{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:14:14Z","timestamp":1781205254171,"version":"3.54.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1007\/s10822-008-9244-1","type":"journal-article","created":{"date-parts":[[2008,10,6]],"date-time":"2008-10-06T14:51:03Z","timestamp":1223304663000},"page":"113-127","source":"Crossref","is-referenced-by-count":20,"title":["Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking"],"prefix":"10.1007","volume":"23","author":[{"given":"Sivaprakasam","family":"Prasanna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj R.","family":"Daga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Doerksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,10,7]]},"reference":[{"key":"9244_CR1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1096\/fasebj.9.8.7768349","volume":"9","author":"SK Hanks","year":"1995","unstructured":"Hanks SK, Hunter T (1995) FASEB J 9:576","journal-title":"FASEB J"},{"key":"9244_CR2","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1021\/cr000110o","volume":"101","author":"A Ali","year":"2001","unstructured":"Ali A, Hoeflich KP, Woodgett JR (2001) Chem Rev 101:2527. doi: 10.1021\/cr000110o","journal-title":"Chem Rev"},{"key":"9244_CR3","first-page":"41","volume":"39","author":"R Sarabu","year":"2004","unstructured":"Sarabu R, Tilley J (2004) Annu Rep Med Chem 39:41\u201356","journal-title":"Annu Rep Med Chem"},{"key":"9244_CR4","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.2174\/1381612043452668","volume":"10","author":"AS Wagman","year":"2004","unstructured":"Wagman AS, Johnson KW, Bussiere DE (2004) Curr Pharm Des 10:1105. doi: 10.2174\/1381612043452668","journal-title":"Curr Pharm Des"},{"key":"9244_CR5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1158\/1535-7163.MCT-06-0665","volume":"6","author":"M Kunnimalaiyaan","year":"2007","unstructured":"Kunnimalaiyaan M, Vaccaro AM, Ndiaye MA, Chen H (2007) Mol Cancer Ther 6:1151. doi: 10.1158\/1535-7163.MCT-06-0665","journal-title":"Mol Cancer Ther"},{"key":"9244_CR6","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0065-230X(02)84007-6","volume":"84","author":"AS Manoukian","year":"2002","unstructured":"Manoukian AS, Woodgett JR (2002) Adv Cancer Res 84:203\u2013229. doi: 10.1016\/S0065-230X(02)84007-6","journal-title":"Adv Cancer Res"},{"key":"9244_CR7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.onc.1209020","volume":"25","author":"DJ Mulholland","year":"2006","unstructured":"Mulholland DJ, Dedhar S, Wu H, Nelson CC (2006) Oncogene 25:329. doi: 10.1038\/sj.onc.1209020","journal-title":"Oncogene"},{"key":"9244_CR8","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbapap.2005.08.027","volume":"1754","author":"C Doerig","year":"2005","unstructured":"Doerig C, Billker O, Pratt D, Endicott J (2005) Biochim Biophys Acta-Proteins Proteomics 1754:132. doi: 10.1016\/j.bbapap.2005.08.027","journal-title":"Biochim Biophys Acta-Proteins Proteomics"},{"key":"9244_CR9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbapap.2004.04.005","volume":"1700","author":"E Droucheau","year":"2004","unstructured":"Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C et al (2004) Biochim Biophys Acta-Proteins Proteomics 1700:139. doi: 10.1016\/j.bbapap.2004.04.005","journal-title":"Biochim Biophys Acta-Proteins Proteomics"},{"key":"9244_CR10","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbapap.2003.11.023","volume":"1697","author":"E Droucheau","year":"2004","unstructured":"Droucheau E, Primot A, Thomas V, Mattei D, Knockaert M, Richardson C et al (2004) Biochim Biophys Acta-Proteins Proteomics 1697:181. doi: 10.1016\/j.bbapap.2003.11.023","journal-title":"Biochim Biophys Acta-Proteins Proteomics"},{"key":"9244_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2006.09.005","volume":"42","author":"R Kumar","year":"2007","unstructured":"Kumar R, Singh VP, Baker KM (2007) J Mol Cell Cardiol 42:1. doi: 10.1016\/j.yjmcc.2006.09.005","journal-title":"J Mol Cell Cardiol"},{"key":"9244_CR12","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1517\/14728222.9.3.447","volume":"9","author":"E Murphy","year":"2005","unstructured":"Murphy E, Steenbergen