{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T10:38:48Z","timestamp":1779014328910,"version":"3.51.4"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000050","name":"national heart, lung, and blood institute","doi-asserted-by":"publisher","award":["K23HL148640"],"award-info":[{"award-number":["K23HL148640"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Med Syst"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1007\/s10916-021-01779-8","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T09:02:36Z","timestamp":1637830956000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Impact of Functional Dependence and Related Surgical Complications on Postoperative Mortality"],"prefix":"10.1007","volume":"46","author":[{"given":"Jacob C.","family":"Clifton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milo","family":"Engoren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew S.","family":"Shotwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise M.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar D.","family":"Guillamondegui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert E.","family":"Freundlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"1779_CR1","doi-asserted-by":"crossref","unstructured":"Shah, R., et al., Association of Frailty with Failure to Rescue After Low-Risk and High-Risk Inpatient Surgery. JAMA Surg, 2018. 153(5): p. e180214.","DOI":"10.1001\/jamasurg.2018.0214"},{"issue":"3","key":"1779_CR2","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1097\/SLA.0000000000000767","volume":"261","author":"JE Scarborough","year":"2015","unstructured":"Scarborough, J.E., et al., The impact of functional dependency on outcomes after complex general and vascular surgery. Ann Surg, 2015. 261(3): p. 432-7.","journal-title":"Ann Surg"},{"issue":"4","key":"1779_CR3","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1007\/s12603-009-0051-8","volume":"13","author":"RE Pel-Littel","year":"2009","unstructured":"Pel-Littel, R.E., et al., Frailty: defining and measuring of a concept. J Nutr Health Aging, 2009. 13(4): p. 390-4.","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"1779_CR4","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1055\/s-0038-1655756","volume":"4","author":"S Akyar","year":"2018","unstructured":"Akyar, S., et al., The Impact of Frailty on Postoperative Cardiopulmonary Complications in the Emergency General Surgery Population. Surg J (N Y), 2018. 4(2): p. e66-e77.","journal-title":"Surg J (N Y)"},{"issue":"11","key":"1779_CR5","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.jclinepi.2005.03.008","volume":"58","author":"MT Puts","year":"2005","unstructured":"Puts, M.T., P. Lips, and D.J. Deeg, Static and dynamic measures of frailty predicted decline in performance-based and self-reported physical functioning. J Clin Epidemiol, 2005. 58(11): p. 1188-98.","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"1779_CR6","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1503\/cmaj.050051","volume":"173","author":"K Rockwood","year":"2005","unstructured":"Rockwood, K., et al., A global clinical measure of fitness and frailty in elderly people. Cmaj, 2005. 173(5): p. 489-95.","journal-title":"Cmaj"},{"issue":"9","key":"1779_CR7","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1111\/jgs.12420","volume":"61","author":"O Theou","year":"2013","unstructured":"Theou, O., et al., Operationalization of frailty using eight commonly used scales and comparison of their ability to predict all-cause mortality. J Am Geriatr Soc, 2013. 61(9): p. 1537-51.","journal-title":"J Am Geriatr Soc"},{"issue":"975","key":"1779_CR8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1136\/pgmj.2006.048587A","volume":"83","author":"F Lally","year":"2007","unstructured":"Lally F, Crome P. Understanding frailty.\u00a0Postgrad Med J. 2007;83(975):16-20. https:\/\/doi.org\/10.1136\/pgmj.2006.048587A","journal-title":"Postgrad Med J."