{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T01:02:03Z","timestamp":1778634123912,"version":"3.51.4"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100011264","name":"FP7 People: Marie-Curie Actions","doi-asserted-by":"publisher","award":["623995"],"award-info":[{"award-number":["623995"]}],"id":[{"id":"10.13039\/100011264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["289126"],"award-info":[{"award-number":["289126"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/N02348X\/1"],"award-info":[{"award-number":["BB\/N02348X\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Industrial Biotechnology Catalyst","award":["BB\/N02348X\/1"],"award-info":[{"award-number":["BB\/N02348X\/1"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discrete Event Dyn Syst"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1007\/s10626-019-00287-9","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T09:02:58Z","timestamp":1566464578000},"page":"367-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Flexible Nets: a modeling formalism for dynamic systems with uncertain parameters"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7093-228X","authenticated-orcid":false,"given":"Jorge","family":"J\u00falvez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"287_CR1","volume-title":"Modelling with Generalized Stochastic Petri Nets","author":"M Ajmone Marsan","year":"1995","unstructured":"Ajmone Marsan M, Balbo G, Conte G, Donatelli S, Franceschinis G (1995) Modelling with Generalized Stochastic Petri Nets. Wiley, New York"},{"issue":"2","key":"287_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0304-3975(94)90010-8","volume":"126","author":"R Alur","year":"1994","unstructured":"Alur R, Dill DL (1994) A theory of timed automata. Theor Comput Sci 126 (2):183\u2013235","journal-title":"Theor Comput Sci"},{"key":"287_CR3","doi-asserted-by":"publisher","unstructured":"Bertrand N, Bouyer P, Brihaye T, Menet Q, Baier C, Gr\u00f6\u00dfer M, Jurdzi\u0144ski M (2014) Stochastic timed automata. Logical Methods in Computer Science 10(4). \nhttps:\/\/doi.org\/10.2168\/LMCS-10(4:6)","DOI":"10.2168\/LMCS-10(4:6)"},{"issue":"5","key":"287_CR4","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.peva.2013.01.001","volume":"70","author":"L Bortolussi","year":"2013","unstructured":"Bortolussi L, Hillston J, Latella D, Massink M (2013) Continuous approximation of collective system behaviour A tutorial. Perform Eval 70(5):317\u2013349","journal-title":"Perform Eval"},{"key":"287_CR5","volume-title":"Bond Graph Methodology \u2013 Development and Analysis of Multidisciplinay Dynamic System Models","author":"W Borutzky","year":"2010","unstructured":"Borutzky W (2010) Bond Graph Methodology \u2013 Development and Analysis of Multidisciplinay Dynamic System Models. Springer, London. ISBN : 978-1-84882-881-0"},{"key":"287_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-5427-0","volume-title":"Differential equation models. Modules in Applied Mathematics","author":"M Braun","year":"1983","unstructured":"Braun M, Lucas W, Coleman C, Drew D (1983) Differential equation models. Modules in Applied Mathematics. Springer, Berlin"},{"issue":"9","key":"287_CR7","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.automatica.2010.06.013","volume":"46","author":"MP Cabasino","year":"2010","unstructured":"Cabasino MP, Giua A, Seatzu C (2010) Fault detection for discrete event systems using Petri nets with unobservable transitions. Automatica 46(9):1531\u20131539","journal-title":"Automatica"},{"issue":"5","key":"287_CR8","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1109\/3477.790440","volume":"29","author":"J. Cardoso","year":"1999","unstructured":"Cardoso J, Valette R, Dubois D (1999) Possibilistic Petri nets. 29:573\u201382, 02","journal-title":"IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics)"},{"issue":"3","key":"287_CR9","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.entcs.2007.12.008","volume":"194","author":"F Ciocchetta","year":"2008","unstructured":"Ciocchetta F, Hillston J (2008) Bio-PEPA An Extension of the Process Algebra PEPA for Biochemical Networks. Electron Notes Theor Comput Sci 194(3):103\u2013117","journal-title":"Electron