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The enhancement of the presence of the structures like tubular networks in given images can improve image-dependent diagnostics and can also facilitate tasks like segmentation. The two-dimensional (2D) orientation field transform has been proved to be effective at enhancing 2D contours and curves in images by means of top-down processing. It, however, has no counterpart in 3D images due to the extremely complicated orientation in 3D against 2D. Given the rising demand and interest in handling 3D images, we experiment with modularising the concept and generalise the algorithm to 3D curves. In this work, we propose a 3D orientation field transform. It is a vascular structure enhancement algorithm that can cleanly enhance images having very low signal-to-noise ratio, and push the limits of 3D image quality that can be enhanced computationally. This work also utilises the benefits of modularity and offers several combinative options that each yield moderately better enhancement results in different scenarios. In principle, the proposed 3D orientation field transform can naturally tackle any number of dimensions. As a special case, it is also ideal for 2D images, owning a simpler methodology compared to the previous 2D orientation field transform. The concise structure of the proposed 3D orientation field transform also allows it to be mixed with other enhancement algorithms, and as a preliminary filter to other tasks like segmentation and detection. The effectiveness of the proposed method is demonstrated with synthetic 3D images and real-world transmission electron microscopy tomograms ranging from 2D curve enhancement to, the more important and interesting, 3D ones. Extensive experiments and comparisons with existing related methods also demonstrate the excellent performance of the proposed 3D orientation field transform.<\/jats:p>","DOI":"10.1007\/s10044-024-01212-z","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T17:02:29Z","timestamp":1709139749000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["3D orientation field transform"],"prefix":"10.1007","volume":"27","author":[{"given":"Wai-Tsun","family":"Yeung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-2834","authenticated-orcid":false,"given":"Xiaohao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zizhen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Ho","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"issue":"11","key":"1212_CR1","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/j.chembiol.2016.10.006","volume":"23","author":"SR Adams","year":"2016","unstructured":"Adams SR, Mackey MR, Ramachandra R, Lemieux SFP, Steinbach P, Bushong EA, Butko MT, Giepmans BN, Ellisman MH, Tsien RY (2016) Multicolor electron microscopy for simultaneous visualization of multiple molecular species. 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