{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:17:07Z","timestamp":1740122227703,"version":"3.37.3"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s10916-019-1491-2","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T15:04:49Z","timestamp":1575990289000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can we Predict Preoperative Tumor Aggressivity with Hemogram Parameters in Renal Cell Carcinoma? a Novel Calculation Method"],"prefix":"10.1007","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8690-0485","authenticated-orcid":false,"given":"Murat","family":"U\u00e7ar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sedat","family":"Soyupek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylan","family":"Oksay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alper","family":"\u00d6zorak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Akko\u00e7","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Top\u00e7uo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Demir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alim","family":"Ko\u015far","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"1491_CR1","doi-asserted-by":"crossref","unstructured":"Siegel, R. L., and Miller, K. D., Cancer statistics, 2019. 69(1):7\u201334, 2019.","DOI":"10.3322\/caac.21551"},{"issue":"3","key":"1491_CR2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4103\/0973-1482.137924","volume":"10","author":"B Sureka","year":"2014","unstructured":"Sureka, B., Lal, A., Khandelwal, N., Joshi, K., Singh, S. K., Agarwal, M. M., and Mittal, A., Dynamic computed tomography and Doppler findings in different subtypes of renal cell carcinoma with their histopathological correlation. J. Cancer Res. Ther. 10(3):552\u2013557, 2014.","journal-title":"J. Cancer Res. Ther."},{"issue":"4","key":"1491_CR3","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1016\/j.juro.2009.12.035","volume":"183","author":"BC Leibovich","year":"2010","unstructured":"Leibovich, B. C., Lohse, C. M., Crispen, P. L., Boorjian, S. A., Thompson, R. H., Blute, M. L., and Cheville, J. C., Histological subtype is an independent predictor of outcome for patients with renal cell carcinoma. J. Urol. 183(4):1309\u20131315, 2010.","journal-title":"J. Urol."},{"key":"1491_CR4","doi-asserted-by":"crossref","unstructured":"Sobin, L. H., Gospodarowicz, M. K., and Wittekind, C., TNM classification of malignant tumours. John Wiley & Sons, 2011.","DOI":"10.1002\/9780471420194.tnmc26.pub2"},{"issue":"4","key":"1491_CR5","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.eururo.2011.06.041","volume":"60","author":"M Sun","year":"2011","unstructured":"Sun, M., Shariat, S. F., Cheng, C., Ficarra, V., Murai, M., Oudard, S., Pantuck, A. J., Zigeuner, R., and Karakiewicz, P. I., Prognostic factors and predictive models in renal cell carcinoma: A contemporary review. Eur. Urol. 60(4):644\u2013661, 2011.","journal-title":"Eur. Urol."},{"issue":"7203","key":"1491_CR6","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani, A., Allavena, P., Sica, A., and Balkwill, F., Cancer-related inflammation. Nature 454(7203):436\u2013444, 2008.","journal-title":"Nature"},{"issue":"3","key":"1491_CR7","doi-asserted-by":"publisher","first-page":"660","DOI":"10.4103\/0973-1482.139388","volume":"11","author":"SK Mandal","year":"2015","unstructured":"Mandal, S. K., Ganguly, J., Sil, K., Mondal, S. S., Sardar, D., and Sarkar, P., Renal cell carcinoma with paraneoplastic leucocytosis. J. Cancer Res. Ther. 11(3):660, 2015.","journal-title":"J. Cancer Res. Ther."