{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:07:33Z","timestamp":1785362853848,"version":"3.55.0"},"reference-count":109,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T00:00:00Z","timestamp":1749513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Discov Computing"],"DOI":"10.1007\/s10791-025-09574-6","type":"journal-article","created":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T10:11:39Z","timestamp":1749550299000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blockchain enhanced smart healthcare management for chronic diseases"],"prefix":"10.1007","volume":"28","author":[{"given":"Shruti","family":"Saxena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Saxena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikunj","family":"Tahilramani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panem","family":"Charanarur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,10]]},"reference":[{"issue":"1","key":"9574_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.mayocpiqo.2023.08.005","volume":"8","author":"Karen Hacker","year":"2024","unstructured":"Hacker Karen. The burden of chronic disease. Mayo Clin Proc Innov Quality Outcomes. 2024;8(1):112\u20139.","journal-title":"Mayo Clin Proc Innov Quality Outcomes"},{"key":"9574_CR2","first-page":"e50508","volume":"26","author":"Cyd Eaton","year":"2024","unstructured":"Eaton Cyd, et al. User engagement with mHealth interventions to promote treatment adherence and self-management in people with chronic health conditions: systematic review. J Med Int Res. 2024;26:e50508.","journal-title":"J Med Int Res"},{"issue":"1","key":"9574_CR3","first-page":"8839631","volume":"2024","author":"MK Rony","year":"2024","unstructured":"Rony MK, Parvin MR, Wahiduzzaman M, Akter K, et al. Challenges and advancements in the health-related quality of life of older people. Adv Public Health. 2024;2024(1):8839631.","journal-title":"Adv Public Health"},{"key":"9574_CR4","doi-asserted-by":"crossref","unstructured":"Ghareeb B, Kerari A. Evaluating the effectiveness of a self-management program on patients living with chronic diseases. Risk Management and Healthcare Policy 2024:487-496.","DOI":"10.2147\/RMHP.S451692"},{"key":"9574_CR5","first-page":"e53266","volume":"26","author":"P Dhunnoo","year":"2024","unstructured":"Dhunnoo P, et al. Evaluation of telemedicine consultations using health outcomes and user attitudes and experiences: scoping review. J Med Int Res. 2024;26:e53266.","journal-title":"J Med Int Res"},{"issue":"5","key":"9574_CR6","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1016\/j.jpainsymman.2024.08.001","volume":"68","author":"DG Dotolo","year":"2024","unstructured":"Dotolo DG, et al. Financial hardship: a qualitative study exploring perspectives of seriously ill patients and their family. J Pain Symp Manage. 2024;68(5):e382\u201391.","journal-title":"J Pain Symp Manage"},{"issue":"7\u20138","key":"9574_CR7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1089\/hum.2023.114","volume":"35","author":"TE Whittaker","year":"2024","unstructured":"Whittaker TE, et al. Multidimensional response surface methodology for the development of a gene editing protocol for p67phox-deficient chronic granulomatous disease. Hum Gene Ther. 2024;35(7\u20138):298\u2013312.","journal-title":"Hum Gene Ther"},{"issue":"1","key":"9574_CR8","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/17476348.2020.1679628","volume":"14","author":"FF Cruz","year":"2020","unstructured":"Cruz FF, Patricia RMR. The potential of mesenchymal stem cell therapy for chronic lung disease. Expert Rev Resp Med. 2020;14(1):31\u20139.","journal-title":"Expert Rev Resp Med"},{"key":"9574_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2021.01.025","volume":"123","author":"JR Nakkala","year":"2021","unstructured":"Nakkala JR, et al. Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases. Acta Biomater. 2021;123:1\u201330.","journal-title":"Acta Biomater"},{"key":"9574_CR10","doi-asserted-by":"publisher","first-page":"205520762110093","DOI":"10.1177\/20552076211009396","volume":"7","author":"H Bitar","year":"2021","unstructured":"Bitar H, Alismail S. The role of eHealth, telehealth, and telemedicine for chronic disease patients during COVID-19 pandemic: a rapid systematic review. Digital Health. 2021;7:20552076211009396.","journal-title":"Digital Health"},{"issue":"1","key":"9574_CR11","first-page":"1","volume":"27","author":"B Nazli","year":"2020","unstructured":"Nazli B, et al. Digital health interventions for chronic diseases: a scoping review of evaluation frame- works. BMJ Health Care Inf. 2020;27(1):1.","journal-title":"BMJ Health Care Inf"},{"key":"9574_CR12","doi-asserted-by":"crossref","unstructured":"Murugan Kalpana et al. Smart IoT Medication Companion. 