{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:26:47Z","timestamp":1778689607048,"version":"3.51.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Comput Neurosci"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s10827-020-00755-4","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T14:02:47Z","timestamp":1596722567000},"page":"317-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Spatiotemporal regulation of GABA concentration in extracellular space by gliotransmission crucial for extrasynaptic receptor-mediated improvement of sensory tuning performance in schizophrenia"],"prefix":"10.1007","volume":"48","author":[{"given":"Osamu","family":"Hoshino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikiya","family":"Kameno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"755_CR1","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1152\/jn.2002.88.3.1407","volume":"88","author":"L Barakat","year":"2002","unstructured":"Barakat, L., & Bordey, A. (2002). GAT-1 and reversible GABA transport in Bergmann glia in slices. Journal of Neurophysiology, 88, 1407\u20131419.","journal-title":"Journal of Neurophysiology"},{"key":"755_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","volume":"35","author":"G Buzs\u00e1ki","year":"2012","unstructured":"Buzs\u00e1ki, G., & Wang, X. J. (2012). Mechanisms of gamma oscillations. Annual Review of Neuroscience, 35, 203\u201325.","journal-title":"Annual Review of Neuroscience"},{"key":"755_CR3","doi-asserted-by":"publisher","first-page":"10251","DOI":"10.1523\/JNEUROSCI.22-23-10251.2002","volume":"22","author":"CS Chiu","year":"2002","unstructured":"Chiu, C. S., Jensen, K., Sokolova, I., Wang, D., Li, M., Deshpande, P., Davidson, N., Mody, I., Quick, M. W., Quake, S. R., & Lester, H. A. (2002). Number, density, and surface\/cytoplasmic distribution of GABA transporters at presynaptic structures of knock-in mice carrying GABA transporter subtype 1-green fluorescent protein fusions. The Journal of Neuroscience, 22, 10251\u201310266.","journal-title":"The Journal of Neuroscience"},{"key":"755_CR4","unstructured":"Destexhe, A., Mainen, Z. F., & Sejnowski, T. J. (1998). Kinetic models of synaptic transmission. In Koch, C., & Segev, I. (Eds.) Methods in neuronal modeling (pp. 1\u201325). Cambridge: MIT Press."},{"key":"755_CR5","doi-asserted-by":"publisher","first-page":"15721","DOI":"10.1523\/JNEUROSCI.4426-09.2009","volume":"29","author":"RA Edden","year":"2009","unstructured":"Edden, R. A., Muthukumaraswamy, S. D., Freeman, T. C., & Singh, K. D. (2009). Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. The Journal of Neuroscience, 29, 15721\u201315726.","journal-title":"The Journal of Neuroscience"},{"key":"755_CR6","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainresrev.2010.01.003","volume":"63","author":"V Eulenburg","year":"2010","unstructured":"Eulenburg, V., & Gomeza, J. (2010). Neurotransmitter transporters expressed in glial cells as regulators of synapse function. Brain Research Reviews, 63, 103\u2013112.","journal-title":"Brain Research Reviews"},{"key":"755_CR7","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.neuron.2007.11.002","volume":"56","author":"J Glykys","year":"2007","unstructured":"Glykys, J., & Mody, I. (2007). Activation of GABAA receptors: views from outside the synaptic cleft. Neuron, 56, 763\u2013770.","journal-title":"Neuron"},{"key":"755_CR8","doi-asserted-by":"publisher","first-page":"723184","DOI":"10.1155\/2011\/723184","volume":"2011","author":"G Gonzalez-Burgos","year":"2011","unstructured":"Gonzalez-Burgos, G., Fish, K. N., & Lewis, D. A. (2011). GABA neuron alterations, cortical circuit dysfunction and cognitive deficits in schizophrenia. Neural Plasticity, 2011, 723184.","journal-title":"Neural Plasticity"},{"key":"755_CR9","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","volume":"64","author":"G