{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T04:28:19Z","timestamp":1768883299376,"version":"3.49.0"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chromosome Res"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1007\/s10577-006-1066-1","type":"journal-article","created":{"date-parts":[[2006,7,6]],"date-time":"2006-07-06T17:23:49Z","timestamp":1152206629000},"page":"377-392","source":"Crossref","is-referenced-by-count":164,"title":["Histone modification and the control of heterochromatic gene silencing in Drosophila"],"prefix":"10.1007","volume":"14","author":[{"given":"Anja","family":"Ebert","sequence":"first","affiliation":[]},{"given":"Sandro","family":"Lein","sequence":"additional","affiliation":[]},{"given":"Gunnar","family":"Schotta","sequence":"additional","affiliation":[]},{"given":"Gunter","family":"Reuter","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2006,7,4]]},"reference":[{"key":"1066_CR1","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/emboj\/18.7.1923","volume":"18","author":"L Aagaard","year":"1999","unstructured":"Aagaard L, Laible G, Selenko P et al. (1999) Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins that complex with the heterochromatin component M31. EMBO J 18: 1923\u20131938.","journal-title":"EMBO J"},{"key":"1066_CR2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1097-2765(00)80431-1","volume":"5","author":"A Akhtar","year":"2000","unstructured":"Akhtar A, Becker PB (2000) Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila. Mol Cell 5: 367\u2013375.","journal-title":"Mol Cell"},{"key":"1066_CR3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1101\/gad.9.2.218","volume":"9","author":"RC Allshire","year":"1995","unstructured":"Allshire RC, Nimmo ER, Ekwall K, Javerzat J-P, Crabston G (1995) Mutations derepressing silent centromeric domains in fission yeast disrupt chromosome segregation. Genes Dev 9: 218\u2013233.","journal-title":"Genes Dev"},{"key":"1066_CR4","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1093\/emboj\/cdf517","volume":"21","author":"JA Armstrong","year":"2002","unstructured":"Armstrong JA, Papoulas O, Daubresse G et al. (2002) The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J 21: 5245\u20135254.","journal-title":"EMBO J"},{"key":"1066_CR5","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1093\/nar\/29.21.4319","volume":"29","author":"LO Baumbusch","year":"2001","unstructured":"Baumbusch LO, Thorstensen T, Krauss V et al. (2001) The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionary conserved classes. Nucleic Acids Res 29: 4319\u20134333.","journal-title":"Nucleic Acids Res"},{"key":"1066_CR6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nature01126","volume":"419","author":"C Beisel","year":"2002","unstructured":"Beisel C, Imhof A, Greene J, Kremmer E, Sauer F (2002) Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. Nature 419: 857\u2013862.","journal-title":"Nature"},{"key":"1066_CR7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF00364556","volume":"100","author":"ES Belyaeva","year":"1991","unstructured":"Belyaeva ES, Zhimulev IF (1991) Cytogenetic and molecular aspects of position effect variegation in Drosophila III. Continuous and discontinuous compaction of chromosomal material is a result of position effect variegation. Chromosoma 100: 453\u2013466.","journal-title":"Chromosoma"},{"key":"1066_CR8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF00368351","volume":"102","author":"ES Belyaeva","year":"1993","unstructured":"Belyaeva ES, Demakova OV, Umbetova GH, Zhimulev IF (1993) Cytogenetic and molecular aspects of position-effect variegation in Drosophila melanogaster. V. Heterochromatin-associated protein HP1 appears in euchromatic chromosomal regions that are inactivated as a result of position-effect variegation. Chromosoma 102: 53\u2013590.","journal-title":"Chromosoma"},{"key":"1066_CR9","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/dev.128.17.3371","volume":"128","author":"A Birve","year":"2001","unstructured":"Birve A, Sengupta AK, Beuchle D et al. (2001) Su(z)12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants. Development 128: 3371\u20133379.","journal-title":"Development"},{"key":"1066_CR10","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1073\/pnas.1933593100","volume":"100","author":"KN Byrd","year":"2003","unstructured":"Byrd KN, Shearn A (2003) ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Proc Natl Acad Sci USA 100: 11535\u201311540.