},{"issue":"3","key":"1779_CR9","doi-asserted-by":"publisher","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146A","volume":"56","author":"Linda P Fried","year":"2001","unstructured":"Linda P. Fried, Catherine M. Tangen, Jeremy Walston, Anne B. Newman, Calvin Hirsch, John Gottdiener, Teresa Seeman, Russell Tracy, Willem J. Kop, Gregory Burke, Mary Ann McBurnie, Frailty in Older Adults: Evidence for a Phenotype,\u00a0The Journals of Gerontology: Series A, Volume 56, Issue 3, 1 March 2001, Pages M146\u2013M157.\u00a0https:\/\/doi.org\/10.1093\/gerona\/56.3.M146A","journal-title":"The Journals of Gerontology: Series A"},{"key":"1779_CR10","doi-asserted-by":"publisher","unstructured":"Makary\u00a0MA, Segev\u00a0DL, Pronovost\u00a0PJ Syin D, Bandeen-Roche K, Patel P, Takenaga R, Devgan L, Holzmueller CG, Tian J, Fried LP.\u00a0Frailty as a predictor of surgical outcomes in older patients J Am Coll Surg.\u00a02010 Jun;210(6):901\u20138.\u00a0https:\/\/doi.org\/10.1016\/j.jamcollsurg.2010.01.028. Epub 2010 Apr 28 PMID: 20510798.","DOI":"10.1016\/j.jamcollsurg.2010.01.028"},{"issue":"7","key":"1779_CR11","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/gerona\/62.7.731A","volume":"62","author":"H Bergman","year":"2007","unstructured":"Bergman H, Ferrucci L, Guralnik J, et al. Frailty: an emerging research and clinical paradigm--issues and controversies.\u00a0J Gerontol A Biol Sci Med Sci. 2007;62(7):731-737. https:\/\/doi.org\/10.1093\/gerona\/62.7.731A","journal-title":"J Gerontol A Biol Sci Med Sci."},{"issue":"3","key":"1779_CR12","doi-asserted-by":"publisher","first-page":"M255","DOI":"10.1093\/gerona\/59.3.M255A","volume":"59","author":"P Linda","year":"2004","unstructured":"Linda P. Fried, Luigi Ferrucci, Jonathan Darer, Jeff D. Williamson, Gerard Anderson, Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care,\u00a0The Journals of Gerontology: Series A, Volume 59, Issue 3, March 2004, Pages M255\u2013M263.\u00a0https:\/\/doi.org\/10.1093\/gerona\/59.3.M255A","journal-title":"Williamson, Gerard Anderson, Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care, The Journals of Gerontology: Series A"},{"key":"1779_CR13","doi-asserted-by":"publisher","unstructured":"Thomas N. Robinson, Ben Eiseman, Jeffrey I. Wallace, Skotti D. Church, Kim K. McFann, Shirley M. Pfister, Terra J. Sharp, Marc Moss, Redefining Geriatric Preoperative Assessment Using Frailty, Disability and Co-Morbidity, Annals of Surgery: September 2009 - Volume 250 - Issue 3 - p 449\u2013455.\u00a0https:\/\/doi.org\/10.1097\/SLA.0b013e3181b45598","DOI":"10.1097\/SLA.0b013e3181b45598"},{"key":"1779_CR14","doi-asserted-by":"publisher","unstructured":"Cheung\u00a0A, Haas B, Ringer TJ, McFarlan A, Wong CL.\u00a0Canadian Study of Health and Aging Clinical Frailty Scale: Does It Predict Adverse Outcomes among Geriatric Trauma Patients?. J Am Coll Surg.\u00a02017 Nov;225(5):658\u2013665.e3.\u00a0https:\/\/doi.org\/10.1016\/j.jamcollsurg.2017.08.008. Epub 2017 Sep 6. PMID: 28888692.","DOI":"10.1016\/j.jamcollsurg.2017.08.008"},{"issue":"4","key":"1779_CR15","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/j.jamcollsurg.2012.06.017","volume":"215","author":"WB Chow","year":"2012","unstructured":"Chow, W.B., et al., Optimal preoperative assessment of the geriatric surgical patient: a best practices guideline from the American College of Surgeons National Surgical Quality Improvement Program and the American Geriatrics Society. J Am Coll Surg, 2012. 215(4): p. 453-66.","journal-title":"J Am Coll Surg"},{"key":"1779_CR16","doi-asserted-by":"publisher","unstructured":"Hall\u00a0DE, Arya S, Schmid KK, Blaser C, Carlson MA, Bailey TL, Purviance G, Bockman T, Lynch TG, Johanning J.\u00a0Development and Initial Validation of the Risk Analysis Index for Measuring Frailty in Surgical Populations. JAMA Surg.\u00a02017 Feb 1;152(2)175\u2013182.