2024 Third International Conference on Smart Technologies and Systems for Next Generation Computing (ICSTSN). IEEE, 2024.","DOI":"10.1109\/ICSTSN61422.2024.10671211"},{"issue":"3","key":"9574_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/24725579.2023.2267085","volume":"14","author":"S Elkefi","year":"2024","unstructured":"Elkefi S. Access and usage of mobile health (mHealth) for communication, health monitoring, and decision-making among patients with multiple chronic diseases (comorbidities). IISE Trans Healthcare Syst Eng. 2024;14(3):179\u201392.","journal-title":"IISE Trans Healthcare Syst Eng"},{"issue":"1","key":"9574_CR14","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1186\/s12967-020-02658-5","volume":"18","author":"M Subramanian","year":"2020","unstructured":"Subramanian M, Wojtusciszyn A, Favre L, et al. Precision medicine in the era of artificial intelligence: implica- tions in chronic disease management. J Transl Med. 2020;18(1):472.","journal-title":"J Transl Med"},{"key":"9574_CR15","doi-asserted-by":"crossref","unstructured":"Rajendra RK et al. High performance computing education: Current challenges and future directions. Pro- ceedings of the Working Group Reports on Innovation and Technology in Computer Science Education. 2020:51-74","DOI":"10.1145\/3437800.3439203"},{"key":"9574_CR16","doi-asserted-by":"crossref","unstructured":"Mohamed K, Albadawy M. Artificial intelligence for diabetes: enhancing prevention, diagnosis, and effective management. Computer Methods and Programs in Biomedicine Update 2024:100141.","DOI":"10.1016\/j.cmpbup.2024.100141"},{"key":"9574_CR17","unstructured":"Pedrosa Micael. An architecture for secure data management in medical research and aided diagnosis. 2022."},{"key":"9574_CR18","first-page":"e65888","volume":"27","author":"A Naranjo-Rojas","year":"2025","unstructured":"Naranjo-Rojas A, et al. Efficacy and acceptability of a mobile app for monitoring the clinical status of patients with chronic obstructive pulmonary disease receiving home oxygen therapy: randomized controlled trial. J Med Int Res. 2025;27:e65888.","journal-title":"J Med Int Res"},{"issue":"6","key":"9574_CR19","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/17476348.2020.1743181","volume":"14","author":"E Mekov","year":"2020","unstructured":"Mekov E, Miravitlles M, Petkov R, et al. Artificial intelligence and machine learning in respiratory medicine. Expert Rev Respir Med. 2020;14(6):559\u201364.","journal-title":"Expert Rev Respir Med"},{"issue":"2","key":"9574_CR20","doi-asserted-by":"publisher","first-page":"013","DOI":"10.53022\/oarjst.2024.10.2.0044","volume":"10","author":"EP Adeghe","year":"2024","unstructured":"Adeghe EP, Chioma AO, Olumuyiwa TO. Evaluating the impact of blockchain technology in healthcare data management: A review of security, privacy, and patient outcomes. Open Access Res J Sci Technol. 2024;10(2):013\u201320.","journal-title":"Open Access Res J Sci Technol"},{"issue":"1","key":"9574_CR21","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s43926-024-00058-5","volume":"4","author":"I Abrar","year":"2024","unstructured":"Abrar I, Sheikh JA. Current trends of blockchain technology: architecture, applications, challenges, and opportunities. Discov Inte Things. 2024;4(1):7.","journal-title":"Discov Inte Things"},{"key":"9574_CR22","doi-asserted-by":"publisher","first-page":"1390634","DOI":"10.3389\/fmed.2024.1390634","volume":"11","author":"E Ghazizadeh","year":"2024","unstructured":"Ghazizadeh E, et al. Approaches of wearable and implantable biosensor towards of developing in precision medicine. Front Med. 2024;11:1390634.","journal-title":"Front Med"},{"issue":"1","key":"9574_CR23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/nop2.382","volume":"7","author":"Holly Farley","year":"2020","unstructured":"Farley Holly. Promoting self-efficacy in patients with chronic disease beyond traditional education: a literature review. Nursing Open. 2020;7(1):30\u201341.","journal-title":"Nursing Open"},{"issue":"12","key":"9574_CR24","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1111\/jce.16451","volume":"35","author":"Rahul Vyas","year":"2024","unstructured":"Vyas Rahul, et al. Smart watch applications in atrial fibrillation detection: current state and future directions. J Cardiovasc Electrophysiol. 2024;35(12):2474\u201382.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"1","key":"9574_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1108\/MIP-05-2023-0225","volume":"43","author":"MA Khashan","year":"2025","unstructured":"Khashan MA, et al. Understanding physicians\u2019 adoption intentions to use electronic Health Record (EHR) systems in developing countries: an extended TRAM approach. Market Intell Planning. 