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1066_CR11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1101\/sqb.2004.69.419","volume":"69","author":"H Cam","year":"2004","unstructured":"Cam H, Grewal SIS (2004) RNA interference and epigenetic control of heterochromatin assembly in fission yeast. Cold Spring Habor Symp Quant Biol 69: 419\u2013427.","journal-title":"Cold Spring Habor Symp Quant Biol"},{"key":"1066_CR12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S1097-2765(00)80256-7","volume":"5","author":"P Cheung","year":"2000","unstructured":"Cheung P, Tanner KG, Cheung WL, Sassone-Corsi P, Denu JM, Allis CD (2000) Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell 5: 905\u2013915.","journal-title":"Mol Cell"},{"key":"1066_CR13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/embo-reports\/kve243","volume":"21","author":"F Cleard","year":"2001","unstructured":"Cleard F, Spierer P (2001) Position-effect variegation in Drosophila: the modifier Su(var)3-7 is a modular DNA-binding protein. EMBO Rep 21: 1095\u20131100.","journal-title":"EMBO Rep"},{"key":"1066_CR14","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1093\/emboj\/16.17.5280","volume":"16","author":"F Cleard","year":"1997","unstructured":"Cleard F, Delattre M, Spierer P (1997) SU(VAR)3-7 a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J 16: 5280\u20135288.","journal-title":"EMBO J"},{"key":"1066_CR15","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/embo-reports\/kve210","volume":"2","author":"B Czermin","year":"2001","unstructured":"Czermin B, Schotta G, H\u00fclsmann BB et al. (2001) Physical and functional interaction of SU(VAR)3-9 and HDAC1 in Drosophila. EMBO Rep 2: 915\u2013919.","journal-title":"EMBO Rep"},{"key":"1066_CR16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0092-8674(02)00975-3","volume":"111","author":"B Czermin","year":"2002","unstructured":"Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V (2002) Drosophila Enhancer of Zeste\/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 111: 185\u2013196.","journal-title":"Cell"},{"key":"1066_CR17","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1242\/jcs.113.23.4253","volume":"113","author":"M Delattre","year":"2000","unstructured":"Delattre M, Spierer A, Tonka C-H, Spierer P (2000) The genomic silencing of position-effect variegation in Drosophila melanogaster: Interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1. J Cell Sci 113: 4253\u20134261.","journal-title":"J Cell Sci"},{"key":"1066_CR18","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/BF00292003","volume":"238","author":"SA Demakov","year":"1993","unstructured":"Demakov SA, Semeshin VF, Zhimulev IF (1993) Cloning and moleculargenetic analysis of Drosophila melanogaster interband DNA. Mol Gen Genet 238: 437\u2013443.","journal-title":"Mol Gen Genet"},{"key":"1066_CR19","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/genetics\/22.6.641","volume":"22","author":"M Demerec","year":"1937","unstructured":"Demerec M, Slizynska H (1937) Mottled white258-18 of Drosophila melanogaster. Genetics 22: 641\u2013649.","journal-title":"Genetics"},{"key":"1066_CR20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/genetics\/133.2.279","volume":"133","author":"R Dorn","year":"1993","unstructured":"Dorn R, Szidonya J, Korge G et al. (1993). P Transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster. Genetics 133: 279\u2013290.","journal-title":"Genetics"},{"key":"1066_CR21","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1101\/gad.323004","volume":"18","author":"A Ebert","year":"2004","unstructured":"Ebert A, Schotta G, Lein S et al. (2004) Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev 18: 2973\u20132983.","journal-title":"Genes Dev"},{"key":"1066_CR22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/BF00376796","volume":"15","author":"R Egel","year":"1989","unstructured":"Egel R, Willer M, Neisen O (1989) Unblocking of meiotic crossing-over between the silent mating-type cassettes of fission yeast, conditioned by the recessive, pleiotropic mutant rik1. Curr Genet 15: 407\u2013410.","journal-title":"Curr Genet"},{"key":"1066_CR23","doi-asserted-by":"crossref","first-page":"4253","DOI":"10.1242\/jcs.01292","volume":"15","author":"H