{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:27:34Z","timestamp":1772119654036,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Natural Science Foundation Project of Science & Technology Department of Sichuan Province","award":["No. 2023NSFSC0595"],"award-info":[{"award-number":["No. 2023NSFSC0595"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]},{"name":"Key Project of the Affiliated Hospital of North Sichuan Medical College","award":["No. 2023ZD010"],"award-info":[{"award-number":["No. 2023ZD010"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1007\/s10822-025-00711-3","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:40:44Z","timestamp":1767638444000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of circadian rhythm-associated genes and therapeutic targets in myopia with dynamics simulation: a multiomics study using machine learning algorithms and Mendelian randomization"],"prefix":"10.1007","volume":"40","author":[{"given":"Jiahao","family":"Niu","sequence":"first","affiliation":[]},{"given":"Jia","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Xianmei","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Bowen","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Yuanyuan","family":"Hu","sequence":"additional","affiliation":[]},{"given":"Qingqing","family":"Tan","sequence":"additional","affiliation":[]},{"given":"Hongsheng","family":"Bi","sequence":"additional","affiliation":[]},{"given":"Xuan","family":"Liao","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"issue":"7","key":"711_CR1","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1136\/bjophthalmol-2017-311266","volume":"102","author":"TR Fricke","year":"2018","unstructured":"Fricke TR, Jong M, Naidoo KS, Sankaridurg P, Naduvilath TJ, Ho SM, Wong TY, Resnikoff S (2018) Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling. Br J Ophthalmol 102(7):855\u2013862. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-311266","journal-title":"Br J Ophthalmol"},{"key":"711_CR2","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.12.001","volume":"52","author":"K Ohno-Matsui","year":"2016","unstructured":"Ohno-Matsui K, Lai TY, Lai CC, Cheung CM (2016) Updates of pathologic myopia. Prog Retin Eye Res 52:156\u2013187. https:\/\/doi.org\/10.1016\/j.preteyeres.2015.12.001","journal-title":"Prog Retin Eye Res"},{"key":"711_CR3","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.preteyeres.2018.12.001","volume":"70","author":"K Ohno-Matsui","year":"2019","unstructured":"Ohno-Matsui K, Jonas JB (2019) Posterior staphyloma in pathologic myopia. Prog Retin Eye Res 70:99\u2013109. https:\/\/doi.org\/10.1016\/j.preteyeres.2018.12.001","journal-title":"Prog Retin Eye Res"},{"issue":"1\u20132","key":"711_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3238\/arztebl.2014.0012","volume":"111","author":"N Feltgen","year":"2014","unstructured":"Feltgen N, Walter P (2014) Rhegmatogenous retinal detachment\u2013an ophthalmologic emergency. Dtsch Arztebl Int 111(1\u20132):12\u201321. https:\/\/doi.org\/10.3238\/arztebl.2014.0012","journal-title":"Dtsch Arztebl Int"},{"issue":"1","key":"711_CR5","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/s41572-020-00231-4","volume":"6","author":"PN Baird","year":"2020","unstructured":"Baird PN, Saw SM, Lanca C, Guggenheim JA, Smith Iii EL, Zhou X, Matsui KO, Wu PC, Sankaridurg P, Chia A, Rosman M, Lamoureux EL, Man R, He M (2020) Myopia. Nat Rev Dis Primers 6(1):99. https:\/\/doi.org\/10.1038\/s41572-020-00231-4","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"711_CR6","doi-asserted-by":"publisher","first-page":"M89","DOI":"10.1167\/iovs.18-25965","volume":"60","author":"MS Tedja","year":"2019","unstructured":"Tedja MS, Haarman AEG, Meester-Smoor MA, Kaprio J, Mackey DA, Guggenheim JA, Hammond CJ, Verhoeven VJM, Klaver CCW; CREAM Consortium (2019) IMI - myopia genetics report. Invest Ophthalmol Vis Sci 