2025;43(1):1\u201327.","journal-title":"Market Intell Planning"},{"key":"9574_CR26","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s11517-023-02776-4","volume":"61","author":"E Y\u0131ld\u0131r\u0131m","year":"2023","unstructured":"Y\u0131ld\u0131r\u0131m E, Cicio\u011flu M, \u00c7alhan A. Fog-cloud architecture-driven internet of medical things framework for healthcare monitoring. Med Biol Eng Comput. 2023;61:1133\u201347. https:\/\/doi.org\/10.1007\/s11517-023-02776-4.","journal-title":"Med Biol Eng Comput"},{"issue":"1","key":"9574_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s43926-023-00049-y","volume":"4","author":"Tehseen Mazhar","year":"2024","unstructured":"Mazhar Tehseen, et al. Analysis of integration of IoMT with blockchain: issues, challenges and solutions. Discov Int Things. 2024;4(1):1\u201336.","journal-title":"Discov Int Things"},{"key":"9574_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12913-015-1189-1","volume":"15","author":"MR Patel","year":"2015","unstructured":"Patel MR, Shah KS, Shallcross ML. A qualitative study of physician perspectives of cost-related communication and patients\u2019 financial burden with managing chronic disease. BMC Health Serv Res. 2015;15:1\u20137.","journal-title":"BMC Health Serv Res"},{"issue":"1","key":"9574_CR29","doi-asserted-by":"publisher","first-page":"18422","DOI":"10.1038\/s41598-024-68529-x","volume":"14","author":"YY Ghadi","year":"2024","unstructured":"Ghadi YY, et al. The role of blockchain to secure internet of medical things. Sci Rep. 2024;14(1):18422.","journal-title":"Sci Rep"},{"issue":"1","key":"9574_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s43926-025-00095-8","volume":"5","author":"Tehseen Mazhar","year":"2025","unstructured":"Mazhar Tehseen, et al. Generative AI, IoT, and blockchain in healthcare: application, issues, and solutions. Discov Int Things. 2025;5(1):5.","journal-title":"Discov Int Things"},{"key":"9574_CR31","doi-asserted-by":"publisher","first-page":"104163","DOI":"10.1016\/j.compbiomed.2020.104163","volume":"129","author":"Y Guo","year":"2021","unstructured":"Guo Y, Liu X, Chen W, et al. A review of wearable and unobtrusive sensing technologies for chronic disease management. Comput Biol Med. 2021;129:104163.","journal-title":"Comput Biol Med"},{"issue":"16","key":"9574_CR32","first-page":"5589","volume":"21","author":"V Vijayan","year":"2021","unstructured":"Vijayan V, et al. Review of wearable devices and data collection considerations for connected health. Sen- sors. 2021;21(16):5589.","journal-title":"Sen- sors"},{"issue":"1","key":"9574_CR33","doi-asserted-by":"publisher","first-page":"e55455","DOI":"10.2196\/55455","volume":"8","author":"AP Pereira","year":"2025","unstructured":"Pereira AP, et al. Wearable smartphone-based multisensory feedback system for torso posture correction: iterative design and within-subjects study. JMIR Aging. 2025;8(1):e55455.","journal-title":"JMIR Aging"},{"issue":"3","key":"9574_CR34","doi-asserted-by":"publisher","first-page":"183","DOI":"10.3390\/brainsci10030183","volume":"10","author":"A Pilozzi","year":"2020","unstructured":"Pilozzi A, Huang X. Overcoming Alzheimer\u2019s Disease Stigma by Leveraging Artificial Intelligence and Blockchain Technologies. Brain Sci. 2020;10(3):183.","journal-title":"Brain Sci"},{"issue":"5","key":"9574_CR35","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/jamia\/ocaa023","volume":"27","author":"TT Kuo","year":"2020","unstructured":"Kuo TT, Gabriel RA, Ohno-Machado L, et al. EXpectation Propagation LOgistic REgRession on permissioned blockCHAIN (ExplorerChain): decentralized online healthcare\/genomics predictive model learning. J Am Med Inform Assoc. 2020;27(5):747\u201356.","journal-title":"J Am Med Inform Assoc"},{"key":"9574_CR36","doi-asserted-by":"crossref","unstructured":"Vasileios Kontogiannis et al. Cost-Utility Analysis of LifeVest$$\\textcircled {R}$$ in Post-Myocardial Infarction Patients at Risk of Sudden Cardiac Death in England. PharmacoEconomics-Open 2025:1-12.","DOI":"10.1007\/s41669-024-00553-z"},{"key":"9574_CR37","doi-asserted-by":"publisher","first-page":"118726","DOI":"10.1016\/j.jep.2024.118726","volume":"336","author":"L Liu","year":"2025","unstructured":"Liu L, et al. Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53\/MAPK pathways. J Ethnopharmacol. 2025;336:118726.","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"9574_CR38","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.3390\/jcm14041119","volume":"14","author":"Stefan Modzelewski","year":"2025","unstructured":"Modzelewski Stefan, et al. The impact of seasonality on mental health disorders: a narrative review and extension of the immunoseasonal theory. J Clin Med. 2025;14(4):1119.","journal-title":"J Clin Med"},{"key":"9574_CR39","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.jad.2024.09.114","volume":"371","author":"AA Sultan","year":"2025","unstructured":"Sultan AA, et al. Correlates of cannabis use and cannabis use disorder among adolescents with major depressive disorder and bipolar disorder in the national comorbidity survey-adolescent supplement (NCS-A). J Affect Disord. 