Eggert","year":"2004","unstructured":"Eggert H, Gortchakov A, Saumweber H (2004) Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure. J Cell Sci 15: 4253\u20134264.","journal-title":"J Cell Sci"},{"key":"1066_CR24","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0959-437X(00)00058-7","volume":"10","author":"JC Eissenberg","year":"2000","unstructured":"Eissenberg JC, Elgin SC (2000) The HP1 protein family: getting a grip on chromatin. Curr Opin Genet Dev 10: 204\u2013210.","journal-title":"Curr Opin Genet Dev"},{"key":"1066_CR25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/genetics\/136.1.53","volume":"136","author":"K Ekwall","year":"1994","unstructured":"Ekwall K, Ruusala T (1994) Mutations in rik1, clr2, clr3, and clr4 genes asymmetrically derepress the silent mating-type loci in fission yeast. Genetics 136: 53\u201364.","journal-title":"Genetics"},{"key":"1066_CR26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/S0960-9822(02)00901-6","volume":"12","author":"Q Feng","year":"2002","unstructured":"Feng Q, Wang H, Ng HH et al. (2002) Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain. Curr Biol 12: 1052\u20131058.","journal-title":"Curr Biol"},{"key":"1066_CR27","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jplph.2005.10.015","volume":"163","author":"A Fischer","year":"2006","unstructured":"Fischer A, Hofmann I, Naumann K, Reuter G (2006) Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis. J Plant Physiol 163: 358\u2013368.","journal-title":"J Plant Physiol"},{"key":"1066_CR28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S0955-0674(03)00013-9","volume":"15","author":"W Fischle","year":"2003","unstructured":"Fischle W, Wang Y, Allis CD (2003) Histone and chromatin cross-talk. Curr Opin Cell Biol 15: 172\u2013183.","journal-title":"Curr Opin Cell Biol"},{"key":"1066_CR29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1097-2765(04)00024-3","volume":"13","author":"M Freitag","year":"2004","unstructured":"Freitag M, Hickey PC, Khlafallah TK, Read ND, Selker EU (2004) HP1 is essential for DNA methylation in Neurospora. Mol Cell 13: 427\u2013434.","journal-title":"Mol Cell"},{"key":"1066_CR30","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/ng1278","volume":"36","author":"M Garcia-Cao","year":"2003","unstructured":"Garcia-Cao M, O'Sullivan R, Peters AHFM, Jenuwein T, Blasco MA (2003) Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 36: 94\u201399.","journal-title":"Nat Genet"},{"key":"1066_CR31","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1101\/gad.281503","volume":"17","author":"F Greil","year":"2003","unstructured":"Greil F, van der Kraan I, Delrow J et al. (2003) Distinct HP1 and Su(var)3-9 complexes bind to sets of developmentally coexpressed genes depending on chromosomal location. Genes Dev 17: 2825\u20132838.","journal-title":"Genes Dev"},{"key":"1066_CR32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1073\/pnas.232688099","volume":"100","author":"IM Hall","year":"2003","unstructured":"Hall IM, Noma K, Grewal SIS (2003) RNA interference machinery regulates chromosome dynamics during mitosis and meiosis in fission yeast. Proc Natl Acad Sci USA 100: 193\u2013198.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1066_CR33","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/nature01167","volume":"420","author":"A Hochheimer","year":"2002","unstructured":"Hochheimer A, Zhou S, Zheng S, Holmes MC, Tjian R (2002) TRF2 associates with DREF and directs promoter-selective gene expression in Drosophila. Nature 420: 439\u2013445.","journal-title":"Nature"},{"key":"1066_CR34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/566","volume":"19","author":"AV Ivanova","year":"1998","unstructured":"Ivanova AV, Bonaduce MJ, Ivanov SV, Klar AJS (1998) The chromo and SET domains of the Clr4 protein are essential for silencing in fission yeast. Nature Genet 19: 192\u2013195.","journal-title":"Nature Genet"},{"key":"1066_CR35","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nature731","volume":"416","author":"JP Jackson","year":"2002","unstructured":"Jackson JP, Lindroth AM, Cao X, Jacobsen SE (2002) Control of CpNpG DNA methylation by the KRYPONITE histone H3 methyltransferase. Nature 416: 556\u2013560.","journal-title":"Nature"},{"key":"1066_CR36","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00412-004-0275-7","volume":"112","author":"JP