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Furthermore, a number of universities have multiple campuses, thereby requiring these universities to adopt a multi-campus learning model. This setting creates numerous teaching and learning challenges. This paper aims to: (a) explore what major teaching and learning challenges are faced by Central Queensland University (CQU) due to its multiple campuses and a diverse student cohort involving both on-campus and off-campus students, and (b) discuss our teaching pedagogy (including the use of an online learning platform) for an information systems analysis and design (ISAD) unit at CQU with a view to alleviating these teaching\/learning challenges. We analyzed qualitatively and quantitatively the effectiveness of our teaching pedagogy in addressing the teaching\/learning challenges. We performed a two-sample <jats:italic>t<\/jats:italic>-test involving a total of 216 ISAD students and found that, by adopting our teaching pedagogy, there was no significant difference in academic performance between urban (mostly on-campus) and regional (mostly off-campus) students. 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