{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T02:22:12Z","timestamp":1771294932325,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA142555"],"award-info":[{"award-number":["U01CA142555"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U01CA190214"],"award-info":[{"award-number":["1U01CA190214"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1U01CA187947"],"award-info":[{"award-number":["1U01CA187947"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Digit Imaging"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10278-019-00251-x","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T22:02:28Z","timestamp":1565301748000},"page":"287-303","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Automatic Staging of Cancer Tumors Using AIM Image Annotations and Ontologies"],"prefix":"10.1007","volume":"33","author":[{"given":"E. F.","family":"Luque","sequence":"first","affiliation":[]},{"given":"N.","family":"Miranda","sequence":"additional","affiliation":[]},{"given":"D. L.","family":"Rubin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-2225","authenticated-orcid":false,"given":"D. A.","family":"Moreira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"251_CR1","first-page":"359","volume":"2009","author":"M Levy","year":"2009","unstructured":"Levy M, O\u2019Connor MJ, Rubin DL: Semantic reasoning with image annotations for tumor assessment. AMIA Ann Symp Proc 2009: 359\u201363, 2009","journal-title":"AMIA Ann Symp Proc"},{"key":"251_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jbi.2010.12.005","volume":"44","author":"P Wennerberg","year":"2011","unstructured":"Wennerberg P, Schulz K, Buitelaar P: Ontology modularization to improve semantic medical image annotation. J Biomed Inform 44: 155\u2013162, 2011. \nhttps:\/\/doi.org\/10.1016\/j.jbi.2010.12.005","journal-title":"J Biomed Inform"},{"key":"251_CR3","unstructured":"Bretschneider C, Zillner S, Hammon M (2013) Grammar-based lexicon enhancement for aligning German radiology text and images. In: Proceedings of the Recent Advances in Natural Language Processing (RANLP 2013), Hissar, Bulgaria, pp 105\u2013 112"},{"key":"251_CR4","doi-asserted-by":"crossref","unstructured":"Zillner S: Reasoning-based Patient Classification for Enhanced Medical Image Annotation.. In: Extended Semantic Web Conference. Springer, Berlin, 2010, pp 243\u2013257","DOI":"10.1007\/978-3-642-13486-9_17"},{"key":"251_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1593\/tlo.13796","volume":"7","author":"DL Rubin","year":"2014","unstructured":"Rubin DL, Willrett D, O\u2019Connor MJ, Hage C, Kurtz C, Moreira DA: Automated Tracking of Quantitative Assessments of Tumor Burden in Clinical Trials. Transl Oncol 7: 23\u201335, 2014. \nhttps:\/\/doi.org\/10.1593\/tlo.13796","journal-title":"Transl Oncol"},{"key":"251_CR6","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1148\/radiol.2533090135. pMID: 19952021","volume":"253","author":"DS Channin","year":"2009","unstructured":"Channin DS, Mongkolwat P, Kleper V, Rubin DL: The Annotation and Image Mark-up Project. Radiology 253: 590\u2013592, 2009. \nhttps:\/\/doi.org\/10.1148\/radiol.2533090135\n\n. pMID: 19952021","journal-title":"Radiology"},{"key":"251_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s10278-009-9193-9","volume":"23","author":"DS Channin","year":"2010","unstructured":"Channin DS, Mongkolwat P, Kleper V, Sepukar K, Rubin DL: The caBIGTM Annotation and Image Markup Project. J Digit Imaging 23: 217\u2013225, 2010. \nhttps:\/\/doi.org\/10.1007\/s10278-009-9193-9","journal-title":"J Digit Imaging"},{"key":"251_CR8","unstructured":"Rubin DL, Rodriguez C, Shah P, Beaulieu