Hasler","year":"2007","unstructured":"Hasler, G., van der Veen, J. W., Tumonis, T., Meyers, N., Shen, J., & Drevets, W. C. (2007). Reduced prefrontal glutamate\/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Archives of General Psychiatry, 64, 193\u2013200.","journal-title":"Archives of General Psychiatry"},{"key":"755_CR10","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.conb.2011.10.007","volume":"22","author":"RM Hines","year":"2012","unstructured":"Hines, R. M., Davies, P. A., Moss, S. J., & Maguire, J. (2012). Functional regulation of GABAA receptors in nervous system pathologies. Current Opinion in Neurobiology, 22, 552\u2013558.","journal-title":"Current Opinion in Neurobiology"},{"key":"755_CR11","doi-asserted-by":"crossref","unstructured":"Hoshino, O., Zheng, M., & Watanabe, K. (2018a). Improved Perceptual Learning by Control of Ambient GABA Concentration by Astrocytic Gap Junctions. Neural Computation, 30, 184\u2013215.","DOI":"10.1162\/neco_a_01027"},{"key":"755_CR12","doi-asserted-by":"crossref","unstructured":"Hoshino, O., Zheng, M., & Watanabe, K. (2018b). Perceptual judgments via sensory-motor interaction assisted by cortical GABA. Journal of Computational Neuroscience, 44, 233\u2013251.","DOI":"10.1007\/s10827-018-0677-9"},{"key":"755_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0304-3940(90)90682-Y","volume":"117","author":"L H\u00f6sli","year":"1990","unstructured":"H\u00f6sli, L., H\u00f6sli, E., Redle, S., Rojas, J., & Schramek, H. (1990). Action of baclofen, GABA and antagonists on the membrane potential of cultured astrocytes of rat spinal cord. Neuroscience Letters, 117, 307\u2013312.","journal-title":"Neuroscience Letters"},{"key":"755_CR14","doi-asserted-by":"publisher","first-page":"5207","DOI":"10.1523\/JNEUROSCI.5100-07.2008","volume":"28","author":"V Houades","year":"2008","unstructured":"Houades, V., Koulakoff, A., Ezan, P., Seif, I., & Giaume, C. (2008). Gap junction-mediated astrocytic networks in the mouse barrel cortex. The Journal of Neuroscience, 28, 5207\u20135217.","journal-title":"The Journal of Neuroscience"},{"key":"755_CR15","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1523\/JNEUROSCI.05-12-03295.1985","volume":"5","author":"H Kettenmann","year":"1985","unstructured":"Kettenmann, H, & Schachner, M. (1985). Pharmacological properties of gamma-aminobutyric acid-, glutamate-, and aspartate-induced depolarizations in cultured astrocytes. The Journal of Neuroscience, 5, 3295\u20133301.","journal-title":"The Journal of Neuroscience"},{"key":"755_CR16","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.conb.2009.03.006","volume":"19","author":"U Koch","year":"2009","unstructured":"Koch, U., & Magnusson, A. K. (2009). Unconventional GABA release: mechanisms and function. Current Opinion in Neurobiology, 19, 305\u2013310.","journal-title":"Current Opinion in Neurobiology"},{"key":"755_CR17","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/0006-8993(86)91230-8","volume":"384","author":"J Lerma","year":"1986","unstructured":"Lerma, J., Herranz, A. S., Herreras, O., Abraira, V., & Martin, D. R. (1986). In vivo determination of ambient concentration of amino acids in the rat hippocampus: A method based on brain dialysis and computerized analysis. Brain Research, 384, 145\u2013155.","journal-title":"Brain Research"},{"key":"755_CR18","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1126\/science.1082874","volume":"300","author":"AG Leventhal","year":"2003","unstructured":"Leventhal, A. G., Wang, Y., Pu, M., Zhou, Y., & Ma, Y. (2003). GABA and its agonists improved visual cortical function in senescent monkeys. Science, 300, 812\u2013815.","journal-title":"Science"},{"key":"755_CR19","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1126\/science.1150769","volume":"319","author":"G Mongillo","year":"2008","unstructured":"Mongillo, G., Barak, O., & Tsodyks, M. (2008). Synaptic