Jackson","year":"2004","unstructured":"Jackson JP, Johnson L, Jasencakova Z et al. (2004) Dimethylation of histone H3K9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma 112: 308\u2013315.","journal-title":"Chromosoma"},{"key":"1066_CR37","first-page":"833","volume":"9","author":"AS Jacobs","year":"2002","unstructured":"Jacobs AS, Harp JM, Devarakonda S, Kim Y, Rastinejad F, Khoasanizadeh S (2002) The active site of the SET domain is constructed on a knot. Nature Struct Biol 9: 833\u2013838.","journal-title":"Nature Struct Biol"},{"key":"1066_CR38","doi-asserted-by":"crossref","unstructured":"Jaquet Y, Delattre M, Montoya-Burgos J, Spierer A, Spierer P (2006) Conserved domains control heterochromatin localization and silencing properties of SU(VAR)3-7. Chromosoma (In press).","DOI":"10.1007\/s00412-005-0036-2"},{"key":"1066_CR39","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1242\/dev.129.17.3975","volume":"129","author":"Y Jaquet","year":"2002","unstructured":"Jaquet Y, Delattre M, Spierer A, Spierer P (2002) Functional dissection of the Drosophila modifier of variegation Su(var)3-7. Development 129: 3975\u20133982.","journal-title":"Development"},{"key":"1066_CR40","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","volume":"293","author":"T Jenuwein","year":"2001","unstructured":"Jenuwein T, Allis CD (2001) Translating the histone code. Science 293: 1074\u20131080.","journal-title":"Science"},{"key":"1066_CR41","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1126\/science.1099035","volume":"304","author":"S Jia","year":"2004","unstructured":"Jia S, Noma K, Grewal SIS (2004) RNAi-independent heterochromatin nucleation by the stress-activated ATF\/CREB family proteins. Science 304: 1971\u20131976.","journal-title":"Science"},{"key":"1066_CR42","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1128\/MCB.13.10.6357","volume":"13","author":"RS Jones","year":"1993","unstructured":"Jones RS, Gelbart WM (1993) The Drosophila Polycomb-group gene Enhancer of zeste contains a region with seqeunce similarity to trithorax. Mol Cell Biol 13: 6357\u20136366.","journal-title":"Mol Cell Biol"},{"key":"1066_CR43","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1101\/gad.831900","volume":"14","author":"CD Kaplan","year":"2000","unstructured":"Kaplan CD, Morris JR, Wu C, Winston F (2000) Spt5 and Spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster. Genes Dev 14: 2623\u20132634.","journal-title":"Genes Dev"},{"key":"1066_CR44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1101\/gad.1263005","volume":"19","author":"D Karachentsev","year":"2005","unstructured":"Karachentsev D, Sarma K, Reinberg D, Steward R (2005) PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis. Genes Dev 19: 431\u2013435.","journal-title":"Genes Dev"},{"key":"1066_CR45","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1101\/gad.201901","volume":"15","author":"KR Katsani","year":"2001","unstructured":"Katsani KR, Arredondo JJ, Kal AJ, Verrijzer CP (2001) A homeotic mutation in the trithorax SET domain impedes histone binding. Genes Dev 15: 2197\u20132202.","journal-title":"Genes Dev"},{"key":"1066_CR46","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/genetics\/156.3.1157","volume":"156","author":"V Krauss","year":"2000","unstructured":"Krauss V, Reuter G (2000) Two genes become one: the genes encoding heterochromatin protein SU(VAR)3-9 and translation initiation factor subunit eIF-2\u03b3 are joined to a dicistronic unit in holometabloic insects. Genetics 156: 1157\u20131167.","journal-title":"Genetics"},{"key":"1066_CR47","doi-asserted-by":"crossref","unstructured":"Krauss V, Fassl A, Fiebig P, Patties I, Sass H (2006) The evolution of the histone Methyltransferase gene Su(var)3-9 includes a fusion with and a re-fission from a functionally unrelated gene. BMC Evol Biol 6 (In press).","DOI":"10.1186\/1471-2148-6-18"},{"key":"1066_CR48","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/genetics\/157.3.1227","volume":"157","author":"S Kuhfittig","year":"2001","unstructured":"Kuhfittig S, Szabad J, Schotta G, Hoffmann J, M\u00e1th\u00e9 E, Reuter G (2001) PitkinD a novel gain-of-function enhancer of position-effect variegation affects chromatin regulation during oogenesis and early embryogenesis in Drosophila. Genetics 157: 