C (2008) Ipad: semantic annotation and markup of radiological images. In: AMIA Annual Symposium Proceedings, pp 626\u2013630"},{"key":"251_CR9","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jvir.2008.10.022","volume":"20","author":"S Kundu","year":"2009","unstructured":"Kundu S, Itkin M, Gervais D. a., Krishnamurthy VN, Wallace MJ, Cardella JF, Rubin DL, Langlotz CP: The IR Radlex Project: An Interventional Radiology Lexicon-A Collaborative Project of the Radiological Society of North America and the Society of Interventional Radiology. J Vasc Interv Radiol 20: 433\u2013435, 2009. \nhttps:\/\/doi.org\/10.1016\/j.jvir.2008.10.022","journal-title":"J Vasc Interv Radiol"},{"key":"251_CR10","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1007\/s00261-014-0130-0","volume":"39","author":"SC Faria","year":"2014","unstructured":"Faria SC, Szklaruk J, Kaseb AO, Hassabo HM, Elsayes KM: TNM\/Okuda\/Barcelona\/UNOS\/CLIP International Multidisciplinary Classification of Hepatocellular Carcinoma: concepts, perspectives, and radiologic implications. Abdom Imaging 39: 1070\u20131087, 2014. \nhttps:\/\/doi.org\/10.1007\/s00261-014-0130-0","journal-title":"Abdom Imaging"},{"key":"251_CR11","unstructured":"Dameron O, Roques \u00c9, Rubin D, Marquet G, Burgun A (2006) Grading lung tumors using OWL-DL based reasoning, in: 9th International Prot\u00e9g\u00e9 Conference-Presentation Abstracts. Stanford, USA: Stanford University, p 69. \nhttp:\/\/protege.stanford.edu\/conference\/2006\/"},{"key":"251_CR12","unstructured":"Marquet G, Dameron O, Saikali S, Mosser J, Burgun A (2007) Grading glioma tumors using OWL-DL and NCI thesaurus. In: AMIA Annual Symposium Proceedings, volume 2007, American Medical Informatics Association, pp 508\u2013512. \nhttp:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2655830"},{"key":"251_CR13","doi-asserted-by":"publisher","first-page":"2887","DOI":"10.1002\/1097-0142(20000615)88:12<2887::AID-CNCR32>3.0.CO;2-F","volume":"88","author":"P Kleihues","year":"2000","unstructured":"Kleihues P, Sobin LH: World Health Organization classification of tumors. Cancer 88: 2887\u20132887, 2000","journal-title":"Cancer"},{"key":"251_CR14","doi-asserted-by":"crossref","unstructured":"Keet CM: Open World Assumption.. In: Encyclopedia of Systems Biology. Springer, Berlin, 2013, pp 1567\u20131567","DOI":"10.1007\/978-1-4419-9863-7_734"},{"key":"251_CR15","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1109\/BMEI.2008.166","volume":"2","author":"AE Tutac","year":"2008","unstructured":"Tutac AE, Racoceanu D, Putti T, Xiong W, Leow WK, Cretu V: Knowledge-Guided Semantic Indexing of Breast Cancer Histopathology Images. 2008 International Conference on BioMedical Engineering and Informatics 2: 107\u2013112, 2008. \nhttps:\/\/doi.org\/10.1109\/BMEI.2008.166\n\n\n\nhttps:\/\/doi.org\/10.1109\/BMEI.2008.166","journal-title":"2008 International Conference on BioMedical Engineering and Informatics"},{"key":"251_CR16","doi-asserted-by":"publisher","unstructured":"Tutac AE, Cretu VI, Racoceanu D (2010) Spatial representation and reasoning in breast cancer grading ontology. In: 2010 International Joint Conference on Computational Cybernetics and Technical Informatics (ICCC-CONTI), pp 89\u201394. \nhttps:\/\/doi.org\/10.1109\/ICCCYB.2010.5491320","DOI":"10.1109\/ICCCYB.2010.5491320"},{"key":"251_CR17","unstructured":"Massicano F, Sasso A, Tomaz H, Oleynik M, Nobrega C, Patr\u00e3o DFC (2015) An Ontology for TNM Clinical Stage Inference. In: ONTOBRAS"},{"key":"251_CR18","doi-asserted-by":"publisher","unstructured":"Franca F, Schulz S, Bronsert P, Novais P, Boeker M (2015) Feasibility of an ontology