theory of working memory. Science, 319, 1543\u20131546.","journal-title":"Science"},{"key":"755_CR20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1535-7597.2004.46008.x","volume":"4","author":"GB Richerson","year":"2004","unstructured":"Richerson, G. B. (2004). Looking for GABA in all the wrong places: the relevance of extrasynaptic GABA(A) receptors to epilepsy. Epilepsy Currents, 4, 239\u2013242.","journal-title":"Epilepsy Currents"},{"key":"755_CR21","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1152\/jn.00317.2003","volume":"90","author":"GB Richerson","year":"2003","unstructured":"Richerson, G. B., & Wu, Y. (2003). Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore. Journal of Neurophysiology, 90, 1363\u20131374.","journal-title":"Journal of Neurophysiology"},{"key":"755_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S0006-3223(01)01365-8","volume":"52","author":"DC Rojas","year":"2002","unstructured":"Rojas, D. C., Bawn, S. D., Carlson, J. P., Arciniegas, D. B., Teale, P. D., & Reite, M. L. (2002). Alterations in tonotopy and auditory cerebral asymmetry in schizophrenia. Biological Psychiatry, 52, 32\u201339.","journal-title":"Biological Psychiatry"},{"key":"755_CR23","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.schres.2007.08.011","volume":"97","author":"DC Rojas","year":"2007","unstructured":"Rojas, D. C., Slason, E., Teale, P. D., & Reite, M. L. (2007). Neuromagnetic evidence of broader auditory cortical tuning in schizophrenia. Schizophrenia Research, 97, 206\u2013214.","journal-title":"Schizophrenia Research"},{"key":"755_CR24","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3389\/fnhum.2011.00127","volume":"5","author":"A Rokem","year":"2011","unstructured":"Rokem, A., Yoon, J. H., Ooms, R. E., Maddock, R. J., Minzenberg, M. J., & Silver, M. A. (2011). Broader visual orientation tuning in patients with schizophrenia. Frontiers in Human Neuroscience, 5, 127.","journal-title":"Frontiers in Human Neuroscience"},{"key":"755_CR25","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00429-015-1166-9","volume":"222","author":"M R\u00f3zsa","year":"2017","unstructured":"R\u00f3zsa, M., Baka, J., Bord\u00e9, S., R\u00f3zsa, B., Katona, G., & Tam\u00e1s, G. (2017). Unitary GABAergic volume transmission from individual interneurons to astrocytes in the cerebral cortex. Brain Structure and Function, 222, 651\u2013659.","journal-title":"Brain Structure and Function"},{"key":"755_CR26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00422-019-00793-x","volume":"113","author":"R Sakamoto","year":"2019","unstructured":"Sakamoto, R., Kameno, R., Kobayashi, T., Ishiyama, A., Watanabe, K., & Hoshino, O. (2019). Extracellular GABA assisting in organizing dynamic cell assemblies to shorten reaction time to sensory stimulation. Biological Cybernetics, 113, 257\u2013271.","journal-title":"Biological Cybernetics"},{"key":"755_CR27","doi-asserted-by":"publisher","first-page":"10016","DOI":"10.1523\/JNEUROSCI.2520-05.2005","volume":"25","author":"A Scimemi","year":"2005","unstructured":"Scimemi, A., Semyanov, A., Sperk, G., Kullmann, D. M., & Walker, M. C. (2005). Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus. The Journal of Neuroscience, 25, 10016\u201310024.","journal-title":"The Journal of Neuroscience"},{"key":"755_CR28","doi-asserted-by":"publisher","first-page":"17288","DOI":"10.1073\/pnas.0406074101","volume":"101","author":"KM Spencer","year":"2004","unstructured":"Spencer, K. M., Nestor, P. G., Perlmutter, R., Niznikiewicz, M. A., Klump, M. C., Frumin, M., Shenton, M. E., & McCarley, R. W. (2004). Neural synchrony indexes disordered perception and cognition in schizophrenia. Proceedings of the National Academy of Sciences of the USA, 101, 