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Inform. med."],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Segmentation is a routine step in PET image analysis, and few automatic tools have been developed for it. However, excluding supervised methods with their own limitations, they are typically designed for older, small images and the implementations are no longer publicly available. Here, we test if different commonly used building blocks of the automatic methods work with large modern total-body PET images. Dynamic total-body images from five different datasets are used for evaluation purposes, and the tested algorithms cover wide range of different preprocessing approaches and unsupervised segmentation methods. The validation is done by comparing the obtained segments to manually drawn ones using Jaccard index, Dice score, precision, and recall as measures of match. Out of the 17 considered segmentation methods, only 6 were computationally usable and provided enough segments for the needs of this study. Among these six feasible methods, hierarchical clustering and HDBSCAN had systematically the lowest Jaccard indices with the manual segmentations, whereas both GMM and\n                    <jats:italic>k<\/jats:italic>\n                    -means had median Jaccards of 0.58 over different organ segments and data sets. GMM outperformed\n                    <jats:italic>k<\/jats:italic>\n                    -means in human data, but with rat images, the two methods had equally good performance\n                    <jats:italic>k<\/jats:italic>\n                    -means having slightly stronger precision and GMM recall. We conclude that most of the commonly used unsupervised segmentation methods are computationally infeasible with the modern PET images, classical clustering algorithms\n                    <jats:italic>k<\/jats:italic>\n                    -means and especially Gaussian mixture model being the most promising candidates for further method development. Even though preprocessing, particularly denoising, improved the results, small organs remained difficult to segment.\n                  <\/jats:p>","DOI":"10.1007\/s10278-025-01540-4","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:29:58Z","timestamp":1748348998000},"page":"382-399","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Automatic Segmentation and Preprocessing Approaches for Dynamic Total-Body 3D Pet Images with Different Pet Tracers"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7199-0062","authenticated-orcid":false,"given":"Maria K.","family":"Jaakkola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Xiomara","family":"Rivera Pineda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Rantala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"K\u00e4rpijoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teemu","family":"Saari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teemu","family":"Maaniitty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Keller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Louhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saara","family":"Wahlroos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merja","family":"Haaparanta-Solin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olof","family":"Solin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaakko","family":"Hentil\u00e4","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jatta S.","family":"Helin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuuli A.","family":"Nissinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli","family":"Eskola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Rajander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani","family":"Knuuti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsi A.","family":"Virtanen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarna C.","family":"Hannukainen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"L\u00f3pez-Pic\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riku","family":"Kl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"1540_CR1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.compmedimag.2019.04.005","volume":"75","author":"SA Taghanaki","year":"2019","unstructured":"S.\u00a0A. 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Sundar, J.\u00a0Yu, O.\u00a0Muzik, et\u00a0al., \u201cFully automated, semantic segmentation of whole-body 18f-fdg pet\/ct images based on data-centric artificial intelligence,\u201d Journal of Nuclear Medicine 63(12), 1941\u20131948 (2022).","journal-title":"Journal of Nuclear Medicine"},{"key":"1540_CR37","doi-asserted-by":"crossref","unstructured":"J.\u00a0Wasserthal, H.-C. Breit, M.\u00a0T. Meyer, et\u00a0al., \u201cTotalsegmentator: robust segmentation of 104 anatomic structures in ct images,\u201d Radiology: Artificial Intelligence 5(5) (2023).","DOI":"10.1148\/ryai.230024"}],"container-title":["Journal of Imaging Informatics in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-025-01540-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10278-025-01540-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10278-025-01540-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T18:45:58Z","timestamp":1771526758000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10278-025-01540-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,27]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["1540"],"URL":"https:\/\/doi.org\/10.1007\/s10278-025-01540-4","relation":{},"ISSN":["2948-2933"],"issn-type":[{"value":"2948-2933","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,27]]},"assertion":[{"value":"7 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 April 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"While this is a method study, example data was utilised. The licence numbers related to the animal data used here were ESAVI-33741-2019 and ESAVI-4080-2019 (State Provincial Office of Southern Finland). The reference number of the ethical committee decision related to the used FDG human data was 14\/1801\/2022 (Hospital District of South-Western Finland), and for the study containing H2O human data, it was 22\/1801\/2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}