{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:10:43Z","timestamp":1759032643897},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T00:00:00Z","timestamp":1298332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Neurosci"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1007\/s10827-011-0317-0","type":"journal-article","created":{"date-parts":[[2011,2,21]],"date-time":"2011-02-21T13:40:18Z","timestamp":1298295618000},"page":"385-400","source":"Crossref","is-referenced-by-count":31,"title":["Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling"],"prefix":"10.1007","volume":"31","author":[{"given":"Sherry-Ann","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion I.","family":"Moraru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Schaff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie M.","family":"Loew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,2,22]]},"reference":[{"key":"317_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","volume":"1","author":"M Berridge","year":"2000","unstructured":"Berridge, M., Lipp, P., & Bootman, M. (2000). The versatility and universality of calcium signalling. Nature Reviews. Molecular Cell Biology, 1, 11\u201321.","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"317_CR2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0166-2236(92)90009-W","volume":"15","author":"U Bhalla","year":"1992","unstructured":"Bhalla, U., Bilitch, D., & Bower, J. (1992). Rallpacks: a set of benchmarks for neuronal simulators. Trends in Neurosciences, 15, 453\u2013458.","journal-title":"Trends in Neurosciences"},{"key":"317_CR3","doi-asserted-by":"crossref","unstructured":"Booth, V., Rinzel, J., & Kiehn, O. (1997). Compartmental model of vertebrate motoneurons for Ca2+-dependent spiking and plateau potentials under pharmacological treatment. J Neurophysiol, 78, 3371\u20133385.","DOI":"10.1152\/jn.1997.78.6.3371"},{"key":"317_CR4","unstructured":"Bower, J. M. & Beeman, D. (2003) The Book of GENESIS: Exploring Realistic Neural Models with the GEneral NEural SImulation System (Free Internet Version). New York, New York: Springer-Verlag."},{"key":"317_CR5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/978-1-59745-520-6_7","volume":"401","author":"J Bower","year":"2007","unstructured":"Bower, J., & Beeman, D. (2007). Constructing realistic neural simulations with GENESIS. Methods Mol Biol, 401, 103\u2013125.","journal-title":"Methods Mol Biol"},{"key":"317_CR6","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1529\/biophysj.108.130195","volume":"95","author":"S Brown","year":"2008","unstructured":"Brown, S., Morgan, F., Watras, J., & Loew, L. M. (2008). Analysis of phosphatidylinositol-4, 5-bisphosphate signaling in cerebellar Purkinje spines. Biophysical Journal, 95, 1795\u20131812.","journal-title":"Biophysical Journal"},{"key":"317_CR7","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1152\/jn.1994.72.5.2302","volume":"72","author":"R Burke","year":"1994","unstructured":"Burke, R., Fyffe, R., & Moschovakis, A. (1994). Electrotonic architecture of cat gamma motoneurons. J Neurophysiol, 72, 2302\u20132316.","journal-title":"J Neurophysiol"},{"key":"317_CR8","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0165-0270(93)90151-G","volume":"46","author":"P Bush","year":"1993","unstructured":"Bush, P., & Sejnowski, T. (1993). Reduced compartmental models of neocortical pyramidal cells. J Neurosci Methods, 46, 159\u2013166.","journal-title":"J Neurosci Methods"},{"key":"317_CR9","doi-asserted-by":"crossref","unstructured":"Clements, J., & Redman, S. (1989). Cable properties of cat spinal motoneurones measured by combining voltage clamp, current clamp and intracellular staining. J Physiol, 409, 63\u201387.","DOI":"10.1113\/jphysiol.1989.sp017485"},{"key":"317_CR10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1152\/jn.1994.71.1.375","volume":"71","author":"E Schutter De","year":"1994","unstructured":"De Schutter, E., & Bower, J. (1994). An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. Journal of Neurophysiology, 71, 375\u2013400.","journal-title":"Journal of Neurophysiology"},{"issue":"Pt 2","key":"317_CR11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/bj3220575","volume":"322","author":"H Smedt De","year":"1997","unstructured":"De Smedt, H., Missiaen, L., Parys, J., Henning, R., Sienaert, I., Vanlingen, S., et al. (1997). Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin. The Biochemical Journal, 322(Pt 2), 575\u2013583.","journal-title":"The Biochemical Journal"},{"key":"317_CR12","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/S0006-3495(93)81190-1","volume":"65","author":"A Destexhe","year":"1993","unstructured":"Destexhe, A., Babloyantz, A., & Sejnowski, T. (1993). Ionic mechanisms for intrinsic slow oscillations in thalamic relay neurons. Biophysical Journal, 65, 1538\u20131552.","journal-title":"Biophysical Journal"},{"key":"317_CR13","doi-asserted-by":"crossref","unstructured":"Di Gregorio, E., Orsi, L., Godani, M., Vaula, G., Jensen, S., Salmon, E., et al. (2010) Two Italian families with ITPR1 gene deletion presenting a broader phenotype of SCA15. Cerebellum.","DOI":"10.1007\/s12311-009-0154-0"},{"key":"317_CR14","first-page":"381","volume-title":"Single neuron computation","author":"R Douglas","year":"1993","unstructured":"Douglas, R., & Martin, K. (1993). Exploring cortical microcircuits: A combined anatomical, physiological, and computational approach. In T. McKenna et al. (Eds.), Single neuron computation (pp. 381\u2013412). Orlando, FL: Academic Press."},{"key":"317_CR15","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/25541","volume":"396","author":"E Finch","year":"1998","unstructured":"Finch, E., & Augustine, G. (1998). Local calcium signalling by inositol-1, 4, 5-trisphosphate in Purkinje cell dendrites. Nature, 396, 753\u2013756.","journal-title":"Nature"},{"key":"317_CR16","doi-asserted-by":"crossref","unstructured":"Fleshman, J., Segev, I., & Burke, R. (1988). Electrotonic architecture of type-identified alpha-motoneurons in the cat spinal cord. J Neurophysiol, 60, 60\u201385.","DOI":"10.1152\/jn.1988.60.1.60"},{"key":"317_CR17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0006-8993(77)90997-0","volume":"128","author":"P Gilbert","year":"1977","unstructured":"Gilbert, P., & Thach, W. (1977). Purkinje cell activity during motor learning. Brain Research, 128, 309\u2013328.","journal-title":"Brain Research"},{"key":"317_CR18","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1212\/01.wnl.0000311277.71046.a0","volume":"71","author":"K Hara","year":"2008","unstructured":"Hara, K., Shiga, A., Nozaki, H., Mitsui, J., Takahashi, Y., Ishiguro, H., et al. (2008). Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families. Neurology, 71, 547\u2013551.","journal-title":"Neurology"},{"key":"317_CR19","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1523\/JNEUROSCI.08-12-04455.1988","volume":"8","author":"K Harris","year":"1988","unstructured":"Harris, K., & Stevens, J. (1988). Dendritic spines of rat cerebellar Purkinje cells: serial electron microscopy with reference to their biophysical characteristics. The Journal of Neuroscience, 8, 4455\u20134469.","journal-title":"The Journal of Neuroscience"},{"key":"317_CR20","unstructured":"Hendrickson, E., Edgerton, J., & Jaeger, D. (2010). The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. J Comput Neurosci."},{"key":"317_CR21","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1529\/biophysj.105.065771","volume":"89","author":"N Hernjak","year":"2005","unstructured":"Hernjak, N., Slepchenko, B. M., Fernald, K., Fink, C. C., Fortin, D., Moraru, I. I., et al. (2005). Modeling and analysis of calcium signaling events leading to long-term depression in cerebellar purkinje cells. Biophysical Journal, 89, 3790\u20133806.","journal-title":"Biophysical Journal"},{"key":"317_CR22","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1162\/neco.1997.9.6.1179","volume":"9","author":"ML Hines","year":"1997","unstructured":"Hines, M. L., & Carnevale, N. T. (1997). The NEURON simulation environment. Neural Computation, 9, 1179\u20131209.","journal-title":"Neural Computation"},{"key":"317_CR23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/107385840100700207","volume":"7","author":"ML Hines","year":"2001","unstructured":"Hines, M. L., & Carnevale, N. T. (2001). NEURON: a tool for neuroscientists. The Neuroscientist, 7, 123\u2013135.","journal-title":"The Neuroscientist"},{"key":"317_CR24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","volume":"117","author":"AL Hodgkin","year":"1952","unstructured":"Hodgkin, A. L., & Huxley, A. F. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of Physiology, 117, 500\u2013544.","journal-title":"The Journal of Physiology"},{"key":"317_CR25","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0304-3940(82)90380-9","volume":"33","author":"M Ito","year":"1982","unstructured":"Ito, M., & Kano, M. (1982). Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neuroscience Letters, 33, 253\u2013258.","journal-title":"Neuroscience Letters"},{"key":"317_CR26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/jmg.2007.053942","volume":"45","author":"A Iwaki","year":"2008","unstructured":"Iwaki, A., Kawano, Y., Miura, S., Shibata, H., Matsuse, D., Li, W., et al. (2008). Heterozygous deletion of ITPR1, but not SUMF1, in spinocerebellar ataxia type 16. Journal of Medical Genetics, 45, 32\u201335.","journal-title":"Journal of Medical Genetics"},{"key":"317_CR27","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1073\/pnas.89.15.7051","volume":"89","author":"A Konnerth","year":"1992","unstructured":"Konnerth, A., Dreessen, J., & Augustine, G. (1992). Brief dendritic calcium signals initiate long-lasting synaptic depression in cerebellar Purkinje cells. Proceedings of the National Academy of Sciences of the United States of America, 89, 7051\u20137055.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"317_CR28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0167-7799(01)01740-1","volume":"19","author":"L Loew","year":"2001","unstructured":"Loew, L., & Schaff, J. (2001). The virtual cell: a software environment for computational cell biology. Trends in Biotechnology, 19, 401\u2013406.","journal-title":"Trends in Biotechnology"},{"key":"317_CR29","doi-asserted-by":"crossref","first-page":"4613","DOI":"10.1523\/JNEUROSCI.14-08-04613.1994","volume":"14","author":"G Major","year":"1994","unstructured":"Major, G., Larkman, A., Jonas, P., Sakmann, B., & Jack, J. (1994). Detailed passive cable models of whole-cell recorded CA3 pyramidal neurons in rat hippocampal slices. The Journal of Neuroscience, 14, 4613\u20134638.","journal-title":"The Journal of Neuroscience"},{"key":"317_CR30","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0006-3495(91)82178-6","volume":"60","author":"Y Manor","year":"1991","unstructured":"Manor, Y., Gonczarowski, J., & Segev, I. (1991). Propagation of action potentials along complex axonal trees. Model and implementation. Biophys J, 60, 1411\u20131423.","journal-title":"Biophys J"},{"key":"317_CR31","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/379168a0","volume":"379","author":"M Matsumoto","year":"1996","unstructured":"Matsumoto, M., Nakagawa, T., Inoue, T., Nagata, E., Tanaka, K., Takano, H., et al. (1996). Ataxia and epileptic seizures in mice lacking type 1 inositol 1, 4, 5-trisphosphate receptor. Nature, 379, 168\u2013171.","journal-title":"Nature"},{"key":"317_CR32","doi-asserted-by":"crossref","unstructured":"McCormick, D., & Huguenard, J. (1992). A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol, 68, 1384\u20131400.","DOI":"10.1152\/jn.1992.68.4.1384"},{"key":"317_CR33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0006-8993(00)03206-6","volume":"891","author":"T Miyasho","year":"2001","unstructured":"Miyasho, T., Takagi, H., Suzuki, H., Watanabe, S., Inoue, M., Kudo, Y., et al. (2001). Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain Research, 891, 106\u2013115.","journal-title":"Brain Research"},{"key":"317_CR34","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/j.1749-6632.2002.tb04535.x","volume":"971","author":"II Moraru","year":"2002","unstructured":"Moraru, I. I., Schaff, J. C., Slepchenko, B. M., & Loew, L. M. (2002). The virtual cell: an integrated modeling environment for experimental and computational cell biology. Annals of the New York Academy of Sciences, 971, 595\u2013596.","journal-title":"Annals of the New York Academy of Sciences"},{"key":"317_CR35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/cne.902740204","volume":"274","author":"R Napper","year":"1988","unstructured":"Napper, R., & Harvey, R. (1988a). Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. The Journal of Comparative Neurology, 274, 168\u2013177.","journal-title":"The Journal of Comparative Neurology"},{"key":"317_CR36","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/cne.902740203","volume":"274","author":"R Napper","year":"1988","unstructured":"Napper, R., & Harvey, R. (1988b). Quantitative study of the Purkinje cell dendritic spines in the rat cerebellum. The Journal of Comparative Neurology, 274, 158\u2013167.","journal-title":"The Journal of Comparative Neurology"},{"key":"317_CR37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0166-4328(01)00187-5","volume":"122","author":"H Ogura","year":"2001","unstructured":"Ogura, H., Matsumoto, M., & Mikoshiba, K. (2001). Motor discoordination in mutant mice heterozygous for the type 1 inositol 1, 4, 5-trisphosphate receptor. Behavioural Brain Research, 122, 215\u2013219.","journal-title":"Behavioural Brain Research"},{"key":"317_CR38","doi-asserted-by":"crossref","unstructured":"Pinsky, P., & Rinzel, J. (1994). Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci, 1, 39\u201360.","DOI":"10.1007\/BF00962717"},{"key":"317_CR39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0006-3495(62)86953-7","volume":"2","author":"W RALL","year":"1962","unstructured":"RALL, W. (1962). Electrophysiology of a dendritic neuron model. Biophysical Journal, 2, 145\u2013167.","journal-title":"Biophysical Journal"},{"key":"317_CR40","doi-asserted-by":"crossref","unstructured":"Rall, W. (1969). Time constants and electrotonic length of membrane cylinders and neurons. Biophysical Journal, 9, 1483\u20131508.","DOI":"10.1016\/S0006-3495(69)86467-2"},{"key":"317_CR41","doi-asserted-by":"crossref","unstructured":"Rall, W., Rinzel, J. (1973). Branch input resistance and steady attenuation for input to one branch of a dendritic neuron model. Biophys J, 13, 648\u2013687.","DOI":"10.1016\/S0006-3495(73)86014-X"},{"key":"317_CR42","unstructured":"Rall, W., & Agmon-Snir, H. (1998). Cable theory for dendritic neurons. In C. Koch & I. Segev (Eds.), Methods in neuronal modeling: From ions to networks. Cambridge: MIT."},{"key":"317_CR43","doi-asserted-by":"crossref","unstructured":"Rapp, M., Yarom, Y., & Segev, I. (1992). The impact of parallel fiber background activity on the cable properties of cerebellar Purkinje cells. Neural Computation, 4, 518\u2013533.","DOI":"10.1162\/neco.1992.4.4.518"},{"key":"317_CR44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1113\/jphysiol.1994.sp020006","volume":"474","author":"M Rapp","year":"1994","unstructured":"Rapp, M., Segev, I., & Yarom, Y. (1994). Physiology, morphology and detailed passive models of guinea-pig cerebellar Purkinje-cells. Journal of Physiology, London, 474, 101\u2013118.","journal-title":"Journal of Physiology, London"},{"key":"317_CR45","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0896-6273(94)90216-X","volume":"12","author":"W Regehr","year":"1994","unstructured":"Regehr, W., & Mintz, I. (1994). Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses. Neuron, 12, 605\u2013613.","journal-title":"Neuron"},{"key":"317_CR46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0006-3495(74)85948-5","volume":"14","author":"J Rinzel","year":"1974","unstructured":"Rinzel, J., & Rall, W. (1974). Transient response in a dendritic neuron model for current injected at one branch. Biophys J, 14, 759\u2013790.","journal-title":"Biophys J"},{"key":"317_CR47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1523\/JNEUROSCI.1729-07.2008","volume":"28","author":"D Sarkisov","year":"2008","unstructured":"Sarkisov, D., & Wang, S. (2008). Order-dependent