{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:20:19Z","timestamp":1778692819504,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971150"],"award-info":[{"award-number":["31971150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"DOI":"10.1007\/s10822-026-00831-4","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:57:55Z","timestamp":1778684275000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A systematic evaluation of protein allosteric site prediction tools with independent datasets"],"prefix":"10.1007","volume":"40","author":[{"given":"Yuanbao","family":"Ai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"issue":"19","key":"831_CR1","doi-asserted-by":"publisher","first-page":"3882","DOI":"10.1016\/j.bpj.2023.08.010","volume":"122","author":"LJ Manley","year":"2023","unstructured":"Manley LJ, Lin MM (2023) Kinetic and thermodynamic allostery in the Ras protein family. Biophys J 122(19):3882\u20133893","journal-title":"Biophys J"},{"issue":"5","key":"831_CR2","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1042\/BST20170569","volume":"46","author":"HR Mott","year":"2018","unstructured":"Mott HR, Owen D (2018) Allostery and dynamics in small G proteins. Biochem Soc Trans 46(5):1333\u20131343","journal-title":"Biochem Soc Trans"},{"issue":"9","key":"831_CR3","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1016\/j.jmb.2012.11.028","volume":"425","author":"HR Saibil","year":"2013","unstructured":"Saibil HR, Fenton WA, Clare DK, Horwich AL (2013) Structure and allostery of the chaperonin GroEL. J Mol Biol 425(9):1476\u20131487","journal-title":"J Mol Biol"},{"issue":"6","key":"831_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1038\/nsmb.2836","volume":"21","author":"LA Amos","year":"2014","unstructured":"Amos LA, Lowe J (2014) The subtle allostery of microtubule dynamics. Nat Struct Mol Biol 21(6):505\u2013506","journal-title":"Nat Struct Mol Biol"},{"issue":"3","key":"831_CR5","doi-asserted-by":"publisher","first-page":"105672","DOI":"10.1016\/j.jbc.2024.105672","volume":"300","author":"M McCullagh","year":"2024","unstructured":"McCullagh M, Zeczycki TN, Kariyawasam CS et al (2024) What is allosteric regulation? Exploring the exceptions that prove the rule!. J Biol Chem 300(3):105672","journal-title":"J Biol Chem"},{"key":"831_CR6","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.sbi.2020.01.011","volume":"62","author":"J Xie","year":"2020","unstructured":"Xie J, Lai L (2020) Protein topology and allostery. Curr Opin Struct Biol 62:158\u2013165","journal-title":"Curr Opin Struct Biol"},{"key":"831_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sbi.2017.10.002","volume":"50","author":"JG Greener","year":"2018","unstructured":"Greener JG, Sternberg MJ (2018) Structure-based prediction of protein allostery. Curr Opin Struct Biol 50:1\u20138","journal-title":"Curr Opin Struct Biol"},{"issue":"5","key":"831_CR8","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.cell.2016.08.015","volume":"166","author":"JP Changeux","year":"2016","unstructured":"Changeux JP, Christopoulos A (2016) Allosteric modulation as a unifying mechanism for receptor function and regulation. Cell 166(5):1084\u20131102","journal-title":"Cell"},{"issue":"2","key":"831_CR9","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.cell.2013.03.034","volume":"153","author":"R Nussinov","year":"2013","unstructured":"Nussinov R, Tsai CJ (2013) Allostery in disease and in drug discovery. Cell 153(2):293\u2013305","journal-title":"Cell"},{"issue":"1","key":"831_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.drudis.2019.10.006","volume":"25","author":"S Lu","year":"2020","unstructured":"Lu S, Qiu Y, Ni D et al (2020) Emergence of allosteric drug-resistance mutations: new challenges for allosteric drug discovery. Drug Discov Today 25(1):177\u2013184","journal-title":"Drug Discov Today"},{"issue":"4","key":"831_CR11","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1039\/D4CB00282B","volume":"6","author":"R Zhu","year":"2025","unstructured":"Zhu R, Wu C, Zha J et al (2025) Decoding allosteric landscapes: computational methodologies for enzyme modulation and drug discovery. RSC Chem Biol 6(4):539\u2013554","journal-title":"RSC Chem Biol"},{"issue":"8061","key":"831_CR12","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/s41586-025-08766-w","volume":"641","author":"T Shahid","year":"2025","unstructured":"Shahid T, Danazumi AU, Tehseen M et al (2025) Structural dynamics of DNA unwinding by a replicative helicase. Nature 641(8061):240\u2013249","journal-title":"Nature"},{"issue":"6","key":"831_CR13","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.str.2022.03.008","volume":"30","author":"ZL