2025;371:268\u201378.","journal-title":"J Affect Disord"},{"key":"9574_CR40","doi-asserted-by":"crossref","unstructured":"Liaqat D. Using mobile sensing to predict episodes of medical conditions; ACM Press: New York, NY, USA, 2016:7-8","DOI":"10.1145\/2930056.2933323"},{"key":"9574_CR41","doi-asserted-by":"crossref","unstructured":"erry M. Wearable health monitors: real-time, patient-friendly data collection. Telemed. E-Health 2010;16, 134-138.","DOI":"10.1089\/tmj.2010.9994"},{"key":"9574_CR42","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.resp.2009.03.013","volume":"167","author":"L Kent","year":"2009","unstructured":"Kent L, O\u2019Neill B, Davison G, Nevill A, Stuart Elborn J, Bradley JM. Validity and reliability of cardiores- piratory measurements recorded by the LifeShirt during exercise tests. Respir Physiol Neurobiol. 2009;167:162\u20137.","journal-title":"Respir Physiol Neurobiol"},{"key":"9574_CR43","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1590\/1413-81232018244.01222019","volume":"24","author":"Miriam Schenker","year":"2019","unstructured":"Schenker Miriam, Daniella da HC. Advances and challenges of health care of the elderly population with chronic diseases in Primary Health Care. Ciencia Saude Coletiva. 2019;24:1369\u201380.","journal-title":"Ciencia Saude Coletiva"},{"key":"9574_CR44","volume-title":"Estudiantes dise\u00f1an pulsera-monitor de uso m\u00e9dico","author":"A Gutierrez","year":"2017","unstructured":"Gutierrez A. Estudiantes dise\u00f1an pulsera-monitor de uso m\u00e9dico. Prensa: Conacyt; 2017."},{"key":"9574_CR45","first-page":"253","volume":"2014","author":"MPRS Kiran","year":"2014","unstructured":"Kiran MPRS, Rajalakshmi P, Bharadwaj K, et al. Adaptive rule engine based IoT enabled remote health care data acquisition and smart transmission system. IEEE World For Int Thing. 2014;2014:253\u20138.","journal-title":"IEEE World For Int Thing"},{"key":"9574_CR46","doi-asserted-by":"publisher","first-page":"5592472","DOI":"10.1155\/2021\/5592472","volume":"2021","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Yu H, Dong R, et al. Application prospect of artificial intelligence in rehabilitation and management of myasthenia gravis. Biomed Res Int. 2021;2021:5592472.","journal-title":"Biomed Res Int"},{"issue":"10","key":"9574_CR47","doi-asserted-by":"publisher","first-page":"3397","DOI":"10.3390\/s18103397","volume":"18","author":"WC Hsu","year":"2018","unstructured":"Hsu WC, Sugiarto T, Lin YJ, et al. Multiple-WearableSensor-based gait classification and analysis in patients with neurological disorders. Sensors. 2018;18(10):3397.","journal-title":"Sensors"},{"key":"9574_CR48","doi-asserted-by":"crossref","first-page":"117693510600200","DOI":"10.1177\/117693510600200030","volume":"2","author":"Joseph A Cruz","year":"2006","unstructured":"Cruz Joseph A, Wishart David S. Applications of machine learning in cancer prediction and prognosis. Cancer Inf. 2006;2:117693510600200030.","journal-title":"Cancer Inf"},{"issue":"10","key":"9574_CR49","doi-asserted-by":"publisher","first-page":"e28613","DOI":"10.2196\/28613","volume":"23","author":"Y Xie","year":"2021","unstructured":"Xie Y, Zhang J, Wang H, et al. Applications of blockchain in the medical field: narrative review. J Med Internet Res. 2021;23(10):e28613.","journal-title":"J Med Internet Res"},{"issue":"2","key":"9574_CR50","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1109\/COMST.2020.2973314","volume":"22","author":"YA Qadri","year":"2020","unstructured":"Qadri YA, Nauman A, Kim SW, et al. The future of healthcare internet of things: a survey of emerging tech- nologies. IEEE Commun Surv Tutor. 2020;22(2):1121\u201367.","journal-title":"IEEE Commun Surv Tutor"},{"key":"9574_CR51","doi-asserted-by":"crossref","unstructured":"Koydemir HC, Ozcan A. Wearable and implantable sensors for biomedical applications. Annu Rev Anal Chem (Palo Alto Calif ), 2018,12,11(1):127-146.","DOI":"10.1146\/annurev-anchem-061417-125956"},{"issue":"6","key":"9574_CR52","doi-asserted-by":"publisher","first-page":"e13583","DOI":"10.2196\/13583","volume":"21","author":"X Zheng","year":"2019","unstructured":"Zheng X, Sun S, Ordieres-Mer\u00e9 J, et al. Accelerating health data sharing: a solution based on the internet of things and distributed ledger technologies. J Med Internet Res. 2019;21(6):e13583.","journal-title":"J Med Internet Res"},{"issue":"1","key":"9574_CR53","doi-asserted-by":"publisher","first-page":"11143","DOI":"10.1038\/s41598-022-15342-z","volume":"12","author":"NM