMoa0806994","journal-title":"N Engl J Med"},{"issue":"suppl 7","key":"3245_CR69","first-page":"32","volume":"62","author":"I Kurzthaler","year":"2001","unstructured":"Kurzthaler I, Fleischhacker WW (2001) The clinical implications of weight gain in schizophrenia. J Clin Psychiatry 62(suppl 7):32\u201337","journal-title":"J Clin Psychiatry"},{"issue":"3","key":"3245_CR70","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S0735-1097(00)00804-4","volume":"36","author":"JS Alpert","year":"2000","unstructured":"Alpert JS, Thygesen K, Antman E, Bassand JP (2000) Myocardial infarction redefined\u2014a consensus document of The Joint European Society of Cardiology\/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 36(3):959\u2013969","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"3245_CR71","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/clinchem\/47.3.377","volume":"47","author":"FS Apple","year":"2001","unstructured":"Apple FS, Wu AH (2001) Myocardial infarction redefined: role of cardiac troponin testing. Clin Chem 47(3):377\u2013379","journal-title":"Clin Chem"},{"issue":"2","key":"3245_CR72","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1192\/apt.12.2.100","volume":"12","author":"N Abdelmawla","year":"2006","unstructured":"Abdelmawla N, Mitchell A (2006) Sudden cardiac death and antipsychotics. Part 2: monitoring and prevention. Adv Psychiatr Treat 12(2):100\u2013109","journal-title":"Adv Psychiatr Treat"},{"key":"3245_CR73","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1177\/070674370505000909","volume":"50","author":"MJ Poulin","year":"2005","unstructured":"Poulin MJ, Cortese L, Williams R, Wine N, McIntyre RS (2005) Atypical antipsychotics in psychiatric practice: practical implications for clinical monitoring. Can J Psychiatry 50:555\u2013562","journal-title":"Can J Psychiatry"},{"issue":"8","key":"3245_CR74","first-page":"444","volume":"50","author":"K Nupura","year":"2008","unstructured":"Nupura K, Beth LA, Robert C, Lawrence AL, Sarah H, Robert S, Moumita B, Susan S, Ahmed M, Mark P, Laura RP, Lori W, Tammy S, Adam L, Casimir S, Shree B (2008) Atypical antipsychotics, schizophrenia, and cardiovascular risk: what family physicians need to know. BCMJ 50(8):444\u2013450","journal-title":"BCMJ"},{"key":"3245_CR75","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0304-4076(01)00063-X","volume":"104","author":"MY Zhang","year":"2001","unstructured":"Zhang MY, Russell JR, Tsay RS (2001) A nonlinear autoregressive conditional duration model with applications to financial transaction data. J Econom 104:179\u2013207","journal-title":"J Econom"},{"key":"3245_CR76","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1103\/PhysRevE.60.1073","volume":"60","author":"K Epifanio Bagarinao","year":"1999","unstructured":"Epifanio Bagarinao K, Pakdaman Taishin Nomura, Sato Shunsuke (1999) Reconstructing bifurcation diagrams from noisy time series using nonlinear autoregressive models. Phys Rev E 60:1073\u20131076","journal-title":"Phys Rev E"},{"key":"3245_CR77","doi-asserted-by":"crossref","unstructured":"Lee MY, Yu SN (August 31 2010\u2013September 4 2010) Improving discriminality in heart rate variability analysis using simple artifact and trend removal preprocessors. In: Conference proceedings of the IEEE engineering in medicine and biology society, Buenos Aires, Argentina, pp 4574\u20134577","DOI":"10.1109\/IEMBS.2010.5626022"},{"issue":"1\u20133","key":"3245_CR78","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S0925-2312(98)00056-3","volume":"22","author":"AK Barros","year":"1998","unstructured":"Barros AK, Mansour A, Ohnishi N (1998) Removing artifacts from electrocardiographic signals using independent components analysis. Neurocomputing 22(1\u20133):173\u2013186","journal-title":"Neurocomputing"},{"key":"3245_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1201\/9781420027532","volume-title":"The Hilbert-Huang transform in engineering, chapter 1","author":"N Huang","year":"2005","unstructured":"Huang N, Attoh-Okine NO (2005) The Hilbert-Huang transform in engineering, chapter 1. Taylor & Francis Group, LLC Publisher, Boca Raton, pp 1\u201322"},{"issue":"9","key":"3245_CR80","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1109\/TBME.2010.2051440","volume":"57","author":"B Mijovi","year":"2010","unstructured":"Mijovi B, De Vos M, Gligorijevi I, Taelman J (2010) Source separation from single-channel recordings by combining empirical- mode decomposition and independent component analysis. IEEE Trans Biomed Eng 57(9):2188\u20132196","journal-title":"IEEE Trans