{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:21:17Z","timestamp":1777526477018,"version":"3.51.4"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"7-8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s10822-006-9053-3","type":"journal-article","created":{"date-parts":[[2006,11,6]],"date-time":"2006-11-06T12:16:58Z","timestamp":1162815418000},"page":"405-416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer"],"prefix":"10.1007","volume":"20","author":[{"given":"Marta","family":"Filizola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon X.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harel","family":"Weinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"issue":"1","key":"9053_CR1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/sj.embor.7400052","volume":"5","author":"S Terrillon","year":"2004","unstructured":"Terrillon S, Bouvier M (2004) EMBO Rep 5(1):30","journal-title":"EMBO Rep"},{"issue":"5","key":"9053_CR2","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1124\/mol.104.006320","volume":"66","author":"JA Javitch","year":"2004","unstructured":"Javitch JA (2004) Mol Pharmacol 66(5):1077","journal-title":"Mol Pharmacol"},{"issue":"1","key":"9053_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/mol.104.000497.","volume":"66","author":"G Milligan","year":"2004","unstructured":"Milligan G (2004) Mol Pharmacol 66(1):1","journal-title":"Mol Pharmacol"},{"issue":"2","key":"9053_CR4","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0898-6568(03)00128-1","volume":"16","author":"M Bai","year":"2004","unstructured":"Bai M (2004) Cell Signal 16(2):175","journal-title":"Cell Signal"},{"issue":"50","key":"9053_CR5","doi-asserted-by":"publisher","first-page":"15643","DOI":"10.1021\/bi047907k","volume":"43","author":"PS Park","year":"2004","unstructured":"Park PS, Filipek S, Wells JW, Palczewski K (2004) Biochemistry 43(50):15643","journal-title":"Biochemistry"},{"issue":"5","key":"9053_CR6","first-page":"577","volume":"8","author":"M Filizola","year":"2005","unstructured":"Filizola M, Weinstein H (2005) Curr Opin Drug Discov Devel 8(5):577","journal-title":"Curr Opin Drug Discov Devel"},{"issue":"2","key":"9053_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.sbi.2006.03.013","volume":"16","author":"D Fotiadis","year":"2006","unstructured":"Fotiadis D, Jastrzebska B, Philippsen A, Muller DJ, Palczewski K, Engel A (2006) Curr Opin Struct Biol 16(2):252","journal-title":"Curr Opin Struct Biol"},{"issue":"48","key":"9053_CR8","doi-asserted-by":"publisher","first-page":"17495","DOI":"10.1073\/pnas.0508950102","volume":"102","author":"W Guo","year":"2005","unstructured":"Guo W, Shi L, Filizola M, Weinstein H, Javitch JA (2005) Proc Natl Acad Sci USA 102(48):17495","journal-title":"Proc Natl Acad Sci USA"},{"issue":"25","key":"9053_CR9","doi-asserted-by":"publisher","first-page":"9050","DOI":"10.1073\/pnas.0501112102","volume":"102","author":"M Waldhoer","year":"2005","unstructured":"Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, Whistler JL (2005) Proc Natl Acad Sci USA 102(25):9050","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"9053_CR10","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1039\/b315661c","volume":"3","author":"S Filipek","year":"2004","unstructured":"Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, Palczewski K (2004) Photochem Photobiol Sci 3(6):628","journal-title":"Photochem Photobiol Sci"},{"key":"9053_CR11","doi-asserted-by":"publisher","first-page":"21655","DOI":"10.1074\/jbc.M302536200","volume":"278","author":"Y Liang","year":"2003","unstructured":"Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, Engel A (2003) J Biol Chem 278:21655","journal-title":"J Biol Chem"},{"issue":"52","key":"9053_CR12","doi-asserted-by":"publisher","first-page":"54663","DOI":"10.1074\/jbc.M408691200","volume":"279","author":"B