Notes Theor Comput Sci"},{"key":"287_CR10","first-page":"132","volume-title":"Stochastic Process Algebras","author":"A Clark","year":"2007","unstructured":"Clark A, Gilmore S, Hillston J, Tribastone M (2007) Stochastic Process Algebras. Springer, Berlin, pp 132\u2013179"},{"issue":"4","key":"287_CR11","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1287\/deca.1050.0047","volume":"2","author":"A Detwarasiti","year":"2005","unstructured":"Detwarasiti A, Shachter RD (2005) Influence Diagrams for Team Decision Analysis. Decis Anal 2(4):207\u2013228","journal-title":"Decis Anal"},{"key":"287_CR12","unstructured":"Gurobi Optimization, Inc. (2015) Gurobi Optimizer Reference Manual"},{"key":"287_CR13","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-58821-6","volume-title":"Pyomo\u2013optimization modeling in Python, 2nd edn., vol 67","author":"WE Hart","year":"2017","unstructured":"Hart WE, Laird CD, Watson J-P, Woodruff DL, Hackebeil GA, Nicholson BL, Siirola JD (2017) Pyomo\u2013optimization modeling in Python, vol 67, 2nd edn. Springer Science & Business Media, Berlin"},{"issue":"3","key":"287_CR14","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s12532-011-0026-8","volume":"3","author":"WE Hart","year":"2011","unstructured":"Hart WE, Watson J-P, Woodruff DL (2011) Pyomo: modeling and solving mathematical programs in Python. Math Programm Comput 3(3):219\u2013260","journal-title":"Math Programm Comput"},{"key":"287_CR15","unstructured":"IBM ILOG CPLEX Optimizer (2010) ."},{"key":"287_CR16","unstructured":"Jim\u00e9nez E, J\u00falvez J, Recalde L, Silva M (2004) Relaxed continuous views of discrete event systems: considerations on F,orrester diagrams and Petri nets. In: 2004 IEEE International Conference on Systems, Man and Cybernetics (IEEE Cat. No.04CH37583), vol 5, pp 4897\u20134904"},{"issue":"1","key":"287_CR17","doi-asserted-by":"publisher","first-page":"7,1","DOI":"10.1038\/s41540-017-0044-x","volume":"4","author":"J J\u00falvez","year":"2018","unstructured":"J\u00falvez J, Dikicioglu D, Oliver SG (2018) Handling variability and incompleteness of biological data by flexible nets: a case study for Wilson disease. npj Syst Biol Appl 4(1):7,1","journal-title":"npj Syst Biol Appl"},{"key":"287_CR18","doi-asserted-by":"crossref","unstructured":"Kouvaritakis B, Cannon M (2016) Model Predictive Control. Classical, Robust and Stochastic. Springer International Publishing","DOI":"10.1007\/978-1-4471-5058-9_7"},{"issue":"1","key":"287_CR19","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1109\/21.87067","volume":"18","author":"CG Looney","year":"1988","unstructured":"Looney CG (1988) Fuzzy Petri nets for rule-based decisionmaking. IEEE Trans Syst Man Cybern 18(1):178\u2013183","journal-title":"IEEE Trans Syst Man Cybern"},{"issue":"9","key":"287_CR20","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1109\/TCOM.1976.1093424","volume":"24","author":"P Merlin","year":"1976","unstructured":"Merlin P, Faber DJ (1976) Recoverability of communication protocols. IEEE Trans Commun 24(9):1036\u20131043","journal-title":"IEEE Trans Commun"},{"issue":"4","key":"287_CR21","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1109\/5.24143","volume":"77","author":"T Murata","year":"1989","unstructured":"Murata T (1989) Petri Nets: Properties, Analysis and Applications. Procs IEEE 77(4):541\u2013580","journal-title":"Procs IEEE"},{"issue":"8","key":"287_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pcbi.0030129","volume":"3","author":"CJ Needham","year":"2007","unstructured":"Needham CJ, Bradford JR, Bulpitt AJ, Westhead DR (2007) A Primer on Learning in Bayesian Networks for Computational Biology. PLOS Comput Biol 3 (8):1\u20138, 08","journal-title":"PLOS Comput Biol"},{"issue":"1","key":"287_CR23","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/msb.2011.65","volume":"7","author":"Jeffrey D Orth","year":"2011","unstructured":"Orth JD, Conrad TM, Na J, Lerman JA, Nam H, Feist AM, Palsson B\u00d8 (2011) A comprehensive genome-scale reconstruction of Escherichia coli metabolism. Mol Syst Biol 7:1\u20139","journal-title":"Molecular Systems Biology"},{"issue":"1","key":"287_CR24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0020-0190(01)00214-9","volume":"80","author":"C