60(3):M89\u2013M105. https:\/\/doi.org\/10.1167\/iovs.18-25965","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"711_CR7","doi-asserted-by":"publisher","first-page":"102878","DOI":"10.1016\/j.ebiom.2020.102878","volume":"57","author":"F Zhao","year":"2020","unstructured":"Zhao F, Zhang D, Zhou Q, Zhao F, He M, Yang Z, Su Y, Zhai Y, Yan J, Zhang G, Xue A, Tang J, Han X, Shi Y, Zhu Y, Liu T, Zhuang W, Huang L, Hong Y, Wu D, Li Y, Lu Q, Chen W, Jiao S, Wang Q, Srinivasalu N, Wen Y, Zeng C, Qu J, Zhou X (2020) Scleral HIF-1\u03b1 is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis. EBioMedicine 57:102878. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102878","journal-title":"EBioMedicine"},{"issue":"6","key":"711_CR8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.preteyeres.2012.06.004","volume":"31","author":"DI Flitcroft","year":"2012","unstructured":"Flitcroft DI (2012) The complex interactions of retinal, optical and environmental factors in myopia aetiology. Prog Retin Eye Res 31(6):622\u2013660. https:\/\/doi.org\/10.1016\/j.preteyeres.2012.06.004","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"711_CR9","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/opo.12453","volume":"38","author":"R Chakraborty","year":"2018","unstructured":"Chakraborty R, Ostrin LA, Nickla DL, Iuvone PM, Pardue MT, Stone RA (2018) Circadian rhythms, refractive development, and myopia. Ophthalmic Physiol Opt 38(3):217\u2013245. https:\/\/doi.org\/10.1111\/opo.12453","journal-title":"Ophthalmic Physiol Opt"},{"issue":"2","key":"711_CR10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cmet.2016.07.001","volume":"24","author":"T Papagiannakopoulos","year":"2016","unstructured":"Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T (2016) Circadian rhythm disruption promotes lung tumorigenesis. Cell Metab 24(2):324\u2013331. https:\/\/doi.org\/10.1016\/j.cmet.2016.07.001","journal-title":"Cell Metab"},{"issue":"12","key":"711_CR11","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1038\/s41591-018-0271-8","volume":"24","author":"S Masri","year":"2018","unstructured":"Masri S, Sassone-Corsi P (2018) The emerging link between cancer, metabolism, and circadian rhythms. Nat Med 24(12):1795\u20131803. https:\/\/doi.org\/10.1038\/s41591-018-0271-8","journal-title":"Nat Med"},{"issue":"6","key":"711_CR12","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1111\/opo.13214","volume":"43","author":"A Hussain","year":"2023","unstructured":"Hussain A, Gopalakrishnan A, Scott H, Seby C, Tang V, Ostrin L, Chakraborty R (2023) Associations between systemic melatonin and human myopia: a systematic review. Ophthalmic Physiol Opt 43(6):1478\u20131490. https:\/\/doi.org\/10.1111\/opo.13214","journal-title":"Ophthalmic Physiol Opt"},{"issue":"10","key":"711_CR13","doi-asserted-by":"publisher","first-page":"R432","DOI":"10.1016\/j.cub.2016.04.011","volume":"26","author":"T Roenneberg","year":"2016","unstructured":"Roenneberg T, Merrow M (2016) The circadian clock and human health. Curr Biol 26(10):R432\u2013R443. https:\/\/doi.org\/10.1016\/j.cub.2016.04.011","journal-title":"Curr Biol"},{"issue":"1","key":"711_CR14","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41598-023-50684-2","volume":"14","author":"RA Stone","year":"2024","unstructured":"Stone RA, Tobias JW, Wei W, Schug J, Wang X, Zhang L, Iuvone PM, Nickla DL (2024) Diurnal retinal and choroidal gene expression patterns support a role for circadian biology in myopia pathogenesis. Sci Rep 14(1):533. https:\/\/doi.org\/10.1038\/s41598-023-50684-2","journal-title":"Sci Rep"},{"issue":"1","key":"711_CR15","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s42003-022-03774-2","volume":"5","author":"VK Jidigam","year":"2022","unstructured":"Jidigam VK, Sawant OB, Fuller RD, Wilcots K, Singh R, Lang RA, Rao S (2022) Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice. Commun Biol 