Biomed Eng"},{"issue":"3","key":"3245_CR81","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1109\/5.993400","volume":"90","author":"E Meijering","year":"2002","unstructured":"Meijering E (2002) A chronology of interpolation: from ancient astronomy to modern signal and image processing. Proc IEEE 90(3):319\u2013342. doi: 10.1109\/5.993400","journal-title":"Proc IEEE"},{"issue":"8","key":"3245_CR82","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1097\/PSY.0b013e3181b8bb7a","volume":"71","author":"M Koschke","year":"2009","unstructured":"Koschke M, Boettger MK, Schulz S, Berger S, Terhaar J, Voss A, Yeragani VK, B\u00e4r KJ (2009) Autonomy of autonomic dysfunction in major depression. Psychosom Med 71(8):852\u2013860","journal-title":"Psychosom Med"},{"issue":"4","key":"3245_CR83","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1037\/0021-843X.114.4.560","volume":"114","author":"MB First","year":"2005","unstructured":"First MB (2005) Clinical utility: a prerequisite for the adoption of a dimensional approach in DSM. J Abnorm Psychol 114(4):560\u2013564","journal-title":"J Abnorm Psychol"},{"key":"3245_CR84","doi-asserted-by":"crossref","unstructured":"Heymann S, Latapy M, Magnien C (26\u201329 August 2012) Outskewer: using skewness to spot outliers in samples and time series. Advances in social networks analysis and mining (ASONAM), 2012 IEEE\/ACM international conference, Istanbul, pp 527\u2013534","DOI":"10.1109\/ASONAM.2012.91"},{"key":"3245_CR85","first-page":"100","volume-title":"Basic statistics for business & economics, chapter 4","author":"DA Lind","year":"2006","unstructured":"Lind DA, Marchal WG, Wathen SA (2006) Basic statistics for business & economics, chapter 4, 5th edn. McGraw-Hill Companies, Asia, pp 100\u2013119","edition":"5"},{"key":"3245_CR86","unstructured":"Saini BS, Singh D, Uddin M, Kumar V (2008) Improved power spectrum estimation for RR-interval time series. World Acad Sci Eng Technol Int Sci Index 22:43\u201348"},{"issue":"3","key":"3245_CR87","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1093\/oxfordjournals.eurheartj.a014868","volume":"17","author":"M Malik","year":"1996","unstructured":"Malik M (1996) Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 17(3):354\u2013381","journal-title":"Eur Heart J"},{"key":"3245_CR88","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-6333-3","volume-title":"A practical guide to splines","author":"C Boor De","year":"1978","unstructured":"De Boor C (1978) A practical guide to splines. Springer, New York"},{"issue":"16","key":"3245_CR89","first-page":"1587","volume":"45","author":"Jesica Escobar","year":"2012","unstructured":"Escobar Jesica, Enqvist Martin (2012) On the detection of nonlinearities in sampled data. IFAC 45(16):1587\u20131592","journal-title":"IFAC"},{"key":"3245_CR90","doi-asserted-by":"crossref","unstructured":"Partington JR (2004) Linear operators and linear systems. London Mathematical Society Student Texts (60). Cambridge University Press, p 75. ISBN: 0-521-54619-2","DOI":"10.1017\/CBO9780511616693"},{"issue":"2","key":"3245_CR91","first-page":"1137","volume":"14","author":"R Kohavi","year":"1995","unstructured":"Kohavi R (1995) A study of cross-validation and bootstrap for accuracy estimation and model selection. Ijcai 14(2):1137\u20131145","journal-title":"Ijcai"},{"issue":"4","key":"3245_CR92","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1175\/1520-0434(1992)007<0613:TISLSW>2.0.CO;2","volume":"7","author":"GB Anthony","year":"1992","unstructured":"Anthony GB (1992) Correspondence among the correlation, RMSE, and Heidke forecast verification measures; refinement of the Heidke score. Weather Forecast 7(4):699\u2013709","journal-title":"Weather Forecast"}],"container-title":["Neural Computing and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00521-017-3245-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-017-3245-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00521-017-3245-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T20:07:12Z","timestamp":1750968432000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00521-017-3245-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":92,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["3245"],"URL":"https:\/\/doi.org\/10.1007\/s00521-017-3245-8","relation":{},"ISSN":["0941-0643","1433-3058"],"issn-type":[{"type":"print","value":"0941-0643"},{"type":"electronic","value":"1433-3058"}],"subject":[],"published":{"date-parts":[[2017,10,30]]},"assertion":[{"value":"12 April 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}