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Therefore, the effect of immersive 360\u00b0 VR video learning compared with two-dimensional (2D) VR video learning in clinical skills acquisition should be evaluated. This randomized, intervention-controlled clinical trial was aimed to assess whether immersive 360\u00b0 VR video improves undergraduate medical students' learning effectiveness and reduces the cognitive load in history taking and physical examination (H&amp;P) training. From May 1 2018 to October 30 2018, 64 senior undergraduate medical students in a tertiary academic hospital were randomized to receive a 10-min immersive 360\u00b0 (360\u00b0 VR video group; <jats:italic>n<\/jats:italic>\u2009=\u200932) or 2D VR instructional video (2D VR video group; <jats:italic>n<\/jats:italic>\u2009=\u200932), including essential knowledge and competency of H&amp;P. The demographic characteristics of the two groups were comparable for age, sex, and cognitive style. The total procedure skill score, physical examination score, learner\u2019s satisfaction score, and total cognitive load in the 360\u00b0 VR video group were significantly higher than those in the 2D VR video group (effect sizes [95% confidence interval]: 0.72 [0.21\u20131.22], 0.63 [0.12\u20131.13], 0.56 [0.06\u20131.06], and 0.53 [0.03\u20131.03], respectively). This study suggested that a10-minute 360\u00b0 VR video instruction helped undergraduate medical students perform fundamental H&amp;P skills as effectively as 2D VR video. Furthermore, the 360\u00b0 VR video might result in significantly better procedural metrics of physical examinations with higher learner satisfaction despite the higher cognitive load.<\/jats:p>","DOI":"10.1007\/s10055-022-00664-0","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T12:03:05Z","timestamp":1660651385000},"page":"637-650","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Comparison of the effect of 360\u00b0 versus two-dimensional virtual reality video on history taking and physical examination skills learning among undergraduate medical students: a randomized controlled trial"],"prefix":"10.1007","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1681-5410","authenticated-orcid":false,"given":"Yi-Ping","family":"Chao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-9396","authenticated-orcid":false,"given":"Chung-Jan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-4016","authenticated-orcid":false,"given":"Hai-Hua","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2450-4257","authenticated-orcid":false,"given":"Ming-Ju","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-8490","authenticated-orcid":false,"given":"Yu-Che","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7107-3632","authenticated-orcid":false,"given":"Terry B. 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