{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:05:28Z","timestamp":1767859528997,"version":"3.49.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1007\/s10916-017-0688-5","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T04:38:23Z","timestamp":1485146303000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Integrated Soft Computing Approach to Hughes Syndrome Risk Assessment"],"prefix":"10.1007","volume":"41","author":[{"given":"Jo\u00e3o","family":"Vilhena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ros\u00e1rio Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-7773","authenticated-orcid":false,"given":"Henrique","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Gra\u00f1eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Caldeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Gusm\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Neves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"688_CR1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1078\/0171-2985-00213","volume":"207","author":"R Cervera","year":"2003","unstructured":"Cervera, R., and Asherson, R.A., Clinical and epidemiological aspects in the antiphospholipid syndrome. Immunobiology. 207:5\u201311, 2003.","journal-title":"Immunobiology"},{"key":"688_CR2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","volume":"4","author":"S Miyakis","year":"2006","unstructured":"Miyakis, S., Lockshin, M.D., Atsumi, T., Branch, D.W., Brey, R.L., Cervera, R., Derksen, R.H.W.M., De Groot, P.G., Koike, T., Meroni, P.L., Reber, G., Shoenfeld, Y., Tincani, A., Vlachoyiannopoulos, P.G., and Krilis, S.A., International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thrombosis Haemostasis. 4:295\u2013306, 2006.","journal-title":"Thrombosis Haemostasis"},{"key":"688_CR3","doi-asserted-by":"crossref","unstructured":"Keeling D, Mackie I, Moore GW, Greer IA, Greaves M, British Committee for Standards in Haematology (2012) Guidelines on the investigation and management of antiphospholipid syndrome. British Journal of Haematology 157:47\u201358","DOI":"10.1111\/j.1365-2141.2012.09037.x"},{"key":"688_CR4","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/rheumatology\/keg273","volume":"42","author":"O Amengual","year":"2003","unstructured":"Amengual, O., Atsumi, T., and Khamashta, M.A., Tissue factor in antiphospholipid syndrome: shifting the focus from coagulation to endothelium. Rheumatology. 42:1029\u20131031, 2003.","journal-title":"Rheumatology"},{"key":"688_CR5","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1373\/clinchem.2009.133678","volume":"56","author":"K Devreese","year":"2010","unstructured":"Devreese, K., and Hoylaerts, M.F., Challenges in the diagnosis of the antiphospholipid syndrome. Clinical Chemistry. 56:930\u2013940, 2010.","journal-title":"Clinical Chemistry"},{"key":"688_CR6","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/1529-0131(200002)43:2<440::AID-ANR26>3.0.CO;2-N","volume":"43","author":"MD Lockshin","year":"2000","unstructured":"Lockshin, M.D., Sammaritano, L.R., and Schwartzman, S., Validation of the Sapporo criteria for antiphospholipid syndrome. Arthritis & Rheumatology. 43:440\u2013443, 2000.","journal-title":"Arthritis & Rheumatology"},{"key":"688_CR7","doi-asserted-by":"crossref","unstructured":"Rand JH, Wolgast LR (2013) The Antiphospholipid Syndrome. In Marder JV, Aird WC, Bennett JS, Schulman S, White GC (eds) Hemostasis and Thrombosis. Basic Principles and Clinical Practice, 6th Edition, Wolters Kluwer, Lippincott Williams & Wilkins, Philadelphia, pp. 1216\u20131231","DOI":"10.1016\/B978-1-4557-2296-9.00020-8"},{"key":"688_CR8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/ar4549","volume":"16","author":"PL Meroni","year":"2014","unstructured":"Meroni, P.L., Chighizola, C.B., Rovelli, F., and Gerosa, M., Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers. Arthritis Research & Therapy. 