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Accurate stress measurement is critical for effective interventions, yet research is hindered by incomplete datasets and inconsistent methodologies, slowing the development of reliable predictive models. This paper introduces a framework for cross-contextual stress prediction, enabling the generation of general stress prediction models adaptable to specific domain challenges. The methodology leverages two general daily life datasets and three domain-specific datasets, employing steps such as dataset selection, feature extraction, significant feature identification, feature preprocessing, fine-tuning, domain adaptation, and application to specific contexts. Through this framework, key vital signs were identified as significant predictors of stress, including electrocardiography (ECG), heart rate (HR), heart rate variability (HRV) - low frequency (LF), electrodermal activity (EDA), body temperature (TEMP), and skin conductance response (SCR). The experiments conducted include: 1) Utilizing HR and HRV-LF through domain adaptation from general to automobile driving datasets; 2) Applying EDA, HR, and TEMP from general to specific nurse activity datasets; and 3) Adapting ECG, HR, and TEMP from general to automobile driving datasets. Results demonstrate the potential of the proposed framework for cross-contextual stress prediction, with HR and HRV-LF identified as pivotal features. When applied to target datasets specific to stress scenarios, the model achieved a 62% F1 score, demonstrating the effectiveness of the feature-based Correlation Alignment (CORAL) technique combined with Random Forest models in transferring learned knowledge across domains. These findings highlight the robustness of the approach in adapting general stress prediction models to specific contexts, paving the way for real-world applications such as stress monitoring in driving and nursing during high-stress periods like COVID-19.<\/jats:p>","DOI":"10.1007\/s10489-025-06277-9","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T11:52:36Z","timestamp":1738929156000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Cross-contextual stress prediction: Simple methodology for comparing features and sample domain adaptation techniques in vital sign analysis"],"prefix":"10.1007","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5279-6053","authenticated-orcid":false,"given":"Samson","family":"Mihirette","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-7544","authenticated-orcid":false,"given":"Enrique A.","family":"De la Cal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6447-2133","authenticated-orcid":false,"given":"Qing","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4191-8438","authenticated-orcid":false,"given":"Javier","family":"Sedano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"issue":"3","key":"6277_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/ICB\/42.3.508","volume":"42","author":"N Greenberg","year":"2002","unstructured":"Greenberg N, Carr JA, Summers CH (2002) Causes and Consequences of Stress. 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