{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:15:32Z","timestamp":1767093332558,"version":"3.32.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T00:00:00Z","timestamp":1158019200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1007\/s10916-006-9023-2","type":"journal-article","created":{"date-parts":[[2006,9,11]],"date-time":"2006-09-11T16:40:39Z","timestamp":1157992839000},"page":"389-394","source":"Crossref","is-referenced-by-count":28,"title":["Support Vector Machine-Based Feature Selection for Classification of Liver Fibrosis Grade in Chronic Hepatitis C"],"prefix":"10.1007","volume":"30","author":[{"given":"Zheng","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Yamauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Kuroyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,9,12]]},"reference":[{"key":"9023_CR1","doi-asserted-by":"crossref","first-page":"2S","DOI":"10.1002\/hep.510260701","volume":"26","author":"National Institute of Health Consensus Development Conference Panel Statement","year":"1997","unstructured":"National Institute of Health Consensus Development Conference Panel Statement, Management of hepatitis C. Hepatology 26:2S\u201310S, 1997.","journal-title":"Hepatology"},{"key":"9023_CR2","doi-asserted-by":"crossref","first-page":"57S","DOI":"10.1002\/hep.510260710","volume":"26","author":"R. P. Perrilo","year":"1997","unstructured":"Perrilo, R. P., The role of liver biopsy in hepatitis C. Hepatology 26:57S\u201361S, 1997.","journal-title":"Hepatology"},{"key":"9023_CR3","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1002\/hep.1840360720","volume":"36","author":"J. Dienstag","year":"2002","unstructured":"Dienstag, J., The role of liver biopsy in chronic hepatitis C. Hepatology 36:S152\u2013S160, 2002.","journal-title":"Hepatology"},{"key":"9023_CR4","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/jhep.2000.16602","volume":"32","author":"J. F. Cadranel","year":"2000","unstructured":"Cadranel, J. F., Rufat, P., and Degos, F., Practices of liver biopsy in France: Results of a prospective nationwide survey. Hepatology 32:477\u2013481, 2000.","journal-title":"Hepatology"},{"key":"9023_CR5","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1155\/2000\/107982","volume":"14","author":"T. Poynard","year":"2000","unstructured":"Poynard, T., Ratziu, V., and Bedossa, P., Appropriateness of liver biopsy. Can. J. Gastroenterol. 14:543\u2013548, 2000.","journal-title":"Can. J. Gastroenterol."},{"key":"9023_CR6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","volume":"38","author":"P. Bedossa","year":"2003","unstructured":"Bedossa, P., Dargere, D., and Paradis, V., Sampling variability of liver fibrosis in chronic hepatitis C. Hepatology 38:1449\u20131457, 2003.","journal-title":"Hepatology"},{"key":"9023_CR7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/hep.1840200104","volume":"20","author":"P. Bedossa","year":"1994","unstructured":"Bedossa, P., Poynard, T., and the Metavir Cooperative Group, Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 20:15\u201320, 1994.","journal-title":"Hepatology"},{"key":"9023_CR8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1478-3231.1999.tb00033.x","volume":"19","author":"J. Westin","year":"1999","unstructured":"Westin, J., Lagging, L. M., Wejstal, R., Norkans, G., and Dhillon, A. P., Interobserver study of liver histology using the Ishak score in patients with chronic hepatitis C virus infection. Liver 19:183\u2013187, 1999.","journal-title":"Liver"},{"key":"9023_CR9","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","volume":"97","author":"A. Regev","year":"2002","unstructured":"Regev, A., Berho, M., Jeffers, L. J., Milikowaki, C., Molina, E. G., Pyrsopoulos, N. T., Feng, Z. Z., et\u00a0al., Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection. Am. J. Gastroenterol. 97:2614\u20132618, 2002.","journal-title":"Am. J. Gastroenterol."},{"key":"9023_CR10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2893.1997.00141.x","volume":"4","author":"T. Poynard","year":"1997","unstructured":"Poynard, T., and Bedossa, P., Age and platelet count: A simple index for predicting the presence of histological lesions in patients with antibodies to hepatitis C virus. METAVIR and CLINVIR Cooperative Study Groups. J. Viral. Hepatol. 4:199\u2013208, 1997.","journal-title":"J. Viral. Hepatol."},{"key":"9023_CR11","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1111\/j.1572-0241.2001.05268.x","volume":"96","author":"A. Pohl","year":"2001","unstructured":"Pohl, A., Behing, C., Oliver, D., Kilani, M., Monson, P., and Hassanein, T., Serum aminotransferase levels and platelet counts as predictors of degree of fibrosis in chronic hepatitis C virus infection. Am. J. Gastroenterol. 