},{"issue":"3","key":"1491_CR8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/bju.12767","volume":"115","author":"M de Martino","year":"2015","unstructured":"de Martino, M., Leitner, C. V., Seemann, C., Hofbauer, S. L., Lucca, I., Haitel, A., Shariat, S. F., and Klatte, T., Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma (RCC). BJU Int. 115(3):397\u2013404, 2015.","journal-title":"BJU Int."},{"issue":"8","key":"1491_CR9","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/bjc.2014.450","volume":"111","author":"SL Hofbauer","year":"2014","unstructured":"Hofbauer, S. L., Stangl, K. I., de Martino, M., Lucca, I., Haitel, A., Shariat, S. F., and Klatte, T., Pretherapeutic gamma-glutamyltransferase is an independent prognostic factor for patients with renal cell carcinoma. Br. J. Cancer 111(8):1526\u20131531, 2014.","journal-title":"Br. J. Cancer"},{"issue":"12","key":"1491_CR10","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1007\/s00345-015-1559-7","volume":"33","author":"I Lucca","year":"2015","unstructured":"Lucca, I., de Martino, M., Hofbauer, S. L., Zamani, N., Shariat, S. F., and Klatte, T., Comparison of the prognostic value of pretreatment measurements of systemic inflammatory response in patients undergoing curative resection of clear cell renal cell carcinoma. World J. Urol. 33(12):2045\u20132052, 2015.","journal-title":"World J. Urol."},{"issue":"2","key":"1491_CR11","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1245\/s10434-015-4869-5","volume":"23","author":"H Yodying","year":"2016","unstructured":"Yodying, H., Matsuda, A., Miyashita, M., Matsumoto, S., Sakurazawa, N., Yamada, M., and Uchida, E., Prognostic significance of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in oncologic outcomes of esophageal Cancer: A systematic review and meta-analysis. Ann. Surg. Oncol. 23(2):646\u2013654, 2016.","journal-title":"Ann. Surg. Oncol."},{"key":"1491_CR12","doi-asserted-by":"crossref","unstructured":"Mano, R., Flynn, J., Blum, K. A., Silagy, A. W., DiNatale, R. G., Marcon, J., Wang, A., Sanchez, A., Coleman, J. A., Russo, P., Ostrovnaya, I., and Hakimi, A. A., The predictive role of preoperative and postoperative neutrophil-lymphocyte ratio in sarcomatoid renal cell carcinoma. Urol. Oncol., Seminars and Original Investigations. Elsevier, 2019.","DOI":"10.1016\/j.urolonc.2019.09.006"},{"issue":"9","key":"1491_CR13","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.4103\/njcp.njcp_35_19","volume":"22","author":"SO Ikuerowo","year":"2019","unstructured":"Ikuerowo, S. O., Ojewuyi, O. O., Omisanjo, O. A., Abolarinwa, A. A., Bioku, M. J., and Doherty, A. F., Paraneoplastic syndromes and oncological outcomes in renal cancer. Niger. J. Clin. Pract. 22(9):1271\u20131275, 2019.","journal-title":"Niger. J. Clin. Pract."},{"key":"1491_CR14","doi-asserted-by":"crossref","unstructured":"Muijs, D., Doing quantitative research in education with SPSS. In: Bivariate analysis: comparing two groups, pp 126, Sage, 2010.","DOI":"10.4135\/9781849203241"},{"issue":"1","key":"1491_CR15","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1245\/s10434-011-1814-0","volume":"19","author":"B Azab","year":"2012","unstructured":"Azab, B., Bhatt, V. R., Phookan, J., Murukutla, S., Kohn, N., Terjanian, T., and Widmann, W. D., Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann. Surg. Oncol. 19(1):217\u2013224, 2012.","journal-title":"Ann. Surg. Oncol."},{"issue":"3","key":"1491_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1245\/s10434-008-0267-6","volume":"16","author":"Y Kishi","year":"2009","unstructured":"Kishi, Y., Kopetz, S., Chun, Y. S., Palavecino, M., Abdalla, E. K., and Vauthey, J. N., Blood neutrophil-to-lymphocyte ratio predicts survival in patients with colorectal liver metastases treated with systemic chemotherapy. Ann. Surg. Oncol. 16(3):614\u2013622, 2009.","journal-title":"Ann. Surg. Oncol."