{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:32:43Z","timestamp":1772832763655,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T00:00:00Z","timestamp":1176336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pattern Anal Applic"],"published-print":{"date-parts":[[2007,10,10]]},"DOI":"10.1007\/s10044-007-0069-7","type":"journal-article","created":{"date-parts":[[2007,4,18]],"date-time":"2007-04-18T09:43:24Z","timestamp":1176889404000},"page":"301-319","source":"Crossref","is-referenced-by-count":32,"title":["Segmentation of microscope images of living cells"],"prefix":"10.1007","volume":"10","author":[{"given":"Anna","family":"Korzynska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Strojny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hoppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Wertheim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Hoser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,4,12]]},"reference":[{"key":"69_CR1","volume-title":"Cell movement","author":"D Bary","year":"2002","unstructured":"Bary D (2002) Cell movement. Garland, New York"},{"key":"69_CR2","volume-title":"Cells, gels and the engines of life, 2001","author":"H Pollack Gerald","year":"2001","unstructured":"Pollack Gerald H (2001) Cells, gels and the engines of life, 2001. Ebner & Sons, Seattle"},{"key":"69_CR3","volume-title":"Motion analysis of living cells","author":"DR Soll","year":"1998","unstructured":"Soll DR, Wessels D (1998) Motion analysis of living cells. Wiley-Liss, New York"},{"key":"69_CR4","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1126\/science.8493552","volume":"260","author":"TP Stossel","year":"1993","unstructured":"Stossel TP (1993) On the crawling of animal cells. Science 260:1086\u20131094","journal-title":"Science"},{"key":"69_CR5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0014-4827(53)90098-6","volume":"5","author":"M Abercrombie","year":"1953","unstructured":"Abercrombie M, Heaysman JEM (1953) Observation on the social behaviour of cells in tissue culture. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. Exp Cell Res 5:111\u2013131","journal-title":"Exp Cell Res"},{"key":"69_CR6","first-page":"87","volume":"2","author":"J Doroszewski","year":"1993","unstructured":"Doroszewski J, Nowak-Wyrzykowska M, Stoowska L (1993) The method of moments as applied to the study of granulocytes\u2019 shape and movement. Mater Med Polonia 2:87\u201392","journal-title":"Mater Med Polonia"},{"issue":"2","key":"69_CR7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jbm.a.30238","volume":"72","author":"HM Kowalczynska","year":"2005","unstructured":"Kowalczynska HM, Nowak-Wyrzykowska M, Kolos R, Dobkowski J, Kaminski J (2005) Fibronectin adsorption and arrangement on copolymer surfaces and their significance in cell adhesion. J Biomed Mater Res A 72(2):228\u201336","journal-title":"J Biomed Mater Res A"},{"key":"69_CR8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2818.1990.tb02981.x","volume":"158","author":"J Litniewaski","year":"1990","unstructured":"Litniewaski J, Bereiter-Hahn J (1990) Measurment of cells in culture by scanning acustic microscopy. J Microsc 158:95\u2013107","journal-title":"J Microsc"},{"issue":"3\u20134","key":"69_CR9","first-page":"123","volume":"46","author":"Z Madeja","year":"1998","unstructured":"Madeja Z, Kupiec M, Korohoda W (1998) Morphometric analysis of LPS-stimulated humane monocytes computer-assisted image analysis. Folia Biol 46(3\u20134):123\u2013128","journal-title":"Folia Biol"},{"key":"69_CR10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0074-7696(08)62209-3","volume":"163","author":"DR Soll","year":"1995","unstructured":"Soll DR (1995) The use of computer in understanding how animal cells crawl. Int Rev Cytol 163:43\u2013104","journal-title":"Int Rev Cytol"},{"key":"69_CR11","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF02473315","volume":"10","author":"W Warchol","year":"1996","unstructured":"Warchol