\u00a0https:\/\/doi.org\/10.1001\/jamasurg.2016.4202.\u00a0PMID: 27893030; PMCID: PMC7140150.","DOI":"10.1001\/jamasurg.2016.4202"},{"key":"1779_CR17","doi-asserted-by":"publisher","unstructured":"Subramaniam\u00a0S, Aalberg JJ, Soriano RP, Divino CM.\u00a0New 5-Factor Modified Frailty Index Using American College of Surgeons NSQIP Data. J Am Coll Surg.\u00a02018 Feb;226(2)173\u2013181.e8.\u00a0https:\/\/doi.org\/10.1016\/j.jamcollsurg.2017.11.005. Epub 2017 Nov 16. PMID: 29155268.","DOI":"10.1016\/j.jamcollsurg.2017.11.005"},{"key":"1779_CR18","doi-asserted-by":"publisher","unstructured":"E Dent P Kowal EO Hoogendijk 2016 Jun Frailty measurement in research and clinical practice: A review Eur J Intern Med. 31 3 10 https:\/\/doi.org\/10.1016\/j.ejim.2016.03.007. Epub 2016 Mar 31 PMID: 27039014","DOI":"10.1016\/j.ejim.2016.03.007"},{"key":"1779_CR19","doi-asserted-by":"publisher","unstructured":"McDonald\u00a0VS, Thompson KA, Lewis PR, Sise CB, Sise MJ, Shackford SR.\u00a0Frailty in trauma: A systematic review of the surgical literature for clinical assessment tools. J Trauma Acute Care Surg.\u00a02016 May;80(5)824\u2013834.\u00a0https:\/\/doi.org\/10.1097\/TA.0000000000000981. PMID: 26881488.","DOI":"10.1097\/TA.0000000000000981"},{"key":"1779_CR20","doi-asserted-by":"publisher","unstructured":"Joseph B, Pandit V, Zangbar B, Kulvatunyou N, Tang A, O'Keeffe T, Green DJ, Vercruysse G, Fain MJ, Friese RS, Rhee P. Validating trauma-specific frailty index for geriatric trauma patients: a prospective analysis. J Am Coll Surg. 2014 Jul;219(1):10\u201317.e1.\u00a0https:\/\/doi.org\/10.1016\/j.jamcollsurg.2014.03.020. Epub 2014 Mar 19. Erratum in: J Am Coll Surg. 2016 Mar;222(3):336. PMID: 24952434.","DOI":"10.1016\/j.jamcollsurg.2014.03.020"},{"key":"1779_CR21","unstructured":"Program, A.C.o.S.N.S.Q.I. User Guide for the 2017 ACS NSQIP Participant Use Data File. 12\/16\/2020]; Available from: https:\/\/www.facs.org\/~\/media\/files\/quality%20programs\/nsqip\/nsqip_puf_userguide_2017.ashx."},{"key":"1779_CR22","doi-asserted-by":"crossref","unstructured":"Fried, L.P., et al.,\u00a0Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci,\u00a02004;59(3): p. 255\u2013263.","DOI":"10.1093\/gerona\/59.3.M255"},{"issue":"5","key":"1779_CR23","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1007\/s00464-012-2678-5","volume":"27","author":"MA Khan","year":"2013","unstructured":"Khan, M.A., et al., Perioperative risk factors for 30-day mortality after bariatric surgery: is functional status important? Surg Endosc, 2013. 27(5): p. 1772-7.","journal-title":"Surg Endosc"},{"issue":"11","key":"1779_CR24","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/gerona\/58.11.M1049","volume":"58","author":"M Ponzetto","year":"2003","unstructured":"Ponzetto, M., et al., Risk factors for early and late mortality in hospitalized older patients: the continuing importance of functional status. J Gerontol A Biol Sci Med Sci, 2003. 58(11): p. 1049-54.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"1779_CR25","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1097\/SLA.0b013e31819eda21","volume":"249","author":"ME Cohen","year":"2009","unstructured":"Cohen, M.E., et al., Effect of subjective preoperative variables on risk-adjusted assessment of hospital morbidity and mortality. Ann Surg, 2009. 249(4): p. 682-9.","journal-title":"Ann Surg"},{"key":"1779_CR26","doi-asserted-by":"crossref","unstructured":"Kilic, A., et al., Functional status is highly predictive of outcomes after redo lung transplantation: an analysis of 390 cases in the modern era. Ann Thorac Surg, 2013. 