17288\u201317293.","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"755_CR29","doi-asserted-by":"crossref","unstructured":"Stagg, C. J., Bachtiar, V., & Johansen-Berg, H. (2011a). The role of GABA in human motor learning. Current Biology, 21, 480\u2013484.","DOI":"10.1016\/j.cub.2011.01.069"},{"key":"755_CR30","doi-asserted-by":"crossref","unstructured":"Stagg, C. J., Bachtiar, V., & Johansen-Berg, H. (2011b). What are we measuring with GABA magnetic resonance spectroscopy?. Communicative & Integrative Biology, 4, 573\u2013575.","DOI":"10.4161\/cib.16213"},{"key":"755_CR31","doi-asserted-by":"crossref","unstructured":"Stagg, C. J., Bestmann, S., Constantinescu, A. O., Moreno, L. M., Allman, C., Mekle, R., Woolrich, M., Near, J., Johansen-Berg, H., & Rothwell, J.C. (2011c). Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex. Journal of Physiology, 589, 5845\u20135855.","DOI":"10.1113\/jphysiol.2011.216978"},{"key":"755_CR32","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1111\/j.1748-1716.1986.tb07938.x","volume":"127","author":"U Tossman","year":"1986","unstructured":"Tossman, U., Jonsson, G., & Ungerstedt, U. (1986). Regional distribution and ambient levels of amino acids in rat central nervous system. Acta Physiologica Scandinavica, 127, 533\u2013545.","journal-title":"Acta Physiologica Scandinavica"},{"key":"755_CR33","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1038\/373612a0","volume":"373","author":"MA Whittington","year":"1995","unstructured":"Whittington, M. A., Traub, R. D., & Jefferys, J. G. (1995). Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature, 373, 612\u2013615.","journal-title":"Nature"},{"key":"755_CR34","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/j.neuron.2007.10.021","volume":"56","author":"Y Wu","year":"2007","unstructured":"Wu, Y., Wang, W., Diez-Sampedro, A., & Richerson, G. B. (2007). Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron, 56, 851\u2013865.","journal-title":"Neuron"},{"key":"755_CR35","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1152\/jn.00856.2002","volume":"89","author":"Y Wu","year":"2003","unstructured":"Wu, Y., Wang, W., & Richerson, G. B. (2003). Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release. Journal of Neurophysiology, 89, 2021\u20132034.","journal-title":"Journal of Neurophysiology"},{"key":"755_CR36","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1017\/S0952523802191097","volume":"19","author":"X Xu","year":"2002","unstructured":"Xu, X., Ichida, J., Shostak, Y., Bonds, A. B., & Casagrande, V. A. (2002). Are primate lateral geniculate nucleus (LGN) cells really sensitive to orientation or direction? Visual Neuroscience, 19, 97\u2013108.","journal-title":"Visual Neuroscience"},{"key":"755_CR37","doi-asserted-by":"publisher","first-page":"3777","DOI":"10.1523\/JNEUROSCI.6158-09.2010","volume":"30","author":"JH Yoon","year":"2010","unstructured":"Yoon, J. H., Maddock, R. J., Rokem, A., Silver, M. A., Minzenberg, M. J., Ragland, J. D., & Carter, C. S. (2010). GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. The Journal of Neuroscience, 30, 3777\u20133781.","journal-title":"The Journal of Neuroscience"}],"container-title":["Journal of Computational Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10827-020-00755-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10827-020-00755-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10827-020-00755-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T23:50:14Z","timestamp":1628207414000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10827-020-00755-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["755"],"URL":"https:\/\/doi.org\/10.1007\/s10827-020-00755-4","relation":{},"ISSN":["0929-5313","1573-6873"],"issn-type":[{"value":"0929-5313","type":"print"},{"value":"1573-6873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"29 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Conflict of interest"}}]}}