{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:34:49Z","timestamp":1767857689165,"version":"3.49.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cientco e Tecnologico","doi-asserted-by":"publisher","award":["301715\/2018-1"],"award-info":[{"award-number":["301715\/2018-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordenacao de Aperfeicoamento de Pessoal de Nl Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Digit Imaging"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s10278-021-00454-1","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T20:03:05Z","timestamp":1620158585000},"page":"678-690","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Automatic Segmentation of Bone Canals in Histological Images"],"prefix":"10.1007","volume":"34","author":[{"given":"Pedro Henrique Campos Cunha","family":"Gondim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Justino Oliveira","family":"Limirio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviana Soares","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas Dantas","family":"Batista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Dechichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Augusto Nassif","family":"Traven\u00e7olo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7486-4253","authenticated-orcid":false,"given":"Andr\u00e9 Ricardo","family":"Backes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"454_CR1","unstructured":"Ross M, Kaye G, Pawlina W: Histology: A Text and Atlas with Cell and Molecular Biology. Online access: Lippincott LWW Health Library: Integrated Basic Sciences Collection. Lippincott Williams & Wilkins, 2003"},{"key":"454_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s13402-014-0172-x","volume":"37","author":"J Baik","year":"2014","unstructured":"Baik J, Ye Q, Zhang L, Poh C, Rosin M, Macaulay C, Guillaud M: Automated classification of oral premalignant lesions using image cytometry and random forests-based algorithms. Cell Oncol\u00a037:193\u2013202, 2014.","journal-title":"Cell Oncol"},{"key":"454_CR3","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1002\/jemt.20826","volume":"73","author":"GD Rabelo","year":"2010","unstructured":"Rabelo GD, Beletti ME, Dechichi P: Histological analysis of the alterations on cortical bone channels network after radiotherapy: A rabbit study. Micorscop Res Tech, 73:1015\u20131018,2010","journal-title":"MICROSCOPY RESEARCH AND TECHNIQUE"},{"key":"454_CR4","unstructured":"Cui Y, Zhang G, Liu Z, Xiong Z, Hu J: A deep learning algorithm for one-step contour aware nuclei segmentation of histopathological images. CoRR,\u00a02018\u00a0https:\/\/arxiv.org\/abs\/1803.02786"},{"issue":"10","key":"454_CR5","first-page":"1","volume":"29","author":"F Xing","year":"2017","unstructured":"Xing F, Xie Y, Su H, Liu F, Yang L: Deep learning in microscopy image analysis: A survey. IEEE Trans Neural Netw Learn Sys\u00a029(10):1\u201319,2017","journal-title":"IEEE Transactions on Neural Networks and Learning Systems"},{"key":"454_CR6","doi-asserted-by":"crossref","unstructured":"Rabelo GD, Traven\u00e7olo BAN, Oliveira MA, Beletti ME, Gallottini M, de Silveira FRX: Changes in cortical bone channels network and osteocyte organization after the use of zoledronic acid. Arch Endocrin Metabol 59(6):507\u2013514,2015","DOI":"10.1590\/2359-3997000000097"},{"key":"454_CR7","doi-asserted-by":"crossref","unstructured":"da\u00a0Fontoura\u00a0Costa L, Viana MP, Beletti ME: Complex channel networks of bone structure. Appl Phys Lett\u00a088(3):033903,2006","DOI":"10.1063\/1.2166473"},{"key":"454_CR8","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1109\/RBME.2013.2295804","volume":"7","author":"H Irshad","year":"2014","unstructured":"Irshad H, Veillard A, Roux L, Racoceanu D: Methods for nuclei detection, segmentation and classification in digital histopathology: A review current status and future potential. IEEE Rev Biomed Eng\u00a07:97\u2013114,2014.","journal-title":"IEEE Reviews in Biomedical Engineering"},{"key":"454_CR9","doi-asserted-by":"crossref","unstructured":"Veta M, van Diest PJ, Kornegoor R, Huisman A, Viergever MA, JPW: Pluim1 Automatic nuclei segmentation in h&e stained breast cancer histopathology images. PLOS ONE, 8(7),2013.","DOI":"10.1371\/journal.pone.0070221"},{"key":"454_CR10","doi-asserted-by":"crossref","unstructured":"Loy G, Zelinsky A: Fast radial symmetry for detecting points of interest. IEEE Trans Patt Anal Mach Intell, 25(8), 2003","DOI":"10.1109\/TPAMI.2003.1217601"},{"issue":"7\u20138","key":"454_CR11","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.compmedimag.2013.08.003","volume":"37","author":"IS Hage","year":"2013","unstructured":"Hage IS, Hamade RF: Segmentation of histology slides of cortical bone using pulse coupledneural networks optimized by particle-swarm optimization. Comp Med Imag Graph\u00a037(7-8):466\u2013474,2013","journal-title":"Computerized Medical Imaging and Graphics"},{"key":"454_CR12","doi-asserted-by":"crossref","unstructured":"Tosta