{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T18:02:36Z","timestamp":1762452156649,"version":"build-2065373602"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006356","name":"University of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Designing reaction pathways that maximize the production of a target compound in a given metabolic network is a fundamental problem in systems biology. In this study, we systematically explore the non-oxidative glycolysis metabolic network, guided by the principle that reactions with negative Gibbs free energy differences are thermodynamically favored. We enumerate alternative pathways that implement the net non-oxidative glycolysis reaction, categorized by their length. Our analysis reveals several alternative thermodynamically favorable pathways beyond the experimentally reported ones. Additionally, we identify molecules within the network, such as 3-hydroxypropionic acid, that may have significant potential for further investigation.<\/jats:p>","DOI":"10.1007\/s10822-025-00604-5","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:15:17Z","timestamp":1750065317000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thermodynamic free energy map for the non-oxidative glycolysis pathways"],"prefix":"10.1007","volume":"39","author":[{"given":"Adittya","family":"Pal","sequence":"first","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"604_CR1","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nature12575","volume":"502","author":"IW Bogorad","year":"2013","unstructured":"Bogorad IW, Lin T-S, Liao JC (2013) Synthetic non-oxidative glycolysis enables complete carbon conservation. 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