1227\u20131244.","journal-title":"Genetics"},{"key":"1066_CR49","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1242\/jcs.00493","volume":"116","author":"M Lachner","year":"2003","unstructured":"Lachner M, O'Sullivan RJ, Jenuwein T (2003) An epigenetic road map for histone lysine methylation. J Cell Sci 116: 2117\u20132124.","journal-title":"J Cell Sci"},{"key":"1066_CR50","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1093\/emboj\/16.11.3219","volume":"16","author":"G Laible","year":"1997","unstructured":"Laible G, Wolf A, Dorn R et al. (1997). Mammalian homologs of Enhancer of zeste mediate position-effect variegation in Drosophila and restore telomeric silencing in S. cerevisiae. EMBO J 16: 3219\u20133232.","journal-title":"EMBO J"},{"key":"1066_CR51","doi-asserted-by":"crossref","first-page":"4146","DOI":"10.1038\/sj.emboj.7600430","volume":"23","author":"MA Lindroth","year":"2004","unstructured":"Lindroth MA, Shultis D, Jasencakova Z et al. (2004) Dual histone H3 methylation marks at lysine 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J 23: 4146\u20134155.","journal-title":"EMBO J"},{"key":"1066_CR52","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0378-1119(94)90619-X","volume":"143","author":"AK Lorentz","year":"1994","unstructured":"Lorentz AK, Ostermann K, Fleck O, Schmidt H (1994) Switching gene swi6, involved in repression of silent mating-type loci in fission yeast, encodes a homologue of chromatin-associated proteins from Drosophila and mammals. Gene 143: 323\u2013330.","journal-title":"Gene"},{"key":"1066_CR53","first-page":"828","volume":"9","author":"J Min","year":"2002","unstructured":"Min J, Zhang X, Cheng X, Grewal SS, Xu R-M (2002) Structure of the SET domain histine lysine methyltransferase Clr4. Nature Struct Biol 9: 828\u2013832.","journal-title":"Nature Struct Biol"},{"key":"1066_CR54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1101\/gad.359506","volume":"20","author":"B Miotto","year":"2006","unstructured":"Miotto B, Sagnier T, Berenger H, Bohmann D, Pradel J, Graba Y (2006) Chameau HAT and Drpd3 HDAC function as antagonistic cofactors of JNK\/AP-1-dependent transcription during Drosophila metamorphosis. Genes Dev 20: 101\u2013112.","journal-title":"Genes Dev"},{"key":"1066_CR55","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/genetics\/154.2.657","volume":"154","author":"R Mottus","year":"2000","unstructured":"Mottus R, Sobels RE, Grigliatti TA (2000) Mutational analysis of a histone deacetylase in Drosophila melanogaster: missence mutations suppress gene silencing associated with position effect variegation. Genetics 154: 657\u2013668.","journal-title":"Genetics"},{"key":"1066_CR56","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(02)00976-5","volume":"111","author":"J M\u00fcller","year":"2002","unstructured":"M\u00fcller J, Hart CM, Francis NJ et al. (2002) Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 111: 197\u2013208.","journal-title":"Cell"},{"key":"1066_CR57","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/S1097-2765(02)00740-2","volume":"10","author":"T Nakamura","year":"2002","unstructured":"Nakamura T, Mori T, Tada S, Krajewski W et al. (2002) ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 10: 1119\u20131128.","journal-title":"Mol Cell"},{"key":"1066_CR58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1126\/science.1060118","volume":"292","author":"J Nakayama","year":"2001","unstructured":"Nakayama J, Rice JD, Stahl BD, Allis CD, Grenwal SIS (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110\u2013113.","journal-title":"Science"},{"key":"1066_CR59","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.emboj.7600604","volume":"24","author":"K Naumann","year":"2005","unstructured":"Naumann K, Fischer A, Hofmann I et al. (2005) Pivotal role of AtSUVH2 in control of heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J 24: 1418\u20131429.","journal-title":"EMBO J"},{"key":"1066_CR60","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S1097-2765(02)00548-8","volume":"9","author":"K Nishioka","year":"2002","unstructured":"Nishioka K, Rice JC, Sarma K et al. (2002) PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin. Mol Cell 9: 1201\u20131213.","journal-title":"Mol Cell"},{"key":"1066_CR61","doi-asserted-by":"crossref","first-page":"16438","DOI":"10.1073\/pnas.182436399","volume":"99","author":"K Noma","year":"2002","unstructured":"Noma K, Grewal SIS (2002) Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci USA 99: 16438\u201316445.