{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:11:50Z","timestamp":1776118310219,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1007\/s10822-011-9451-z","type":"journal-article","created":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T11:45:51Z","timestamp":1309866351000},"page":"607-610","source":"Crossref","is-referenced-by-count":23,"title":["Fragment-based lead discovery: challenges and opportunities"],"prefix":"10.1007","volume":"25","author":[{"given":"Chaohong","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Petros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip J.","family":"Hajduk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,7,6]]},"reference":[{"key":"9451_CR1","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1126\/science.274.5292.1531","volume":"274","author":"SB Shuker","year":"1996","unstructured":"Shuker SB, Hajduk PJ, Meadows RP, Fesik SW (1996) Science 274:1531\u20131534","journal-title":"Science"},{"key":"9451_CR2","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.drudis.2009.03.009","volume":"14","author":"GE Kloe de","year":"2009","unstructured":"de Kloe GE, Bailey D, Leurs R, de Esch IJ (2009) Drug Discov Today 14:630\u2013646","journal-title":"Drug Discov Today"},{"key":"9451_CR3","doi-asserted-by":"crossref","first-page":"3661","DOI":"10.1021\/jm8000373","volume":"51","author":"M Congreve","year":"2008","unstructured":"Congreve M, Chessari G, Tisi D, Woodhead AJ (2008) J Med Chem 51:3661\u20133680","journal-title":"J Med Chem"},{"key":"9451_CR4","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.drudis.2007.08.005","volume":"12","author":"G Siegal","year":"2007","unstructured":"Siegal G, Ab E, Schultz J (2007) Drug Discov Today 12:1032\u20131039","journal-title":"Drug Discov Today"},{"key":"9451_CR5","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.2174\/156802607782341091","volume":"7","author":"JS Albert","year":"2007","unstructured":"Albert JS, Blomberg N, Breeze AL, Brown AJ, Burrows JN, Edwards PD, Folmer RH, Geschwindner S, Griffen EJ, Kenny PW, Nowak T, Olsson LL, Sanganee H, Shapiro AB (2007) Curr Top Med Chem 7:1600\u20131629","journal-title":"Curr Top Med Chem"},{"key":"9451_CR6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.copbio.2006.10.007","volume":"17","author":"DA Erlanson","year":"2006","unstructured":"Erlanson DA (2006) Curr Opin Biotechnol 17:643\u2013652","journal-title":"Curr Opin Biotechnol"},{"key":"9451_CR7","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nchembio1206-658","volume":"2","author":"PJ Hajduk","year":"2006","unstructured":"Hajduk PJ (2006) Nat Chem Biol 2:658\u2013659","journal-title":"Nat Chem Biol"},{"key":"9451_CR8","doi-asserted-by":"crossref","first-page":"6972","DOI":"10.1021\/jm060511h","volume":"49","author":"PJ Hajduk","year":"2006","unstructured":"Hajduk PJ (2006) J Med Chem 49:6972\u20136976","journal-title":"J Med Chem"},{"key":"9451_CR9","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd1467","volume":"3","author":"DC Rees","year":"2004","unstructured":"Rees DC, Congreve M, Murray CW, Carr R (2004) Nat Rev Drug Discov 3:660\u2013672","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR10","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrd2220","volume":"6","author":"PJ Hajduk","year":"2007","unstructured":"Hajduk PJ, Greer J (2007) Nat Rev Drug Discov 6:211\u2013219","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR11","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2009.04.007","volume":"14","author":"G Chessari","year":"2009","unstructured":"Chessari G, Woodhead AJ (2009) Drug Discov Today 14:668\u2013675","journal-title":"Drug Discov Today"},{"key":"9451_CR12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd3078","volume":"9","author":"SM Paul","year":"2010","unstructured":"Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, Schacht AL (2010) Nat Rev Drug Discov 9:203\u2013214","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR13","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.mib.2003.08.003","volume":"6","author":"SJ Projan","year":"2003","unstructured":"Projan SJ (2003) Curr Opin Microbiol 6:427\u2013430","journal-title":"Curr Opin Microbiol"},{"key":"9451_CR14","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S1359-6446(05)03539-7","volume":"10","author":"F Sams-Dodd","year":"2005","unstructured":"Sams-Dodd F (2005) Drug Discov Today 10:1049\u20131056","journal-title":"Drug Discov Today"},{"key":"9451_CR15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S1359-6446(04)03316-1","volume":"10","author":"F Sams-Dodd","year":"2005","unstructured":"Sams-Dodd F (2005) Drug Discov Today 10:139\u2013147","journal-title":"Drug Discov Today"},{"key":"9451_CR16","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.drudis.2006.04.014","volume":"11","author":"SE Hall","year":"2006","unstructured":"Hall SE (2006) Drug Discov Today 11:495\u2013502","journal-title":"Drug Discov Today"},{"key":"9451_CR17","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/nrd2826","volume":"8","author":"EE Schadt","year":"2009","unstructured":"Schadt EE, Friend SH, Shaywitz DA (2009) Nat Rev Drug Discov 8:286\u2013295","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR18","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nrd1904","volume":"4","author":"J Greef van der","year":"2005","unstructured":"van der Greef J, McBurney RN (2005) Nat Rev Drug Discov 4:961\u2013967","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR19","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/j.1476-5381.2009.00476.x","volume":"159","author":"M Congreve","year":"2010","unstructured":"Congreve M, Marshall F (2010) Br J Pharmacol 159:986\u2013996","journal-title":"Br J Pharmacol"},{"key":"9451_CR20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuropharm.2010.07.016","volume":"60","author":"RE Hubbard","year":"2010","unstructured":"Hubbard RE (2010) Neuropharmacology 60:7\u201323","journal-title":"Neuropharmacology"},{"key":"9451_CR21","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/B978-0-12-381274-2.00005-4","volume":"493","author":"M Congreve","year":"2011","unstructured":"Congreve M, Rich RL, Myszka DG, Figaroa F, Siegal G, Marshall FH (2011) Methods Enzymol 493:115\u2013136","journal-title":"Methods Enzymol"},{"key":"9451_CR22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/nrd3040","volume":"8","author":"M Goodman","year":"2009","unstructured":"Goodman M (2009) Nat Rev Drug Discov 8:837","journal-title":"Nat Rev Drug Discov"},{"key":"9451_CR23","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/biot.200790064","volume":"2","author":"NS Wong","year":"2007","unstructured":"Wong NS, Kocher HP, Yap MG (2007) Biotechnol J 2:657\u2013658","journal-title":"Biotechnol J"},{"key":"9451_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1747-0285.2007.00535.x","volume":"70","author":"JR Huth","year":"2007","unstructured":"Huth JR, Park C, Petros AM, Kunzer AR, Wendt MD, Wang X, Lynch CL, Mack JC, Swift KM, Judge RA, Chen J, Richardson PL, Jin S, Tahir SK, Matayoshi ED, Dorwin SA, Ladror US, Severin JM, Walter KA, Bartley DM, Fesik SW, Elmore SW, Hajduk PJ (2007) Chem Biol Drug Des 70:1\u201312","journal-title":"Chem Biol Drug Des"},{"key":"9451_CR25","doi-asserted-by":"crossref","first-page":"8452","DOI":"10.1002\/anie.200903821","volume":"48","author":"AW Hung","year":"2009","unstructured":"Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C (2009) Angew Chem Int Ed Engl 48:8452\u20138456","journal-title":"Angew Chem Int Ed Engl"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-011-9451-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10822-011-9451-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-011-9451-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T19:11:55Z","timestamp":1560366715000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10822-011-9451-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["9451"],"URL":"https:\/\/doi.org\/10.1007\/s10822-011-9451-z","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}