Jastrzebska","year":"2004","unstructured":"Jastrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, Palczewski K (2004) J Biol Chem 279(52):54663","journal-title":"J Biol Chem"},{"issue":"6919","key":"9053_CR13","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1038\/421127a","volume":"421","author":"D Fotiadis","year":"2003","unstructured":"Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, Palczewski K (2003) Nature 421(6919):127","journal-title":"Nature"},{"key":"9053_CR14","doi-asserted-by":"publisher","first-page":"7761","DOI":"10.1021\/bi0155091","volume":"40","author":"DC Teller","year":"2001","unstructured":"Teller DC, Okada T, Behnke CA, Palczewski K, Stenkamp RE (2001) Biochemistry 40:7761","journal-title":"Biochemistry"},{"issue":"9","key":"9053_CR15","doi-asserted-by":"publisher","first-page":"3054","DOI":"10.1073\/pnas.0510982103","volume":"103","author":"P Kota","year":"2006","unstructured":"Kota P, Reeves PJ, Rajbhandary UL, Khorana HG (2006) Proc Natl Acad Sci USA 103(9):3054","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"9053_CR16","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1111\/j.1742-4658.2005.04728.x","volume":"272","author":"JP Pin","year":"2005","unstructured":"Pin JP, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, Prezeau L (2005) Febs J 272(12):2947","journal-title":"Febs J"},{"issue":"5","key":"9053_CR17","doi-asserted-by":"publisher","first-page":"3236","DOI":"10.1074\/jbc.M108900200","volume":"277","author":"B Duthey","year":"2002","unstructured":"Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prezeau L (2002) J Biol Chem 277(5):3236","journal-title":"J Biol Chem"},{"issue":"9","key":"9053_CR18","doi-asserted-by":"publisher","first-page":"2152","DOI":"10.1093\/emboj\/20.9.2152","volume":"20","author":"T Galvez","year":"2001","unstructured":"Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prezeau L, Pin JP (2001) Embo J 20(9):2152","journal-title":"Embo J"},{"key":"9053_CR19","doi-asserted-by":"publisher","first-page":"14643","DOI":"10.1073\/pnas.251554798","volume":"98","author":"M Margeta-Mitrovic","year":"2001","unstructured":"Margeta-Mitrovic M, Jan YN, Jan LY (2001) Proc Natl Acad Sci USA 98:14643","journal-title":"Proc Natl Acad Sci USA"},{"issue":"26","key":"9053_CR20","doi-asserted-by":"crossref","first-page":"24380","DOI":"10.1074\/jbc.M502642200","volume":"280","author":"C Goudet","year":"2005","unstructured":"Goudet C, Kniazeff J, Hlavackova V, Malhaire F, Maurel D, Acher F, Blahos J, Prezeau L, Pin JP (2005) J Biol Chem 280(26):24380","journal-title":"J Biol Chem"},{"issue":"3","key":"9053_CR21","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/sj.emboj.7600557","volume":"24","author":"V Hlavackova","year":"2005","unstructured":"Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prezeau L, Pin JP, Blahos J (2005) Embo J 24(3):499","journal-title":"Embo J"},{"issue":"5\u20136","key":"9053_CR22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/ardp.200400995","volume":"338","author":"RE Stenkamp","year":"2005","unstructured":"Stenkamp RE, Teller DC, Palczewski K (2005) Arch Pharm (Weinheim) 338(5\u20136):209","journal-title":"Arch Pharm (Weinheim)"},{"issue":"4","key":"9053_CR23","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1208\/aapsj070485","volume":"7","author":"H Weinstein","year":"2006","unstructured":"Weinstein H (2006) AAPS J 7(4):871","journal-title":"AAPS J"},{"issue":"9","key":"9053_CR24","doi-asserted-by":"publisher","first-page":"5982","DOI":"10.1073\/pnas.082666399","volume":"99","author":"T Okada","year":"2002","unstructured":"Okada T, Fujiyoshi Y, Silow M, Navarro J, Landau EM, Shichida Y (2002) Proc Natl Acad Sci USA 99(9):5982","journal-title":"Proc Natl Acad Sci