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1066_CR62","doi-asserted-by":"crossref","first-page":"9423","DOI":"10.1128\/MCB.20.24.9423-9433.2000","volume":"20","author":"D O\u2019Carroll","year":"2000","unstructured":"O'Carroll D, Scherthan H, Peters AH et al. (2000) Isolation and characterization of Suvh39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. Mol Cell Biol 20: 9423\u20139433.","journal-title":"Mol Cell Biol"},{"key":"1066_CR63","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1126\/science.1092653","volume":"303","author":"M Pal-Bhadra","year":"2004","unstructured":"Pal-Bhadra M, Leibovitch BA, Gandhi SG et al. (2004) Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science 303: 669\u2013672.","journal-title":"Science"},{"key":"1066_CR64","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(01)00542-6","volume":"107","author":"AHFM Peters","year":"2001","unstructured":"Peters AHFM, O\u2019Carroll D, Scherthan H et al. (2001) Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell 107: 323\u2013337.","journal-title":"Cell"},{"key":"1066_CR65","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S1097-2765(03)00477-5","volume":"12","author":"AHFM Peters","year":"2003","unstructured":"Peters AHFM, Kubicek S, Mechtler K et al. (2003) Partitioning and plasticity of repressive histone methylation states in mammalian chromatin. Mol Cell 12: 1577\u20131589.","journal-title":"Mol Cell"},{"key":"1066_CR66","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF02986099","volume":"48","author":"AA Prokofyeva-Belgovskaya","year":"1947","unstructured":"Prokofyeva-Belgovskaya AA (1947) Heterochromatization as a change of chromosome cycle. J Genet 48: 80\u201398.","journal-title":"J Genet"},{"key":"1066_CR67","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/35020506","volume":"406","author":"S Rea","year":"2000","unstructured":"Rea S, Eisenhaber F, O\u2019Carroll D, Stahl BD et al. (2000) Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature 406: 593\u2013599.","journal-title":"Nature"},{"key":"1066_CR68","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF00327349","volume":"85","author":"G Reuter","year":"1982","unstructured":"Reuter G, Werner W, Hoffman HJ (1982) Mutants affecting position effect heterochromatinization in Drosophila melanogaster. Chromosoma 85: 539\u2013551.","journal-title":"Chromosoma"},{"key":"1066_CR69","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/344219a0","volume":"344","author":"G Reuter","year":"1990","unstructured":"Reuter G, Giarre N, Farah J, Gausz J, Spierer A, Spierer P (1990) Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein. Nature 344: 219\u2013223.","journal-title":"Nature"},{"key":"1066_CR70","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S1097-2765(03)00479-9","volume":"12","author":"JC Rice","year":"2003","unstructured":"Rice JC, Briggs SD, Ueberheide B et al. (2003) Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell 12: 1591\u20131598.","journal-title":"Mol Cell"},{"key":"1066_CR71","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1093\/emboj\/20.24.7137","volume":"20","author":"A Roguev","year":"2001","unstructured":"Roguev A, Schaft D, Shevchenko A et al. (2001) The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J 20: 7137\u20137148.","journal-title":"EMBO J"},{"key":"1066_CR72","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cell.2004.11.009","volume":"119","author":"SL Sanders","year":"2004","unstructured":"Sanders SL, Portoso M, Mata J, B\u00e4hler J, Allshire RC, Kouzarides T (2004) Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage. Cell 119: 603\u2013614.","journal-title":"Cell"},{"key":"1066_CR73","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature01080","volume":"419","author":"H Santos-Rosa","year":"2002","unstructured":"Santos-Rosa H, Schneider R, Bannister AJ et al. (2002) Active genes are trimethylated at K4 of histone H3. Nature 419: 407\u2013411.","journal-title":"Nature"},{"key":"1066_CR74","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/emboj\/21.5.1121","volume":"21","author":"G Schotta","year":"2002","unstructured":"Schotta G, Ebert A, Krauss V et al. (2002) Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J 21: 1121\u20131131.","journal-title":"EMBO