Priami","year":"2001","unstructured":"Priami C, Regev A, Shapiro E, Silverman W (2001) Application of a stochastic name-passing calculus to representation and simulation of molecular processes. Inf Process Lett 80(1):25\u201331. Process Algebra","journal-title":"Inf Process Lett"},{"issue":"4","key":"287_CR25","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1109\/TRA.2003.814503","volume":"19","author":"A Ramirez-Trevino","year":"2003","unstructured":"Ramirez-Trevino A, Rivera-Rangel I, Lopez-Mellado E (2003) Observability of discrete event systems modeled by interpreted Petri nets. IEEE Trans Robot Autom 19(4):557\u2013565","journal-title":"IEEE Trans Robot Autom"},{"issue":"2","key":"287_CR26","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1093\/bioinformatics\/18.2.261","volume":"18","author":"I Shmulevich","year":"2002","unstructured":"Shmulevich I, Dougherty ER, Kim S, Zhang W (2002) Probabilistic Boolean networks: a rule-based uncertainty model for gene regulatory networks. Bioinformatics 18(2):261\u2013274","journal-title":"Bioinformatics"},{"key":"287_CR27","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/3-540-65306-6_19","volume":"1491","author":"M Silva","year":"1998","unstructured":"Silva M, Teruel E, Colom JM (1998) Linear Algebraic and Linear Programming Techniques for the Analysis of Net Systems. Lect Notes Comput Sci 1491:309\u2013373","journal-title":"Lect Notes Comput Sci"},{"issue":"4","key":"287_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s10626-011-0116-9","volume":"21","author":"M Silva","year":"2011","unstructured":"Silva M, J\u00falvez J, Mahulea C, V\u00e1zquez CR (2011) On fluidization of discrete event models: observation and control of continuous Petri nets. Discret Event Dyn Syst: Theory Appl 21(4):427\u2013497","journal-title":"Discret Event Dyn Syst: Theory Appl"},{"issue":"7","key":"287_CR29","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nrc3081","volume":"11","author":"JJ Tyson","year":"2011","unstructured":"Tyson JJ, Baumann WT, Chen C, Verdugo A, Tavassoly I, Wang Y, Weiner LM, Clarke R (2011) Dynamic modelling of oestrogen signalling and cell fate in breast cancer cells. Nat Rev Cancer 11(7):523\u201332","journal-title":"Nat Rev Cancer"},{"key":"287_CR30","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1109\/TCST.2007.903085","volume":"16","author":"R van den Berg","year":"2008","unstructured":"van den Berg R, Lefeber E, Rooda K (2008) Modeling and control of a manufacturing flow line using partial differential equations. IEEE Trans Control Syst Technol 16:130\u2013136, 02","journal-title":"IEEE Trans Control Syst Technol"},{"issue":"10","key":"287_CR31","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/nbt1094-994","volume":"12","author":"A Varma","year":"1994","unstructured":"Varma A, Palsson B\u00d8 (1994) Metabolic Flux Balancing: Basic Concepts, Scientific and Practical Use. Nat Biotechnol 12(10):994\u2013998","journal-title":"Nat Biotechnol"},{"issue":"5","key":"287_CR32","doi-asserted-by":"publisher","first-page":"055001","DOI":"10.1088\/1478-3975\/9\/5\/055001","volume":"9","author":"RS Wang","year":"2012","unstructured":"Wang RS, Saadatpour A, Albert R (2012) Boolean modeling in systems biology: an overview of methodology and applications. Phys Biol 9(5):055001","journal-title":"Phys Biol"}],"container-title":["Discrete Event Dynamic Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10626-019-00287-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10626-019-00287-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10626-019-00287-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:09:56Z","timestamp":1597964996000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10626-019-00287-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,22]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["287"],"URL":"https:\/\/doi.org\/10.1007\/s10626-019-00287-9","relation":{},"ISSN":["0924-6703","1573-7594"],"issn-type":[{"value":"0924-6703","type":"print"},{"value":"1573-7594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,22]]},"assertion":[{"value":"30 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}