W, Warchol JB, Filipiak K, Karas Z, Jaroszyk F (1996) Analysis of spermatozoa movement using a video imaging technique. Histochem bell Biol 10:521\u2013526","journal-title":"Histochem bell Biol"},{"key":"69_CR12","first-page":"160","volume":"59","author":"M Zylicz","year":"2005","unstructured":"Zylicz M, Bocian K, Korczak-Kowalska G (2005) Regulatory cells: their development, mechanisms and effects of action, and their potential use in transplantation. Postepy Hig Med Dosw (Online) 59:160\u201371","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"69_CR13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2818.1995.tb03609.x","volume":"179","author":"D Zicha","year":"1995","unstructured":"Zicha D, Dann G (1995) An image processing system for cell behaviour studies in subconfluent cultures. J Microsc 179:11\u201321","journal-title":"J Microsc"},{"key":"69_CR14","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/3-540-32390-2_74","volume-title":"Computer recognition systems","author":"L Miroslaw","year":"2005","unstructured":"Miroslaw L, Chorazyczewski A, Buchholz F, Kittler R (2005) Correlation-based method for automatic mitotic cell detection in phase contrast microscopy. In: Kurzynski M, Puchala E, Wozniak M, Zolnierek A (eds) Computer recognition systems. Springer, Berlin, pp 627\u2013634"},{"key":"69_CR15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/3-540-32390-2_52","volume-title":"Computer recognition systems","author":"M Smereka","year":"2005","unstructured":"Smereka M (2005) Detection of ellipsoidal shapes using contour grouping. In: Kurzynski M, Puchala E, Wozniak M, Zolnierek A (eds) Computer recognition systems. Springer, Berlin, pp 443\u2013450"},{"key":"69_CR16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/jcs.106.4.1005","volume":"106","author":"T Killich","year":"1993","unstructured":"Killich T, Plath PJ, WeiX, Bultmann H, Rensing L, Vicker MG (1993) The locomotion, shape and pseudopodial dynamics of unstimulated dictostelium cell are not random. J Cell Sci 106:1005\u20131013","journal-title":"J Cell Sci"},{"issue":"10","key":"69_CR17","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1182\/blood.V92.10.3616","volume":"92","author":"K Francis","year":"1998","unstructured":"Francis K, Ramakishna R, Holloway W, Palsson BO (1998) Two new pseudopod morphologies displayed by the human hematopoietic KG1a progenitor cell line and by primary human CD34+ cells. Blood 92(10):3616\u20133623","journal-title":"Blood"},{"key":"69_CR18","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1242\/jcs.87.5.609","volume":"87","author":"ASG Curtis","year":"1998","unstructured":"Curtis ASG (1998) Cell activation and adhesion. J Cell Sci 87:609\u2013611","journal-title":"J Cell Sci"},{"key":"69_CR19","first-page":"88","volume":"8","author":"E Lazarides","year":"1979","unstructured":"Lazarides E, Revel JP (1979) The molecular basis of cell movement. Sci Am 8:88\u2013100","journal-title":"Sci Am"},{"key":"69_CR20","doi-asserted-by":"crossref","DOI":"10.1007\/978-94-009-4071-0","volume-title":"Cell movement ind cell behaviour","author":"JM Lackie","year":"1986","unstructured":"Lackie JM (1986) Cell movement ind cell behaviour. Allen & Unwin, London"},{"key":"69_CR21","first-page":"59","volume":"161","author":"OS Walmod","year":"2001","unstructured":"Walmod OS, Hartman-Petersen R, Berezin A, Prag S, Kiselyov VV, Berezin V, Bock E (2001) Evaluation of individual-cell motility. Methods Mol Biol 161:59\u201383","journal-title":"Methods Mol Biol"},{"key":"69_CR22","first-page":"53","volume":"5","author":"N Zama","year":"1988","unstructured":"Zama N, Katow H (1988) A method of quantitative analysis of cell migration using a computerized time-lapse videomicroscopy. Zool Sci 5:53\u201360","journal-title":"Zool Sci"},{"key":"69_CR23","first-page":"25","volume-title":"Motion analysis of living cells","author":"DR Soll","year":"1998","unstructured":"Soll DR, Voss E (1998) Two- and three-dimensional computer