16:209\u2013223, 2014.","journal-title":"Arthritis Research & Therapy"},{"key":"688_CR9","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1161\/01.CIR.102.25.3137","volume":"102","author":"R Cooper","year":"2000","unstructured":"Cooper, R., Cutler, J., Desvigne-Nickens, P., Fortmann, S.P., Friedman, L., Havlik, R., Hogelin, G., Marler, J., McGovern, P., Morosco, G., Mosca, L., Pearson, T., Stamler, J., Stryer, D., and Thom, T., Trends and disparities in coronary heart disease, stroke, and other cardiovascular diseases in the United States: findings of the national conference on cardiovascular disease prevention. Circulation. 102:3137\u20133147, 2000.","journal-title":"Circulation"},{"key":"688_CR10","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1182\/blood-2011-03-340232","volume":"118","author":"V Pengo","year":"2011","unstructured":"Pengo, V., Ruffatti, A., Legnani, C., Testa, S., Fierro, T., Marongiu, F., De Micheli, V., Gresele, P., Tonello, M., Ghirarduzzi, A., Bison, E., Denas, G., Banzato, A., Padayattil, J.S., and Iliceto, S., Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood. 118:4714\u20134718, 2011.","journal-title":"Blood"},{"key":"688_CR11","first-page":"50","volume-title":"Proceedings of the annual conference of the ACM on the fifth generation challenge","author":"J Neves","year":"1984","unstructured":"Neves, J., A logic interpreter to handle time and negation in logic databases. In: Muller, R.L., and Pottmyer, J.J. (Eds.), Proceedings of the annual conference of the ACM on the fifth generation challenge. Association for Computing Machinery, New York, pp. 50\u201354, 1984."},{"key":"688_CR12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/978-3-540-77002-2_14","volume-title":"Progress in Artificial Intelligence, LNAI","author":"J Neves","year":"2007","unstructured":"Neves, J., Machado, J., Analide, C., Abelha, A., and Brito, L., The halt condition in genetic programming. In: Neves, J., Santos, M.F., and Machado, J. (Eds.), Progress in Artificial Intelligence, LNAI. Vol. 4874. Springer, Berlin, pp. 160\u2013169, 2007."},{"key":"688_CR13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1023\/B:HEUR.0000034714.09838.1e","volume":"10","author":"P Cortez","year":"2004","unstructured":"Cortez, P., Rocha, M., and Neves, J., Evolving time series forecasting ARMA models. Journal of Heuristics. 10:415\u2013429, 2004.","journal-title":"Journal of Heuristics"},{"key":"688_CR14","volume-title":"Neural networks and learning machines","author":"S Haykin","year":"2009","unstructured":"Haykin, S., Neural networks and learning machines. Pearson Education, New Jersey, 2009."},{"key":"688_CR15","first-page":"291","volume-title":"Proceedings of the ESM 2008","author":"J Machado","year":"2008","unstructured":"Machado, J., Abelha, A., Novais, P., Neves, J., and Neves, J., Quality of service in healthcare units. In: Bertelle, C., and Ayesh, A. (Eds.), Proceedings of the ESM 2008. Eurosis \u2013 ETI Publication, Ghent, pp. 291\u2013298, 2008."},{"key":"688_CR16","doi-asserted-by":"crossref","unstructured":"Cardoso L, Marins F, Magalh\u00e3es R, Marins N, Oliveira T, Vicente H, Abelha A, Machado J, Neves J (2015) Abstract Computation in Schizophrenia Detection through Artificial Neural Network based Systems. The Scientific World Journal 2015:Article ID 467178","DOI":"10.1155\/2015\/467178"},{"key":"688_CR17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/978-0-85729-412-8_23","volume-title":"Research and developments in intelligent systems XX","author":"P Lucas","year":"2004","unstructured":"Lucas, P., Quality checking of medical guidelines through logical abduction. In: Coenen, F., Preece, A., and Mackintosh, A. (Eds.), Research and developments in intelligent systems XX. Springer, London pp, pp. 309\u2013321, 2004."},{"key":"688_CR18","first-page":"235","volume-title":"Handbook of logic in artificial intelligence and logic programming","author":"A Kakas","year":"1998","unstructured":"Kakas, A., Kowalski, R., and Toni, F., The role of abduction in logic programming. In: Gabbay, D., Hogger, C., and Robinson, I. (Eds.), Handbook of logic in artificial intelligence and logic programming. Vol. 5. Oxford University Press, Oxford, pp. 235\u2013324, 1998."