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Pharmacological analgesics have been used for managing pain, but with ineffective results and negative side effects. Studies on pain management for burn patients suggested that Virtual Reality can treat procedural pain. This paper describes the process of designing, testing, and deploying a Virtual Reality system into a hospital setting. Firstly, a workshop was conducted to identify the most suitable types of Virtual Reality contents for the needs of burn-injured patients. Then, an experimental study, with 15 healthy adults, explored the analgesic impact of the Virtual Reality contents. The pain was induced through a cold pressor. Finally, we deployed the Virtual Reality system into the hospital to examine its efficiency on burn-injured inpatients. This study presents factors for the effective design and deployment of Virtual Reality for burn-injured patients residing in a hospital. Those factors refer to the use of cartoonish features and a choice of content based on each patient\u2019s interests to increase the positive emotions and the use of interactive features, portable equipment to reduce pain and increase the feasibility of the technology in clinical settings. Finally, our results indicated that the extension of the VR use after the therapeutic session could support more effective pain treatment.<\/jats:p><jats:p><jats:italic>Trial registration number<\/jats:italic> Protocol ID: AA8434.<\/jats:p>","DOI":"10.1007\/s10055-021-00552-z","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T12:14:51Z","timestamp":1624364091000},"page":"201-215","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Designing effective virtual reality environments for pain management in burn-injured patients"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5120-8256","authenticated-orcid":false,"given":"Ivan","family":"Phelan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4916-8800","authenticated-orcid":false,"given":"Penny J","family":"Furness","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3804-5565","authenticated-orcid":false,"given":"Maria","family":"Matsangidou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-9069","authenticated-orcid":false,"given":"Nathan T.","family":"Babiker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-6427","authenticated-orcid":false,"given":"Orla","family":"Fehily","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-7222","authenticated-orcid":false,"given":"Andrew","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7815-1472","authenticated-orcid":false,"given":"Alicia","family":"Carrion-Plaza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8797-6780","authenticated-orcid":false,"given":"Shirley A.","family":"Lindley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"issue":"5","key":"552_CR1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.burns.2009.08.009","volume":"36","author":"MM Berger","year":"2010","unstructured":"Berger MM, Davadant M, Marin C, Wasserfallen JB, Pinget C, Maravic P, Koch N, Raffoul W, Chiolero RL (2010) Impact of a pain protocol including hypnosis in major burns. 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Parental and age-appropriate children's information sheets were developed, in accordance with good practice when working with children. To ensure the participants\u2019 voluntary participation, parents were asked to discuss the study with their child before giving consent. Ongoing consent was also checked verbally with the child before and during procedures.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Phase 1 and Phase 2 were approved by University\u2019s Research Ethics Committee (PHE-298 and 328-FUR). Phase 3 was approved by the Patient and Public Involvement (PPI) Panel, Directorate of Therapeutics and Palliative Care, Sheffield Teaching Hospitals National Health Service (NHS) Foundation Trust, and NHS Research Ethics Committee (IRAS: 221071).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}