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We draw on resource orchestration theory and analyse data stemming from US healthcare to discuss how the US healthcare system structured, bundled and reconfigured resources (i.e. number of hospital beds, and vaccines) during the COVID-19 pandemic. Following a comprehensive and robust econometric analysis of two key resources (i.e. hospital beds and vaccines), we discuss its effect on the outcomes of the pandemic measured in terms of confirmed cases and deaths, and draw insights on how the learning curve effect and other factors might influence in the efficient and effective control of the pandemic outcomes through the resource usage. Our contribution lies in revealing how different resources are orchestrated (\u2018structured\u2019, \u2018bundled\u2019, and \u2018leveraged\u2019) to help planning responses to and dealing with the disruptions to create resilient humanitarian operations. Managerial implications, limitations and future research directions are also discussed.\n<\/jats:p>","DOI":"10.1007\/s10479-022-04963-2","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T17:04:01Z","timestamp":1664471041000},"page":"1819-1848","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The role of resource orchestration in humanitarian operations: a COVID-19 case in the US healthcare"],"prefix":"10.1007","volume":"348","author":[{"given":"Konstantinos","family":"Baltas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranadeva","family":"Jayasekera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gazi Salah","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-1136","authenticated-orcid":false,"given":"Thanos","family":"Papadopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"4963_CR1","first-page":"120e146","volume-title":"Large-scale disasters: prediction control and mitigation","author":"N Altay","year":"2008","unstructured":"Altay, N. 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