},{"key":"688_CR19","first-page":"51","volume-title":"New advances in intelligent decision technologies \u2013 results of the first KES International symposium IDT 2009, studies in computational intelligence","author":"LM Pereira","year":"2009","unstructured":"Pereira, L.M., and Anh, H.T., Evolution prospection. In: Nakamatsu, K. (Ed.), New advances in intelligent decision technologies \u2013 results of the first KES International symposium IDT 2009, studies in computational intelligence. Vol. 199. Springer, Berlin, pp. 51\u201364, 2009."},{"key":"688_CR20","doi-asserted-by":"crossref","unstructured":"Fernandes F, Vicente H, Abelha A, Machado J, Novais P, Neves J (2015) Artificial Neural Networks in Diabetes Control. In: Proceedings of the 2015 Science and Information Conference, IEEE Edition, pp. 362\u2013370","DOI":"10.1109\/SAI.2015.7237169"},{"key":"688_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/978-3-319-31232-3_15","volume-title":"New advances in information systems and technologies \u2013 1, advances in intelligent systems and computing","author":"J Vilhena","year":"2016","unstructured":"Vilhena, J., Vicente, H., Martins, M.R., Gra\u00f1eda, J., Caldeira, F., Gusm\u00e3o, R., Neves, J., and Neves, J., Antiphospholipid syndrome risk evaluation. In: Rocha, \u00c1., Correia, A.M., Adeli, H., Reis, L.P., and Teixeira, M.M. (Eds.), New advances in information systems and technologies \u2013 1, advances in intelligent systems and computing. Vol. 444. Springer International Publishing, Cham, pp. 157\u2013167, 2016."},{"key":"688_CR22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1109\/72.977258","volume":"13","author":"S Mitra","year":"2002","unstructured":"Mitra, S., Pal, S., and Mitra, P., Data mining in soft computing framework: a survey. IEEE Transactions on Neural Networks. 13:3\u201314, 2002.","journal-title":"IEEE Transactions on Neural Networks"},{"key":"688_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0920-5489(94)90017-5","volume":"16","author":"M Riedmiller","year":"1994","unstructured":"Riedmiller, M., Advanced supervised learning in multilayer perceptrons \u2013 from backpropagation to adaptive learning algorithms. Computer Standards & Interfaces. 16:265\u2013278, 1994.","journal-title":"Computer Standards & Interfaces"},{"key":"688_CR24","first-page":"20","volume-title":"Evaluating pruning methods","author":"G Thimm","year":"1995","unstructured":"Thimm, G., and Fiesler, E., Evaluating pruning methods. Proceedings of the International Symposium on Artificial Neural Networks, In, pp. 20\u201325, 1995."},{"key":"688_CR25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1109\/72.572102","volume":"8","author":"T Kwok","year":"1997","unstructured":"Kwok, T., and Yeung, D., Constructive algorithms for structure learning in feedforward neural networks for regression problems: a survey. IEEE Transactions on Neural Networks. 8:630\u2013645, 1997.","journal-title":"IEEE Transactions on Neural Networks"},{"key":"688_CR26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2478\/v10136-012-0031-x","volume":"11","author":"F Amato","year":"2013","unstructured":"Amato, F., L\u00f3pez, A., Pe\u00f1a-M\u00e9ndez, E.M., Va\u0148hara, P., Hampl, A., and Havel, J., Artificial neural networks in medical diagnosis. Journal of Applied Biomedicine. 11:47\u201358, 2013.","journal-title":"Journal of Applied Biomedicine"},{"key":"688_CR27","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1016\/j.eswa.2014.01.011","volume":"41","author":"N Esfandiari","year":"2014","unstructured":"Esfandiari, N., Babavalian, M.R., Moghadam, A.-M., and Tabar, V.K., Knowledge discovery in medicine: current issue and future trend. Expert Systems with Applications. 