{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:19:36Z","timestamp":1777540776738,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"S3","license":[{"start":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T00:00:00Z","timestamp":1517616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016FM28"],"award-info":[{"award-number":["ZR2016FM28"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cluster Comput"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s10586-018-1790-2","type":"journal-article","created":{"date-parts":[[2018,2,3]],"date-time":"2018-02-03T03:51:30Z","timestamp":1517629890000},"page":"6019-6030","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Research and application of biological potency soft sensor modeling method in the industrial fed-batch chlortetracycline fermentation process"],"prefix":"10.1007","volume":"22","author":[{"given":"Yu-mei","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ni","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-yan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-guang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-wen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,2,3]]},"reference":[{"key":"1790_CR1","unstructured":"Fu, J.: The Balancing Process Optimization and Metabolic Parameters Related to the Calculation of Chlortetracycline Fermentation Process. East China University of Science and Technology, Shanghai (2003) (Chinese)"},{"issue":"5","key":"1790_CR2","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","volume":"65","author":"AK Sarmah","year":"2006","unstructured":"Sarmah, A.K., Meyer, M.T., Boxall, A.: A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65(5), 725\u2013759 (2006)","journal-title":"Chemosphere"},{"key":"1790_CR3","unstructured":"Shi, Z., Feng, P.: Fermentation Process Analysis, Control and Measurement Technology, pp. 1\u20132. Chemical Industry Press, Beijing (2010) (Chinese)"},{"key":"1790_CR4","doi-asserted-by":"crossref","DOI":"10.1201\/9780203911358","volume-title":"Batch Fermentation: Modeling: Monitoring, and Control","author":"A Cinar","year":"2003","unstructured":"Cinar, A., Parulekar, S.J., Undey, C., et al.: Batch Fermentation: Modeling: Monitoring, and Control. CRC Press, New York (2003)"},{"issue":"1","key":"1790_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1080\/00401706.1995.10485888","volume":"37","author":"P Nomikos","year":"1995","unstructured":"Nomikos, P., MacGregor, J.F.: Multivariate SPC charts for monitoring batch processes. Technometrics 37(1), 41\u201359 (1995)","journal-title":"Technometrics"},{"key":"1790_CR6","unstructured":"Li, J., Bao, J., Chen, Y.: Assay of the fermentation concentration of active substance in the fermentation broth. J. Hebei Acad. Sci. 22(1), 52\u201353, 57 (2005) (Chinese)"},{"key":"1790_CR7","unstructured":"Xu, Y., Peng, W., Wang, D., et al.: Determination of lipstatin concentration in fermentation broth by RP-HPLC. J. Shenyang Pharm. Univ. 30(1), 31\u201334 (2013) (Chinese)"},{"key":"1790_CR8","unstructured":"Li, H., Liu, L., Guan, L.: Rapid determination of streptomycin in broth by spectrophotometry. Sci. Technol. Eng. 13(20), 6011\u20136014 (2013) (Chinese)"},{"key":"1790_CR9","unstructured":"Zhang, Y., Ni, Z., Liu, L., et al.: Rapid detection of bacitracin in fermentation broth by spectrophotometry. China Brew. (4), 171\u2013172 (2011) (Chinese)"},{"key":"1790_CR10","unstructured":"Chen, L.: Study on the fermentation process technology of chlortetracycline. Strait Pharm. J. 22(6), 23\u201325 (2010) (Chinese)"},{"key":"1790_CR11","unstructured":"Wang, P.: Study on the Breeding and Fermentation Process Optimization of CTC-Producing Strains. Inner Mongolia University, Hohhot (2013) (Chinese)"},{"key":"1790_CR12","unstructured":"He, J., Ruan, C., Tu, X., et al.: Study on determination of Honggumycin potency in fermentation by biological method. Sci. Technol. Food Ind. 32(11), 411\u2013442 (2011) (Chinese)"},{"key":"1790_CR13","unstructured":"Gao, F., Chen, T., Gou, L., et al.: Effect of Vitreoscilla hemoglobin gene (vgb) expression on growth and metabolism of Streptomyces venezuelae var. qinlingensis and its effect on Zuelacmycin valence. J. Agric. Biotechnol. 18(6), 1182\u20131188 (2010) (Chinese)"},{"key":"1790_CR14","unstructured":"Liao, A., Chen, K., Zhang, H.: Microbiological assay of gentamicin in broth with paper discuss method. Pharm. Biotechnol. 