Xi","year":"2022","unstructured":"Xi NM, Lin W, Chuanjia Y. Improving the diagnosis of thyroid cancer by machine learning and clinical data. Sci Rep. 2022;12(1):11143.","journal-title":"Sci Rep"},{"key":"9574_CR54","doi-asserted-by":"crossref","unstructured":"Abe Y, Ito M, T anaka C, et al. A novel and simple method using pocket-sized echocardiography to screen for aortic stenosis. J Am Soc Echocardiogr, 2013,26:589- 596.","DOI":"10.1016\/j.echo.2013.03.008"},{"issue":"2","key":"9574_CR55","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1210\/jc.2012-2968","volume":"98","author":"SC Kamran","year":"2013","unstructured":"Kamran SC, et al. Thyroid nodule size and prediction of cancer. J Clin Endocrinol Metabol. 2013;98(2):564\u201370.","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"9574_CR56","doi-asserted-by":"publisher","first-page":"11143","DOI":"10.1038\/s41598-022-15342-z","volume":"12","author":"NM Xi","year":"2022","unstructured":"Xi NM, Lin W, Chuanjia Y. Improving the diagnosis of thyroid cancer by machine learning and clinical data. Sci Rep. 2022;12(1):11143.","journal-title":"Sci Rep"},{"key":"9574_CR57","first-page":"1","volume":"12","author":"X Mousheng","year":"2011","unstructured":"Mousheng X, et al. Genome wide association study to predict severe asthma exacerbations in children using random forests classifiers. BMC Med Genet. 2011;12:1\u20138.","journal-title":"BMC Med Genet"},{"key":"9574_CR58","doi-asserted-by":"publisher","first-page":"100593","DOI":"10.1016\/j.entcom.2023.100593","volume":"47","author":"A Chandramouli","year":"2023","unstructured":"Chandramouli A, et al. Diabetes prediction using Hybrid Bagging Classifier. Entertain Comput. 2023;47:100593.","journal-title":"Entertain Comput"},{"key":"9574_CR59","doi-asserted-by":"crossref","unstructured":"Taser, Pelin Yildirim. Application of bagging and boosting approaches using decision tree-based algorithms in diabetes risk prediction. Proceedings. 74. No. 1. MDPI, 2021.","DOI":"10.3390\/proceedings2021074006"},{"issue":"1","key":"9574_CR60","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s42979-020-00446-y","volume":"2","author":"DC Yadav","year":"2021","unstructured":"Yadav DC, Saurabh P. An experimental study of diversity of diabetes disease features by bagging and boosting ensemble method with rule based machine learning classifier algorithms. SN Comput Sci. 2021;2(1):50.","journal-title":"SN Comput Sci"},{"issue":"15","key":"9574_CR61","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.3390\/s19153319","volume":"19","author":"TM Fern\u00e1ndez-Caram\u00e9s","year":"2019","unstructured":"Fern\u00e1ndez-Caram\u00e9s TM, Froiz-M\u00edguez I, Blanco-Novoa O, et al. Enabling the internet of mobile crowdsourcing health things: a mobile fog computing, blockchain and iot based continuous glucose monitoring system for diabetes mellitus research and care. Sensors. 2019;19(15):3319.","journal-title":"Sensors"},{"issue":"4","key":"9574_CR62","doi-asserted-by":"publisher","first-page":"e0215133","DOI":"10.1371\/journal.pone.0215133","volume":"14","author":"ZG Merali","year":"2019","unstructured":"Merali ZG, Witiw CD, Badhiwala JH, et al. Using a machine learning approach to predict outcome after surgery for degenerative cervical myelopathy. PLoS One. 2019;14(4):e0215133.","journal-title":"PLoS One"},{"key":"9574_CR63","doi-asserted-by":"publisher","first-page":"577537","DOI":"10.3389\/fendo.2020.577537","volume":"11","author":"Wu Yijun","year":"2020","unstructured":"Yijun Wu, et al. Machine learning algorithms for the prediction of central lymph node metastasis in patients with papillary thyroid cancer. Front Endocrinol. 2020;11:577537.","journal-title":"Front Endocrinol"},{"issue":"4","key":"9574_CR64","doi-asserted-by":"publisher","first-page":"e0215133","DOI":"10.1371\/journal.pone.0215133","volume":"14","author":"ZG Merali","year":"2019","unstructured":"Merali ZG, Witiw CD, Badhiwala JH, et al. Using a machine learning approach to predict outcome after surgery for degenerative cervical myelopathy. PLoS One. 2019;14(4):e0215133.","journal-title":"PLoS One"},{"issue":"1","key":"9574_CR65","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/mt.2010.232","volume":"19","author":"M Grez","year":"2011","unstructured":"Grez M, et al. Gene therapy of chronic granulomatous disease: the engraftment dilemma. Mol Ther. 2011;19(1):28\u201335.","journal-title":"Mol Ther"},{"issue":"1","key":"9574_CR66","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1080\/17476348.2020.1679628","volume":"14","author":"FF Cruz","year":"2020","unstructured":"Cruz FF, Patricia RMRocco. The potential of mesenchymal stem cell therapy for chronic lung disease. Expert Rev Resp Med. 2020;14(1):31\u20139.","journal-title":"Expert Rev Resp Med"},{"key":"9574_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2021.01.025","volume":"123","author":"Jayachandra Reddy Nakkala","year":"2021","unstructured":"Nakkala Jayachandra Reddy, et al. Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases. Acta Biomater. 2021;123:1\u201330.","journal-title":"Acta Biomater"},{"key":"9574_CR68","first-page":"1","volume":"27","author":"A Peyvandi","year":"2021","unstructured":"Peyvandi A, Majidi B, Patra J, et al. Computer-aidedDiagnosis as a service on decentralized medical cloud for efficient and rapid emergency response intelligence. New Gener Comput. 2021;27:1\u201324.","journal-title":"New Gener Comput"},{"key":"9574_CR69","unstructured":"Sagnik D, Namasudra S. Blockchain-based smart contract model for securing healthcare transactions by using consumer electronics and mobile edge computing. IEEE Trans Consum Electron 2024."},{"key":"9574_CR70","doi-asserted-by":"publisher","first-page":"101256","DOI":"10.1016\/j.iot.2024.101256","volume":"27","author":"NFM Shari","year":"2024","unstructured":"Shari NFM, Malip A. Enhancing privacy and security in smart healthcare: a blockchain-powered decentralized data dissemination scheme. Int Things. 2024;27:101256.","journal-title":"Int Things"},{"key":"9574_CR71","doi-asserted-by":"publisher","unstructured":"Rani D, Tripathi S, Tomar A. BSAS: blockchain-based shareable authentication scheme for smart healthcare. Cluster Comput. 2024. https:\/\/doi.org\/10.1007\/s10586-024-04358-x.","DOI":"10.1007\/s10586-024-04358-x"},{"key":"9574_CR72","doi-asserted-by":"crossref","unstructured":"Vimal SP, Vadivel M, Baskar VV, Sivakumar VG, Srinivasan C. Integrating IoT and Machine Learning for Real-Time Patient Health Monitoring with Sensor Networks, 2023 4th International Conference on Smart Electronics and Communication (ICOSEC), Trichy, India, 2023;574-578.","DOI":"10.1109\/ICOSEC58147.2023.10275890"},{"issue":"11","key":"9574_CR73","doi-asserted-by":"publisher","first-page":"e18907","DOI":"10.2196\/18907","volume":"8","author":"L Lu","year":"2020","unstructured":"Lu L, Zhang J, Ye Z, et al. Wearable health devices in health care: narrative systematic review. JMIR Mhealth Uhealth. 2020;8(11):e18907.","journal-title":"JMIR Mhealth Uhealth"},{"key":"9574_CR74","first-page":"1","volume":"1","author":"W Jiang","year":"2021","unstructured":"Jiang W, Majumder S, Monday T, et al. A wearable tele-health system towards monitoring COVID-19 and chronic diseases. IEEE Rev Biomed Eng. 2021;1:1.","journal-title":"IEEE Rev Biomed Eng"},{"issue":"2","key":"9574_CR75","doi-asserted-by":"publisher","first-page":"326","DOI":"10.3390\/s19020326","volume":"19","author":"AD Dwivedi","year":"2019","unstructured":"Dwivedi AD, Srivastava G, Singh R, et al. A decentralized privacy-preserving healthcare blockchain for IoT. Sensors. 2019;19(2):326.","journal-title":"Sensors"},{"key":"9574_CR76","doi-asserted-by":"crossref","unstructured":"Kalid N, Zaidan AA, Muzammil H, et al. Based Real Time Remote Health Monitoring Systems: A Review on Patients Prioritization and Related \u201cBig Data\u201d Using Body Sensors Inf Commun Technol. J Med Syst. 2017;42(2):30.","DOI":"10.1007\/s10916-017-0883-4"},{"key":"9574_CR77","unstructured":"Yanze W et al. Decision support for selecting blockchain-based application design patterns with layered taxonomy and quality attributes. IEEE Transactions on Software Engineering 2025."},{"key":"9574_CR78","doi-asserted-by":"crossref","unstructured":"Chait-Roth Devora, Kedar S Namjoshi. Constructing trustworthy smart contracts. International Conference on Verification, Model Checking, and Abstract Interpretation. Cham: Springer Nature Switzerland, 2025.","DOI":"10.1007\/978-3-031-82703-7_11"},{"issue":"1","key":"9574_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1145\/3697011","volume":"34","author":"S Ahmadjee","year":"2025","unstructured":"Ahmadjee S, et al. Decision support model for selecting the optimal blockchain oracle platform: an evaluation of key factors. ACM Trans Softw Eng Methodol. 2025;34(1):1\u201335.","journal-title":"ACM Trans Softw Eng Methodol"},{"issue":"2","key":"9574_CR80","first-page":"171","volume":"4","author":"F Yusuf","year":"2025","unstructured":"Yusuf F, et al. A comprehensive framework for enhancing blockchain security and privacy. Blockchain Front Technol. 2025;4(2):171\u201382.","journal-title":"Blockchain Front Technol"},{"key":"9574_CR81","unstructured":"Colin F et al. SoK: Time to be selfless?! Demystifying the landscape of selfish mining strategies and models. Cryptology ePrint Archive 2025."},{"key":"9574_CR82","unstructured":"Zubaida R et al. Eclipse attacks in blockchain networks: detection, prevention, and future directions. IEEE Access 2025."