{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:48:58Z","timestamp":1761745738653,"version":"3.37.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["MICIN\/AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MICIN\/AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016028","name":"Valencian Innovation Agency","doi-asserted-by":"crossref","award":["INNEST\/2021\/57"],"award-info":[{"award-number":["INNEST\/2021\/57"]}],"id":[{"id":"10.13039\/501100016028","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UPV-FISABIO","award":["A36-GMAC\/2019"],"award-info":[{"award-number":["A36-GMAC\/2019"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Softw Syst Model"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s10270-022-01039-4","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T03:41:20Z","timestamp":1663299680000},"page":"159-174","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Integration of clinical and genomic data to enhance precision medicine: a case of study applied to the retina-macula"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9598-1301","authenticated-orcid":false,"given":"Jos\u00e9 Fabi\u00e1n","family":"Reyes\u00a0Rom\u00e1n","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-8893","authenticated-orcid":false,"given":"Ana","family":"Le\u00f3n\u00a0Palacio","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5910-4363","authenticated-orcid":false,"given":"Alberto","family":"Garc\u00eda\u00a0Sim\u00f3n","sequence":"additional","affiliation":[]},{"given":"Rub\u00e9n Cabrera","family":"Beyrouti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1320-8471","authenticated-orcid":false,"given":"Oscar","family":"Pastor","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"1039_CR1","unstructured":"National Eye Institute: Age-related macular degeneration (2021) https:\/\/www.nei.nih.gov\/learn-about-eye-health\/eye-conditions-and-diseases\/age-related-macular-degeneration"},{"key":"1039_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/B978-0-12-816222-4.00010-1","volume":"1","author":"EK de Jong","year":"2020","unstructured":"de Jong, E.K., Geerlings, M.J., den Hollander, A.I.: Age-related macular degeneration. Genet. Genom. Eye Dis. 1, 155\u2013180 (2020). https:\/\/doi.org\/10.1016\/B978-0-12-816222-4.00010-1","journal-title":"Genet. Genom. Eye Dis."},{"issue":"4","key":"1039_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s12041-009-0064-4","volume":"88","author":"S Katta","year":"2009","unstructured":"Katta, S., Kaur, I., Chakrabarti, S.: The molecular genetic basis of age-related macular degeneration: an overview. J. Genet. 88(4), 425\u2013449 (2009). https:\/\/doi.org\/10.1007\/s12041-009-0064-4","journal-title":"J. Genet."},{"key":"1039_CR4","first-page":"844","volume":"82","author":"S Resnikoff","year":"2004","unstructured":"Resnikoff, S., Pascolini, D., Etya\u2019Ale, D., Kocur, I., Pararajasegaram, R., Pokharel, G.P., Mariotti, S.P.: Global data on visual impairment in the year 2002. Bull. World Health Organ. 82, 844\u2013851 (2004)","journal-title":"Bull. World Health Organ."},{"issue":"3","key":"1039_CR5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1097\/IAE.0000000000000036","volume":"34","author":"R Velez-Montoya","year":"2014","unstructured":"Velez-Montoya, R., Oliver, S.C., Olson, J.L., Fine, S.L., Quiroz-Mercado, H., Mandava, N.: Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention. Retina 34(3), 423\u2013441 (2014). https:\/\/doi.org\/10.1097\/IAE.0000000000000036","journal-title":"Retina"},{"issue":"7","key":"1039_CR6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1097\/IAE.0b013e318050d2ec","volume":"27","author":"A