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They have proven capable of tasks such as prediction, learning and adaptation based on experience and can be used in virtually any scientific application, ranging from biomedical, robotic, to business decision applications, and others. However, the lack of domain knowledge for a particular application can make feature extraction ineffective or even unattainable. Furthermore, even in the presence of pre-processed datasets, the iterative process of optimizing Machine Learning parameters, which do not translate from one domain to another, maybe difficult for inexperienced practitioners. To address these issues, we present in this paper a Vectorized Automated ML Pre-processIng and post-pRocEssing framework, approximately named (<jats:italic>VAMPIRE<\/jats:italic>), which implements feature extraction algorithms capable of converting large time-series recordings into datasets. Also, it introduces a new concept, the <jats:italic>Activation Engine<\/jats:italic>, which is attached to the output of a Multi Layer Perceptron and extracts the optimal threshold to apply binary classification. Moreover, a tree-based algorithm is used to achieve multi-class classification using the <jats:italic>Activation Engine<\/jats:italic>. Furthermore, the internet of things gives rise to new applications such as remote sensing and communications, so consequently applying Machine Learning to improve operation accuracy, latency, and reliability is beneficial in such systems. Therefore, all classifications in this paper were performed on the edge in order to reach high accuracy with limited resources. Moreover, forecasts were applied on three unrelated biomedical datasets, and on two other pre-processed urban and activity detection datasets. Features were extracted when required, and training and testing were performed on the Raspberry Pi remotely, where high accuracy and inference speed were achieved in every experiment. Additionally, the board remained competitive in terms of power consumption when compared with a laptop which was optimized using a Graphical Processing Unit.\n<\/jats:p>","DOI":"10.1007\/s00607-022-01096-z","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T20:30:02Z","timestamp":1655929802000},"page":"2453-2487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["VAMPIRE: vectorized automated ML pre-processing and post-processing framework for edge applications"],"prefix":"10.1007","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-0204","authenticated-orcid":false,"given":"Ali W.","family":"Daher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Muselli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Chible","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele D.","family":"Caviglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"1096_CR1","doi-asserted-by":"crossref","unstructured":"Muselli M (2005) Switching neural networks: A new connectionist model for classification. 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