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Studies informed by theoretical underpinned co-creation frameworks and utilization of theoretical informed evaluations are scarce in literature. Thus, this study internationally evaluated the efficacy of three virtual reality reusable e-resources (VRReRs), co-created based on the ASPIRE framework, for teaching clinical skills to university students. The study followed a mixed-methods approach, combining SUS, SUS Presence Questionnaire, TAM, and UTAUT2 with a focus group discussion. Additionally, for one VRReR, a quantitative pre\/post evaluation of knowledge and comparison with lecture notes followed. Results demonstrated moderately to highly usability, effectively facilitated a strong sense of presence, confidence while using them, and willingness to continue using VRReRs in the future, while increased knowledge of the learners, highlighted their effectiveness. Although some usability issues were identified, these were considered easy to address. This work evidence, in an international context, that co-created VR resources are highly acceptable and effective, similar to other types of digital or traditional resources developed through participatory inquiry paradigm. By leveraging the benefits of VR technology, VRReRs have the potential to transform and enhance the learning experience in the field of clinical skills, ultimately advancing the digitalization of higher education.<\/jats:p>","DOI":"10.1007\/s00779-024-01805-9","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T22:01:38Z","timestamp":1713996098000},"page":"643-654","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Virtual reality reusable e-resources for clinical skills training: a mixed-methods evaluation"],"prefix":"10.1007","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5049-6863","authenticated-orcid":false,"given":"Matthew","family":"Pears","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2650-9529","authenticated-orcid":false,"given":"Panagiotis E.","family":"Antoniou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-6605","authenticated-orcid":false,"given":"Eirini","family":"Schiza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-9905","authenticated-orcid":false,"given":"Georgios","family":"Ntakakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4959-9432","authenticated-orcid":false,"given":"James","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2543-8194","authenticated-orcid":false,"given":"Fotos","family":"Frangoudes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6074-5173","authenticated-orcid":false,"given":"Maria M.","family":"Nikolaidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5916-1827","authenticated-orcid":false,"given":"Evangelia","family":"Gkougkoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1271-8151","authenticated-orcid":false,"given":"Constantinos S.","family":"Pattichis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9936-5805","authenticated-orcid":false,"given":"Panagiotis D.","family":"Bamidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-4559","authenticated-orcid":false,"given":"Stathis Th.","family":"Konstantinidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"1805_CR1","doi-asserted-by":"publisher","first-page":"433","DOI":"10.3233\/shti230167","volume":"302","author":"P Antoniou","year":"2023","unstructured":"Antoniou P, Sidiropoulos E, Stathakarou N, Chatzimallis C, Chondrokostas E, Sumunar D et al (2023) Streamlining tangible 3D printed and intangible XR content creation and evaluation: the ENTICE experience. 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