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As of today, there is no broadly accepted method for the diagnosis of hepatic steatosis in contrast-enhanced CT images. This retrospective study evaluates the potential of quantitative iodine values in portal venous phase iodine images in dual-energy CT (DECT) by measuring iodine concentrations in regions of interest (ROI) and analyzing the absolute iodine concentration of the liver parenchyma as well as three different blood-normalized iodine concentrations in a study cohort of 251 patients. An independent two sample <jats:italic>t<\/jats:italic>-test (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) was used to compare the iodine concentrations of healthy and fatty liver. Diagnostic performance was assessed by ROC (receiver operating characteristic) curve analysis. The results showed significant differences between the average iodine concentration of healthy and fatty liver parenchyma for the absolute and for the blood-normalized iodine concentrations. The study concludes that the iodine uptake of the liver parenchyma is impaired by hepatic steatosis, and that the measurement of iodine concentration can provide a suitable method for the detection of hepatic steatosis in quantitative iodine images. Suitable thresholds of quantitative iodine concentration values for the diagnosis of hepatic steatosis are provided.\n<\/jats:p>","DOI":"10.1007\/s10278-022-00682-z","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T17:04:05Z","timestamp":1658768645000},"page":"1738-1747","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Iodine Images in Dual-energy CT: Detection of Hepatic Steatosis by Quantitative Iodine Concentration Values"],"prefix":"10.1007","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-4249","authenticated-orcid":false,"given":"Stefanie","family":"Beck","sequence":"first","affiliation":[]},{"given":"Laurenz","family":"Jahn","sequence":"additional","affiliation":[]},{"given":"Dominik","family":"Deniffel","sequence":"additional","affiliation":[]},{"given":"Isabelle","family":"Riederer","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Sauter","sequence":"additional","affiliation":[]},{"given":"Marcus R.","family":"Makowski","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Pfeiffer","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"682_CR1","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1056\/NEJMra011775","volume":"346","author":"P Angulo","year":"2002","unstructured":"Angulo P: Nonalcoholic fatty liver disease. 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The study was approved by the Institutional Ethics Committee of Klinikum Rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen (protocol code 127\/17S), and informed consent was waived by the local Ethics Committee of the Klinikum Rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen in view of the retrospective nature of the study and all the procedures being performed as part of the routine care.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Informed consent was waived by the local Ethics Committee of\nthe Klinikum Rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen in view of the\nretrospective nature of the study and all the procedures being performed as\npart of the routine care and due to the anonymization of any patient data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Informed consent was waived by the local Ethics Committee of the Klinikum Rechts der Isar der Technischen Universit\u00e4t M\u00fcnchen in view of the retrospective nature of the study and all the procedures being performed as part of the routine care and due to the anonymization of any patient data.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}