{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:19:19Z","timestamp":1771881559212,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T00:00:00Z","timestamp":1469232000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1007\/s10916-016-0552-z","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T00:36:29Z","timestamp":1469234189000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ultrasound Color Doppler Image Segmentation and Feature Extraction in MCP and Wrist Region in Evaluation of Rheumatoid Arthritis"],"prefix":"10.1007","volume":"40","author":[{"given":"U.","family":"Snekhalatha","sequence":"first","affiliation":[]},{"given":"V.","family":"Muthubhairavi","sequence":"additional","affiliation":[]},{"given":"M.","family":"Anburajan","sequence":"additional","affiliation":[]},{"given":"Neelkanth","family":"Gupta","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,7,23]]},"reference":[{"key":"552_CR1","doi-asserted-by":"crossref","unstructured":"Carol A, Hitchon and Hani S, Gabalawy EI (2011). The synovium in Rheumatoid arthritis. The open Rheumatology Journal 5:107\u2013114","DOI":"10.2174\/1874312901105010107"},{"key":"552_CR2","first-page":"579","volume":"20","author":"DMFM Vander Heijde","year":"1993","unstructured":"Vander Heijde, D.M.F.M., Vant Hof, M.A., Van Riel, P.L.C.M., and de putte LBA, v., Development of a disease activity score based on judgement in clinical practice by rheumatologists. J Rheumatol. 20:579\u2013581, 1993.","journal-title":"J Rheumatol"},{"key":"552_CR3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/art.1780360601","volume":"36","author":"DT Felson","year":"1993","unstructured":"Felson, D.T., Anderson, J.J., Boers, M., Bombardier, C., Chernoff, M., Fried, B., et al., The American college of rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum. 36:729\u2013740, 1993.","journal-title":"Arthritis Rheum"},{"key":"552_CR4","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/art.20926","volume":"53","author":"AK Brown","year":"2005","unstructured":"Brown, A.K., Connor, P.J., Roberts, T.J., Wakefield, R.J., Karim, Z., and Emery, P., Recommendations for musculoskeletal ultrasonography by rheumatologists: setting global standards for best practice by expert consencus. Arthritis Rheum. 53:83\u201392, 2005.","journal-title":"Arthritis Rheum"},{"key":"552_CR5","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1136\/ard.2003.015982","volume":"63","author":"B Bresnihan","year":"2004","unstructured":"Bresnihan, B., and Kane, D., Sonography and subclinical synovitis. Ann Rheum Dis. 63:333\u2013334, 2004.","journal-title":"Ann Rheum Dis"},{"key":"552_CR6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1521-6942(02)00099-2","volume":"17","author":"W Grassi","year":"2003","unstructured":"Grassi, W., Filippucci, E., Carotti, M., and Salaffi, F., Imaging modalities for identifying the origin of regional musculoskeletal pain. Best pract Res Clin Rheumatol. 17:17\u201332, 2003.","journal-title":"Best pract Res Clin Rheumatol"},{"key":"552_CR7","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/ard.2003.007062","volume":"63","author":"RJ Wakefield","year":"2004","unstructured":"Wakefield, R.J., Green, M.J., Marzo-Ortega, H., et al., Should oligoarthritis be reclassified? Ultrasound reveals a high prevalence of subclinical disease. Ann Rheum Dis. 63:382\u2013385, 2004.","journal-title":"Ann Rheum Dis"},{"key":"552_CR8","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/BOR.0b013e3280119648","volume":"19","author":"W Grassi","year":"2007","unstructured":"Grassi, W., and Filippucci, Ultrasonography and the rheumatologist. Current opinion in Rheumatology. 