96:3142\u20133146, 2001.","journal-title":"Am. J. Gastroenterol."},{"key":"9023_CR12","first-page":"1302","volume":"92","author":"M. Bonacini","year":"1997","unstructured":"Bonacini, M., Hadi, G., Govindarajan, S., and Linsday, K. L., Utility of a discriminant score for diagnosing advanced fibrosis or cirrhosis in patients with chronic hepatitis C virus infection. Am. J. Gastroenterol. 92:1302\u20131304, 1997.","journal-title":"Am. J. Gastroenterol."},{"issue":"suppl 1","key":"9023_CR13","first-page":"M1610","volume":"122","author":"K. Patel","year":"2002","unstructured":"Patel, K., McHutchison, J. G., Oh, E., Nguyen, P., and Rose, S., Evaluation and optimization of a panel of serum markers for liver fibrosis in chronic hepatitis C patients. Gastroenterology 122(suppl 1):M1610, 2002.","journal-title":"Gastroenterology"},{"key":"9023_CR14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0140-6736(00)04258-6","volume":"357","author":"F. Imbert-Bismut","year":"2001","unstructured":"Imbert-Bismut, F., Ratziu, V., Pieroni, L., Charlotte, F., Benhamou, Y., and Poynard, T., Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: A prospective study. Lancet 357:1069\u20131075, 2001.","journal-title":"Lancet"},{"key":"9023_CR15","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1373\/49.3.450","volume":"49","author":"E. Rossi","year":"2003","unstructured":"Rossi, E., Adams, L., Prins, A., Bulsara, M., de Boer, B., Garas, G., et\u00a0al., Validation of the FibroTest biochemical markers score in assessing liver fibrosis in hepatitis C patients. Clin. Chem. 49:450\u2013454, 2003.","journal-title":"Clin. Chem."},{"key":"9023_CR16","doi-asserted-by":"crossref","first-page":"188A","DOI":"10.1016\/S0270-9139(03)80111-8","volume":"38","author":"P. Halfon","year":"2003","unstructured":"Halfon, P., Bourliere, M., Deydier, R., Portal, I., Renou, C., Bertrand, J. J., et\u00a0al., Independent prospective multicenter validation of biochemical markers (Fibrotest-Actitest) for the prediction of liver fibrosis and activity in patients with chronic hepatitis C. 54th Annual Meeting of the AASLD, Hepatology 38:188A, 2003.","journal-title":"Hepatology"},{"key":"9023_CR17","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1053\/jhep.2002.36128","volume":"36","author":"X. Forns","year":"2003","unstructured":"Forns, X., Ampurdanes, S., Llovet, J., Aponte, J., Quinto, L., and Martinez-Bauer, E., Identification of chronic hepatitis C patients without hepatic fibrosis by a simple predictive model. Hepatology 36:986\u2013992, 2003.","journal-title":"Hepatology"},{"key":"9023_CR18","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1053\/jhep.2003.50346","volume":"38","author":"C. T. Wai","year":"2003","unstructured":"Wai, C. T., Greenson, J. K., Fontana, R. J., Kalbfleisch, J. D., Marrero, J. A., Conjeevaram, H. S., and Lok, A. S., A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 38:518\u2013526, 2003.","journal-title":"Hepatology"},{"key":"9023_CR19","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","volume":"24","author":"P. Bedossa","year":"1996","unstructured":"Bedossa, P., and Poynard, T., For the French METAVIR Cooperative Study Group. An algorithm for grading activity in chronic hepatitis C. Hepatology 24:289\u2013293, 1996.","journal-title":"Hepatology"},{"key":"9023_CR20","doi-asserted-by":"crossref","unstructured":"Cortes, C., and Vapnik, V., Machine Learn. 20:273\u2013297, 1995.","DOI":"10.1023\/A:1022627411411"},{"key":"9023_CR21","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2440-0","volume-title":"The Nature of Statistical Learning Theory","author":"V. Vapnik","year":"1995","unstructured":"Vapnik, V., The Nature of Statistical Learning Theory, Springer, Berlin, 1995."},{"key":"9023_CR22","volume-title":"Statistical Learning Theory","author":"V. Vapnik","year":"1998","unstructured":"Vapnik, V., Statistical Learning Theory, Wiley, New York, 1998."},{"key":"9023_CR23","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0097-8485(01)00113-9","volume":"26","author":"Y. D. Cai","year":"2002","unstructured":"Cai, Y. D., Liu, X. J., Xu, X., and Chou, K. C., Prediction of protein structural classes by support vector machines. Comput. Chem. 26:293\u2013296, 2002.","journal-title":"Comput. Chem."},{"key":"9023_CR24","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0097-8485(01)00094-8","volume":"26","author":"R. Burbidge","year":"2001","unstructured":"Burbidge, R., Trotter, M., Buxton, B., and Holden, S., Drug design by machine learning: Support vector machines for pharmaceutiacal data alalysis. Comput. Chem. 26:5\u201314, 2001.","journal-title":"Comput. Chem."