J"},{"key":"1066_CR75","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1084-9521(02)00138-6","volume":"14","author":"G Schotta","year":"2003","unstructured":"Schotta G, Ebert A, Dorn R, Reuter G (2003a) Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. Sem Cell Dev Biol 14: 67\u201375.","journal-title":"Sem Cell Dev Biol"},{"key":"1066_CR76","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1022923508198","volume":"117","author":"G Schotta","year":"2003","unstructured":"Schotta G, Ebert A, Reuter G (2003b) SU(VAR)3-9 a conserved key function in heterochromatic gene silencing. Genetica 117: 149\u2013158.","journal-title":"Genetica"},{"key":"1066_CR77","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1101\/gad.300704","volume":"18","author":"G Schotta","year":"2004","unstructured":"Schotta G, Lachner M, Sarma K et al. (2004) A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev 18: 1251\u20131262.","journal-title":"Genes Dev"},{"key":"1066_CR78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1073\/pnas.22.1.27","volume":"22","author":"J Schultz","year":"1936","unstructured":"Schultz J (1936) Variegation in Drosophila and the inert chromosome regions. Proc Natl Acad Sci USA 22: 27\u201333.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1066_CR79","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/nature02080","volume":"426","author":"Y Sedkov","year":"2003","unstructured":"Sedkov Y, Cho E, Petruk S et al. (2003) Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature 426: 78\u201383.","journal-title":"Nature"},{"key":"1066_CR80","doi-asserted-by":"crossref","first-page":"6208","DOI":"10.1021\/bi047749x","volume":"44","author":"K Seeger","year":"2005","unstructured":"Seeger K, Lein S, Reuter G, Berger S (2005) STD-measurements with SU(VAR)3-9 and S-adenosyl-l-methionine. Biochemistry 44: 6208\u20136213.","journal-title":"Biochemistry"},{"key":"1066_CR81","first-page":"1968","volume":"25","author":"VF Semeshin","year":"1989","unstructured":"Semeshin VF, Demakov SA, Zhimulev IF (1989) Characteristics of structures of Drosophila polytene chromosomes formed by transposable DNA fragments. Genetica (Russ) 25: 1968\u20131978.","journal-title":"Genetica (Russ)"},{"key":"1066_CR82","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1534\/genetics.104.033191","volume":"169","author":"GA Shanower","year":"2005","unstructured":"Shanower GA, Muller M, Blanton JL, Honti V, Gyurkovics H, Schedl P (2005) Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase. Genetics 169: 173\u2013184.","journal-title":"Genetics"},{"key":"1066_CR83","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.cell.2004.12.012","volume":"119","author":"Y Shi","year":"2004","unstructured":"Shi Y, Lan F, Matson C et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119: 941\u2013953.","journal-title":"Cell"},{"key":"1066_CR84","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1128\/MCB.20.1.312-318.2000","volume":"20","author":"ER Smith","year":"2000","unstructured":"Smith ER, Pannuti A, Gu W et al. (2000) The Drosophila MSL complex acetylates histone H4 at lysine 16, a chromatin modification linked to dosage compensation. Mol Cell Biol 20: 312\u2013318.","journal-title":"Mol Cell Biol"},{"key":"1066_CR85","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1242\/jcs.02623","volume":"118","author":"A Spierer","year":"2005","unstructured":"Spierer A, Seum C, Delattre M, Spierer P (2005) Loss of the modifier of variegation Su(var)3-7 or HP1 impacts male X polytene chromosome morphology and dosage compensation. J Cell Sci 118: 5047\u20135057.","journal-title":"J Cell Sci"},{"key":"1066_CR86","doi-asserted-by":"crossref","first-page":"7137","DOI":"10.1073\/pnas.93.14.7137","volume":"93","author":"DG Stokes","year":"1996","unstructured":"Stokes DG, Tartof KD, Perry RP (1996) CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes. Proc Natl Acad Sci USA 93: 7137\u20137142.