5(1):792. https:\/\/doi.org\/10.1038\/s42003-022-03774-2","journal-title":"Commun Biol"},{"issue":"1","key":"711_CR16","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/imr.13264","volume":"319","author":"SA Lieffrig","year":"2023","unstructured":"Lieffrig SA, Gyimesi G, Mao Y, Finnemann SC (2023) Clearance phagocytosis by the retinal pigment epithelial during photoreceptor outer segment renewal: molecular mechanisms and relation to retinal inflammation. Immunol Rev 319(1):81\u201399. https:\/\/doi.org\/10.1111\/imr.13264","journal-title":"Immunol Rev"},{"issue":"1","key":"711_CR17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40101-024-00354-7","volume":"43","author":"S Biswas","year":"2024","unstructured":"Biswas S, El Kareh A, Qureshi M, Lee DMX, Sun CH, Lam JSH, Saw SM, Najjar RP (2024) The influence of the environment and lifestyle on myopia. J Physiol Anthropol 43(1):7. https:\/\/doi.org\/10.1186\/s40101-024-00354-7","journal-title":"J Physiol Anthropol"},{"issue":"12","key":"711_CR18","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S (2014) Moderated Estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol 15(12):550. https:\/\/doi.org\/10.1186\/s13059-014-0550-8","journal-title":"Genome Biol"},{"key":"711_CR19","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-024-01020-z","author":"S Xu","year":"2024","unstructured":"Xu S, Hu E, Cai Y, Xie Z, Luo X, Zhan L, Tang W, Wang Q, Liu B, Wang R, Xie W, Wu T, Xie L, Yu G (2024) Using clusterprofiler to characterize multiomics data. Nat Protoc. https:\/\/doi.org\/10.1038\/s41596-024-01020-z","journal-title":"Nat Protoc"},{"issue":"1","key":"711_CR20","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s12967-019-2057-2","volume":"17","author":"B Ye","year":"2019","unstructured":"Ye B, Liu K, Cao S, Sankaridurg P, Li W, Luan M, Zhang B, Zhu J, Zou H, Xu X, He X (2019) Discrimination of indoor versus outdoor environmental state with machine learning algorithms in myopia observational studies. J Transl Med 17(1):314. https:\/\/doi.org\/10.1186\/s12967-019-2057-2","journal-title":"J Transl Med"},{"issue":"1","key":"711_CR21","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12967-024-05075-0","volume":"22","author":"J Zhao","year":"2024","unstructured":"Zhao J, Yu Y, Li Y, Li F, Zhang Z, Jian W, Chen Z, Shen Y, Wang X, Ye Z, Huang C, Zhou X (2024) Development and validation of predictive models for myopia onset and progression using extensive 15-year refractive data in children and adolescents. J Transl Med 22(1):289. https:\/\/doi.org\/10.1186\/s12967-024-05075-0","journal-title":"J Transl Med"},{"issue":"4","key":"711_CR22","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1021\/acs.jcim.0c01450","volume":"61","author":"A Gomes","year":"2021","unstructured":"Gomes A, da Silva A, Lakkaraju GF, Guimar\u00e3es SK, MacKerell BG, Magalh\u00e3es AD Jr (2021) Insights into glucose-6-phosphate allosteric activation of \u03b2-glucosidase A. J Chem Inf Model 61(4):1931\u20131941. https:\/\/doi.org\/10.1021\/acs.jcim.0c01450","journal-title":"J Chem Inf Model"},{"issue":"11","key":"711_CR23","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1002\/jcc.20945","volume":"29","author":"S Jo","year":"2008","unstructured":"Jo S, Kim T, Iyer VG, Im W (2008) CHARMM-GUI: a web-based graphical user interface for CHARMM. J Comput Chem 29(11):1859\u20131865. https:\/\/doi.org\/10.1002\/jcc.20945","journal-title":"J Comput Chem"},{"key":"711_CR24","doi-asserted-by":"publisher","first-page":"687975","DOI":"10.3389\/fimmu.2021.687975","volume":"12","author":"D Zeng","year":"2021","unstructured":"Zeng D, Ye Z, Shen R, Yu G, Wu J, Xiong Y, Zhou R, Qiu W, Huang N, Sun L, Li X, Bin J, Liao Y, Shi M, Liao W (2021) IOBR: multi-omics immuno-oncology biological research to decode tumor microenvironment and signatures. Front Immunol 12:687975. https:\/\/doi.org\/10.3389\/fimmu.2021.687975","journal-title":"Front