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MR image segmentation, as a robust and simple method for PET attenuation correction, has been clinically adopted in commercial PET\/MR scanners. The general approach in this method is to segment the MR image into different tissue types, each assigned an attenuation constant as in an X-ray CT image. Machine learning techniques such as clustering, classification and deep networks are extensively used for brain MR image segmentation. However, only limited work has been reported on using deep learning in brain PET attenuation correction. In addition, there is a lack of clinical evaluation of machine learning methods in this application. The aim of this review is to study the use of machine learning methods for MR image segmentation and its application in attenuation correction for PET brain imaging. Furthermore, challenges and future opportunities in MR image-based PET attenuation correction are discussed.<\/jats:p>","DOI":"10.1007\/s10278-020-00361-x","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T19:05:07Z","timestamp":1593543907000},"page":"1224-1241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["MR Image-Based Attenuation Correction of Brain PET Imaging: Review of Literature on Machine Learning Approaches for Segmentation"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-4200","authenticated-orcid":false,"given":"Imene","family":"Mecheter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lejla","family":"Alic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysam","family":"Abbod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbes","family":"Amira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,30]]},"reference":[{"issue":"1","key":"361_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s40658-018-0225-8","volume":"5","author":"F Liu","year":"2018","unstructured":"Liu F, Jang H, Kijowski R, Zhao G, Bradshaw T, McMillan AB: A deep learning approach for 18f-FDG PET attenuation correction. 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