system for analysing how animal cells crawl. In: Soll DR, Wessels D (eds) Motion analysis of living cells. Wieley-liss, New York, pp 25\u201352"},{"key":"69_CR24","first-page":"341","volume-title":"Hepatocyte growth FACTOR-scatter fector and C-met receptor","author":"MM Bhargava","year":"1993","unstructured":"Bhargava MM, Li Y, Joseph A, Jin L, Rosen EM, Goldberg ID (1993) HGF-SF: effects on motility and morphlogy of normal and tumor cells. In: Golberg ID, Rosen EM (eds) Hepatocyte growth FACTOR-scatter fector and C-met receptor. Birkhausser Verlag, Basel, pp 341\u2013349"},{"key":"69_CR25","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/978-3-0348-7494-6_14","volume-title":"Cell motility factors","author":"G Thuston","year":"1991","unstructured":"Thuston G, Spadinger I, Palcic B (1991) Computer automation inmeasurment and analysis of cell motility in vitro. In: Goldberg ID (eds) Cell motility factors. Birkhausser Verlag, Basel, pp 206\u2013222"},{"issue":"4","key":"69_CR26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF02513323","volume":"37","author":"A Hoppe","year":"1999","unstructured":"Hoppe A, Wertheim D, Jiang WG, Williams R, Harding K (1999) Interactive image processing system for assessment of cell movement. Med Biol Eng Comput 37(4):419\u2013423","journal-title":"Med Biol Eng Comput"},{"key":"69_CR27","unstructured":"Korzynska A (2001) Computer aided neutrophil granulocytes movement and shape assessment. Ph.D. thesis, Prace Instytutu Biocybernetyki i Inzynierii Biomedycznej, 57, Warsaw (Polish)"},{"key":"69_CR28","volume-title":"Selected topics in biomedical image processing","author":"A Korzynska","year":"1993","unstructured":"Korzynska A (1993) A method of cells\u2019 movement investigation. In: Kulikowski JL (ed) Selected topics in biomedical image processing. Polish Academy of Sciences, Warsaw"},{"key":"69_CR29","unstructured":"Korzynska A, Nechay A, Bernatowska-Matuszkiewicz E, Skopczynska H (1996) Comparison of chosen movement parameters of neutrophils in healthy children and the Chediak\u2013Higashi\u2019s syndrome patient; signal investigation. In: Abstrakty III Konferncji Naukowej: Wybrane Zagadnienia z Immunologii Klinicznej, Warsaw, pp 18"},{"key":"69_CR30","unstructured":"Korzynska A (1996) Analysis of some parameters in selected phases of cell\u2019s motility: an image of normal and disordered crawling movement of human neutrophils in computer aided video enhanced microscopy. In: Proceedings of Cytokinematics\u201996"},{"key":"69_CR31","unstructured":"Korzyska A, Nechay A, Mazur P, Pietka D, Kowal M (1997) Computer aided microscopy system on investigation of cell\u2019s motility. In: Book of Abstract of 4th European Conference on Engineering and Medicine, Warszawa, pp 360\u2013361"},{"key":"69_CR32","unstructured":"Korzynska A, Hoppe A, Strojny W, Wertheim D (2003) Segmentation of neutrophil images using texture analysis and a contour based technique. In: Abstract book of KOSYR2003, Wroclaw, pp 29\u201333"},{"key":"69_CR33","volume-title":"Image processing handbook","author":"JC Russ","year":"1995","unstructured":"Russ JC (1995) Image processing handbook, 2nd edn. CRC Press, Boca Raton, Ann Arbor, London, Tokyo","edition":"2nd"},{"key":"69_CR34","volume-title":"Molecular biology of the cell","author":"B Alberts","year":"1994","unstructured":"Alberts B, Bray D, Lewis J, Raff M, Roberts K, Watson JD (1994) Molecular biology of the cell, 3rd edn. Garland Publishing Inc., New York & London","edition":"3rd"},{"key":"69_CR35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0031-3203(81)90028-5","volume":"13","author":"KS Fu","year":"1981","unstructured":"Fu KS, Mui JK (1981) A survey on image segmentation. Pattern Recognit 13:3\u201316","journal-title":"Pattern Recognit"},{"key":"69_CR36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1146\/annurev.bioeng.2.1.315","volume":"2","author":"DL Pham","year":"2000","unstructured":"Pham DL, Chenyang X, Prince JL (2000) Current methods