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The main anaplerotic substrates are pyruvate, glutamine\/glutamate and precursors of propionyl\u2010CoA (odd\u2010chain fatty acids, specific amino acids, C<jats:sub>5<\/jats:sub>\u2010ketone bodies). Cataplerosis balances anaplerosis by removing excess intermediates from the citric acid cycle. The properties of the main anaplerotic substrates are reviewed from the point of view of potential clinical applications to the treatment of some inherited and acquired conditions.<\/jats:p>","DOI":"10.1007\/s10545-006-0320-1","type":"journal-article","created":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T03:09:10Z","timestamp":1149822550000},"page":"327-331","source":"Crossref","is-referenced-by-count":173,"title":["Anaplerotic molecules: Current and future"],"prefix":"10.1002","volume":"29","author":[{"given":"Henri","family":"Brunengraber","sequence":"first","affiliation":[{"name":"Department of Nutrition Case Western Reserve University  10900 Euclid Avenue Cleveland OH 44106\u20134906 USA"}]},{"given":"Charles R.","family":"Roe","sequence":"additional","affiliation":[{"name":"Institute of Metabolic Disease Baylor University Medical Center  Dallas Texas USA"}]}],"member":"311","published-online":{"date-parts":[[2005,12,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-152818-8.50014-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2080743"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.5.H2431"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/31.3.436"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)44057-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(86)80905-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2003.10.001"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116657"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.20.4.A740-b"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1998.0647"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1010242"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00777.2003"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.3.E446"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00218.2004"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.49.070180.002143"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198905000-00016"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2004.09.007"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.6.E1022"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302013200"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-006-0290-3"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215311"},{"key":"e_1_2_1_23_1","first-page":"H1756","article-title":"Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate","volume":"261","author":"Russell RR","year":"1991","journal-title":"Am J Physiol"},{"key":"e_1_2_1_24_1","first-page":"H441","article-title":"Propionyl\u2010l\u2010carnitine\u2010mediated improvement in contractile function of rat hearts oxidizing acetoacetate","volume":"268","author":"Russell RR","year":"1995","journal-title":"Am J Physiol"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00074.x"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026163921643"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93669-0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.20.5.A862"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-006-0320-1","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1007\/s10545-006-0320-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T09:09:08Z","timestamp":1694768948000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1007\/s10545-006-0320-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,27]]},"references-count":27,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1007\/s10545-006-0320-1"],"URL":"https:\/\/doi.org\/10.1007\/s10545-006-0320-1","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,27]]}}}