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Psychology has undergone several theoretical changes, and the current use of artificial intelligence (AI) and machine learning, particularly LLMs, promises to open up new research directions. We aim to provide a detailed exploration of how LLMs are transforming psychological research. We discuss the impact of LLMs across various branches of psychology\u2014including cognitive and behavioral, clinical and counseling, educational and developmental, and social and cultural psychology\u2014highlighting their ability to model patterns, cognition, and behavior similar to those observed in humans. Furthermore, we explore the ability of such models to generate coherent, contextually relevant text, offering innovative tools for literature reviews, hypothesis generation, experimental designs, experimental subjects, and data analysis in psychology. We emphasize the importance of addressing technical and ethical challenges, including data privacy, the ethics of using LLMs in psychological research, and the need for a deeper understanding of these models\u2019 limitations. Researchers should use LLMs responsibly in psychological studies, adhering to ethical standards and considering the potential consequences of deploying these technologies in sensitive areas. Overall, this review provides a comprehensive overview of the current state of LLMs in psychology, exploring the potential benefits and challenges. We hope it can serve as a call to action for researchers to responsibly leverage LLMs\u2019 advantages while addressing the associated risks.<\/jats:p>","DOI":"10.1007\/s10462-025-11297-5","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T03:14:55Z","timestamp":1752290095000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Exploring the frontiers of LLMs in psychological applications: a comprehensive review"],"prefix":"10.1007","volume":"58","author":[{"given":"Luoma","family":"Ke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiping","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"11297_CR1","doi-asserted-by":"publisher","first-page":"103978","DOI":"10.1016\/j.ijmedinf.2019.103978","volume":"132","author":"AA Abd-Alrazaq","year":"2019","unstructured":"Abd-Alrazaq AA, Alajlani M, Alalwan AA, Bewick BM, Gardner P, Househ M (2019) An overview of the features of chatbots in mental health: A scoping review. 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