C (2005) Expert Opin Ther Targets 9:447. doi: 10.1517\/14728222.9.3.447","journal-title":"Expert Opin Ther Targets"},{"key":"9244_CR13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1034\/j.1399-5618.2002.01150.x","volume":"4","author":"G Alvarez","year":"2002","unstructured":"Alvarez G, Munoz-Montano JR, Satrustegui J, Avila J, Bogonez E, Diaz-Nido J (2002) Bipolar Disord 4:153. doi: 10.1034\/j.1399-5618.2002.01150.x","journal-title":"Bipolar Disord"},{"key":"9244_CR14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000067423","volume":"11","author":"RV Bhat","year":"2002","unstructured":"Bhat RV, Budd SL (2002) Neurosignals 11:251. doi: 10.1159\/000067423","journal-title":"Neurosignals"},{"key":"9244_CR15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1471-4159.2004.02422.x","volume":"89","author":"RV Bhat","year":"2004","unstructured":"Bhat RV, Haeberlein SLB, Avila J (2004) J Neurochem 89:1313. doi: 10.1111\/j.1471-4159.2004.02422.x","journal-title":"J Neurochem"},{"key":"9244_CR16","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2174\/1389450110607011389","volume":"7","author":"HC Huang","year":"2006","unstructured":"Huang HC, Klein PS (2006) Curr Drug Targets 7:1389","journal-title":"Curr Drug Targets"},{"key":"9244_CR17","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nature01640","volume":"423","author":"CJ Phiel","year":"2003","unstructured":"Phiel CJ, Wilson CA, Lee VMY, Klein PS (2003) Nature 423:435. doi: 10.1038\/nature01640","journal-title":"Nature"},{"key":"9244_CR18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4088\/JCP.v65n0103","volume":"65","author":"TD Gould","year":"2004","unstructured":"Gould TD, Zarate CA, Manji HK (2004) J Clin Psychiatry 65:10","journal-title":"J Clin Psychiatry"},{"key":"9244_CR19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","volume":"32","author":"RS Jope","year":"2007","unstructured":"Jope RS, Yuskaitis CJ, Beurel E (2007) Neurochem Res 32:577. doi: 10.1007\/s11064-006-9128-5","journal-title":"Neurochem Res"},{"key":"9244_CR20","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/156720507779939832","volume":"4","author":"SY Aghdam","year":"2007","unstructured":"Aghdam SY, Barger SW (2007) Curr Alzheimer Res 4:21. doi: 10.2174\/156720507779939832","journal-title":"Curr Alzheimer Res"},{"key":"9244_CR21","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1074\/jbc.M605178200","volume":"282","author":"MH Liang","year":"2007","unstructured":"Liang MH, Chuang DM (2007) J Biol Chem 282:3904. doi: 10.1074\/jbc.M605178200","journal-title":"J Biol Chem"},{"key":"9244_CR22","doi-asserted-by":"crossref","first-page":"8210","DOI":"10.1016\/j.bmc.2006.09.021","volume":"14","author":"P Sivaprakasam","year":"2006","unstructured":"Sivaprakasam P, Xie AH, Doerksen RJ (2006) Bioorg Med Chem 14:8210. doi: 10.1016\/j.bmc.2006.09.021","journal-title":"Bioorg Med Chem"},{"key":"9244_CR23","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/89624","volume":"8","author":"E ter Haar","year":"2001","unstructured":"ter Haar E, Coll JT, Austen DA, Hsiao HM, Swenson L, Jain J (2001) Nat Struct Biol 8:593. doi: 10.1038\/89624","journal-title":"Nat Struct Biol"},{"key":"9244_CR24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jmb.2003.08.031","volume":"333","author":"JA Bertrand","year":"2003","unstructured":"Bertrand JA, Thieffine S, Vulpetti A, Cristiani C, Valsasina B, Knapp S et al (2003) J Mol Biol 333:393. doi: 10.1016\/j.jmb.2003.08.031","journal-title":"J Mol Biol"},{"key":"9244_CR25","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2174\/0929867043455738","volume":"11","author":"M Alonso","year":"2004","unstructured":"Alonso M, Martinez A (2004) Curr Med Chem 11:755. doi: 10.2174\/0929867043455738","journal-title":"Curr Med Chem"},{"key":"9244_CR26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0960-894X(00)00721-6","volume":"11","author":"DG Smith","year":"2001","unstructured":"Smith DG, Buffet M, Fenwick AE, Haigh D, Ife RJ, Saunders M et al (2001) Bioorg Med Chem Lett 11:635. doi: 10.1016\/S0960-894X(00)00721-6","journal-title":"Bioorg Med Chem Lett"},{"key":"9244_CR27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S1074-5521(00)00025-9","volume":"7","author":"MP