{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T20:51:19Z","timestamp":1763326279826,"version":"3.45.0"},"reference-count":4,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Artif Life Robotics"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nailfold capillaries, which are located at the base of the fingernail, provide a non-invasive window into peripheral microcirculation and are valuable for the early detection of systemic diseases such as diabetes mellitus and scleroderma, with abnormalities in capillary morphology, such as twisting and enlargement, indicative of vascular damage due to factors such as glucose accumulation. Traditional imaging modalities such as ultrasound and laser imaging have been used to evaluate peripheral blood vessels; however, such methods are often expensive and burdensome. Recently, the use of machine learning with microscopic imaging has shown promise in classifying capillary structures. However, these methods typically require large, annotated datasets, limiting the practicality; thus, we propose a novel approach that uses transfer learning to classify the shape of nailfold capillaries, specifically the presence or absence of capillary twisting. A pre-trained model based on fundus vessel images was fine-tuned for this task, leveraging the structural similarity between retinal and nailfold capillaries. The proposed method was found to achieve accurate and efficient classification even with a limited nailfold dataset, demonstrating its potential for practical clinical use.<\/jats:p>","DOI":"10.1007\/s10015-025-01052-y","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:10:38Z","timestamp":1757362238000},"page":"653-657","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Shape classification of nailfold capillaries using convolutional neural network"],"prefix":"10.1007","volume":"30","author":[{"given":"Rio","family":"Ishiguro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Toyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norimichi","family":"Tsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"1052_CR1","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s42358-018-0046-4","volume":"59","author":"C Kayser","year":"2019","unstructured":"Kayser C, Andrade LE, Brito AC et al (2019) Position article and guidelines: 2018 recommendations of the Brazilian Society of Rheumatology for the indication, interpretation and performance of nailfold capillaroscopy. Adv Rheumatol 59:8","journal-title":"Adv Rheumatol"},{"issue":"11","key":"1052_CR2","first-page":"1706","volume":"27","author":"CE Riva","year":"1986","unstructured":"Riva CE, Grunwald JE, Petrig BL (1986) Autoregulation of human retinal blood flow. an investigation with laser Doppler velocimetry. Invest Ophthalmol Vis Sci 27(11):1706\u20131712","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"1052_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1109\/TMI.2004.825627","volume":"23","author":"J Staal","year":"2004","unstructured":"Staal J, Abramoff MD, Niemeijer M, Viergever MA, van Ginneken B (2004) Ridge-based vessel segmentation in color images of the retina. IEEE Trans Med Imaging 23(4):501\u2013509","journal-title":"IEEE Trans Med Imaging"},{"issue":"5","key":"1052_CR4","first-page":"560","volume":"38","author":"TL Abramson","year":"2022","unstructured":"Abramson TL, Wright GA, Sharma M et al (2022) Canadian cardiovascular society 2022 guidelines for peripheral arterial disease. Can J Cardiol 38(5):560\u2013587","journal-title":"Can J Cardiol"}],"container-title":["Artificial Life and Robotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10015-025-01052-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10015-025-01052-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10015-025-01052-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T20:47:59Z","timestamp":1763326079000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10015-025-01052-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":4,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1052"],"URL":"https:\/\/doi.org\/10.1007\/s10015-025-01052-y","relation":{},"ISSN":["1433-5298","1614-7456"],"issn-type":[{"type":"print","value":"1433-5298"},{"type":"electronic","value":"1614-7456"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"29 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}