},{"key":"9023_CR25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/ci025620t","volume":"43","author":"M. K. Warmuth","year":"2003","unstructured":"Warmuth, M. K., Liao, J., Ratsch, G., Mathieson, M., Putta, S., and Lemmen, C., Active learning with support vector machines in the drug discovery process. J. Chem. Inf. Comput. Sci. 43:667\u2013673, 2003.","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"9023_CR26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-5793(02)02835-1","volume":"521","author":"L. Bao","year":"2002","unstructured":"Bao, L., and Sun, Z. R., Identifying genes related to drug anticancer mechanisms using support vector machine. FEBS Lett. 521:109\u2013114, 2002.","journal-title":"FEBS Lett."},{"issue":"3","key":"9023_CR27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10916-005-5187-4","volume":"29","author":"N. F. Guler","year":"2005","unstructured":"Guler, N. F., and Kocer, S., Use of support vector machines and neural network in diagnosis of neuromuscular disorders. J. Med. Syst. 29(3):271\u2013284, 2005.","journal-title":"J. Med. Syst."},{"issue":"11","key":"9023_CR28","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0167-8655(94)90127-9","volume":"15","author":"P. Pudil","year":"1994","unstructured":"Pudil, P., Novovicova, J., and Kittler, J., Floating search methods in feature selection. Pattern Recognit. Lett. 15(11):1119\u20131125, 1994.","journal-title":"Pattern Recognit. Lett."},{"key":"9023_CR29","volume-title":"Pattern Recognition","author":"R. Schalkoff","year":"1994","unstructured":"Schalkoff, R., Pattern Recognition, Wiley, New York, 1994."},{"key":"9023_CR30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1046\/j.1365-2893.1998.00108.x","volume":"5","author":"G. H. Haydon","year":"1998","unstructured":"Haydon, G. H., Jalan, R., Ala-Korpela, M., Hiltunen, Y., Hanley, J., Jarvis, L. M., Ludlum, C. A., and Hayes, P. C., Prediction of cirrhosis in patients with chronic hepatitis C infection by artificial neural network analysis of virus and clinical factors. J. Viral. Hepatol. 5:255\u2013264, 1998.","journal-title":"J. Viral. Hepatol."},{"issue":"2","key":"9023_CR31","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1373\/clinchem.2004.041764","volume":"51","author":"T. C. Poon","year":"2005","unstructured":"Poon, T. C., Hui, A. Y., Chan, H. L., Ang, I. L., Chow, S. M., Wong, N., and Sung, J. J., Prediction of liver fibrosis and cirrhosis in chronic hepatitis B infection by serum proteomic fingerprinting: A pilot study. Clin. Chem. 51(2):328\u2013335, 2005.","journal-title":"Clin. Chem."},{"issue":"9","key":"9023_CR32","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0301-5629(03)01010-X","volume":"29","author":"W. Yeh","year":"2003","unstructured":"Yeh, W., Huang, S. W., and Li, P. C., Liver fibrosis grade classification with B-mode ultrasound. Ultrasound Med. Biol. 29(9):1229\u20131235, 2003.","journal-title":"Ultrasound Med. Biol."},{"key":"9023_CR33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1046\/j.1365-2893.1998.00100.x","volume":"5","author":"V. S. Wong","year":"1998","unstructured":"Wong, V. S., Hughes, V., Trull, A., Wight, D. G., Petrik, J., and Alexander, G. J., Serum hyaluronic acid is a useful marker of liver fibrosis in chronic hepatitis C virus infection. J. Viral. Hepatol. 5:187\u2013192, 1998.","journal-title":"J. Viral. Hepatol."},{"key":"9023_CR34","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S1386-6346(00)00074-7","volume":"18","author":"K. Ikeda","year":"2000","unstructured":"Ikeda, K., Saitoh, S., Kobayashi, M., Suzuki, F., Arase, Y., et\u00a0al., Distinction between chronic hepatitis C virus infection: Practical discriminant function using common laboratory data. Hepatol. Res. 18:252\u2013266, 2000.","journal-title":"Hepatol. Res."}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-006-9023-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10916-006-9023-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-006-9023-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T20:35:05Z","timestamp":1736541305000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10916-006-9023-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,12]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["9023"],"URL":"https:\/\/doi.org\/10.1007\/s10916-006-9023-2","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"type":"print","value":"0148-5598"},{"type":"electronic","value":"1573-689X"}],"subject":[],"published":{"date-parts":[[2006,9,12]]}}}