Li","year":"2022","unstructured":"Li ZL, Mattos C, Buck M (2022) Computational studies of the principle of dynamic-change-driven protein interactions. Structure 30(6):909\u2013916","journal-title":"Structure"},{"issue":"18","key":"831_CR14","doi-asserted-by":"publisher","first-page":"8699","DOI":"10.1021\/acs.jctc.5c01094","volume":"21","author":"AP Kornev","year":"2025","unstructured":"Kornev AP (2025) LSP-MD: a fast computational method to study allostery driven by thermal vibrations. J Chem Theory Comput 21(18):8699\u20138710","journal-title":"J Chem Theory Comput"},{"key":"831_CR15","doi-asserted-by":"publisher","first-page":"103159","DOI":"10.1016\/j.sbi.2025.103159","volume":"95","author":"VG Fidan","year":"2025","unstructured":"Fidan VG, Ilim K, Gursoy A et al (2025) Rewiring enzyme regulation: allosteric drugs and predictive tools. Curr Opin Struct Biol 95:103159","journal-title":"Curr Opin Struct Biol"},{"issue":"8","key":"831_CR16","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1016\/j.bbapap.2010.10.008","volume":"1814","author":"A Peracchi","year":"2011","unstructured":"Peracchi A, Mozzarelli A (2011) Exploring and exploiting allostery: models, evolution, and drug targeting. Biochim Biophys Acta 1814(8):922\u2013933","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"831_CR17","doi-asserted-by":"publisher","first-page":"100408","DOI":"10.1016\/j.patter.2021.100408","volume":"3","author":"N Wu","year":"2022","unstructured":"Wu N, Stromich L, Yaliraki SN (2022) Prediction of allosteric sites and signaling: insights from benchmarking datasets. Patterns (N Y) 3(1):100408","journal-title":"Patterns (N Y)"},{"issue":"12","key":"831_CR18","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.tips.2011.08.004","volume":"32","author":"R Nussinov","year":"2011","unstructured":"Nussinov R, Tsai C, Csermely P (2011) Allo-network drugs: harnessing allostery in cellular networks. Trends Pharmacol Sci 32(12):686\u2013693","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"831_CR19","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.cell.2016.08.015","volume":"166","author":"J Changeux","year":"2016","unstructured":"Changeux J, Christopoulos A (2016) Allosteric modulation as a unifying mechanism for receptor function and regulation. Cell 166(5):1084\u20131102","journal-title":"Cell"},{"issue":"7712","key":"831_CR20","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41586-018-0259-z","volume":"559","author":"DM Thal","year":"2018","unstructured":"Thal DM, Glukhova A, Sexton PM et al (2018) Structural insights into G-protein-coupled receptor allostery. Nature 559(7712):45\u201353","journal-title":"Nature"},{"issue":"1","key":"831_CR21","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.ccell.2025.09.014","volume":"44","author":"EL Diamond","year":"2026","unstructured":"Diamond EL, Emile JF, Fujino T et al (2026) RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition. Cancer Cell 44(1):203\u2013220","journal-title":"Cancer Cell"},{"issue":"4","key":"831_CR22","doi-asserted-by":"publisher","first-page":"e197192","DOI":"10.1172\/JCI197192","volume":"136","author":"R Xu","year":"2026","unstructured":"Xu R, Wang D, Ma G et al (2026) Cotargeting DNA topoisomerase II enhances efficacy of RAS-targeted therapy in KRAS-mutant cancer models. J Clin Invest 136(4):e197192","journal-title":"J Clin Invest"},{"key":"831_CR23","doi-asserted-by":"publisher","first-page":"103159","DOI":"10.1016\/j.sbi.2025.103159","volume":"95","author":"VG Fidan","year":"2025","unstructured":"Fidan VG, Ilim K, Gursoy A, Ozkan SB, Keskin O (2025) Rewiring enzyme regulation: allosteric drugs and predictive tools. Curr Opin Struct Biol 95:103159","journal-title":"Curr Opin Struct Biol"},{"issue":"25","key":"831_CR24","doi-asserted-by":"publisher","first-page":"7057","DOI":"10.1039\/D2SC06272K","volume":"14","author":"G La Sala","year":"2023","unstructured":"La Sala G, Pfleger C, K\u00e4ck H et al (2023) Combining structural and coevolution information to unveil allosteric sites. Chem Sci 14(25):7057\u20137067","journal-title":"Chem Sci"},{"issue":"15","key":"831_CR25","doi-asserted-by":"publisher","first-page":"16766","DOI":"10.1021\/acs.jmedchem.5c01619","volume":"68","author":"X Qiao","year":"2025","unstructured":"Qiao X, Zhu C, Lan X et al (2025) Identification of an unexplored dynamic allosteric site on the activation pathway of the vasopressin V2 receptor. J Med Chem 68(15):16766\u201316780","journal-title":"J Med Chem"},{"issue":"1","key":"831_CR26","doi-asserted-by":"publisher","first-page":"8130","DOI":"10.1038\/s41467-024-52399-y","volume":"15","author":"X