driven tumor-node-metastasis classifier application: A study on colorectal cancer. In: 2015 International Symposium on Innovations in Intelligent SysTems and Applications (INISTA), pp 1\u20137. \nhttps:\/\/doi.org\/10.1109\/INISTA.2015.7276757","DOI":"10.1109\/INISTA.2015.7276757"},{"key":"251_CR19","unstructured":"Zillner S (2009) Towards the Ontology-based Classification of Lymphoma Patients using Semantic Image Annotations. In: SWAT4LS, Citeseer"},{"key":"251_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/s13326-016-0106-9","volume":"7","author":"M Boeker","year":"2016","unstructured":"Boeker M, Fran\u00e7a F, Bronsert P, Schulz S: TNM-O: ontology support for staging of malignant tumours. Journal of Biomedical Semantics 7: 64, 2016. \nhttps:\/\/doi.org\/10.1186\/s13326-016-0106-9","journal-title":"Journal of Biomedical Semantics"},{"key":"251_CR21","unstructured":"Boeker M, Faria R, Schulz S (2014) A Proposal for an Ontology for the Tumor-Node-Metastasis Classification of Malignant Tumors: a Study on Breast Tumors, et al., Ontologies and Data in Life Sciences (ODLS 2014), IMISEREPORTS Leipzig. \nhttp:\/\/www.onto-med.de\/obml\/ws2014\/odls2014report.pdf"},{"key":"251_CR22","doi-asserted-by":"crossref","unstructured":"Seneviratne O, Rashid SM, Chari S, McCusker JP, Bennett KP, Hendler JA, McGuinness DL (2018) Knowledge Integration for Disease Characterization: A Breast Cancer Example. arXiv:\n1807.07991","DOI":"10.1007\/978-3-030-00668-6_14"},{"key":"251_CR23","unstructured":"Meriem B, Yamina T, Pathology A (2012) Interpretation breast cancer imaging by using ontology, Cyber Journals: Multidisciplinary Journals in Science and Technology. Journal of Selected Areas in Bioengineering (JSAB). pp 1\u20136. \nhttp:\/\/www.cyberjournals.com\/Papers\/Mar2012\/06.pdf"},{"key":"251_CR24","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.compmedimag.2014.09.004","volume":"42","author":"D Racoceanu","year":"2015","unstructured":"Racoceanu D, Capron F: Towards semantic-driven high-content image analysis: An operational instantiation for mitosis detection in digital histopathology. Comput Med Imaging Graph 42: 2\u201315, 2015. \nhttps:\/\/doi.org\/10.1016\/j.compmedimag.2014.09.004","journal-title":"Comput Med Imaging Graph"},{"key":"251_CR25","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-3-642-29764-9-3","volume-title":"A Spatio-anatomical Medical Ontology and Automatic Plausibility Checks","author":"M M\u00f6ller","year":"2013","unstructured":"M\u00f6ller M., Sonntag D, Er\u00f1st P: A Spatio-anatomical Medical Ontology and Automatic Plausibility Checks Berlin: Springer, 2013, pp 41\u201355. \nhttps:\/\/doi.org\/10.1007\/978-3-642-29764-9-3"},{"key":"251_CR26","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s13721-012-0003-9","volume":"1","author":"S Zillner","year":"2012","unstructured":"Zillner S, Sonntag D: Image metadata reasoning for improved clinical decision support. Network Modeling Analysis in Health Informatics and Bioinformatics 1: 37\u201346, 2012. \nhttps:\/\/doi.org\/10.1007\/s13721-012-0003-9","journal-title":"Network Modeling Analysis in Health Informatics and Bioinformatics"},{"key":"251_CR27","doi-asserted-by":"publisher","unstructured":"Gimenez F, Xu J, Liu Y, Liu TT, Beaulieu CF, Rubin DL, Napel S (2011) On the Feasibility of Predicting Radiological Observations from Computational Imaging Features of Liver Lesions in CT Scans, in: 2011 First IEEE International Conference on Healthcare Informatics, Imaging and Systems Biology (HISB), pp 346\u2013350. \nhttps:\/\/doi.org\/10.1109\/HISB.2011.37","DOI":"10.1109\/HISB.2011.37"},{"key":"251_CR28","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1016\/j.media.2014.06.009","volume":"18","author":"C