},{"issue":"23","key":"1491_CR17","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1158\/1078-0432.CCR-10-2245","volume":"16","author":"SC Kao","year":"2010","unstructured":"Kao, S. C., Pavlakis, N., Harvie, R., Vardy, J. L., Boyer, M. J., van Zandwijk, N., and Clarke, S. J., High blood neutrophil-to-lymphocyte ratio is an indicator of poor prognosis in malignant mesothelioma patients undergoing systemic therapy. Clin. Cancer Res.: an official journal of the American Association for Cancer Research 16(23):5805\u20135813, 2010.","journal-title":"Clin. Cancer Res.: an official journal of the American Association for Cancer Research"},{"issue":"5","key":"1491_CR18","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3109\/0886022X.2012.668741","volume":"34","author":"B Azab","year":"2012","unstructured":"Azab, B., Daoud, J., Naeem, F. B., Nasr, R., Ross, J., Ghimire, P., Siddiqui, A., Azzi, N., Rihana, N., Abdallah, M., Azzi, N., Patel, P., Kleiner, M., and el-Sayegh, S., Neutrophil-to-lymphocyte ratio as a predictor of worsening renal function in diabetic patients (3-year follow-up study). Ren. Fail. 34(5):571\u2013576, 2012.","journal-title":"Ren. Fail."},{"issue":"1","key":"1491_CR19","first-page":"8151","volume":"23","author":"WM Bazzi","year":"2016","unstructured":"Bazzi, W. M., Tin, A. L., Sjoberg, D. D., Bernstein, M., and Russo, P., The prognostic utility of preoperative neutrophil-to-lymphocyte ratio in localized clear cell renal cell carcinoma. Can. J. Urol. 23(1):8151\u20138154, 2016.","journal-title":"Can. J. Urol."},{"issue":"4","key":"1491_CR20","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/bjc.2013.28","volume":"108","author":"M Pichler","year":"2013","unstructured":"Pichler, M., Hutterer, G. C., Stoeckigt, C., Chromecki, T. F., Stojakovic, T., Golbeck, S., Eberhard, K., Gerger, A., Mannweiler, S., Pummer, K. et al., Validation of the pre-treatment neutrophil-lymphocyte ratio as a prognostic factor in a large European cohort of renal cell carcinoma patients. Br. J. Cancer 108(4):901\u2013907, 2013.","journal-title":"Br. J. Cancer"},{"issue":"2","key":"1491_CR21","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ejca.2011.09.001","volume":"48","author":"D Keizman","year":"2012","unstructured":"Keizman, D., Ish-Shalom, M., Huang, P., Eisenberger, M. A., Pili, R., Hammers, H., and Carducci, M. A., The association of pre-treatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur. J. Cancer (Oxford, England : 1990) 48(2):202\u2013208, 2012.","journal-title":"Eur. J. Cancer (Oxford, England : 1990)"},{"issue":"6","key":"1491_CR22","first-page":"3463","volume":"35","author":"GC Hutterer","year":"2015","unstructured":"Hutterer, G. C., Krieger, D., Mrsic, E., Pohlmann, K., Bezan, A., Stojakovic, T., Pummer, K., Zigeuner, R., and Pichler, M., Preoperative Leucocytosis, thrombocytosis and Anemia as potential prognostic factors in non-metastatic renal cell carcinoma. Anticancer Res. 35(6):3463\u20133469, 2015.","journal-title":"Anticancer Res."},{"issue":"6","key":"1491_CR23","first-page":"3175","volume":"37","author":"L Xia","year":"2017","unstructured":"Xia, L., Hu, G., and Guzzo, T. J., Prognostic significance of preoperative Anemia in patients undergoing surgery for renal cell carcinoma: A meta-analysis. Anticancer Res. 37(6):3175\u20133181, 2017.","journal-title":"Anticancer Res."},{"issue":"2","key":"1491_CR24","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00383-013-3321-9","volume":"30","author":"EC Rhodes","year":"2014","unstructured":"Rhodes, E. C., Parikh, S. P., and Bhattacharyya, N., Severe autoimmune hemolytic anemia with renal neoplasm. Pediatr. Surg. Int. 30(2):243\u2013244, 2014.","journal-title":"Pediatr. Surg. Int."