Loewenstein","year":"2007","unstructured":"Loewenstein, A.: The significance of early detection of age-related macular degeneration: Richard and Hinda Rosenthal foundation lecture, the macula society 29th annual meeting. Retina 27(7), 873\u2013878 (2007). https:\/\/doi.org\/10.1097\/IAE.0b013e318050d2ec","journal-title":"Retina"},{"issue":"2","key":"1039_CR7","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.ophtha.2006.10.045","volume":"114","author":"DS Boyer","year":"2007","unstructured":"Boyer, D.S., Antoszyk, A.N., Awh, C.C., Bhisitkul, R.B., Shapiro, H., Acharya, N.R., MARINA Study Group: Subgroup analysis of the MARINA study of ranibizumab in neovascular age-related macular degeneration. Ophthalmology 114(2), 246\u2013252 (2007). https:\/\/doi.org\/10.1016\/j.ophtha.2006.10.045","journal-title":"Ophthalmology"},{"key":"1039_CR8","doi-asserted-by":"crossref","unstructured":"Oliv\u00e9, A.: Conceptual Modeling of Information Systems. Springer Science and Business Media, Berlin (2007). https:\/\/doi.org\/10.1007\/978-3-540-39390-0","DOI":"10.1007\/978-3-540-39390-0"},{"key":"1039_CR9","doi-asserted-by":"publisher","unstructured":"Reyes Rom\u00e1n, J. F., Marco-Palomares, A., Garc\u00eda S. A., Pastor, O.: A model-based application for the effective and efficient management of data associated with retina-macula pathology. In: Enterprise, Business-Process and Information Systems Modeling, pp. 366\u2013379. Springer, Cham (2021). https:\/\/doi.org\/10.1007\/978-3-030-79186-5_24","DOI":"10.1007\/978-3-030-79186-5_24"},{"key":"1039_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bdr.2021.100253","volume":"26","author":"A Le\u00f3n","year":"2021","unstructured":"Le\u00f3n, A., Pastor, \u00d3.: Enhancing precision medicine: a big data-driven approach for the management of genomic data. Big Data Res. 26, 100253 (2021). https:\/\/doi.org\/10.1016\/j.bdr.2021.100253","journal-title":"Big Data Res."},{"key":"1039_CR11","doi-asserted-by":"publisher","unstructured":"Reyes Rom\u00e1n, J. F. (2018). Dise\u00f1o y desarrollo de un sistema de informaci\u00f3n gen\u00f3mica basado en un modelo conceptual hol\u00edstico del genoma humano (Doctoral dissertation, Universitat Polit\u00e8cnica de Val\u00e8ncia). https:\/\/doi.org\/10.4995\/Thesis\/10251\/99565","DOI":"10.4995\/Thesis\/10251\/99565"},{"key":"1039_CR12","doi-asserted-by":"publisher","first-page":"197111","DOI":"10.1109\/ACCESS.2020.3034793","volume":"8","author":"A Garc\u00eda","year":"2020","unstructured":"Garc\u00eda, A., Le\u00f3n Palacio, A., Reyes Rom\u00e1n, J.F., Casamayor, J.C., Pastor, O.: Towards the understanding of the human genome: a holistic conceptual modeling approach. IEEE Access 8, 197111\u2013197123 (2020). https:\/\/doi.org\/10.1109\/ACCESS.2020.3034793","journal-title":"IEEE Access"},{"key":"1039_CR13","doi-asserted-by":"crossref","unstructured":"Aguilera, D., G\u00f3mez, C., Oliv\u00e9, A.: Enforcement of conceptual schema quality issues in current integrated development environments. In: International Conference on Advanced Information Systems Engineering, pp. 626\u2013640. Springer, Berlin, Heidelberg (2013). https:\/\/doi.org\/10.1007\/978-3-642-38709-8_40","DOI":"10.1007\/978-3-642-38709-8_40"},{"key":"1039_CR14","doi-asserted-by":"crossref","unstructured":"Delcambre, L.M., Liddle, S.W., Pastor, O., Storey, V.C.: A reference framework for conceptual modeling. In: International Conference on Conceptual Modeling, pp. 27\u201342. Springer, Cham (2018). https:\/\/doi.org\/10.1007\/978-3-030-00847-5_4","DOI":"10.1007\/978-3-030-00847-5_4"},{"issue":"6","key":"1039_CR15","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1093\/bioinformatics\/16.6.548","volume":"16","author":"NW Paton","year":"2000","unstructured":"Paton, N.W., Khan, S.A., Hayes, A., Moussouni, F., Brass, A., Eilbeck, K., Oliver, S.G.: Conceptual modelling of genomic information. Bioinformatics 16(6), 548\u2013557 (2000). https:\/\/doi.org\/10.1093\/bioinformatics\/16.6.548","journal-title":"Bioinformatics"},{"issue":"2","key":"1039_CR16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bib\/3.2.166","volume":"3","author":"E Bornberg-Bauer","year":"2002","unstructured":"Bornberg-Bauer, E., Paton, N.W.: Conceptual data modelling for bioinformatics. Brief. Bioinform. 3(2), 166\u2013180 (2002). https:\/\/doi.org\/10.1093\/bib\/3.2.166","journal-title":"Brief. Bioinform."},{"key":"1039_CR17","doi-asserted-by":"crossref","unstructured":"Ram, S., Wei, W.: Modeling the semantics of 3D protein structures. In: International Conference on Conceptual Modeling, pp. 696\u2013708. Springer, Berlin, Heidelberg (2004. https:\/\/doi.org\/10.1007\/978-3-540-30464-7_52","DOI":"10.1007\/978-3-540-30464-7_52"},{"key":"1039_CR18","doi-asserted-by":"publisher","first-page":"R44","DOI":"10.1186\/gb-2005-6-5-r44","volume":"6","author":"K Eilbeck","year":"2005","unstructured":"Eilbeck, K., Lewis, S.E., Mungall, C.J., et al.: The sequence ontology: a tool for the unification of genome annotations. Genome Biol. 6, R44 (2005). https:\/\/doi.org\/10.1186\/gb-2005-6-5-r44","journal-title":"Genome Biol."},{"issue":"2","key":"1039_CR19","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1101\/gr.157495.113","volume":"24","author":"M Vihinen","year":"2014","unstructured":"Vihinen, M.: Variation ontology for annotation of variation effects and mechanisms. Genome Res. 24(2), 356\u2013364 (2014). https:\/\/doi.org\/10.1101\/gr.157495.113","journal-title":"Genome Res."},{"key":"1039_CR20","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","volume":"25","author":"M Ashburner","year":"2000","unstructured":"Ashburner, M., Ball, C., Blake, J., et al.: Gene ontology: tool for the unification of biology. Nat. Genet. 25, 25\u201329 (2000). https:\/\/doi.org\/10.1038\/75556","journal-title":"Nat. Genet."},{"issue":"1","key":"1039_CR21","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/bib\/bbaa100","volume":"22","author":"\u00d3 Pastor","year":"2021","unstructured":"Pastor, \u00d3., Le\u00f3n, A., Reyes Rom\u00e1n, J.F., Garc\u00eda, A.S., Casamayor, J.C.: Using conceptual modeling to improve genome data management. Brief. Bioinform. 22(1), 45\u201354 (2021). https:\/\/doi.org\/10.1093\/bib\/bbaa100","journal-title":"Brief. Bioinform."},{"key":"1039_CR22","doi-asserted-by":"publisher","unstructured":"Burriel Coll, V. (2017). Dise\u00f1o y desarrollo de un sistema de informaci\u00f3n para la gesti\u00f3n de informaci\u00f3n sobre C\u00e1ncer de mama (Doctoral dissertation, Universitat Polit\u00e8cnica de Val\u00e8ncia). https:\/\/doi.org\/10.4995\/Thesis\/10251\/86158","DOI":"10.4995\/Thesis\/10251\/86158"},{"key":"1039_CR23","unstructured":"Arevshatyan, S., Reyes Rom\u00e1n, J.F., Burriel, V., Ca\u00f1ete, A., Castel, V., Pastor, \u00d3.: Integration and analysis of clinical and genomic data of neuroblastoma applying conceptual modeling. (2019)"},{"key":"1039_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-662-43839-8","volume-title":"Design Science Methodology for Information Systems and Software Engineering","author":"R Wieringa","year":"2014","unstructured":"Wieringa, R.: Design Science Methodology for Information Systems and Software Engineering, pp. 1\u2013332. Springer-Verlag, Berlin Heidelberg (2014). https:\/\/doi.org\/10.1007\/978-3-662-43839-8"},{"key":"1039_CR25","unstructured":"Marco Palomares, A.: Desarrollo dirigido por modelos para el an\u00e1lisis y gesti\u00f3n de los datos asociados a la patolog\u00eda macular. (Master Thesis, Universitat Polit\u00e8cnica de Val\u00e8ncia) (2020). http:\/\/hdl.handle.net\/10251\/151886"},{"key":"1039_CR26","unstructured":"Jenny Preece, H.S., Rogers, Y.: Interaction design: beyond human-computer interaction. (2015)"},{"issue":"5","key":"1039_CR27","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1167\/iovs.08-3064","volume":"50","author":"JM Seddon","year":"2009","unstructured":"Seddon, J.M., Reynolds, R., Maller, J., Fagerness, J.A., Daly, M.J., Rosner, B.: Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Investig. Ophthalmol. Vis. Sci. 50(5), 2044\u20132053 (2009). https:\/\/doi.org\/10.1167\/iovs.08-3064","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"1039_CR28","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1146\/annurev-genom-090413-025610","volume":"15","author":"LG Fritsche","year":"2014","unstructured":"Fritsche, L.G., Fariss, R.N., Stambolian, D., Abecasis, G.R., Curcio, C.A., Swaroop, A.: Age-related macular degeneration: genetics and biology coming together. Annu. Rev. Genom. Hum. Genet. 15, 151\u2013171 (2014). https:\/\/doi.org\/10.1146\/annurev-genom-090413-025610","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"issue":"6588","key":"1039_CR29","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1126\/science.abj6987","volume":"376","author":"S Nurk","year":"2022","unstructured":"Nurk, S., Koren, S., Rhie, A., Rautiainen, M., et al.: The complete sequence of a human genome. Science 376(6588), 44\u201353 (2022). https:\/\/doi.org\/10.1126\/science.abj6987","journal-title":"Science"},{"issue":"12","key":"1039_CR30","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","volume":"15","author":"C Bonnans","year":"2014","unstructured":"Bonnans, C., Chou, J., Werb, Z.: Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15(12), 786\u2013801 (2014). https:\/\/doi.org\/10.1038\/nrm3904","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"1039_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.med.57.121304.131306","volume":"57","author":"J Folkman","year":"2006","unstructured":"Folkman, J.: Angiogenesis. Annu. Rev. Med. 57, 1\u201318 (2006). https:\/\/doi.org\/10.1146\/annurev.med.57.121304.131306","journal-title":"Annu. Rev. Med."},{"issue":"2","key":"1039_CR32","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0039-6257(00)00140-5","volume":"45","author":"S Beatty","year":"2000","unstructured":"Beatty, S., Koh, H.H., Phil, M., Henson, D., Boulton, M.: The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 45(2), 115\u2013134 (2000). https:\/\/doi.org\/10.1016\/S0039-6257(00)00140-5","journal-title":"Surv. Ophthalmol."},{"issue":"4","key":"1039_CR33","doi-asserted-by":"publisher","first-page":"E696","DOI":"10.1073\/pnas.1718059115","volume":"115","author":"DG Vavvas","year":"2018","unstructured":"Vavvas, D.G., Small, K.W., Awh, C.C., Zanke, B.W., Tibshirani, R.J., Kustra, R.: CFH and ARMS2 genetic risk determines progression to neovascular age-related macular degeneration after antioxidant and zinc supplementation. Proc. Natl. Acad. Sci. 115(4), E696\u2013E704 (2018). https:\/\/doi.org\/10.1073\/pnas.1718059115","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"1039_CR34","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1136\/bjophthalmol-2016-308624","volume":"100","author":"JM Seddon","year":"2016","unstructured":"Seddon, J.M., Silver, R.E., Rosner, B.: Response to AREDS supplements according to genetic factors: survival analysis approach using the eye as the unit of analysis. Br. J. Ophthalmol. 