{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:28Z","timestamp":1786981468435,"version":"3.56.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s10916-019-1412-4","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T09:40:15Z","timestamp":1562233215000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Basic Research in Diabetic Nephropathy Health Care: A study of the Renoprotective Mechanism of Metformin"],"prefix":"10.1007","volume":"43","author":[{"given":"Jing","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuxing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"1412_CR1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1111\/1753-0407.12265","volume":"7","author":"Q Wan","year":"2015","unstructured":"Wan, Q., Xu, Y., and Dong, E., Diabetic nephropathy research in China: Data analysis and review from the National Natural Science Foundation of China. Journal of Diabetes 7:307\u2013314, 2015.","journal-title":"Journal of Diabetes"},{"key":"1412_CR2","doi-asserted-by":"publisher","first-page":"2515","DOI":"10.1001\/jama.2017.7596","volume":"317","author":"L Wang","year":"2017","unstructured":"Wang, L., Gao, P., Zhang, M. et al., Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 317:2515\u20132523, 2017.","journal-title":"JAMA"},{"key":"1412_CR3","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.2215\/CJN.11491116","volume":"12","author":"RZ Alicic","year":"2017","unstructured":"Alicic, R. Z., Rooney, M. T., and Tuttle, K. R., Diabetic kidney disease: Challenges, progress, and possibilities. Clinical Journal of the American Society of Nephrology 12:2032\u20132045, 2017.","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"1412_CR4","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1038\/nrneph.2012.44","volume":"8","author":"SJ Allison","year":"2012","unstructured":"Allison, S. J., and disease, C. k., Study warns of burgeoning health burden of CKD in China. Nature Reviews Nephrology 8:251, 2012.","journal-title":"Nature Reviews Nephrology"},{"key":"1412_CR5","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1053\/j.ajkd.2015.12.002","volume":"67","author":"IH De Boer","year":"2016","unstructured":"De Boer, I. H., Afkarian, M., and Tuttle, K. R., The surging tide of diabetes: Implications for nephrology. American Journal of Kidney Diseases 67:364\u2013366, 2016.","journal-title":"American Journal of Kidney Diseases"},{"key":"1412_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/36285","volume":"390","author":"M Kuro-o","year":"1997","unstructured":"Kuro-o, M., Matsumura, Y., Aizawa, H. et al., Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390:45\u201351, 1997.","journal-title":"Nature"},{"issue":"8","key":"1412_CR7","doi-asserted-by":"publisher","first-page":"pe11","DOI":"10.1126\/sageke.2006.8.pe11","volume":"2006","author":"Y.-i. Nabeshima","year":"2006","unstructured":"Nabeshima, Y. I., Toward a better understanding of klotho. Science of Aging Knowledge Environment 2006:pe11, 2006.","journal-title":"Science of Aging Knowledge Environment"},{"key":"1412_CR8","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1126\/science.1112766","volume":"309","author":"H Kurosu","year":"2005","unstructured":"Kurosu, H., Yamamoto, M., Clark, J. D. et al., Suppression of aging in mice by the hormone Klotho. Science 309:1829\u20131833, 2005.","journal-title":"Science"},{"key":"1412_CR9","first-page":"5691","volume":"14","author":"Y Xu","year":"2017","unstructured":"Xu, Y., Peng, H., and Ke, B., \u03b1-klotho and anemia in patients with chronic kidney disease patients: A new perspective. Experimental and Therapeutic Medicine 14:5691\u20135695, 2017.","journal-title":"Experimental and Therapeutic Medicine"},{"key":"1412_CR10","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12882-018-1094-z","volume":"19","author":"D Zou","year":"2018","unstructured":"Zou, D., Wu, W., He, Y. et al., The role of klotho in chronic kidney disease. BMC Nephrology 19:285, 2018.","journal-title":"BMC Nephrology"},{"key":"1412_CR11","doi-asserted-by":"publisher","first-page":"3855","DOI":"10.1210\/en.2013-1053","volume":"154","author":"Y Lin","year":"2013","unstructured":"Lin, Y., Kuro-o, M., and Sun, Z., Genetic deficiency of anti-aging gene Klotho exacerbates early nephropathy in STZ-induced diabetes in male mice. Endocrinology 154:3855\u20133863, 2013.","journal-title":"Endocrinology"},{"key":"1412_CR12","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.dsx.2015.02.008","volume":"9","author":"J Ahmad","year":"2015","unstructured":"Ahmad, J., Management of diabetic nephropathy: Recent progress and future perspective. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 9:343\u2013358, 2015.","journal-title":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews"},{"key":"1412_CR13","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1093\/oxfordjournals.jmicro.a023700","volume":"48","author":"K Ina","year":"1999","unstructured":"Ina, K., Kitamura, H., Nagai, K. et al., Ultrastructural and functional changes of the proximal tubular epithelial cells in the renal cortex from spontaneously diabetic KKAy mice. Microscopy 48:443\u2013448, 1999.","journal-title":"Microscopy"},{"key":"1412_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.18","volume":"1","author":"MC Thomas","year":"2015","unstructured":"Thomas, M. C., Brownlee, M., Susztak, K. et al., Diabetic kidney disease. Nature Reviews Disease Primers 1:15018, 2015.","journal-title":"Nature Reviews Disease Primers"},{"key":"1412_CR15","first-page":"73","volume":"2","author":"H Shahbazian","year":"2013","unstructured":"Shahbazian, H., and Rezaii, I., Diabetic kidney disease; review of the current knowledge. Journal of Renal Injury Prevention 2:73\u201380, 2013.","journal-title":"Journal of Renal Injury Prevention"},{"key":"1412_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1053\/j.ackd.2017.12.002","volume":"25","author":"RZ Alicic","year":"2018","unstructured":"Alicic, R. Z., Johnson, E. J., and Tuttle, K. R., Inflammatory mechanisms as new biomarkers and therapeutic targets for diabetic kidney disease. Advances in Chronic Kidney Disease 25:181\u2013191, 2018.","journal-title":"Advances in Chronic Kidney Disease"},{"key":"1412_CR17","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ejphar.2016.08.022","volume":"791","author":"N Bhattacharjee","year":"2016","unstructured":"Bhattacharjee, N., Barma, S., Konwar, N. et al., Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update. European Journal of Pharmacology 791:8\u201324, 2016.","journal-title":"European Journal of Pharmacology"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-019-1412-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10916-019-1412-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-019-1412-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:21:28Z","timestamp":1593717688000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10916-019-1412-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["1412"],"URL":"https:\/\/doi.org\/10.1007\/s10916-019-1412-4","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"value":"0148-5598","type":"print"},{"value":"1573-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"12 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors have no conflicts of interest with the contents of this paper to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human studies"}}],"article-number":"266"}}