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A head-mounted display for virtual reality (HMD-VR) offers a consistent visual environment and may be effective for measuring RT. This study aims to determine the feasibility, reliability, and validity of using HMD-VR software to assess simple reaction time (SRT). Thirty healthy participants took part in the study, performing a 100-trial SRT test using a VIVE ProEye (HTC, Inc.). We analyzed the median SRT for each 25-trial block to observe any decrease in performance over time. The one-week reliability of median SRT was assessed using the intraclass correlation coefficient (ICC) for varying test lengths. We also compared the VR-based SRT with a PC-based SRT test (RehaCom\u00ae by HASOMED, Inc.) to evaluate convergent validity. The median SRTs for VR-based and PC-based tests were 326.0\u00a0ms and 319.5\u00a0ms, respectively. The VR-based method showed a significantly longer SRT in the final 25-trial block for the non-dominant hand. The ICC was 0.71 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), indicating good reliability. There was a high correlation (r\u2009=\u20090.85\u20130.89) and good agreement between the VR-based and PC-based tests, with the VR-based SRT being 9\u201310\u00a0ms longer, as shown by Bland\u2013Altman plots. The study demonstrated good reliability and high convergent validity for HMD-VR-based RT testing. A 50-trial test is recommended as it strikes an optimal balance between minimizing performance decline and ensuring sufficient measurement reliability. This program can be used in future studies focusing on spatial-specific RT, providing a standardized environment.\n                  <\/jats:p>","DOI":"10.1007\/s10055-025-01165-6","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T08:43:32Z","timestamp":1752223412000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of a virtual reality-based measurement of simple reaction time in adults: a psychometric evaluation"],"prefix":"10.1007","volume":"29","author":[{"given":"Ying-Chun","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Wen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"issue":"3","key":"1165_CR1","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3758\/s13428-020-01485-2","volume":"53","author":"I Amato","year":"2021","unstructured":"Amato I, Nanev A, Piantella S, Wilson K-E, Bicknell R, Heckenberg R, Horan B, Maruff P, Wright B (2021) Assessing the utility of a virtual-reality neuropsychological test battery, \u2018CONVIRT\u2019, in detecting alcohol-induced cognitive impairment. 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