11(3), 187\u2013189 (2004) (Chinese)"},{"key":"1790_CR15","unstructured":"Gao, R., Zhao, Y.: A novel approach for accurate estimating the potency of antibiotics in fermentative fluid. J. Shandong Univ. 40(6), 112\u2013116 (2005) (Chinese)"},{"issue":"1","key":"1790_CR16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3168\/jds.2008-1141","volume":"92","author":"LO Tedeschi","year":"2009","unstructured":"Tedeschi, L.O., Kononoff, P.J., Karges, K., et al.: Effects of chemical composition variation on the dynamics of ruminal fermentation and biological value of corn milling (co)products. J. Dairy Sci. 92(1), 401\u2013413 (2009)","journal-title":"J. Dairy Sci."},{"issue":"4","key":"1790_CR17","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/j.1365-2621.2005.tb07205.x","volume":"70","author":"L Abecia-Soria","year":"2005","unstructured":"Abecia-Soria, L., Pezoa-Garc\u00eda, N.H., Amaya-Farfan, J.: Soluble albumin and biological value of protein in cocoa (Theobroma cacao L.) beans as a function of roasting time. J. Food Sci. 70(4), 294\u2013298 (2005)","journal-title":"J. Food Sci."},{"issue":"7","key":"1790_CR18","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.3382\/ps\/pex031","volume":"96","author":"JC Han","year":"2017","unstructured":"Han, J.C., Chen, G.H., Zhang, J.L., et al.: Relative biological value of 1 $$\\alpha $$ \u03b1 -hydroxycholecalciferol to 25-hydroxycholecalciferol in broiler chicken diets. Poult. Sci. 96(7), 2330\u20132335 (2017)","journal-title":"Poult. Sci."},{"issue":"2","key":"1790_CR19","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jscs.2015.11.002","volume":"21","author":"B Mistry","year":"2017","unstructured":"Mistry, B., Patel, R.V., Keum, Y.-S., et al.: Evaluation of the biological potencies of newly synthesized berberine derivatives bearing benzothiazole moieties with substituted functionalities[J]. J. Saudi Chem. Soc. 21(2), 210\u2013219 (2017)","journal-title":"J. Saudi Chem. Soc."},{"issue":"4","key":"1790_CR20","first-page":"197","volume":"96","author":"J Jatkauskas","year":"2009","unstructured":"Jatkauskas, J., Vrotniakiene, V.: The influence of application of a biological additive on the fermentation and nutritive value of Lucerne silage. Zemdirb. Agric. 96(4), 197\u2013208 (2009)","journal-title":"Zemdirb. Agric."},{"issue":"2","key":"1790_CR21","first-page":"93","volume":"27","author":"Q Tu","year":"2015","unstructured":"Tu, Q., Zhao, H., Chen, J.: Optimization of medium for biological potency of fermentation supernatant of Paenibacillus brasilensis YS-1. Minerva. Biotecnol. 27(2), 93\u201398 (2015)","journal-title":"Minerva. Biotecnol."},{"issue":"11\u2014-12","key":"1790_CR22","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10337-016-3086-0","volume":"79","author":"B Chen","year":"2016","unstructured":"Chen, B., Li, R., Guo, Y., et al.: Purification and preparation of moenomycin A from fermentation broth by multidimensional chromatography. Chromatographia 79(11\u2014-12), 667\u2013674 (2016)","journal-title":"Chromatographia"},{"issue":"3","key":"1790_CR23","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1271\/bbb.69.515","volume":"69","author":"M Kobayashi","year":"2005","unstructured":"Kobayashi, M., Kanasaki, R., Sato, I., et al.: FR207944, an antifungal antibiotic from Chaetomium sp. no. 217\u2014I. Taxonomy, fermentation, and biological properties. Biosci. Biotechnol. Biochem. 69(3), 515\u2013521 (2005)","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"1790_CR24","unstructured":"Wan, F., Feng, F., Huang, Y., et al.: Development of a titer measuring system based on light emitting diodes. Mod. Instrum. Med. Treat. 22(1), 13\u201315 (2016) (Chinese)"},{"key":"1790_CR25","unstructured":"He, K., Zhao, L., Wang, J., et al.: Soft-sensor modeling method in a fermentation process based on the samples of a sparse Gaussian process. J. Beijing Univ. Chem. Technol. (Nat. Sci.) 41(3), 108\u2013113 (2014) (Chinese)"},{"key":"1790_CR26","unstructured":"Yu, T., Wang, J., He, K., et al.: Staged soft-sensor modeling method for fermentation process based on MPCA-GP. Chin. J. Sci. Instrum. 34(12), 2703\u20132708 (2013) (Chinese)"},{"issue":"12","key":"1790_CR27","doi-asserted-by":"publisher","first-page":"1728","DOI":"10.1016\/j.engstruct.2006.03.008","volume":"28","author":"HS Tang","year":"2006","unstructured":"Tang, H.S., Xue, S.T., Chen, R., et al.: Online weighted LS-SVM for hysteretic structural system V identification. Eng. Struct. 28(12), 1728\u20131735 (2006)","journal-title":"Eng. Struct."