TAA, de Abreu AF, Traven\u00e7olo BAN, de Nascimento MZ, Neves LA: Unsupervised segmentation of leukocytes images using thresholding neighborhood valley-emphasis. In 2015 IEEE 28th Int Symp Comp-Based Med Sys, pages 93\u201394,2015","DOI":"10.1109\/CBMS.2015.27"},{"key":"454_CR13","doi-asserted-by":"crossref","unstructured":"do\u00a0Nascimento MZ, Martins AS, Tosta TAA, Neves LA: Lymphoma images analysis using morphological and non-morphological descriptors for classification. Comp Meth Prog Biomed 163:65-77,2018","DOI":"10.1016\/j.cmpb.2018.05.035"},{"issue":"2","key":"454_CR14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/00016357.2017.1392601","volume":"76","author":"GE Do\u011fan","year":"2017","unstructured":"Do\u011fan GE, Halici Z, Karakus E, Erdemci B, Alsaran A, Cinar I: Dose-dependent effect of radiation on resorbable blast material titanium implants: an experimental study in rabbits. Acta Odontologica Scandinavica\u00a076(2):130\u2013134,2017","journal-title":"Acta Odontologica Scandinavica"},{"issue":"2","key":"454_CR15","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/clr.12116","volume":"25","author":"JY Li","year":"2013","unstructured":"Li JY, Pow EHN, Zheng LW, Ma L, Kwong DLW, Cheung LK: Dose-dependent effect of radiation on titanium implants: a quantitative study in rabbits. Clin Oral Impl Res\u00a025(2):260\u2013265,2013","journal-title":"Clinical Oral Implants Research"},{"key":"454_CR16","unstructured":"Vincent L: Morphological grayscale reconstruction: Definition, efficient algorithm and applications in image analysis. IEEE Conf Comp Vis Patt Recogn, pages 633\u2013635,1992"},{"key":"454_CR17","unstructured":"Gonzalez RC, Woods RC: Processamento Digital de Imagens. Pearson, 3 edition, 2010"},{"key":"454_CR18","doi-asserted-by":"crossref","unstructured":"Otsu N: A threshold selection method from gray-level histograms. IEEE Trans Sys, Man, and Cybernetics,\u00a0SMC-9(1):62\u201366,1979","DOI":"10.1109\/TSMC.1979.4310076"},{"key":"454_CR19","unstructured":"Chen TW, Chen YL, Chien SY: Fast image segmentation based on k-means clustering with histograms in hsv color space. IEEE 10th Workshop on Multimedia Signal Processing, pages 322\u2013325,2008"},{"key":"454_CR20","first-page":"764","volume":"54","author":"N Dhanachandra","year":"2015","unstructured":"Dhanachandra N, Manglem K, Chanu YJ: Image segmentation using k-means clustering algorithm and subtractive clustering algorithm. Int Multi-Con Info Proc 54:764\u2013771,2015","journal-title":"International Multi-Conference on Information Processing"},{"key":"454_CR21","unstructured":"Duda RO, Hart PE, Stork DG: Pattern Classification. Wiley, 2 edition, 2012."},{"issue":"7","key":"454_CR22","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1109\/TPAMI.2002.1017616","volume":"24","author":"T Kanungo","year":"2002","unstructured":"Kanungo T, Mount DM, Netanyahu NS, Piatko CD, Silverman R, Wu AY: An efficient k-means clustering algorithm: Analysis and implementation. IEEE Trans Patt Anal Mach Intell 24(7):881\u2013892,2002","journal-title":"IEEE Transactions on Pattern Analysis and Machine Intelligence"},{"key":"454_CR23","doi-asserted-by":"crossref","unstructured":"Likasa A, Vlassisb N, Verbeekb J: The global k-means clustering algorithm. J Patt Recogn Soc,\u00a0pages 451\u2013461,2003.","DOI":"10.1016\/S0031-3203(02)00060-2"},{"key":"454_CR24","doi-asserted-by":"crossref","unstructured":"Wang CW, Ka SM, Chen A: Robust image registration of biological microscopic images. Nature - Sci Rep, 2014","DOI":"10.1038\/srep06050"},{"key":"454_CR25","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1016\/j.patrec.2006.03.009","volume":"27","author":"H-F Ng","year":"2006","unstructured":"Ng HF: Automatic thresholding for defect detection. Patt Recogn Lett- Elsevier, 27:1644\u20131649,2006","journal-title":"Pattern Recognition Letters - Elsevier"},{"issue":"6","key":"454_CR26","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.patrec.2011.12.009","volume":"33","author":"J-L Fan","year":"2012","unstructured":"Fan JL, Lei B: A modified valley-emphasis method for automatic thresholding. Patt Recog Lett, 33(6):703\u2013708,2012","journal-title":"Pattern Recognition Letters"}],"container-title":["Journal of Digital Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-021-00454-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10278-021-00454-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-021-00454-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T17:12:41Z","timestamp":1627924361000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10278-021-00454-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["454"],"URL":"https:\/\/doi.org\/10.1007\/s10278-021-00454-1","relation":{},"ISSN":["0897-1889","1618-727X"],"issn-type":[{"value":"0897-1889","type":"print"},{"value":"1618-727X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,4]]},"assertion":[{"value":"18 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}