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1066_CR87","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/35104508","volume":"414","author":"H Tamaru","year":"2001","unstructured":"Tamaru H, Selker EU (2001) A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414: 277\u2013283.","journal-title":"Nature"},{"key":"1066_CR88","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1093\/genetics\/131.2.287","volume":"131","author":"G Thon","year":"1992","unstructured":"Thon G, Klar AJS (1992) The clr1 locus regulates the expression of the cryptic mating-type loci of fission yeast. Genetics 131: 287\u2013296.","journal-title":"Genetics"},{"key":"1066_CR89","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/genetics\/155.2.551","volume":"155","author":"G Thon","year":"2000","unstructured":"Thon G, Verhein-Hansen J (2000) Four-chromo-domain proteins of Schizosaccharomyces pombe differentially repress transcription at various chromosomal locations. Genetics 155: 551\u2013568.","journal-title":"Genetics"},{"key":"1066_CR90","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/genetics\/138.1.29","volume":"138","author":"G Thon","year":"1994","unstructured":"Thon G, Cohen A, Klar AJS (1994) Three additional linkage groups that repress transcription and meiotic recombination in the mating-type region of Schizosaccharomyces pombe. Genetics 138: 29\u201338.","journal-title":"Genetics"},{"key":"1066_CR91","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0092-8674(02)01000-0","volume":"111","author":"RC Trievel","year":"2002","unstructured":"Trievel RC, Beach BM, Dirk LMA, Houtz RL, Hurley JH (2002) Structure and catalytic mechanism of a SET domain protein methyltransferase. Cell 111: 91\u2013103.","journal-title":"Cell"},{"key":"1066_CR92","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1002\/j.1460-2075.1994.tb06693.x","volume":"13","author":"B Tschiersch","year":"1994","unstructured":"Tschiersch B, Hofmann A, Krauss V, Dorn R, Korge G, Reuter G (1994) The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes. EMBO J 13: 3822\u20133831.","journal-title":"EMBO J"},{"key":"1066_CR93","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","volume":"439","author":"Y Tsukada","year":"2006","unstructured":"Tsukada Y, Fang J, Erdjument-Bromage H et al. (2006) Histone demethylation by a family of JmjC domain-containing proteins. Nature 439: 811\u2013816","journal-title":"Nature"},{"key":"1066_CR94","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/nar\/30.2.475","volume":"30","author":"O Vaute","year":"2002","unstructured":"Vaute O, Nicolas E, Vandal L, Trouche D (2002) Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases. Nucleic Acids Res 30: 475\u2013481.","journal-title":"Nucleic Acids Res"},{"key":"1066_CR95","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0092-8674(01)00325-7","volume":"105","author":"Y Wang","year":"2001","unstructured":"Wang Y, Zhang W, Jin Y, Johansen J, Johansen KM (2001) The JIL-1 tandem kinase mediates histone H3 phosphorylation and is required for maintenance of chromatin structure in Drosophila. Cell 105: 433\u2013443.","journal-title":"Cell"},{"key":"1066_CR96","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/BF02464926","volume":"217","author":"G Wustmann","year":"1989","unstructured":"Wustmann G, Szidonya J, Taubert H, Reuter G (1989) The genetics of position-effect modifying loci in Drosophila melanogaster. Mol Gen Genet 217: 520\u2013527.","journal-title":"Mol Gen Genet"},{"key":"1066_CR97","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0092-8674(02)00999-6","volume":"111","author":"X Zhang","year":"2002","unstructured":"Zhang X, Tamaru H, Khan SI et al. (2002) Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell 111: 117\u2013127.","journal-title":"Cell"},{"key":"1066_CR98","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2660(08)60476-9","volume":"39","author":"IF Zhimulev","year":"1999","unstructured":"Zhimulev IF (1999) Genetic organization of polytene chromosomes. Advanc Genet 39: 1\u2013599.","journal-title":"Advanc Genet"}],"container-title":["Chromosome Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10577-006-1066-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10577-006-1066-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10577-006-1066-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T08:19:15Z","timestamp":1627546755000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10577-006-1066-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":98,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["1066"],"URL":"https:\/\/doi.org\/10.1007\/s10577-006-1066-1","relation":{},"ISSN":["0967-3849","1573-6849"],"issn-type":[{"value":"0967-3849","type":"print"},{"value":"1573-6849","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}