USA"},{"key":"9053_CR25","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/prot.10330","volume":"51","author":"SA Hassan","year":"2003","unstructured":"Hassan SA, Mehler EL, Zhang D, Weinstein H (2003) Proteins 51:109","journal-title":"Proteins"},{"issue":"3","key":"9053_CR26","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1002\/prot.20470","volume":"60","author":"XF Li","year":"2005","unstructured":"Li XF, Hassan SA, Mehler EL (2005) Proteins Struct Funct Bioinform 60(3):464","journal-title":"Proteins Struct Funct Bioinform"},{"issue":"11","key":"9053_CR27","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1023\/A:1023845015343","volume":"16","author":"EL Mehler","year":"2002","unstructured":"Mehler EL, Periole X, Hassan SA, Weinstein HJ (2002) Comput Aided Mol Des 16(11):841","journal-title":"Comput Aided Mol Des"},{"issue":"2","key":"9053_CR28","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.jmb.2004.07.044","volume":"342","author":"T Okada","year":"2004","unstructured":"Okada T, Sugihara M, Bondar AN, Elstner M, Entel P, Buss V (2004) J Mol Biol 342(2):571","journal-title":"J Mol Biol"},{"issue":"22","key":"9053_CR29","doi-asserted-by":"publisher","first-page":"6858","DOI":"10.1021\/bi049949e","volume":"43","author":"X Periole","year":"2004","unstructured":"Periole X, Ceruso MA, Mehler EL (2004) Biochemistry 43(22):6858","journal-title":"Biochemistry"},{"key":"9053_CR30","doi-asserted-by":"publisher","first-page":"7451","DOI":"10.1021\/ja00095a076","volume":"116","author":"H Resat","year":"1994","unstructured":"Resat H, Mezei M (1994) J Am Chem Soc 116:7451","journal-title":"J Am Chem Soc"},{"issue":"3","key":"9053_CR31","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0006-3495(96)79322-0","volume":"71","author":"H Resat","year":"1996","unstructured":"Resat H, Mezei M (1996) Biophys J 71(3):1179","journal-title":"Biophys J"},{"key":"9053_CR32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1002\/pro.5560070305","volume":"7","author":"TJ Marrone","year":"1998","unstructured":"Marrone TJ, Resat H, Hodge CN, Chang C-H, McCammon JA (1998) Protein Sci 7:573","journal-title":"Protein Sci"},{"key":"9053_CR33","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0010-4655(95)00042-E","volume":"91","author":"HJC Berendsen","year":"1995","unstructured":"Berendsen HJC, van der Spoel D, van Drunen R (1995) Comp Phys Comm 91:43","journal-title":"Comp Phys Comm"},{"issue":"16","key":"9053_CR34","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1002\/jcc.20291","volume":"26","author":"D Van Der Spoel","year":"2005","unstructured":"Van Der Spoel D, Lindahl E, Hess B, Groenhof G, Mark AE, Berendsen HJ (2005) J Comput Chem 26(16):1701","journal-title":"J Comput Chem"},{"issue":"2","key":"9053_CR35","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0006-3495(00)76626-4","volume":"78","author":"E Tajkhorshid","year":"2000","unstructured":"Tajkhorshid E, Baudry J, Schulten K, Suhai S (2000) Biophys J 78(2):683","journal-title":"Biophys J"},{"key":"9053_CR36","doi-asserted-by":"publisher","first-page":"8021","DOI":"10.1021\/jp971283t","volume":"101","author":"E Tajkhorshid","year":"1997","unstructured":"Tajkhorshid E, Paizs B, Suhai S (1997) J Phys Chem B 101:8021","journal-title":"J Phys Chem B"},{"key":"9053_CR37","doi-asserted-by":"publisher","first-page":"5581","DOI":"10.1021\/jp983742b","volume":"103","author":"E Tajkhorshid","year":"1999","unstructured":"Tajkhorshid E, Suhai S (1999) J Phys Chem B 103:5581","journal-title":"J Phys Chem B"},{"key":"9053_CR38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0006-3495(95)80184-0","volume":"68","author":"M Nina","year":"1995","unstructured":"Nina M, Roux B, Smith J (1995) Biophys J 68:25","journal-title":"Biophys