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M.W.S. was supported by a National Heart, Lung, and Blood Institute (NHLBI) T32 award (HL087738 09). E.W.S. received support from the Vanderbilt Center for Kidney Disease (VCKD) and the VA Health Services Research and Development Service (HSR&D IIR-13-073). W.H.S was supported in part by K23GM110469 from the National Institute of General Medical Sciences. J.P.W received support from by the Foundation for Anesthesia Education and Research (FAER, Schaumburg, IL, USA) and Anesthesia Quality Institute (AQI, Schaumburg, IL, USA)\u2019s Health Service Research Mentored Research Training Grant (HSR-MRTG). The funding institutions had no role in (1) conception, design, or conduct of the study, (2) collection, management, analysis, interpretation, or presentation of the data, or (3) preparation, review, or approval of the manuscript. All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. The authors declare no potential conflicts of interest. T.W.R. reported serving on an advisory board for Avisa Pharma, LLC and as a DSMB member for GlaxoSmithKline PLC. W.H.S. reported serving on advisory boards for BioFire Diagnostics, Inc and Venaxis, Inc.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Source of Funding and Conflicts of Interest"}}],"article-number":"167"}}