},{"issue":"1","key":"9574_CR83","doi-asserted-by":"publisher","first-page":"199","DOI":"10.55145\/ajest.2025.04.01.020","volume":"4","author":"AF Mahdi","year":"2025","unstructured":"Mahdi AF, Furkan R. An Overview of Blockchain Technology in Architecture and Consensus with Key Advances. Al-Salam J Eng Technol. 2025;4(1):199\u2013219.","journal-title":"Al-Salam J Eng Technol"},{"issue":"10","key":"9574_CR84","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.3390\/electronics11101624","volume":"11","author":"Z Mahmood","year":"2022","unstructured":"Mahmood Z, Jusas V. Blockchain-enabled: multi-layered security federated learning platform for preserving data privacy. Electronics. 2022;11(10):1624.","journal-title":"Electronics"},{"issue":"5","key":"9574_CR85","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.3390\/en17051007","volume":"17","author":"P Koukaras","year":"2024","unstructured":"Koukaras P, et al. Integrating blockchain in smart grids for enhanced demand response: challenges, strategies, and future directions. Energies. 2024;17(5):1007.","journal-title":"Energies"},{"issue":"1","key":"9574_CR86","doi-asserted-by":"publisher","first-page":"128","DOI":"10.51594\/estj.v5i1.732","volume":"5","author":"OI Oriekhoe","year":"2024","unstructured":"Oriekhoe OI, et al. Blockchain in supply chain management: a systematic review: evaluating the implementation, challenges, and future prospects of blockchain technology in supply chains. Eng Sci Technol J. 2024;5(1):128\u201351.","journal-title":"Eng Sci Technol J"},{"issue":"16","key":"9574_CR87","doi-asserted-by":"publisher","first-page":"9386","DOI":"10.3390\/su13169386","volume":"13","author":"C-L Chen","year":"2021","unstructured":"Chen C-L, et al. A traceable online insurance claims system based on blockchain and smart contract technology. Sustainability. 2021;13(16):9386.","journal-title":"Sustainability"},{"key":"9574_CR88","doi-asserted-by":"crossref","unstructured":"Mannonov KM, Myeong S. Citizens\u2019 perception of blockchain-based e-voting systems: focusing on TAM. Sustainability 2024;16(11):4387.","DOI":"10.3390\/su16114387"},{"key":"9574_CR89","unstructured":"Amani A. A blockchain-based solution for transparent intellectual property rights management: smart contracts as enablers. Kybernetes 2024."},{"issue":"32","key":"9574_CR90","doi-asserted-by":"publisher","first-page":"6569","DOI":"10.2174\/0929867328666201218122633","volume":"28","author":"V Visco","year":"2021","unstructured":"Visco V, et al. Artificial intelligence as a business partner in cardiovascular precision medicine: an emerg- ing approach for disease detection and treatment optimization. Curr Med Chem. 2021;28(32):6569\u201390.","journal-title":"Curr Med Chem"},{"key":"9574_CR91","doi-asserted-by":"publisher","unstructured":"Andras J, William S, Matthias P, Robert D. 1988. Heart disease. UCI Mach Learn Repos. https:\/\/doi.org\/10.24432\/C52P4X","DOI":"10.24432\/C52P4X"},{"key":"9574_CR92","doi-asserted-by":"publisher","unstructured":"Zwitter Matjaz, Soklic Milan. 1988. Breast cancer. UCI Machine Learning Repository. https:\/\/doi.org\/10.24432\/C51P4M","DOI":"10.24432\/C51P4M"},{"key":"9574_CR93","doi-asserted-by":"publisher","unstructured":"Quinlan Ross. 1987. Thyroid disease. UCI Machine Learning Repository. https:\/\/doi.org\/10.24432\/C5D010","DOI":"10.24432\/C5D010"},{"key":"9574_CR94","doi-asserted-by":"publisher","unstructured":"Michael K. Diabetes. UCI Machine Learning Repository. https:\/\/doi.org\/10.24432\/C5T59G.","DOI":"10.24432\/C5T59G"},{"key":"9574_CR95","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1007\/s12652-022-03823-y","volume":"13","author":"SV Jansi Rani","year":"2022","unstructured":"Jansi Rani SV, Chandran KR, Ranganathan A, Chandrasekharan M, Janani B, Deepsheka G. Smart wearable model for predicting heart disease using machine learning. J Ambient Intell Humaniz Comput. 2022;13:4321\u201332.","journal-title":"J Ambient Intell Humaniz Comput"},{"key":"9574_CR96","doi-asserted-by":"crossref","unstructured":"Jenifer A, Jeba G, Paulraj L, Kumar N, Yuvaraj T, Alen G, Rozario P, Amoli R. Edge-based Heart Disease Prediction Device using Internet of Things. In Proceedings of the 2022 International Conference on Applied Artificial Intelligence and Computing (ICAAIC), Salem, India, 9-11 May 2022; pp. 1500-1504.","DOI":"10.1109\/ICAAIC53929.2022.9793104"},{"key":"9574_CR97","doi-asserted-by":"crossref","unstructured":"Golec M, Gill SS, Parlikad AK, Uhlig S. HealthFaaS: AI-based smart healthcare system for heart patients using serverless computing, in IEEE Internet of Things Journal, vol. 10, no. 21, pp. 18469-18476, 1 Nov.1, 2023.","DOI":"10.1109\/JIOT.2023.3277500"},{"key":"#cr-split#-9574_CR98.1","doi-asserted-by":"crossref","unstructured":"Singh A, Kumar R. Heart disease prediction using machine learning algorithms. In Proceedings of the 2020 Int Conf Elect Electron Eng (ICE3), Gorakhpur, India, 14-15 February 2020","DOI":"10.1109\/ICE348803.2020.9122958"},{"key":"#cr-split#-9574_CR98.2","unstructured":"IEEE: Piscataway, NJ, USA, 2020:452-457."