J"},{"issue":"6","key":"9053_CR39","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.1016\/S0006-3495(98)77986-X","volume":"74","author":"DP Tieleman","year":"1998","unstructured":"Tieleman DP, Berendsen HJ (1998) Biophys J 74(6):2786","journal-title":"Biophys J"},{"issue":"50","key":"9053_CR40","doi-asserted-by":"publisher","first-page":"17554","DOI":"10.1021\/bi981802y","volume":"37","author":"DP Tieleman","year":"1998","unstructured":"Tieleman DP, Forrest LR, Sansom MS, Berendsen HJ (1998) Biochemistry 37(50):17554","journal-title":"Biochemistry"},{"issue":"5","key":"9053_CR41","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/S0006-3495(00)76479-4","volume":"79","author":"R Sankararamakrishnan","year":"2000","unstructured":"Sankararamakrishnan R, Weinstein H (2000) Biophys J 79(5):2331","journal-title":"Biophys J"},{"key":"9053_CR42","doi-asserted-by":"publisher","first-page":"11802","DOI":"10.1021\/jp048969n","volume":"108","author":"R Sankararamakrishnan","year":"2004","unstructured":"Sankararamakrishnan R, Weinstein H (2004) J Phys Chem B 108:11802","journal-title":"J Phys Chem B"},{"key":"9053_CR43","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1021\/jp012174o","volume":"106","author":"R Sankararamakrishnan","year":"2002","unstructured":"Sankararamakrishnan R, Weinstein H (2002) J Phys Chem B 106:209","journal-title":"J Phys Chem B"},{"key":"9053_CR44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0076-6879(02)43145-X","volume":"343","author":"I Visiers","year":"2002","unstructured":"Visiers I, Ballesteros JA, Weinstein H (2002) Meth Enzymol 343:329","journal-title":"Meth Enzymol"},{"issue":"9","key":"9053_CR45","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1021\/cr000095n","volume":"105","author":"F Fanelli","year":"2005","unstructured":"Fanelli F, De Benedetti PG (2005) Chem Rev 105(9):3297","journal-title":"Chem Rev"},{"key":"9053_CR46","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1016\/S0006-3495(97)78845-3","volume":"72","author":"O Berger","year":"1997","unstructured":"Berger O, Edholm O, Jahnig F (1997) Biophys J 72:2002","journal-title":"Biophys J"},{"key":"9053_CR47","doi-asserted-by":"publisher","first-page":"10089","DOI":"10.1063\/1.464397","volume":"98","author":"T Darden","year":"1993","unstructured":"Darden T, York D, Pederson L (1993) J Chem Phys 98:10089","journal-title":"J Chem Phys"},{"key":"9053_CR48","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","volume":"18","author":"B Hess","year":"1997","unstructured":"Hess B, Bekker H, Berendsen HJC, Fraaije JGEM (1997) J Comput Chem 18:1463","journal-title":"J Comput Chem"},{"key":"9053_CR49","unstructured":"Berendsen HJC, Postma JPM, Gunsteren WF, Hermans J (1981) Intermolecular forces. Riedel, Dordrecht"},{"issue":"1","key":"9053_CR50","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/prot.340220107","volume":"22","author":"DM van Aalten","year":"1995","unstructured":"van Aalten DM, Amadei A, Linssen AB, Eijsink VG, Vriend G, Berendsen HJ (1995) Proteins 22(1):45","journal-title":"Proteins"},{"issue":"9","key":"9053_CR51","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/protein\/13.9.603","volume":"13","author":"I Visiers","year":"2000","unstructured":"Visiers I, Braunheim BB, Weinstein H (2000) Protein Eng 13(9):603","journal-title":"Protein Eng"},{"issue":"2","key":"9053_CR52","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10822-006-9039-1","volume":"20","author":"M Mezei","year":"2006","unstructured":"Mezei M, Filizola, M (2006) J Comp Aid Mol Des. 20(2):97","journal-title":"J Comp Aid Mol Des."