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These models offer intriguing opportunities for novel approaches in healthcare, such as disease phenotyping, risk prediction, and personalized precision care. The combination of data and information in a graph model to create knowledge graphs has rapidly expanded in biomedical research, but the integration of real-world data from the electronic health record has been limited. To broadly apply knowledge graphs to EHR and other real-world data, a deeper understanding of how to represent these data in a standardized graph model is needed. We provide an overview of the state-of-the-art research for clinical and biomedical data integration and summarize the potential to accelerate healthcare and precision medicine research through insight generation from integrated knowledge graphs.<\/jats:p>","DOI":"10.1007\/s10916-023-01951-2","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T08:04:35Z","timestamp":1684310675000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["From Data to Wisdom: Biomedical Knowledge Graphs for Real-World Data Insights"],"prefix":"10.1007","volume":"47","author":[{"given":"Katrin","family":"H\u00e4nsel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah N.","family":"Dudgeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei-Hoi","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J. 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S.N.D. reports no competing financial or non-financial interests. K-H.C. reports no competing financial or non-financial interests. T.J.S.D. was a consultant for Roche, a diagnostics company (fees); was a consultant for Instrumentation Laboratories, a diagnostics company (fees). W.L.S. was a technical consultant to HugoHealth, a personal health information platform (equity, fees); is a cofounder of Refactor Health, an AI-augmented data management platform for healthcare (equity); was a consultant for Abbott, a diagnostics company (fees); received a speaker honorarium from Instrumentation Laboratories, a diagnostics company.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"65"}}