Coghlan","year":"2000","unstructured":"Coghlan MP, Culbert AA, Cross DAE, Corcoran SL, Yates JW, Pearce NJ et al (2000) Chem Biol 7:793. doi: 10.1016\/S1074-5521(00)00025-9","journal-title":"Chem Biol"},{"key":"9244_CR28","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/jm00050a010","volume":"37","author":"G Klebe","year":"1994","unstructured":"Klebe G, Abraham U, Mietzner T (1994) J Med Chem 37:4130. doi: 10.1021\/jm00050a010","journal-title":"J Med Chem"},{"key":"9244_CR29","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1021\/ja01062a035","volume":"86","author":"C Hansch","year":"1964","unstructured":"Hansch C (1964) J Am Chem Soc 86:1616. doi: 10.1021\/ja01062a035","journal-title":"J Am Chem Soc"},{"key":"9244_CR30","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/157340607781024375","volume":"3","author":"PR Duchowicz","year":"2007","unstructured":"Duchowicz PR, Castro EA (2007) Med Chem 3:393. doi: 10.2174\/157340607781024375","journal-title":"Med Chem"},{"key":"9244_CR31","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/j.1747-0285.2006.00430.x","volume":"68","author":"N Dessalew","year":"2006","unstructured":"Dessalew N, Bharatam PV (2006) Chem Biol Drug Des 68:154. doi: 10.1111\/j.1747-0285.2006.00430.x","journal-title":"Chem Biol Drug Des"},{"key":"9244_CR32","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1016\/j.bmc.2007.03.048","volume":"15","author":"N Dessalew","year":"2007","unstructured":"Dessalew N, Bharatam PV (2007) Bioorg Med Chem 15:3728. doi: 10.1016\/j.bmc.2007.03.048","journal-title":"Bioorg Med Chem"},{"key":"9244_CR33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jmgm.2006.08.009","volume":"25","author":"N Dessalew","year":"2007","unstructured":"Dessalew N, Patel DS, Bharatam PV (2007) J Mol Graph Model 25:885. doi: 10.1016\/j.jmgm.2006.08.009","journal-title":"J Mol Graph Model"},{"key":"9244_CR34","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1016\/j.bmc.2006.03.009","volume":"14","author":"AR Katritzky","year":"2006","unstructured":"Katritzky AR, Pacureanu LM, Dobchev DA, Fara DC, Duchowicz PR, Karelson M (2006) Bioorg Med Chem 14:4987. doi: 10.1016\/j.bmc.2006.03.009","journal-title":"Bioorg Med Chem"},{"key":"9244_CR35","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1021\/ci050008y","volume":"45","author":"E Lescot","year":"2005","unstructured":"Lescot E, Bureau R, Santos JSD, Rochais C, Lisowski V, Lancelot JC et al (2005) J Chem Inf Model 45:708. doi: 10.1021\/ci050008y","journal-title":"J Chem Inf Model"},{"key":"9244_CR36","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.1021\/jm040895g","volume":"48","author":"A Martinez","year":"2005","unstructured":"Martinez A, Alonso M, Castro A, Dorronsoro I, Gelpi JL, Luque FJ et al (2005) J Med Chem 48:7103. doi: 10.1021\/jm040895g","journal-title":"J Med Chem"},{"key":"9244_CR37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10822-006-9036-4","volume":"20","author":"DS Patel","year":"2006","unstructured":"Patel DS, Bharatam PV (2006) J Comput Aided Mol Des 20:55. doi: 10.1007\/s10822-006-9036-4","journal-title":"J Comput Aided Mol Des"},{"key":"9244_CR38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/protein\/gzi074","volume":"19","author":"JF Xiao","year":"2006","unstructured":"Xiao JF, Guo ZR, Guo YS, Chu FM, Sun PY (2006) Protein Eng Des Sel 19:47. doi: 10.1093\/protein\/gzi074","journal-title":"Protein Eng Des Sel"},{"key":"9244_CR39","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bmcl.2004.10.060","volume":"15","author":"M Zeng","year":"2005","unstructured":"Zeng M, Jiang YJ, Zhang B, Zheng KW, Zhang N, Yu QS (2005) Bioorg Med Chem Lett 15:395. doi: 10.1016\/j.bmcl.2004.10.060","journal-title":"Bioorg Med Chem Lett"},{"key":"9244_CR40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ejmech.2005.10.018","volume":"41","author":"N Zhang","year":"2006","unstructured":"Zhang N, Jiang YJ, Zou JW, Zhang B, Jin HX, Wang YH et al (2006) Eur J Med Chem 41:373. doi: 10.1016\/j.ejmech.2005.10.018","journal-title":"Eur J Med Chem"},{"key":"9244_CR41","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/ja00226a005","volume":"110","author":"RD