coincidence detection in cerebellar Purkinje neurons at the inositol trisphosphate receptor. The Journal of Neuroscience, 28, 133\u2013142.","journal-title":"The Journal of Neuroscience"},{"key":"317_CR48","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/S0006-3495(97)78146-3","volume":"73","author":"J Schaff","year":"1997","unstructured":"Schaff, J., Fink, C., Slepchenko, B., Carson, J., & Loew, L. (1997). A general computational framework for modeling cellular structure and function. Biophysical Journal, 73, 1135\u20131146.","journal-title":"Biophysical Journal"},{"key":"317_CR49","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0306-4522(85)90168-X","volume":"14","author":"D Shelton","year":"1985","unstructured":"Shelton, D. (1985). Membrane resistivity estimated for the Purkinje neuron by means of a passive computer model. Neuroscience, 14, 111\u2013131.","journal-title":"Neuroscience"},{"key":"317_CR50","unstructured":"Stratford, K., Mason, A., Larkman, A., Major, G., Jack, J. (1989). The modelling of pyramidal neurones in the visual cortex. In: The Computing Neuron (Durbin, R. et al., eds), pp 296-321 London, England: Addison-Wesley."},{"key":"317_CR51","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1523\/JNEUROSCI.17-02-00635.1997","volume":"17","author":"V Street","year":"1997","unstructured":"Street, V., Bosma, M., Demas, V., Regan, M., Lin, D., Robinson, L., et al. (1997). The type 1 inositol 1, 4, 5-trisphosphate receptor gene is altered in the opisthotonos mouse. The Journal of Neuroscience, 17, 635\u2013645.","journal-title":"The Journal of Neuroscience"},{"key":"317_CR52","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/25547","volume":"396","author":"H Takechi","year":"1998","unstructured":"Takechi, H., Eilers, J., & Konnerth, A. (1998). A new class of synaptic response involving calcium release in dendritic spines. Nature, 396, 757\u2013760.","journal-title":"Nature"},{"key":"317_CR53","doi-asserted-by":"crossref","unstructured":"Traub, R., Wong, R., Miles, R., Michelson, H. (1991). A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances. J Neurophysiol, 66, 635\u2013650.","DOI":"10.1152\/jn.1991.66.2.635"},{"key":"317_CR54","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1371\/journal.pgen.0030108","volume":"3","author":"J Leemput van de","year":"2007","unstructured":"van de Leemput, J., Chandran, J., Knight, M., Holtzclaw, L., Scholz, S., Cookson, M., et al. (2007). Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genetics, 3, e108.","journal-title":"PLoS Genetics"},{"key":"317_CR55","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1038\/81792","volume":"3","author":"S Wang","year":"2000","unstructured":"Wang, S., Denk, W., & H\u00e4usser, M. (2000). Coincidence detection in single dendritic spines mediated by calcium release. Nature Neuroscience, 3, 1266\u20131273.","journal-title":"Nature Neuroscience"},{"key":"317_CR56","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1620\/tjem.214.175","volume":"214","author":"M Watanabe","year":"2008","unstructured":"Watanabe, M. (2008). Molecular mechanisms governing competitive synaptic wiring in cerebellar Purkinje cells. The Tohoku Journal of Experimental Medicine, 214, 175\u2013190.","journal-title":"The Tohoku Journal of Experimental Medicine"}],"container-title":["Journal of Computational Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10827-011-0317-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10827-011-0317-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10827-011-0317-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,8]],"date-time":"2019-06-08T14:00:23Z","timestamp":1560002423000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10827-011-0317-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,22]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["317"],"URL":"https:\/\/doi.org\/10.1007\/s10827-011-0317-0","relation":{},"ISSN":["0929-5313","1573-6873"],"issn-type":[{"value":"0929-5313","type":"print"},{"value":"1573-6873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,22]]}}}