19:55\u201360, 2007.","journal-title":"Current opinion in Rheumatology"},{"key":"552_CR9","first-page":"630","volume":"25","author":"K Albrecht","year":"2007","unstructured":"Albrecht, K., Muller-Ladner, U., and Strunk, J., Quantification of the synovial perfusion in rheumatoid arthritis using Doppler ultrasonography. Clin Exp Rheumatol. 25:630\u2013638, 2007.","journal-title":"Clin Exp Rheumatol"},{"key":"552_CR10","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/ard.60.7.690","volume":"60","author":"E Qvistgaard","year":"2001","unstructured":"Qvistgaard, E., Rogind, H., Torp-Pedersen, S., Terslev, L., Danneskiold-samsoe, B., and Bliddal, H., Quantitative ultrasonography in rheumatoid arthritis: Evaluation of inflammation by Doppler technique. Ann Rheum Dis. 60:690\u2013693, 2001.","journal-title":"Ann Rheum Dis"},{"key":"552_CR11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/ard.2005.041814","volume":"65","author":"AK Scheel","year":"2006","unstructured":"Scheel, A.K., Hermann, K.G., Ohmdorf, S., et al., Prospective 7\u00a0year follow up imaging study comparing radiography, ulrasonography, and magnetic resonance imaging in rheumatoid arthritis finger joints. Ann Rheum Dis. 65:595\u2013600, 2006.","journal-title":"Ann Rheum Dis"},{"key":"552_CR12","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1002\/1529-0131(200012)43:12<2762::AID-ANR16>3.0.CO;2-#","volume":"43","author":"RJ Wakefield","year":"2000","unstructured":"Wakefield, R.J., Gibbon, W.W., Conaghan, P.G., et al., The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography. Arthritis rheum. 43:2762\u20132770, 2000.","journal-title":"Arthritis rheum"},{"key":"552_CR13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1136\/ard.62.11.1049","volume":"62","author":"L Tersley","year":"2003","unstructured":"Tersley, L., Torp-Pedersen, S., Qyistgaard, E., Danneskiold-Samsoe, B., and Bliddal, H., Estimation of inflammation by Doppler ultrasound: Quantitative changes after intra-articular treatment in rheumatoid arthritis. Ann Rheum Dis. 62:1049\u20131053, 2003.","journal-title":"Ann Rheum Dis"},{"key":"552_CR14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00256-007-0356-9","volume":"37","author":"EG McNally","year":"2008","unstructured":"McNally, E.G., Ultrasound of the small joints of the hands and feet: current status. Skeletal Radiol. 37:99\u2013113, 2008.","journal-title":"Skeletal Radiol"},{"key":"552_CR15","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.1007\/s10916-012-9869-4","volume":"36","author":"Y Liu","year":"2012","unstructured":"Liu, Y., Cheng, H.D., Huang, J.H., Zhang, Y.T., Tang, X.L., Tian, J.W., and Wang, Y., Computer aided diagnosis system for breast cancer based on color Doppler flow imaging. J Med Syst. 36:3975\u20133982, 2012.","journal-title":"J Med Syst"},{"key":"552_CR16","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s10916-010-9461-8","volume":"35","author":"XF Diao","year":"2011","unstructured":"Diao, X.F., Zhang, X.Y., Wang, T.F., Chen, S.P., Yang, Y., and Zhong, L., Highly sensitive computer aided diagnosis system for breast tumor based on color Doppler flow images. J Med Syst. 35:801\u2013809, 2011.","journal-title":"J Med Syst"},{"key":"552_CR17","doi-asserted-by":"crossref","first-page":"121","DOI":"10.7863\/jum.1994.13.2.121","volume":"13","author":"CC Branas","year":"1994","unstructured":"Branas, C.C., Weingarten, M.S., Czeredarczuk, M., and Schafer, P.F., Examination of carotid arteries with quantitative color Doppler flow imaging. J Ultrasound Med. 13:121\u2013127, 1994.","journal-title":"J Ultrasound Med"},{"issue":"2","key":"552_CR18","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10916-008-9169-1","volume":"33","author":"M