96(5): p. 1804\u201311; discussion 1811.","DOI":"10.1016\/j.athoracsur.2013.05.080"},{"key":"1779_CR27","doi-asserted-by":"crossref","unstructured":"de la Fuente,\u00a0S.G., K.M. Bennett, and J.E. Scarborough,\u00a0Functional status determines postoperative outcomes in elderly patients undergoing hepatic resections. J Surg Oncol,\u00a02013;107(8):865\u201370.","DOI":"10.1002\/jso.23335"},{"key":"1779_CR28","doi-asserted-by":"crossref","unstructured":"Lentine, K.L., et al., Impact of Functional Status on Outcomes of Simultaneous Pancreas-kidney Transplantation: Risks and Opportunities for Patient Benefit. Transplant Direct, 2020. 6(9): p. e599.","DOI":"10.1097\/TXD.0000000000001043"},{"key":"1779_CR29","doi-asserted-by":"crossref","unstructured":"Stienen,\u00a0M.N. et al.,\u00a0The influence of preoperative dependency on mortality, functional recovery and complications after microsurgical resection of intracranial tumors. J Neurooncol,\u00a02018;139(2):441\u2013448.","DOI":"10.1007\/s11060-018-2882-9"},{"key":"1779_CR30","unstructured":"Network, E. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: guidelines for reporting observational studies. 12\/16\/20]; Available from: https:\/\/www.equator-network.org\/reporting-guidelines\/strobe\/."},{"key":"1779_CR31","doi-asserted-by":"crossref","unstructured":"White, I.R., P. Royston, and A.M. Wood,\u00a0Multiple imputation using chained equations: Issues and guidance for practice. Stat Med,\u00a02011;30(4): p. 377\u201399.","DOI":"10.1002\/sim.4067"},{"key":"1779_CR32","doi-asserted-by":"crossref","unstructured":"Buuren, S. and C. Groothuis-Oudshoorn, MICE: Multivariate Imputation by Chained Equations in R. Journal of Statistical Software, 2011. 45.","DOI":"10.18637\/jss.v045.i03"},{"issue":"1","key":"1779_CR33","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1186\/s12874-017-0442-1","volume":"17","author":"JC Jakobsen","year":"2017","unstructured":"Jakobsen, J.C., et al., When and how should multiple imputation be used for handling missing data in randomised clinical trials - a practical guide with flowcharts. BMC Med Res Methodol, 2017. 17(1): p. 162.","journal-title":"BMC Med Res Methodol"},{"key":"1779_CR34","doi-asserted-by":"crossref","unstructured":"Little,\u00a0R.J., et al.,\u00a0The prevention and treatment of missing data in clinical trials. The New England journal of medicine,\u00a02012;367(14): p. 1355\u20131360.","DOI":"10.1056\/NEJMsr1203730"},{"issue":"11","key":"1779_CR35","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1503\/cmaj.110977","volume":"184","author":"RH Groenwold","year":"2012","unstructured":"Groenwold, R.H., et al., Missing covariate data in clinical research: when and when not to use the missing-indicator method for analysis. Cmaj, 2012. 184(11): p. 1265-9.","journal-title":"Cmaj"},{"issue":"433","key":"1779_CR36","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1080\/01621459.1996.10476680","volume":"91","author":"MP Jones","year":"1996","unstructured":"Jones, M.P., Indicator and Stratification Methods for Missing Explanatory Variables in Multiple Linear Regression. Journal of the American Statistical Association, 1996. 91(433): p. 222-230.","journal-title":"Journal of the American Statistical Association"},{"issue":"2","key":"1779_CR37","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1080\/00031305.2016.1154108","volume":"70","author":"RL Wasserstein","year":"2016","unstructured":"Wasserstein, R.L. and N.A. Lazar, The ASA Statement on p-Values: Context, Process, and Purpose. The American Statistician, 2016. 70(2): p. 129-133.","journal-title":"The American Statistician"},{"issue":"1","key":"1779_CR38","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.2517-6161.1996.tb02080.x","volume":"58","author":"R Tibshirani","year":"1996","unstructured":"Tibshirani, R., Regression Shrinkage and Selection Via the Lasso. Journal of the Royal Statistical Society: Series B (Methodological), 1996. 58(1): p. 267-288.","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"issue":"3","key":"1779_CR39","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1214\/13-AOS1096","volume":"41","author":"J Bien","year":"2013","unstructured":"Bien, J., J. Taylor, and R. Tibshirani, A LASSO FOR HIERARCHICAL INTERACTIONS. Ann Stat, 2013. 