Cramer","year":"1988","unstructured":"Cramer RD, Patterson DE, Bunce JD (1988) J Am Chem Soc 110:5959. doi: 10.1021\/ja00226a005","journal-title":"J Am Chem Soc"},{"key":"9244_CR42","unstructured":"Frisch MJ, Trucks GW, Schlegel HB, Scuseria GE, Robb MA, Cheeseman JR, Montgomery JA Jr, Vreven T, Kudin KN, Burant JC, Millam JM, Iyengar SS, Tomasi J, Barone V, Mennucci B, Cossi M, Scalmani G, Rega N, Petersson GA, Nakatsuji H, Hada M, Ehara M, Toyota K, Fukuda R, Hasegawa J, Ishida M, Nakajima T, Honda Y, Kitao O, Nakai H, Klene M, Li X, Knox JE, Hratchian HP, Cross JB, Bakken V, Adamo C, Jaramillo J, Gomperts R, Stratmann RE, Yazyev O, Austin AJ, Cammi R, Pomelli C, Ochterski JW, Ayala PY, Morokuma K, Voth GA, Salvador P, Dannenberg JJ, Zakrzewski VG, Dapprich S, Daniels AD, Strain MC, Farkas O, Malick DK, Rabuck AD, Raghavachari K, Foresman JB, Ortiz JV, Cui Q, Baboul AG, Clifford S, Cioslowski J, Stefanov BB, Liu G, Liashenko A, Piskorz P, Komaromi I, Martin RL, Fox DJ, Keith T, Al-Laham MA, Peng CY, Nanayakkara A, Challacombe M, Gill PMW, Johnson B, Chen W, Wong MW, Gonzalez C, Pople JA, In, Gaussian, Inc., Wallingford CT, 2004"},{"key":"9244_CR43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S1093-3263(01)00123-1","volume":"20","author":"A Golbraikh","year":"2002","unstructured":"Golbraikh A, Tropsha A (2002) J Mol Graph Model 20:269. doi: 10.1016\/S1093-3263(01)00123-1","journal-title":"J Mol Graph Model"},{"key":"9244_CR44","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","volume":"23","author":"MA Larkin","year":"2007","unstructured":"Larkin MA, Blackshields G, BN P, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) Bioinformatics 23:2947. doi: 10.1093\/bioinformatics\/btm404","journal-title":"Bioinformatics"},{"key":"9244_CR45","unstructured":"Schr\u00f6dinger (2008) LLC, New York"},{"key":"9244_CR46","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1006\/jmbi.1996.0477","volume":"261","author":"M Rarey","year":"1996","unstructured":"Rarey M, Kramer B, Lengauer T, Klebe G (1996) J Mol Biol 261:470. doi: 10.1006\/jmbi.1996.0477","journal-title":"J Mol Biol"},{"key":"9244_CR47","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1016\/S0960-894X(03)00645-0","volume":"13","author":"J Witherington","year":"2003","unstructured":"Witherington J, Bordas V, Gaiba A, Garton NS, Naylor A, Rawlings AD et al (2003) Bioorg Med Chem Lett 13:3055. doi: 10.1016\/S0960-894X(03)00645-0","journal-title":"Bioorg Med Chem Lett"},{"key":"9244_CR48","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/S0960-894X(03)00646-2","volume":"13","author":"J Witherington","year":"2003","unstructured":"Witherington J, Bordas V, Gaiba A, Naylor A, Rawlings AD, Slingsby BP et al (2003) Bioorg Med Chem Lett 13:3059. doi: 10.1016\/S0960-894X(03)00646-2","journal-title":"Bioorg Med Chem Lett"},{"key":"9244_CR49","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0960-894X(03)00134-3","volume":"13","author":"J Witherington","year":"2003","unstructured":"Witherington J, Bordas V, Garland SL, Hickey DMB, Ife RJ, Liddle J et al (2003) Bioorg Med Chem Lett 13:1577. doi: 10.1016\/S0960-894X(03)00134-3","journal-title":"Bioorg Med Chem Lett"},{"key":"9244_CR50","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/S0960-894X(03)00135-5","volume":"13","author":"J Witherington","year":"2003","unstructured":"Witherington J, Bordas V, Haigh D, Hickey DMB, Ife RJ, Rawlings AD et al (2003) Bioorg Med Chem Lett 13:1581. doi: 10.1016\/S0960-894X(03)00135-5","journal-title":"Bioorg Med Chem Lett"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-008-9244-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10822-008-9244-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-008-9244-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T01:22:59Z","timestamp":1559265779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10822-008-9244-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,7]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["9244"],"URL":"https:\/\/doi.org\/10.1007\/s10822-008-9244-1","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,7]]}}}