},{"issue":"13","key":"9053_CR53","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1021\/ja042715y","volume":"127","author":"MC Pitman","year":"2005","unstructured":"Pitman MC, Grossfield A, Suits F, Feller SE (2005) J Am Chem Soc 127(13):4576","journal-title":"J Am Chem Soc"},{"issue":"6","key":"9053_CR54","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1016\/S0006-3495(02)75314-9","volume":"83","author":"J Saam","year":"2002","unstructured":"Saam J, Tajkhorshid E, Hayashi S, Schulten K (2002) Biophys J 83(6):3097","journal-title":"Biophys J"},{"issue":"4","key":"9053_CR55","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1016\/S0006-3495(04)74268-X","volume":"86","author":"T Huber","year":"2004","unstructured":"Huber T, Botelho AV, Beyer K, Brown MF (2004) Biophys J 86(4):2078","journal-title":"Biophys J"},{"issue":"4","key":"9053_CR56","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1002\/prot.20257","volume":"57","author":"JD Faraldo-Gomez","year":"2004","unstructured":"Faraldo-Gomez JD, Forrest LR, Baaden M, Bond PJ, Domene C, Patargias G, Cuthbertson J, Sansom MS (2004) Proteins 57(4):783","journal-title":"Proteins"},{"issue":"1","key":"9053_CR57","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s00894-005-0004-z","volume":"12","author":"B Schlegel","year":"2005","unstructured":"Schlegel B, Sippl W, Holtje HD (2005) J Mol Model (Online) 12(1):49","journal-title":"J Mol Model (Online)"},{"issue":"3","key":"9053_CR58","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.jmb.2003.08.045","volume":"333","author":"PS Crozier","year":"2003","unstructured":"Crozier PS, Stevens MJ, Forrest LR, Woolf TB (2003) J Mol Biol 333(3):493","journal-title":"J Mol Biol"},{"key":"9053_CR59","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0076-6879(82)81022-7","volume":"81","author":"SL Fong","year":"1982","unstructured":"Fong SL, Tsin AT, Bridges CD, Liou GI (1982) Methods Enzymol 81:133","journal-title":"Methods Enzymol"},{"key":"9053_CR60","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1016\/S0006-3495(00)76551-9","volume":"79","author":"HI Petrache","year":"2000","unstructured":"Petrache HI, Dodd SW, Brown MF (2000) Biophys J 79:3172","journal-title":"Biophys J"},{"issue":"2","key":"9053_CR61","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/(SICI)1097-0134(19980201)30:2<144::AID-PROT4>3.0.CO;2-N","volume":"30","author":"S Hayward","year":"1998","unstructured":"Hayward S, Berendsen HJ (1998) Proteins 30(2):144","journal-title":"Proteins"},{"issue":"5288","key":"9053_CR62","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1126\/science.274.5288.768","volume":"274","author":"DL Farrens","year":"1996","unstructured":"Farrens DL, Altenbach C, Yang K, Hubbell WL, Khorana HG (1996) Science 274(5288):768","journal-title":"Science"},{"issue":"5474","key":"9053_CR63","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1126\/science.288.5474.2209","volume":"288","author":"B Borhan","year":"2000","unstructured":"Borhan B, Souto ML, Imai H, Shichida Y, Nakanishi K (2000) Science 288(5474):2209","journal-title":"Science"},{"key":"9053_CR64","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S1043-9471(05)80049-7","volume":"25","author":"JA Ballesteros","year":"1995","unstructured":"Ballesteros JA, Weinstein H (1995) Meth Neurosci 25:366","journal-title":"Meth Neurosci"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-006-9053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10822-006-9053-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-006-9053-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-006-9053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T01:39:56Z","timestamp":1652578796000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10822-006-9053-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":64,"journal-issue":{"issue":"7-8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["9053"],"URL":"https:\/\/doi.org\/10.1007\/s10822-006-9053-3","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"7 June 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}