Tokmakc","year":"2009","unstructured":"Tokmakc, M., and Erdogan, N., Investigation of the arterial stiffness on renal artery Doppler sonograms. J Med Syst. 33(2):101\u2013106, 2009.","journal-title":"J Med Syst"},{"issue":"1","key":"552_CR19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.rhu.0000111309.75413.d0","volume":"10","author":"C Saadeh","year":"2004","unstructured":"Saadeh, C., Gaylor, P., Lee, D., Malacara, J., and Gaylor, M., Color Doppler ultrasound of the hand : observations on clinical utility in rheumatoid arthritis. J clin Rheumatol. 10(1):1\u20135, 2004.","journal-title":"J clin Rheumatol"},{"key":"552_CR20","unstructured":"Terslev, Recke, P.V., Torp-pedersen, S., Koenig, M.J., and Bliddal, H., Diagnostic sensitivity and specificity of Doppler ultrasound in rheumatoid arthritis. J Rheumatol. 35:49\u201353."},{"key":"552_CR21","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/art.22461","volume":"57","author":"E Naredo","year":"2007","unstructured":"Naredo, E., Collado, P., Cruz, A., et al., Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis Rheum. 57:116\u2013124, 2007.","journal-title":"Arthritis Rheum"},{"key":"552_CR22","doi-asserted-by":"crossref","unstructured":"Naredo E, Bonilla G, Gamero F, Uson J. Carmano L, Laffon A (2005). Assessment of inflammatory activity in rheumatoid arthritis: A comparative study of clinical evaluation with grey scale and power Doppler ultrasonography. Ann Rheum Dis 64:375\u2013381.","DOI":"10.1136\/ard.2004.023929"},{"key":"552_CR23","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1136\/ard.2005.044628","volume":"65","author":"E Filippucci","year":"2006","unstructured":"Filippucci, E., Iagnocco, A., Salaffi, F., Cerioni, A., Valesini, G., and Grassi, W., Power Doppler sonography monitoring of synovial perfusion at wrist joint in rheumatoid patients treated with adlimumab. Ann Rheum Dis. 65:1433\u20131437, 2006.","journal-title":"Ann Rheum Dis"},{"key":"552_CR24","doi-asserted-by":"crossref","unstructured":"Newman JS, Laing TJ, McCarthy CJ, Adler RS (1996). Power Doppler sonography of synovitis: assessment of therapeutic response. preliminary observations. Radiology 198:582\u2013584.","DOI":"10.1148\/radiology.198.2.8596870"},{"key":"552_CR25","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/1529-0131(199911)42:11<2303::AID-ANR7>3.0.CO;2-4","volume":"42","author":"M Hau","year":"1999","unstructured":"Hau, M., Schultz, H., Tony, H.P., Keberle, M., Jahns, R., Harten, R., et al., Evaluation of pannus and vascularization of the metacarpophalangeal and proximal interphalangeal joints in rheumatoid arthritis by high-resolution ultrasound (multidimensional linear array). Arthritis Rheum. 42:2303\u20132308, 1999.","journal-title":"Arthritis Rheum"},{"key":"552_CR26","doi-asserted-by":"publisher","unstructured":"Mills DM, Cao K, Thiele R, Patwardhan KA (2012). Volumetric ultrasound and computer \u2013assisted analysis at the point of care: A musculoskeletal exemplar. Conf Proc IEEE Eng Med Biol Soc. 2012: 2318\u20132322. doi: 10.1109\/EMBC.2012.6346427.","DOI":"10.1109\/EMBC.2012.6346427."},{"key":"552_CR27","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/978-3-319-15705-4_30.","volume":"9012","author":"J Segen","year":"2015","unstructured":"Segen, J., Kulbacki, M., and Wereszczynski, Registration of ultrasound images for automated assessment of synovitis activity. Intelligent information and database systems, Lecture notes in computer science. 