41:4434\u20134463, 2014.","journal-title":"Expert Systems with Applications"},{"key":"688_CR28","doi-asserted-by":"crossref","unstructured":"Martins MR, Mendes T, Gra\u00f1eda JM, Gusm\u00e3o R. Vicente H, Neves J (2015) Artificial neural networks in acute coronary syndrome screening. In: Ortu\u00f1o F, Rojas I (eds) Bioinformatics and biomedical engineering \u2013 I, lecture notes in computer science, Vol. 9043, Springer International Publishing, Cham, pp. 108\u2013119","DOI":"10.1007\/978-3-319-16483-0_11"},{"key":"688_CR29","unstructured":"CLSI (formerly NCCLS) (2008) Collection, transport, and processing of blood specimens for testing plasma-based coagulation assays and molecular hemostasis assays \u2013 approved guideline. Clinical and Laboratory Standards Institute, Wayne"},{"key":"688_CR30","unstructured":"O'Neil, P., O'Neil, B., and Chen, X., Star Schema Benchmark. Revision 3. (June 5) http:\/\/www.cs.umb.edu\/~poneil\/StarSchemaB.pdf . Accessed 26 May 2016, 2009."},{"issue":"Suppl 1","key":"688_CR31","first-page":"S83","volume":"29","author":"CM Florkowski","year":"2008","unstructured":"Florkowski, C.M., Sensitivity, specificity, receiver-operating characteristic (ROC) curves and likelihood ratios: communicating the performance of diagnostic tests. The Clinical Biochemist Reviews. 29(Suppl 1):S83\u2013S87, 2008.","journal-title":"The Clinical Biochemist Reviews"},{"key":"688_CR32","first-page":"627","volume":"4","author":"K Hajian-Tilaki","year":"2013","unstructured":"Hajian-Tilaki, K., Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Caspian Journal of Internal Medicine. 4:627\u2013635, 2013.","journal-title":"Caspian Journal of Internal Medicine"},{"key":"688_CR33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2166\/aqua.2012.014","volume":"61","author":"H Vicente","year":"2012","unstructured":"Vicente, H., Dias, S., Fernandes, A., Abelha, A., Machado, J., and Neves, J., Prediction of the quality of public water supply using artificial neural networks. Journal of Water Supply: Research and Technology \u2013 AQUA. 61:446\u2013459, 2012.","journal-title":"Journal of Water Supply: Research and Technology \u2013 AQUA"},{"key":"688_CR34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2495\/DNE-V7-N3-309-318","volume":"7","author":"H Vicente","year":"2012","unstructured":"Vicente, H., Couto, C., Machado, J., Abelha, A., and Neves, J., Prediction of water quality parameters in a reservoir using artificial neural networks. International Journal of Design & Nature and Ecodynamics. 7:309\u2013318, 2012.","journal-title":"International Journal of Design & Nature and Ecodynamics"},{"key":"688_CR35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1139\/cjfr-2013-0142","volume":"43","author":"H Vicente","year":"2013","unstructured":"Vicente, H., Roseiro, J., Arteiro, J., Neves, J., and Caldeira, A.T., Prediction of bioactive compound activity against wood contaminant fungi using artificial neural networks. Canadian Journal of Forest Research. 43:985\u2013992, 2013.","journal-title":"Canadian Journal of Forest Research"},{"key":"688_CR36","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/art.33340","volume":"64","author":"K Otomo","year":"2012","unstructured":"Otomo, K., Atsumi, T., Amengual, O., Fujieda, Y., Kato, M., Oku, K., Horita, T., Yasuda, S., and Koike, T., Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events. Arthritis & Rheumatism. 64:504\u2013512, 2012.","journal-title":"Arthritis & Rheumatism"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-017-0688-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10916-017-0688-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-017-0688-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T04:50:47Z","timestamp":1498366247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10916-017-0688-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,23]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["688"],"URL":"https:\/\/doi.org\/10.1007\/s10916-017-0688-5","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"value":"0148-5598","type":"print"},{"value":"1573-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,23]]},"article-number":"40"}}