},{"issue":"23","key":"1491_CR25","doi-asserted-by":"publisher","first-page":"4559","DOI":"10.1200\/JCO.2002.05.111","volume":"20","author":"A Zisman","year":"2002","unstructured":"Zisman, A., Pantuck, A. J., Wieder, J., Chao, D. H., Dorey, F., Said, J. W., deKernion, J. B., Figlin, R. A., and Belldegrun, A. S., Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma. J. Clin. Oncol.: official journal of the American Society of Clinical Oncology 20(23):4559\u20134566, 2002.","journal-title":"J. Clin. Oncol.: official journal of the American Society of Clinical Oncology"},{"issue":"7","key":"1491_CR26","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/cncr.11234","volume":"97","author":"BC Leibovich","year":"2003","unstructured":"Leibovich, B. C., Blute, M. L., Cheville, J. C., Lohse, C. M., Frank, I., Kwon, E. D., Weaver, A. L., Parker, A. S., and Zincke, H., Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma: A stratification tool for prospective clinical trials. Cancer 97(7):1663\u20131671, 2003.","journal-title":"Cancer"},{"issue":"6","key":"1491_CR27","doi-asserted-by":"publisher","first-page":"2395","DOI":"10.1016\/S0022-5347(05)64153-5","volume":"168","author":"I Frank","year":"2002","unstructured":"Frank, I., Blute, M. L., Cheville, J. C., Lohse, C. M., Weaver, A. L., and Zincke, H., An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: The SSIGN score. J. Urol. 168(6):2395\u20132400, 2002.","journal-title":"J. Urol."},{"issue":"8","key":"1491_CR28","doi-asserted-by":"publisher","first-page":"E348","DOI":"10.1111\/bju.12067","volume":"111","author":"M de Martino","year":"2013","unstructured":"de Martino, M., Klatte, T., Seemann, C., Waldert, M., Haitel, A., Schatzl, G., Remzi, M., and Weibl, P., Validation of serum C-reactive protein (CRP) as an independent prognostic factor for disease-free survival in patients with localised renal cell carcinoma (RCC). BJU Int. 111(8):E348\u2013E353, 2013.","journal-title":"BJU Int."},{"issue":"3","key":"1491_CR29","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1158\/1055-9965.EPI-08-0786","volume":"18","author":"T Klatte","year":"2009","unstructured":"Klatte, T., Seligson, D. B., LaRochelle, J., Shuch, B., Said, J. W., Riggs, S. B., Zomorodian, N., Kabbinavar, F. F., Pantuck, A. J., and Belldegrun, A. S., Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. Cancer Epidemiol. Biomarkers Prev.: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 18(3):894\u2013900, 2009.","journal-title":"Cancer Epidemiol. Biomarkers Prev.: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"issue":"1","key":"1491_CR30","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/cncr.26254","volume":"118","author":"M de Martino","year":"2012","unstructured":"de Martino, M., Klatte, T., Haitel, A., and Marberger, M., Serum cell-free DNA in renal cell carcinoma: a diagnostic and prognostic marker. Cancer 118(1):82\u201390, 2012.","journal-title":"Cancer"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-019-1491-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10916-019-1491-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-019-1491-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:53:43Z","timestamp":1695502423000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10916-019-1491-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1491"],"URL":"https:\/\/doi.org\/10.1007\/s10916-019-1491-2","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"type":"print","value":"0148-5598"},{"type":"electronic","value":"1573-689X"}],"subject":[],"published":{"date-parts":[[2019,12,10]]},"assertion":[{"value":"27 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"19"}}