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Recent studies show that various machine learning models have the potential to improve the accuracy of CADx systems. However, existing models suffer from low prediction accuracy. In this work, we present research findings to improve the effectiveness of CADx systems for detecting skin diseases by adopting optimized ensemble machine learning models. The investigation encompasses the exploration of three popular classification methods: linear discriminant analysis (LDA), support vector machine (SVM), and convolutional neural network (CNN); two customized CNN models: LeNet-5 and ResNet; and an ensemble model of CNN with SVM. The ensemble CNN-SVM model is optimized using techniques such as feature aggregation and weight adjustments. Skin lesion images from Kaggle\u2019s Human Against Machine 10000 (HAM10000) are used to train and test all classification models. Through rigorous experiments, the results highlight the compelling efficacy of the ensemble CNN-SVM model, unveiling heightened accuracy of up to 92% (from ResNet accuracy of 88%, CNN accuracy of 85%, SVM accuracy of 83%, LeNet-5 accuracy of 77%, and LDA accuracy of 75%). The models are tested on another dataset from Kaggle\u2019s Melanoma Skin Cancer Dataset of 10000 Images; new results follow a similar trend to those using the HAM10000 dataset. The outcome of this work has profound implications for artificial intelligence (AI) accelerated engineering applications in advancing the effectiveness of skin disease treatment through diagnosis systems.<\/jats:p>","DOI":"10.1007\/s00521-025-11336-w","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T09:21:10Z","timestamp":1749115270000},"page":"16735-16751","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Application of ensemble learning models in computer-aided diagnosis of skin diseases"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-1575","authenticated-orcid":false,"given":"Abu","family":"Asaduzzaman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian C.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fadi N.","family":"Sibai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md J.","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"11336_CR1","doi-asserted-by":"publisher","unstructured":"Afandi MNH, Mandala S, Sutedia EK (2024) Study of the ensemble deep learning algorithm to detect image-based skin cancer melanoma and basal cell carcinoma. 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