in medical image segmentation. Annu Rev Biomed Eng 2:315\u2013337","journal-title":"Annu Rev Biomed Eng"},{"issue":"6","key":"69_CR37","first-page":"610","volume":"3","author":"RM Haralik","year":"1793","unstructured":"Haralik RM, Shanmugan K, Dinstein I (1793) Textual Features for image Clssification. IEEE Trans Syst Man Cybern 3(6):610\u2013621","journal-title":"IEEE Trans Syst Man Cybern"},{"key":"69_CR38","first-page":"75","volume-title":"Picture processing and psychopictorics.","author":"JMS Prewitt","year":"1970","unstructured":"Prewitt JMS (1970) Object enhancement and extraction. In: Lipkin BS, Rosenfeld A (eds) Picture processing and psychopictorics. Academic, New York, pp 75\u2013149"},{"key":"69_CR39","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1749-6632.2002.tb04564.x","volume":"972","author":"A Korzynska","year":"2002","unstructured":"Korzynska A (2002) Neutrophils\u2019 movement in vitro. Ann NY Acad Sci 972:139\u2013143","journal-title":"Ann NY Acad Sci"},{"key":"69_CR40","volume-title":"The theory of splines and their applications","author":"JH Ahlberg","year":"1967","unstructured":"Ahlberg JH, Nilson EN, Wash JL (1967) The theory of splines and their applications. Academic, New York"},{"issue":"3","key":"69_CR41","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1109\/TPAMI.2003.1182096","volume":"25","author":"HT Nguyen","year":"2003","unstructured":"Nguyen HT, Worring M, van den Boomgaard R (2003) Watersnakes: energy-driven watershed segmentation. IEEE Trans Pattern Anal Mach Intell 25(3):330\u2013342","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"69_CR42","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.imavis.2005.03.001","volume":"23","author":"CR Jung","year":"2005","unstructured":"Jung CR, Scharcanski J (2005) Robust watershed segmentation using wavelets. Image Vis Comput 23:661\u2013669","journal-title":"Image Vis Comput"},{"key":"69_CR43","volume-title":"Digtal image processing","author":"C Gonzalez Rafael","year":"2001","unstructured":"Gonzalez Rafael C, Woods Richard E (2001) Digtal image processing. Prentice-Hall, New Jersy"},{"key":"69_CR44","unstructured":"Bovik A (ed) (2000) Handbook of video & image processing. Academic, London"},{"issue":"2","key":"69_CR45","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1109\/TBME.2003.820374","volume":"51","author":"J Tang","year":"2004","unstructured":"Tang J, Acton ST (2004) Vessel boundary tracking for intravital microscopy via multiscale gradient vector flow snakes. IEEE Trans Biomed Eng 51(2):316\u2013324","journal-title":"IEEE Trans Biomed Eng"},{"key":"69_CR46","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF00133570","volume":"1","author":"M Kass","year":"1987","unstructured":"Kass M, Witkin A, Terzopolous D (1987) Snakes: active contour models. Int J Comput Vis 1:321\u2013331","journal-title":"Int J Comput Vis"},{"issue":"3","key":"69_CR47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1109\/83.661186","volume":"7","author":"C Xu","year":"1998","unstructured":"Xu C, Prince JL (1998) Snakes, shapes, and gradient vector flow. IEEE Trans Image Process 7(3):359\u2013369","journal-title":"IEEE Trans Image Process"}],"container-title":["Pattern Analysis and Applications"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10044-007-0069-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10044-007-0069-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10044-007-0069-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T17:23:40Z","timestamp":1628789020000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10044-007-0069-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,12]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10,10]]}},"alternative-id":["69"],"URL":"https:\/\/doi.org\/10.1007\/s10044-007-0069-7","relation":{},"ISSN":["1433-7541","1433-755X"],"issn-type":[{"value":"1433-7541","type":"print"},{"value":"1433-755X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,12]]}}}