Chen","year":"2024","unstructured":"Chen X, Wang K, Chen J et al (2024) Integrative residue-intuitive machine learning and MD approach to unveil allosteric site and mechanism for \u03b22AR. Nat Commun 15(1):8130","journal-title":"Nat Commun"},{"issue":"25","key":"831_CR27","doi-asserted-by":"publisher","first-page":"11277","DOI":"10.1073\/pnas.0914611107","volume":"107","author":"E Laine","year":"2010","unstructured":"Laine E, Goncalves C, Karst JC et al (2010) Use of allostery to identify inhibitors of calmodulin-induced activation of Bacillus anthracis edema factor. Proc Natl Acad Sci USA 107(25):11277\u201311282","journal-title":"Proc Natl Acad Sci USA"},{"key":"831_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1186\/1471-2105-13-273","volume":"13","author":"A Panjkovich","year":"2012","unstructured":"Panjkovich A, Daura X (2012) Exploiting protein flexibility to predict the location of allosteric sites. BMC Bioinform 13:273","journal-title":"BMC Bioinformatics"},{"issue":"3\u20134","key":"831_CR29","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/minf.201500108","volume":"35","author":"AS Chen","year":"2016","unstructured":"Chen AS, Westwood NJ, Brear P et al (2016) A random forest model for predicting allosteric and functional sites on proteins. Mol Inf 35(3\u20134):125\u2013135","journal-title":"Mol Inf"},{"issue":"18","key":"831_CR30","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1093\/bioinformatics\/btt399","volume":"29","author":"W Huang","year":"2013","unstructured":"Huang W, Lu S, Huang Z et al (2013) Allosite: a method for predicting allosteric sites. Bioinformatics 29(18):2357\u20132359","journal-title":"Bioinformatics"},{"issue":"W1","key":"831_CR31","doi-asserted-by":"publisher","first-page":"W33","DOI":"10.1093\/nar\/gkad279","volume":"51","author":"J Zha","year":"2023","unstructured":"Zha J, Li Q, Liu X et al (2023) AlloReverse: multiscale understanding among hierarchical allosteric regulations. Nucleic Acids Res 51(W1):W33\u2013W38","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"831_CR32","doi-asserted-by":"publisher","first-page":"W427","DOI":"10.1093\/nar\/gkad303","volume":"51","author":"H Tian","year":"2023","unstructured":"Tian H, Xiao S, Jiang X et al (2023) PASSer: fast and accurate prediction of protein allosteric sites. Nucleic Acids Res 51(W1):W427\u2013W431","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"831_CR33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.32607\/20758251-2019-11-1-74-80","volume":"11","author":"A Zlobin","year":"2019","unstructured":"Zlobin A, Suplatov D, Kopylov K et al (2019) CASBench: a benchmarking set of proteins with annotated catalytic and allosteric sites in their structures. Acta Nat 11(1):74\u201380","journal-title":"Acta Naturae"},{"issue":"15","key":"831_CR34","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.1093\/bioinformatics\/btv169","volume":"31","author":"W Huang","year":"2015","unstructured":"Huang W, Wang G, Shen Q et al (2015) ASBench: benchmarking sets for allosteric discovery. Bioinformatics 31(15):2598\u20132600","journal-title":"Bioinformatics"},{"issue":"4","key":"831_CR35","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.tibs.2022.12.001","volume":"48","author":"S Xiao","year":"2023","unstructured":"Xiao S, Verkhivker GM, Tao P (2023) Machine learning and protein allostery. Trends Biochem Sci 48(4):375\u2013390","journal-title":"Trends Biochem Sci"},{"key":"831_CR36","doi-asserted-by":"crossref","unstructured":"Huang Z, Zhu L,Cao Y, et al (2011) ASD: a comprehensive database of allosteric proteins and modulators[J]. Nucleic Acids Res 39(Database issue):D663\u2013D669","DOI":"10.1093\/nar\/gkq1022"},{"issue":"2","key":"831_CR37","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.apsb.2021.06.015","volume":"12","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Chen Y, Ni D et al (2022) Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells. Acta Pharm Sin B 12(2):876\u2013889","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"831_CR38","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1039\/D0SC05131D","volume":"12","author":"D Ni","year":"2020","unstructured":"Ni D, Wei J, He X et al (2020) Discovery of cryptic allosteric sites using reversed allosteric communication by a combined computational and experimental strategy. Chem Sci 12(1):464\u2013476","journal-title":"Chem Sci"},{"issue":"1","key":"831_CR39","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1021\/acschemneuro.3c00684","volume":"15","author":"MT Rahman","year":"2024","unstructured":"Rahman MT, Guan D, Chaminda