41(3): p. 1111-1141.","journal-title":"Ann Stat"},{"key":"1779_CR40","doi-asserted-by":"crossref","unstructured":"Zhao, Y. and Q. Long, Variable Selection in the Presence of Missing Data: Imputation-based Methods. Wiley Interdiscip Rev Comput Stat, 2017. 9(5).","DOI":"10.1002\/wics.1402"},{"issue":"1","key":"1779_CR41","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1097\/EDE.0b013e3181c30fb2","volume":"21","author":"EW Steyerberg","year":"2010","unstructured":"Steyerberg, E.W., et al., Assessing the performance of prediction models: a framework for traditional and novel measures. Epidemiology, 2010. 21(1): p. 128-38.","journal-title":"Epidemiology"},{"issue":"1","key":"1779_CR42","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1373\/clinchem.2007.096529","volume":"54","author":"NR Cook","year":"2008","unstructured":"Cook, N.R., Statistical evaluation of prognostic versus diagnostic models: beyond the ROC curve. Clin Chem, 2008. 54(1): p. 17-23.","journal-title":"Clin Chem"},{"issue":"1","key":"1779_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1213\/ANE.0000000000002799","volume":"127","author":"RE Freundlich","year":"2018","unstructured":"Freundlich, R.E., et al., Complications Associated With Mortality in the National Surgical Quality Improvement Program Database. Anesth Analg, 2018. 127(1): p. 55-62.","journal-title":"Anesth Analg"},{"issue":"3","key":"1779_CR44","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/ejcn.2015.196","volume":"70","author":"M Naseer","year":"2016","unstructured":"Naseer, M., H. Forssell, and C. Fagerstr\u00f6m, Malnutrition, functional ability and mortality among older people aged \u2a7e 60 years: a 7-year longitudinal study. Eur J Clin Nutr, 2016. 70(3): p. 399-404.","journal-title":"Eur J Clin Nutr"},{"issue":"7s","key":"1779_CR45","doi-asserted-by":"publisher","first-page":"S348","DOI":"10.1016\/j.arth.2018.12.037","volume":"34","author":"GL Curtis","year":"2019","unstructured":"Curtis, G.L., et al., Dependent Functional Status is a Risk Factor for Perioperative and Postoperative Complications After Total Hip Arthroplasty. J Arthroplasty, 2019. 34(7s): p. S348-s351.","journal-title":"J Arthroplasty"},{"key":"1779_CR46","doi-asserted-by":"crossref","unstructured":"Minhas, S.V., A.S. Mazmudar, and A.A. Patel, Pre-operative functional status as a predictor of morbidity and mortality after elective cervical spine surgery. Bone Joint J, 2017. 99-b(6): p. 824\u2013828.","DOI":"10.1302\/0301-620X.99B6.BJJ-2016-1149.R1"},{"issue":"4","key":"1779_CR47","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/cts.12178","volume":"7","author":"RM Kaplan","year":"2014","unstructured":"Kaplan, R.M., D.A. Chambers, and R.E. Glasgow, Big data and large sample size: a cautionary note on the potential for bias. Clin Transl Sci, 2014. 7(4): p. 342-6.","journal-title":"Clin Transl Sci"}],"container-title":["Journal of Medical Systems"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-021-01779-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10916-021-01779-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10916-021-01779-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T23:58:07Z","timestamp":1726185487000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10916-021-01779-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["1779"],"URL":"https:\/\/doi.org\/10.1007\/s10916-021-01779-8","relation":{},"ISSN":["0148-5598","1573-689X"],"issn-type":[{"value":"0148-5598","type":"print"},{"value":"1573-689X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,25]]},"assertion":[{"value":"28 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Robert Freundlich has stock in Pfizer, 3\u00a0M, Johnson and Johnson, and Gilead Pharmaceuticals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"6"}}