100(12), 1731\u20131737 (2016). https:\/\/doi.org\/10.1136\/bjophthalmol-2016-308624","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"1039_CR35","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.ophtha.2008.10.018","volume":"116","author":"DM Brown","year":"2009","unstructured":"Brown, D.M., Michels, M., Kaiser, P.K., Heier, J.S., Sy, J.P., Ianchulev, T.: Ranibizumab versus verteporfin photodynamic therapy for neovascular age-related macular degeneration: two-year results of the ANCHOR study. Ophthalmology 116(1), 57\u201365 (2009). https:\/\/doi.org\/10.1016\/j.ophtha.2008.10.018","journal-title":"Ophthalmology"},{"key":"1039_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4367631","author":"MK Tsilimbaris","year":"2016","unstructured":"Tsilimbaris, M.K., L\u00f3pez-G\u00e1lvez, M.I., Gallego-Pinazo, R., Margaron, P., Lambrou, G.N.: Epidemiological and clinical baseline characteristics as predictive biomarkers of response to anti-VEGF treatment in patients with neovascular AMD. J. Ophthalmol. (2016). https:\/\/doi.org\/10.1155\/2016\/4367631","journal-title":"J. Ophthalmol."},{"key":"1039_CR37","doi-asserted-by":"publisher","unstructured":"Lor\u00e9s-Motta, L., de Jong, E.K., den Hollander, A.I.: Exploring the use of molecular biomarkers for precision medicine in age-related macular degeneration. Mol. Diagn. Ther. 22(3), 315\u2013343 (2018). https:\/\/doi.org\/10.1007\/s40291-018-0332-1","DOI":"10.1007\/s40291-018-0332-1"},{"key":"1039_CR38","doi-asserted-by":"publisher","unstructured":"Garc\u00eda Sim\u00f3n, A., Costa S\u00e1nchez, M., Pastor, O.: Characterization and treatment of the temporal dimension of genomic variations: a conceptual model-based approach. In: International Conference on Conceptual Modeling, pp. 104\u2013113. Springer, Cham (2021). https:\/\/doi.org\/10.1007\/978-3-030-88358-4_9","DOI":"10.1007\/978-3-030-88358-4_9"},{"key":"1039_CR39","doi-asserted-by":"publisher","unstructured":"Reyes Rom\u00e1n, J.F., Pastor, O., Casamayor, J.C., Valverde, F.: Applying conceptual modeling to better understand the human genome. In: International Conference on Conceptual Modeling, pp. 404\u2013412. Springer, Cham (2016). https:\/\/doi.org\/10.1007\/978-3-319-46397-1_31","DOI":"10.1007\/978-3-319-46397-1_31"},{"key":"1039_CR40","doi-asserted-by":"publisher","unstructured":"Garc\u00eda, A., Le\u00f3n Palacio, A., Reyes Rom\u00e1n, J. F., Casamayor, J. C., Pastor, O.: A conceptual model-based approach to improve the representation and management of omics data in precision medicine. IEEE Access 9, 154071\u2013154085 (2021). https:\/\/doi.org\/10.1109\/ACCESS.2021.3128757","DOI":"10.1109\/ACCESS.2021.3128757"},{"key":"1039_CR41","doi-asserted-by":"publisher","unstructured":"Le\u00f3n Palacio, A., Pastor, \u00d3., Casamayor R\u00f3denas, J.C.: A method to identify relevant genome data: conceptual modeling for the medicine of precision. In: International Conference on Conceptual Modeling, pp. 597\u2013609. Springer, Cham (2018). https:\/\/doi.org\/10.1007\/978-3-030-00847-5_44","DOI":"10.1007\/978-3-030-00847-5_44"},{"key":"1039_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7250\/csimq.2018-17.01","volume":"17","author":"A Le\u00f3n Palacio","year":"2018","unstructured":"Le\u00f3n Palacio, A., Pastor, \u00d3.: Smart data for genomic information systems: the SILE method. Complex Syst. Inform. Model. Q. 17, 1\u201323 (2018). https:\/\/doi.org\/10.7250\/csimq.2018-17.01","journal-title":"Complex Syst. Inform. Model. Q."