},{"issue":"9","key":"1790_CR28","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1109\/5.58325","volume":"78","author":"T Kohonen","year":"1990","unstructured":"Kohonen, T.: The self-organizing map. Proc. IEEE 78(9), 1464\u20131480 (1990)","journal-title":"Proc. IEEE"},{"issue":"8","key":"1790_CR29","doi-asserted-by":"publisher","first-page":"10574","DOI":"10.1016\/j.eswa.2011.02.107","volume":"38","author":"S Ismail","year":"2011","unstructured":"Ismail, S., Shabri, A., Samsudin, R.: A hybrid model of self-organizing maps (SOM) and least square support vector machine (LSSVM) for time-series forecasting. Expert Syst. Appl. 38(8), 10574\u201310578 (2011)","journal-title":"Expert Syst. Appl."},{"issue":"7","key":"1790_CR30","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.envsoft.2007.10.001","volume":"23","author":"AM Kalteh","year":"2008","unstructured":"Kalteh, A.M., Hjorth, P., Berndtsson, R.: Review of the self-organizing map (SOM) approach in water resources: analysis, modelling and application. Environ. Model. Softw. 23(7), 835\u2013845 (2008)","journal-title":"Environ. Model. Softw."},{"issue":"6","key":"1790_CR31","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1109\/3468.983416","volume":"31","author":"EMAM Mendes","year":"2001","unstructured":"Mendes, E.M.A.M., Billings, S.A.: An alternative solution to the model structure selection problem. IEEE Trans. Syst. Man Cybern. A 31(6), 597\u2013608 (2001)","journal-title":"IEEE Trans. Syst. Man Cybern. A"},{"issue":"8","key":"1790_CR32","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.compchemeng.2003.11.004","volume":"28","author":"W Yan","year":"2004","unstructured":"Yan, W., Shao, H., Wang, X.: Soft sensing modeling based on support vector machine and Bayesian model selection. Comput. Chem. Eng. 28(8), 1489\u20131498 (2004)","journal-title":"Comput. Chem. Eng."},{"issue":"4","key":"1790_CR33","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1016\/j.eswa.2009.08.008","volume":"37","author":"G Liu","year":"2010","unstructured":"Liu, G., Zhou, D., Xu, H., et al.: Model optimization of SVM for a fermentation soft sensor. Expert Syst. Appl. 37(4), 2708\u20132713 (2010)","journal-title":"Expert Syst. Appl."},{"issue":"2","key":"1790_CR34","first-page":"217","volume":"34","author":"T Okada","year":"2010","unstructured":"Okada, T., Kaneko, H., Funatsu, K.: Development of a model selection method based on the reliability of a soft sensor model. Sonklanakarin J. Sci. Technol. 34(2), 217 (2010)","journal-title":"Sonklanakarin J. Sci. Technol."},{"issue":"7","key":"1790_CR35","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1109\/9.148346","volume":"37","author":"RS Smith","year":"1992","unstructured":"Smith, R.S., Doyle, J.C.: Model validation: a connection between robust control and identification. IEEE Trans. Autom. Control 37(7), 942\u2013952 (1992)","journal-title":"IEEE Trans. Autom. Control"},{"issue":"5\u20136","key":"1790_CR36","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/(SICI)1099-128X(199609)10:5\/6<521::AID-CEM448>3.0.CO;2-J","volume":"10","author":"F Lindgren","year":"1996","unstructured":"Lindgren, F., Hansen, B., Karcher, W., et al.: Model validation by permutation tests: applications to variable selection. J. Chemom. 10(5\u20136), 521\u2013532 (1996)","journal-title":"J. Chemom."},{"issue":"6","key":"1790_CR37","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1080\/00207179408921513","volume":"60","author":"SA Billings","year":"1994","unstructured":"Billings, S.A., Zhu, Q.M.: Nonlinear model validation using correlation tests. Int. J. Control 60(6), 1107\u20131120 (1994)","journal-title":"Int. J. Control"}],"container-title":["Cluster Computing"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10586-018-1790-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10586-018-1790-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10586-018-1790-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T05:31:01Z","timestamp":1603776661000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10586-018-1790-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,3]]},"references-count":37,"journal-issue":{"issue":"S3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["1790"],"URL":"https:\/\/doi.org\/10.1007\/s10586-018-1790-2","relation":{},"ISSN":["1386-7857","1573-7543"],"issn-type":[{"value":"1386-7857","type":"print"},{"value":"1573-7543","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,3]]},"assertion":[{"value":"11 October 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}