9012:307\u2013316, 2015. doi: 10.1007\/978-3-319-15705-4_30.","journal-title":"Intelligent information and database systems, Lecture notes in computer science"},{"issue":"9","key":"552_CR28","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","volume":"62","author":"D Aletaha","year":"2010","unstructured":"Aletaha, D., Neogi, T., Silman, A.J., Funovitis, J., Felson, D.T., et al., 2010 rheumatoid arthritis classification criteria: an American college of rheumatology\/European league against rheumatism collaborative initiative. Arthritis Rheum. 62(9):2569\u20132581, 2010.","journal-title":"Arthritis Rheum"},{"key":"552_CR29","first-page":"93","volume":"23","author":"J Fransen","year":"2005","unstructured":"Fransen, J., and van Riel, P.L.C.M., \u201cthe disease activity score and EULAR response criteria. Clinical and Experimental Rheumatology. 23:93\u201399, 2005.","journal-title":"Clinical and Experimental Rheumatology."},{"issue":"12","key":"552_CR30","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1093\/rheumatology\/41.12.1457","volume":"41","author":"A Kumar","year":"2002","unstructured":"Kumar, A., Malaviya, A.N., Pandhi, A., and Singh, R., Validation of an Indian version of the health Assessment questionnaire in patients with rheumatoid arthritis. Rheumatology. 41(12):1457\u20131145, 2002.","journal-title":"Rheumatology"},{"key":"552_CR31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00296-011-2314-z","volume":"33","author":"K Ellegaard","year":"2013","unstructured":"Ellegaard K, Torp-Pedersen S, Lund H, Pedersen K, Henriksen M, Danneskiold-samsoe B,, Bliddal H (2013). The effect of isometric exercise of the hand on the synovial blood flow in patients with rheumatoid arthritis measured by color Doppler ultrasound. Rheumatol Int 33:65\u201370","journal-title":"Rheumatol Int"},{"key":"552_CR32","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.7863\/jum.2001.20.12.1329","volume":"20","author":"GS Lin","year":"2001","unstructured":"Lin, G.S., Veena, S., and Naval, M.A., Pattern of Doppler flow indices at the carotid bifurcation: Evaluation by hemodynamic color Doppler imaging. J Ultrasound Med. 20:1329\u20131339, 2001.","journal-title":"J Ultrasound Med"},{"key":"552_CR33","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3325\/cmj.2015.56.280","volume":"56","author":"G Ivanac","year":"2015","unstructured":"Ivanac, G., Vergles, J.M., and Brkljacic, B., Gray scale and color duplex Doppler ultrasound of hand joints in the evaluation of disease activity and treatment in rheumatoid arthritis. Croat Med J. 56:280\u2013289, 2015.","journal-title":"Croat Med J"},{"key":"552_CR34","unstructured":"Mukhopadhyay J, Image and video processing in the compressed domain CRC press pp 157\u2013159."},{"key":"552_CR35","unstructured":"Salvatore D, Reagle D (2012), Theory and problem of statistics and econometric, 2nd edition schaum outline series-Mcgraw-hill."},{"issue":"9","key":"552_CR36","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1002\/art.11245","volume":"48","author":"L Terslev","year":"2003","unstructured":"Terslev, L., Torp-Pedersen, S., Savnik, A., der recke P, V., Qvistgaard, E., Danneskiold-samsoe, B., and Bliddal, H., Doppler ultrasound and Magnetic resonance imaging of synovial inflammation of the hand in Rheumatoid Arthritis: A comparative study. Arthritis Rheum. 48(9):2434\u20132441, 2003.","journal-title":"Arthritis Rheum"},{"issue":"3","key":"552_CR37","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1093\/rheumatology\/ken459","volume":"48","author":"K Ellegaard","year":"2009","unstructured":"Ellegaard, K., Torp-Pedersen, S., Terslev, L., Danneskiold-samsoe, B., Henriksen, M., and Bliddal, H., Ultrasound colour Doppler measurements in a single joint as measure of disease activity in patients with rheumatoid arthritis\u2013assessment of concurrent validity. Rheumatology. 