Immunol"},{"issue":"1","key":"711_CR25","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12943-022-01596-8","volume":"21","author":"X Wang","year":"2022","unstructured":"Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J (2022) Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells. Mol Cancer 21(1):133. https:\/\/doi.org\/10.1186\/s12943-022-01596-8","journal-title":"Mol Cancer"},{"issue":"9","key":"711_CR26","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.tcb.2022.03.010","volume":"32","author":"VK Gupta","year":"2022","unstructured":"Gupta VK, Chaudhuri O (2022) Mechanical regulation of cell-cycle progression and division. Trends Cell Biol 32(9):773\u2013785. https:\/\/doi.org\/10.1016\/j.tcb.2022.03.010","journal-title":"Trends Cell Biol"},{"issue":"3","key":"711_CR27","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1038\/nbt0308-303","volume":"26","author":"M Ringn\u00e9r","year":"2008","unstructured":"Ringn\u00e9r M (2008) What is principal component analysis? Nat Biotechnol 26(3):303\u2013304. https:\/\/doi.org\/10.1038\/nbt0308-303","journal-title":"Nat Biotechnol"},{"issue":"12","key":"711_CR28","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","volume":"16","author":"I Korsunsky","year":"2019","unstructured":"Korsunsky I, Millard N, Fan J, Slowikowski K, Zhang F, Wei K, Baglaenko Y, Brenner M, Loh PR, Raychaudhuri S (2019) Fast, sensitive and accurate integration of single-cell data with harmony. Nat Methods 16(12):1289\u20131296. https:\/\/doi.org\/10.1038\/s41592-019-0619-0","journal-title":"Nat Methods"},{"issue":"1","key":"711_CR29","doi-asserted-by":"publisher","first-page":"zsad265","DOI":"10.1093\/sleep\/zsad265","volume":"47","author":"R Chakraborty","year":"2024","unstructured":"Chakraborty R, Seby C, Scott H, Tang V, Kemps E, Anstice N, Juers E, Lovato N, Taranath DA, Mills RA, Lack LC (2024) Delayed melatonin circadian timing, lower melatonin output, and sleep disruptions in myopic, or short-sighted, children. Sleep 47(1):zsad265. https:\/\/doi.org\/10.1093\/sleep\/zsad265","journal-title":"Sleep"},{"issue":"3","key":"711_CR30","doi-asserted-by":"publisher","first-page":"e14474","DOI":"10.1111\/cns.14474","volume":"30","author":"Y Hu","year":"2024","unstructured":"Hu Y, Lv Y, Long X, Yang G, Zhou J (2024) Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1\/clock interruption. CNS Neurosci Ther 30(3):e14474. https:\/\/doi.org\/10.1111\/cns.14474","journal-title":"CNS Neurosci Ther"},{"issue":"11","key":"711_CR31","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1042\/CS20080014","volume":"115","author":"T Suguro","year":"2008","unstructured":"Suguro T, Watanabe T, Kodate S, Xu G, Hirano T, Adachi M, Miyazaki A (2008) Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in type 2 diabetes. Clin Sci (Lond) 115(11):327\u2013334. https:\/\/doi.org\/10.1042\/CS20080014","journal-title":"Clin Sci (Lond)"},{"key":"711_CR32","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.maturitas.2021.07.004","volume":"152","author":"X Tsekmekidou","year":"2021","unstructured":"Tsekmekidou X, Tsetsos F, Koufakis T, Georgitsi M, Papanas N, Papazoglou D, Roumeliotis A, Panagoutsos S, Thodis E, Theodoridis M, Passadakis P, Maltezos E, Paschou P, Kotsa K (2021) Variants in clock genes could be associated with lower risk of type 2 diabetes in an elderly Greek population. Maturitas 152:20\u201325. https:\/\/doi.org\/10.1016\/j.maturitas.2021.07.004","journal-title":"Maturitas"},{"issue":"1","key":"711_CR33","doi-asserted-by":"publisher","first-page":"16344","DOI":"10.1038\/s41598-019-52735-z","volume":"9","author":"K Muramatsu","year":"2019","unstructured":"Muramatsu K, Chikahisa S, Shimizu N, S\u00e9i H, Inoue Y (2019) Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients\u2019 Sera in a mouse model of restless legs syndrome. Sci Rep 9(1):16344. https:\/\/doi.org\/10.1038\/s41598-019-52735-z","journal-title":"Sci