Lakmal HH et al (2024) Design, synthesis, and structure-activity relationship studies of novel GPR88 agonists (4-substituted-phenyl)acetamides based on the reversed amide scaffold. ACS Chem Neurosci 15(1):169\u2013192","journal-title":"ACS Chem Neurosci"},{"key":"831_CR40","doi-asserted-by":"crossref","unstructured":"Kumar A, Kaynak BT, Dorman KS et al (2023) Predicting allosteric pockets in protein biological assemblages. Bioinformatics 39(5):btad275","DOI":"10.1093\/bioinformatics\/btad275"},{"issue":"3","key":"831_CR41","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S1359-0278(97)00024-2","volume":"2","author":"I Bahar","year":"1997","unstructured":"Bahar I, Atilgan AR, Erman B (1997) Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential. Fold Des 2(3):173\u2013181","journal-title":"Fold Des"},{"key":"831_CR42","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/1471-2105-10-168","volume":"10","author":"V Le Guilloux","year":"2009","unstructured":"Le Guilloux V, Schmidtke P, Tuffery P (2009) Fpocket: an open source platform for ligand pocket detection. BMC Bioinform 10:168","journal-title":"BMC Bioinformatics"},{"issue":"W1","key":"831_CR43","doi-asserted-by":"publisher","first-page":"W374","DOI":"10.1093\/nar\/gky380","volume":"46","author":"Y Xu","year":"2018","unstructured":"Xu Y, Wang S, Hu Q et al (2018) CavityPlus: a web server for protein cavity detection with pharmacophore modelling, allosteric site identification and covalent ligand binding ability prediction. Nucleic Acids Res 46(W1):W374\u2013W379","journal-title":"Nucleic Acids Res"},{"issue":"14","key":"831_CR44","doi-asserted-by":"publisher","first-page":"168141","DOI":"10.1016\/j.jmb.2023.168141","volume":"435","author":"S Wang","year":"2023","unstructured":"Wang S, Xie J, Pei J et al (2023) CavityPlus 2022 update: an integrated platform for comprehensive protein cavity detection and property analyses with user-friendly tools and cavity databases. J Mol Biol 435(14):168141","journal-title":"J Mol Biol"},{"key":"831_CR45","doi-asserted-by":"crossref","unstructured":"Chen T, Guestrin C (2016) XGBoost a scalable tree boosting system. Proceedings of the 22nd ACM sigkdd international conference on knowledge discovery and data mining, pp 785\u2013794","DOI":"10.1145\/2939672.2939785"},{"key":"831_CR46","doi-asserted-by":"crossref","unstructured":"Tian H, Jiang X, Tao P (2021) PASSer: prediction of allosteric sites server. Mach Learn Sci Technol 2(3):035015","DOI":"10.1088\/2632-2153\/abe6d6"},{"key":"831_CR47","doi-asserted-by":"publisher","first-page":"879251","DOI":"10.3389\/fmolb.2022.879251","volume":"9","author":"S Xiao","year":"2022","unstructured":"Xiao S, Tian H, Tao P (2022) PASSer2.0: accurate prediction of protein allosteric sites through automated machine learning. Front Mol Biosci 9:879251","journal-title":"Front Mol Biosci"},{"key":"831_CR48","unstructured":"Erickson N, Mueller J, Shirkov A et al (2020) AutoGluon-tabular robust and accurate AutoML for structured data. arXiv preprint. https:\/\/arxiv.org\/abs\/2003.06505"},{"key":"831_CR49","doi-asserted-by":"publisher","unstructured":"Ke G, Meng Q, Finley T et al (2017) LightGBM:a highly efficient gradient boosting decision tree. in Proceedings of the 31st International Conference on Neural Information Proceeding Systems (NIPS \u201917): 3146-3154 https:\/\/doi.org\/10.5555\/3294996.3295074","DOI":"10.5555\/3294996.3295074"},{"issue":"28","key":"831_CR50","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1002\/jcc.27193","volume":"44","author":"H Tian","year":"2023","unstructured":"Tian H, Xiao S, Jiang X et al (2023) PASSerRank: prediction of allosteric sites with learning to rank. J Comput Chem 44(28):2223\u20132229","journal-title":"J Comput Chem"},{"key":"831_CR51","doi-asserted-by":"publisher","unstructured":"Cheltsov A(2025) Q-MOL high fidelity platform for in silico drug discovery and design. bioRxiv. https:\/\/doi.org\/10.1101\/2025.08.06.668254","DOI":"10.1101\/2025.08.06.668254"}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-026-00831-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10822-026-00831-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10822-026-00831-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:03:12Z","timestamp":1778691792000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10822-026-00831-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["831"],"URL":"https:\/\/doi.org\/10.1007\/s10822-026-00831-4","relation":{},"ISSN":["1573-4951"],"issn-type":[{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"12 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"122"}}