48(3):254\u2013257, 2009. doi: 10.1093\/rheumatology\/ken459 .","journal-title":"Rheumatology"},{"key":"552_CR38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/art.10784","volume":"48","author":"C Weidekamm","year":"2003","unstructured":"Weidekamm, C., Koller, M., Weber, M., and Kainberger, F., Diagnostic value of high-resolution B-mode and Doppler sonography for imaging of hand and finger joints in rheumatoid arthritis. Arthritis Rheum. 48:325\u2013333, 2003.","journal-title":"Arthritis Rheum"},{"key":"552_CR39","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/art.10877","volume":"48","author":"M Szkudlarek","year":"2003","unstructured":"Szkudlarek, M., Court-Payen, M., Jacobsen, S., Klarlund, M., Thomsen, H.S., and Ostergaard, M., Interobserver agreement in Ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum. 48:955\u2013962, 2003.","journal-title":"Arthritis Rheum"},{"key":"552_CR40","first-page":"881","volume":"23","author":"E Naredo","year":"2005","unstructured":"Naredo, E., Gamero, T., Bonilla, G., Uson, J., Carmona, L., and Laffon, A., Ultrasonogrpahic assessment of inflammatory activity in RA: Comparison of extended vs reduced joint evaluation. Clin Exp Rheumatol. 23:881\u2013884, 2005.","journal-title":"Clin Exp Rheumatol."},{"key":"552_CR41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/rheumatology\/kem383","volume":"47","author":"B Hammed","year":"2008","unstructured":"Hammed, B., Pilcker, J., Heron, C., and Kiley, P.D.W., The relation between composite ultrasound measures and the DAS 28 score, Its components and acute phase markers in adult RA. Rheumatology. 47:476\u2013480, 2008.","journal-title":"Rheumatology"},{"key":"552_CR42","first-page":"123","volume":"98","author":"M Midiri","year":"1999","unstructured":"Midiri, M., Iovane, A., Finazzo, M., Brancatelli, G., Gallo, C., and Lagalla, R., Color Doppler-echo in rheumatoid arthritis with extra-articular location: preliminary experience. Radiol Med (Torino). 98:123\u2013126, 1999.","journal-title":"Radiol Med (Torino)"},{"key":"552_CR43","first-page":"2","volume":"53","author":"M Troltzsch","year":"1994","unstructured":"Troltzsch, M., Color Doppler study in patients with rheumatoid arthritis and scleroderma. Z Rheumatol. 53:2\u20136, 1994.","journal-title":"Z Rheumatol"},{"key":"552_CR44","doi-asserted-by":"publisher","unstructured":"Grisan E, Rizzo G, Coran A, Raffeiner B, Stramare R (2015). Quantitative ultrasound for diagnosis and assessment of rheumatoid arthritis. Proc SPIE 2015. doi: 10.1117\/2.1201506.006000","DOI":"10.1117\/2.1201506.006000"},{"key":"552_CR45","doi-asserted-by":"publisher","unstructured":"Grisan, E., Raffeiner, B., Coran, A., Rizzo, G., Liprian, L., et al., A comparison of region based and pixel based CEUS kinetics parameters in the assessment of arthritis. Proc SPIE 9040, Medical imaging 2014. Ultrasonic imaging and Tomography:90400F, 2014. doi: 10.1117\/12.2042801 .","DOI":"10.1117\/12.2042801"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-016-0552-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10916-016-0552-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-016-0552-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T15:03:16Z","timestamp":1498316596000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10916-016-0552-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,23]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["552"],"URL":"https:\/\/doi.org\/10.1007\/s10916-016-0552-z","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"value":"0148-5598","type":"print"},{"value":"1573-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,23]]},"article-number":"197"}}