},{"key":"1039_CR43","doi-asserted-by":"crossref","unstructured":"Plazzotta, F., Luna, D., Bernaldo, Gonz\u00e1lez, de Quir\u00f3s, F.: Sistemas de informaci\u00f3n en salud: integrando datos cl\u00ednicos en diferentes escenarios y usuarios. Rev. Peru. Med. Exp. Salud P\u00fabl. 32(2), 343\u2013351 (2015)","DOI":"10.17843\/rpmesp.2015.322.1630"},{"key":"1039_CR44","unstructured":"Instituto de Microcirug\u00eda Ocular: DMAE: S\u00edntomas y tratamientos | IMO. (2018) https:\/\/www.imo.es\/es\/dmae"},{"key":"1039_CR45","unstructured":"Pardo, I.C., Varona, D.G., de Miranda Remedios, D.I.: Degeneraci\u00f3n macular relacionada con la edad. Arch. M\u00e9d. Camag\u00fcey 12(2), 1\u201322 (2008)"},{"key":"1039_CR46","doi-asserted-by":"crossref","unstructured":"Ruiz-Moreno, J.M., Arias-Barquet, L., Armad\u00e1-Maresca, F., Boixadera-Espax, A., Garc\u00eda-Layana, A., G\u00daIAS-DE PR\u00c1DE PR\u00c1CTICA CL\u00cdNICA DE LA SERV:Tratamiento de la Degeneraci\u00f3n Macular Asociada a la Edad (DMAE) Exudativa y Atr\u00f3fica\u201d. (Segunda revisi\u00f3n) Arch. Soc. Espa\u00f1ola Oftalmol. 84(7),333\u2013344 (2009)","DOI":"10.4321\/S0365-66912009000700004"},{"key":"1039_CR47","doi-asserted-by":"publisher","unstructured":"Garc\u00eda, A., Reyes Rom\u00e1n, J.F., Casamayor, J.C., Pastor, O.: Towards an effective and efficient management of genome data: an information systems engineering perspective. In: International Conference on Advanced Information Systems Engineering, pp. 99\u2013110. Springer, Cham (2019). https:\/\/doi.org\/10.1007\/978-3-030-21297-1_9","DOI":"10.1007\/978-3-030-21297-1_9"},{"issue":"8","key":"1039_CR48","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1111\/j.1442-9071.2009.02136.x","volume":"37","author":"PN Baird","year":"2009","unstructured":"Baird, P.N., Hageman, G.S., Guymer, R.H.: New era for personalized medicine: the diagnosis and management of age-related macular degeneration. Clin. Exp. Ophthalmol. 37(8), 814\u2013821 (2009). https:\/\/doi.org\/10.1111\/j.1442-9071.2009.02136.x","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"8","key":"1039_CR49","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jagp.2019.03.001","volume":"27","author":"H Senra","year":"2019","unstructured":"Senra, H., Macedo, A.F., Nunes, N., Balaskas, K., Aslam, T., Costa, E.: Psychological and psychosocial interventions for depression and anxiety in patients with age-related macular degeneration: a systematic review. Am. J. Geriatr. Psychiatry 27(8), 755\u2013773 (2019). https:\/\/doi.org\/10.1016\/j.jagp.2019.03.001","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"1039_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2015.05.009","author":"S Mehta","year":"2015","unstructured":"Mehta, S.: Age-related macular degeneration. Prim. Care Clin. Off. Pract. (2015). https:\/\/doi.org\/10.1016\/j.pop.2015.05.009","journal-title":"Prim. Care Clin. Off. Pract."}],"container-title":["Software and Systems Modeling"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10270-022-01039-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10270-022-01039-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10270-022-01039-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T06:44:23Z","timestamp":1677048263000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10270-022-01039-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["1039"],"URL":"https:\/\/doi.org\/10.1007\/s10270-022-01039-4","relation":{},"ISSN":["1619-1366","1619-1374"],"issn-type":[{"type":"print","value":"1619-1366"},{"type":"electronic","value":"1619-1374"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"assertion":[{"value":"6 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}