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Artificial Intelligence and simulation techniques can complement such an educational practice. In this paper, we present GLARE-Edu, an innovative system in which AI knowledge-based methodologies and simulation are exploited to train learners \u201chow to act\u201d on patients based on the evidence-based best practices provided by clinical practice guidelines. GLARE-Edu is being developed by a multi-disciplinary team involving physicians and AI experts, within the AI-LEAP (LEArning Personalization of AI and with AI) Italian project. GLARE-Edu is domain-independent: it supports the acquisition of clinical guidelines and case studies in a computer format. Based on acquired guidelines (and case studies), it provides a series of educational facilities: (i) <jats:italic>navigation<\/jats:italic>, to navigate the structured representation of the guidelines provided by GLARE-Edu, (ii) <jats:italic>automated simulation<\/jats:italic>, to show learners how a guideline would suggest to act, step-by-step, on a specific case, and (iii) (self)<jats:italic>verification<\/jats:italic>, asking learners how they would treat a case, and comparing step-by-step the learner\u2019s proposal with the suggestions of the proper guideline. In this paper, we describe GLARE-Edu architecture and general features, and we demonstrate our approach through a concrete application to the melanoma guideline and we propose a preliminary evaluation.<\/jats:p>","DOI":"10.1007\/s10916-024-02139-y","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T06:26:52Z","timestamp":1736404012000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A Symbolic AI Approach to Medical Training"],"prefix":"10.1007","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-128X","authenticated-orcid":false,"given":"Alessio","family":"Bottrighi","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6843-3369","authenticated-orcid":false,"given":"Federica","family":"Grosso","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Ghiglione","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1904-7277","authenticated-orcid":false,"given":"Antonio","family":"Maconi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7626-1411","authenticated-orcid":false,"given":"Stefano","family":"Nera","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-5061","authenticated-orcid":false,"given":"Luca","family":"Piovesan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4617-4992","authenticated-orcid":false,"given":"Erica","family":"Raina","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2484-0963","authenticated-orcid":false,"given":"Annalisa","family":"Roveta","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9014-7537","authenticated-orcid":false,"given":"Paolo","family":"Terenziani","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,1,9]]},"reference":[{"key":"2139_CR1","doi-asserted-by":"publisher","DOI":"10.17226\/1626","volume-title":"Clinical Practice Guidelines: Directions for a New Program","author":"MJ Field","year":"1990","unstructured":"Field MJ, Lohr KN (1990) Clinical Practice Guidelines: Directions for a New Program. 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