Rep"},{"issue":"10","key":"711_CR34","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.7150\/ijms.85746","volume":"20","author":"Q Zhu","year":"2023","unstructured":"Zhu Q, Cao X, Zhang Y, Zhou Y, Zhang J, Zhang X, Zhu Y, Xue L (2023) Repeated low-level red-light therapy for controlling onset and progression of myopia-a review. Int J Med Sci 20(10):1363\u20131376. https:\/\/doi.org\/10.7150\/ijms.85746","journal-title":"Int J Med Sci"},{"issue":"15","key":"711_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1167\/iovs.64.15.9","volume":"64","author":"M Gijs","year":"2023","unstructured":"Gijs M, Adelaar TI, Vergouwen DPC, Visser N, Dickman MM, Ollivier RCI, Berendschot TTJM, Nuijts RMMA (2023) Tear fluid inflammatory proteome analysis highlights similarities between keratoconus and allergic conjunctivitis. Invest Ophthalmol Vis Sci 64(15):9. https:\/\/doi.org\/10.1167\/iovs.64.15.9","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"711_CR36","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41421-023-00588-2","volume":"9","author":"X Zhu","year":"2023","unstructured":"Zhu X, Meng J, Han C, Wu Q, Du Y, Qi J, Wei L, Li H, He W, Zhang K, Lu Y (2023) CCL2-mediated inflammatory pathogenesis underlies high myopia-related anxiety. Cell Discov 9(1):94. https:\/\/doi.org\/10.1038\/s41421-023-00588-2","journal-title":"Cell Discov"},{"issue":"2","key":"711_CR37","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1167\/iovs.65.2.3","volume":"65","author":"RK Ablordeppey","year":"2024","unstructured":"Ablordeppey RK, Lin CR, Song B, Benavente-Perez A (2024) Choroidal morphology and photoreceptor activity are related and affected by myopia development. Invest Ophthalmol Vis Sci 65(2):3. https:\/\/doi.org\/10.1167\/iovs.65.2.3","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"711_CR38","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1186\/s12967-024-05523-x","volume":"22","author":"R Zhang","year":"2024","unstructured":"Zhang R, Wen Y, Liu J, Hao J, Peng Y, Zhang M, Xie Y, Yang Z, Yin X, Shi Y, Bi H, Guo D (2024) The miR-15b-5p\/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia. J Transl Med 22(1):710. https:\/\/doi.org\/10.1186\/s12967-024-05523-x","journal-title":"J Transl Med"},{"issue":"17","key":"711_CR39","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.3390\/ijms241713662","volume":"24","author":"S Draijer","year":"2023","unstructured":"Draijer S, Timmerman R, Pannekeet J, van Harten A, Farshadi EA, Kemmer J, van Gilst D, Chaves I, Hoekman MFM (2023) FoxO3 modulates circadian rhythms in neural stem cells. Int J Mol Sci 24(17):13662. https:\/\/doi.org\/10.3390\/ijms241713662","journal-title":"Int J Mol Sci"},{"key":"711_CR40","doi-asserted-by":"publisher","first-page":"102878","DOI":"10.1016\/j.ebiom.2020.102878","volume":"57","author":"F Zhao","year":"2020","unstructured":"Zhao F, Zhang D, Zhou Q, Zhao F, He M, Yang Z, Su Y, Zhai Y, Yan J, Zhang G, Xue A, Tang J, Han X, Shi Y, Zhu Y, Liu T, Zhuang W, Huang L, Hong Y, Wu D, Li Y, Lu Q, Chen W, Jiao S, Wang Q, Srinivasalu N, Wen Y, Zeng C, Qu J, Zhou X (2020) Scleral HIF-1\u03b1 is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis. EBioMedicine 57:102878. https:\/\/doi.org\/10.1016\/j.ebiom.2020.102878","journal-title":"EBioMedicine"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-025-00711-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10822-025-00711-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-025-00711-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T18:40:45Z","timestamp":1767638445000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10822-025-00711-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["711"],"URL":"https:\/\/doi.org\/10.1007\/s10822-025-00711-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6821540\/v1","asserted-by":"object"}]},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"4 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"36"}}