},{"issue":"4","key":"9574_CR99","doi-asserted-by":"publisher","first-page":"858","DOI":"10.3390\/electronics12040858","volume":"12","author":"THH Aldhyani","year":"2023","unstructured":"Aldhyani THH, Khan MA, Almaiah MA, Alnazzawi N, Hwaitat AKA, Elhag A, Shehab RT, Alshebami AS. A secure internet of medical things framework for breast cancer detection in sustainable smart cities. Electronics. 2023;12(4):858. https:\/\/doi.org\/10.3390\/electronics12040858.","journal-title":"Electronics"},{"key":"9574_CR100","doi-asserted-by":"publisher","unstructured":"Majji RG., O.P.P., Rajeswari R et al. Smart IoT in breast cancer detection using optimal deep learning. J Digit Imaging 2023;36:489-1506. https:\/\/doi.org\/10.1007\/s10278-023-00834-9","DOI":"10.1007\/s10278-023-00834-9"},{"key":"9574_CR101","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s11277-021-08708-5","volume":"127","author":"A Kishor","year":"2022","unstructured":"Kishor A, Chakraborty C. Artificial intelligence and internet of things based healthcare 4.0 monitoring system. Wireless Pers Commun. 2022;127:1615\u201331. https:\/\/doi.org\/10.1007\/s11277-021-08708-5.","journal-title":"Wireless Pers Commun"},{"key":"9574_CR102","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1007\/s41870-021-00671-5","volume":"14","author":"A Sharma","year":"2022","unstructured":"Sharma A, Mishra PK. Performance analysis of machine learning based optimized feature selection approaches for breast cancer diagnosis. Int J Inf Tecnol. 2022;14:1949\u201360. https:\/\/doi.org\/10.1007\/s41870-021-00671-5.","journal-title":"Int J Inf Tecnol"},{"key":"9574_CR103","doi-asserted-by":"crossref","unstructured":"Chen F, Han H, Wan P, Liao H, Liu C, Zhang D. Joint segmentation and differential diagnosis of thyroid nodule in contrast-enhanced ultrasound images, IEEE Transactions on Biomedical Engineering 2023.","DOI":"10.1109\/TBME.2023.3262842"},{"key":"9574_CR104","doi-asserted-by":"publisher","first-page":"106444","DOI":"10.1016\/j.compbiomed.2022.106444","volume":"152","author":"J Sun","year":"2023","unstructured":"Sun J, Wu B, Zhao T, Gao L, Xie K, Lin T, Sui J, Li X, Wu X, Ni X. Classification for thyroid nodule using vit with contrastive learning in ultrasound images. Comput Biol Med. 2023;152:106444.","journal-title":"Comput Biol Med"},{"key":"9574_CR105","doi-asserted-by":"crossref","unstructured":"Wei R, Wang H, Wang L, Hu W, Sun X, Dai Z, Zhu J, Li H, Ge Y, Song B. Radiomics based on multiparametric MRI for extrathyroidal extension feature prediction in papillary thyroid cancer. BMC Med. Imaging 2021, 21, 20.","DOI":"10.1186\/s12880-021-00553-z"},{"issue":"23","key":"9574_CR106","doi-asserted-by":"publisher","first-page":"9558","DOI":"10.3390\/s23239558","volume":"23","author":"S Maqbool","year":"2024","unstructured":"Maqbool S, Bajwa IS, Maqbool S, Ramzan S, Chishty MJ. A smart sensing technologies-based intelligent healthcare system for diabetes patients. Sensors. 2024;23(23):9558. https:\/\/doi.org\/10.3390\/s23239558.","journal-title":"Sensors"},{"issue":"2","key":"9574_CR107","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3390\/fi15020085","volume":"15","author":"S AlZu\u2019bi","year":"2023","unstructured":"AlZu\u2019bi S, Elbes M, Mughaid A, Bdair N, Abualigah L, Forestiero A, Zitar RA. Diabetes monitoring system in smart health cities based on big data intelligence. Fut Int. 2023;15(2):85. https:\/\/doi.org\/10.3390\/fi15020085.","journal-title":"Fut Int"},{"key":"9574_CR108","doi-asserted-by":"crossref","unstructured":"Arkadip Ray. Smart healthcare disease diagnosis and patient management: innovation, improvement and skill development, 3, 15 March 2021, 100011.","DOI":"10.1016\/j.mlwa.2020.100011"}],"container-title":["Discover Computing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10791-025-09574-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10791-025-09574-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10791-025-09574-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T16:03:53Z","timestamp":1749571433000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10791-025-09574-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,10]]},"references-count":109,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["9574"],"URL":"https:\/\/doi.org\/10.1007\/s10791-025-09574-6","relation":{},"ISSN":["2948-2992"],"issn-type":[{"value":"2948-2992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,10]]},"assertion":[{"value":"12 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No Competing interests is declared.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"112"}}