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This approach shall support patients in overcoming the after-effects of therapy effectively with suitable supportive actions and health-care professionals in goal-oriented planning of these actions. Different AI methods are used for analyzing patients\u2019 needs for supportive actions depending on the available health data and for a monitoring of these actions. Decision support methods are used for effective planning of actions based on the AI results of analysis. The solution approach is realized in the form of a web application for health-care professionals, which allows for data analysis and planning of actions, and a mobile application for patients, which facilitates documentation and monitoring of supportive actions. In combination, they facilitate a closed-loop workflow for the effective cooperation of health-care professionals and cancer patients. 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