Kurtz","year":"2014","unstructured":"Kurtz C, Depeursinge A, Napel S, Beaulieu CF, Rubin DL: On combining image-based and ontological semantic dissimilarities for medical image retrieval applications. Med Image Anal 18: 1082\u20131100, 2014. \nhttps:\/\/doi.org\/10.1016\/j.media.2014.06.009","journal-title":"Med Image Anal"},{"key":"251_CR29","unstructured":"Bulu H, Rubin DL (2015) Java Application Programming Interface (API) for Annotation Imaging Markup (AIM). 1\u201312. \nhttps:\/\/sourceforge.net\/projects\/aimapi\/\n\n, [Online; accessed 02-March-2015.]"},{"key":"251_CR30","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1353\/ppp.2011.0045","volume":"18","author":"DL Rubin","year":"2011","unstructured":"Rubin DL: Finding the meaning in images: annotation and image markup. Philos Psychiatry Psychol 18: 311\u2013318, 2011. \nhttps:\/\/doi.org\/10.1353\/ppp.2011.0045","journal-title":"Philos Psychiatry Psychol"},{"key":"251_CR31","unstructured":"Radlex (2016) Radlex, \nhttp:\/\/www.radlex.org\n\n. [Online; accessed 02-October-2016.]"},{"key":"251_CR32","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1109\/JBHI.2014.2298880","volume":"18","author":"N Kokciyan","year":"2014","unstructured":"Kokciyan N, Turkay R, Uskudarli S, Yolum P, Bakir B, Acar B: Semantic description of liver ct images: An ontological approach. IEEE J Biomed Health Inform 18: 1363\u20131369, 2014. \nhttps:\/\/doi.org\/10.1109\/JBHI.2014.2298880","journal-title":"IEEE J Biomed Health Inform"},{"key":"251_CR33","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1007\/s10278-013-9622-7","volume":"26","author":"K Clark","year":"2013","unstructured":"Clark K, Vendt B, Smith K, Freymann J, Kirby J, Koppel P, Moore S, Phillips S, Maffitt D, Pringle M, et al: The Cancer Imaging Archive (tcia): Maintaining and Operating a Public Information Repository. J Digit Imaging 26: 1045\u20131057, 2013. \nhttps:\/\/doi.org\/10.1007\/s10278-013-9622-7","journal-title":"J Digit Imaging"},{"key":"251_CR34","doi-asserted-by":"crossref","unstructured":"Blomqvist E, Seil Sepour A, Presutti V: Ontology Testing - Methodology and Tool.. In: Proceedings of the 18th International Conference on Knowledge Engineering and Knowledge Management, EKAW12. Springer, Berlin, 2012, pp 216\u2013226","DOI":"10.1007\/978-3-642-33876-2_20"},{"key":"251_CR35","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1109\/TMI.2014.2321347","volume":"33","author":"A Depeursinge","year":"2014","unstructured":"Depeursinge A, Kurtz C, Beaulieu C, Napel S, Rubin D: Predicting Visual Semantic Descriptive Terms from Radiological Image Data: Preliminary Results With Liver Lesions in CT. IEEE Trans Med Imaging 33: 1669\u20131676, 2014. \nhttps:\/\/doi.org\/10.1109\/TMI.2014.2321347","journal-title":"IEEE Trans Med Imaging"}],"container-title":["Journal of Digital Imaging"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-019-00251-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10278-019-00251-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-019-00251-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T23:43:22Z","timestamp":1596757402000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10278-019-00251-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["251"],"URL":"https:\/\/doi.org\/10.1007\/s10278-019-00251-x","relation":{},"ISSN":["0897-1889","1618-727X"],"issn-type":[{"value":"0897-1889","type":"print"},{"value":"1618-727X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,8]]},"assertion":[{"value":"8 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}